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    Ttr transthyretin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24856, updated on 9-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Association between rat decompression sickness resistance, transthyretin single nucleotide polymorphism, and expression: A pilot study.

    Association between rat decompression sickness resistance, transthyretin single nucleotide polymorphism, and expression: A pilot study.
    Orsat J, Guernec A, Le Maréchal C, Pichereau V, Guerrero F., Free PMC Article

    08/22/2024
    A low amyloidogenic E61K transthyretin mutation may cause familial amyloid polyneuropathy.

    A low amyloidogenic E61K transthyretin mutation may cause familial amyloid polyneuropathy.
    Murakami T, Yokoyama T, Mizuguchi M, Toné S, Takaku S, Sango K, Nishimura H, Watabe K, Sunada Y.

    06/19/2021
    Data suggest that the mutated transthyretin (TTR) seems to have potential as biomarker for early detection of hepatocellular carcinoma (HCC).

    Novel mutations in transthyretin gene associated with hepatocellular carcinoma.
    P Katare D, Malik S, J Mani R, Ranjpour M, Jain SK.

    12/23/2017
    Serum transthyretin level dramatically decreased in animals displaying decompression sickness symptoms.

    Effect of simulated air dive and decompression sickness on the plasma proteome of rats.
    Lautridou J, Pichereau V, Artigaud S, Buzzacott P, Wang Q, Bernay B, Driad S, Mazur A, Lambrechts K, Théron M, Guerrero F.

    04/22/2017
    We conclude that stress upregulates TTR expression in choroid plexus.

    Stress and glucocorticoids increase transthyretin expression in rat choroid plexus via mineralocorticoid and glucocorticoid receptors.
    Martinho A, Gonçalves I, Costa M, Santos CR.

    01/12/2013
    Decreased trophoblast expression of retinol transport proteins suggest that nitrofen may interfere with the fetal retinol transport resulting in reduced pulmonary RBP and TTR levels and causing pulmonary hypoplasia in CDH.

    Nitrofen interferes with trophoblastic expression of retinol-binding protein and transthyretin during lung morphogenesis in the nitrofen-induced congenital diaphragmatic hernia model.
    Kutasy B, Gosemann JH, Doi T, Fujiwara N, Friedmacher F, Puri P.

    06/16/2012
    Data demonstrate that, in vitro and in vivo, transthyretin is up-regulated by progesterone, and suggest that this response is mediated through a progesterone receptor-mediated mechanism.

    Progesterone enhances transthyretin expression in the rat choroid plexus in vitro and in vivo via progesterone receptor.
    Quintela T, Gonçalves I, Martinho A, Alves CH, Saraiva MJ, Rocha P, Santos CR.

    10/22/2011
    rat and murine TTR have a lower intrinsic beta-aggregation propensity and a similar native beta-structure stability compared with human TTR.

    Amyloidogenic potential of transthyretin variants: insights from structural and computational analyses.
    Cendron L, Trovato A, Seno F, Folli C, Alfieri B, Zanotti G, Berni R., Free PMC Article

    01/21/2010
    Results suggest that transthyretin is up-regulated by estradiol via a pathway involving estrogen receptors alpha and beta.

    17beta-estradiol induces transthyretin expression in murine choroid plexus via an oestrogen receptor dependent pathway.
    Quintela T, Gonçalves I, Baltazar G, Alves CH, Saraiva MJ, Santos CR.

    01/21/2010
    The expression of transthyretin in brain of a transgenic mouse model of Alzheimer's disease is asymmetric and affected by age and sex.

    Asymmetric expression patterns of brain transthyretin in normal mice and a transgenic mouse model of Alzheimer's disease.
    Tsai KJ, Yang CH, Lee PC, Wang WT, Chiu MJ, Shen CK.

    01/21/2010
    Transthyretin is expressed in the pineal gland >30-fold higher than the median expression level in other tissues, at levels similar to those in the choroid plexus.

    Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.
    Bailey MJ, Coon SL, Carter DA, Humphries A, Kim JS, Shi Q, Gaildrat P, Morin F, Ganguly S, Hogenesch JB, Weller JL, Rath MF, Møller M, Baler R, Sugden D, Rangel ZG, Munson PJ, Klein DC., Free PMC Article

    02/24/2009
    Our study provides genetic, behavioural and molecular evidence that TTR is involved in the maintenance of normal cognitive processes during aging by acting on the retinoid signalling pathway.

    Transthyretin: a key gene involved in the maintenance of memory capacities during aging.
    Brouillette J, Quirion R.

    01/21/2010
    Sex hormones may increase TTR synthesis by the liver, and therefore, may contribute to amyloid deposition.

    Transthyretin is up-regulated by sex hormones in mice liver.
    Gonçalves I, Alves CH, Quintela T, Baltazar G, Socorro S, Saraiva MJ, Abreu R, Santos CR.

    01/21/2010
    Ttr mRNA expression in dorsal root ganglia and cauda equina.

    The transthyretin gene is expressed in human and rodent dorsal root ganglia.
    Murakami T, Ohsawa Y, Sunada Y.

    01/21/2010
    Amyloid formation in rat transthyretin: effect of oxidative stress

    Amyloid formation in rat transthyretin: effect of oxidative stress.
    Tajiri T, Ando Y, Hata K, Kamide K, Hashimoto M, Nakamura M, Terazaki H, Yamashita T, Kai H, Haraoka K, Imasato A, Takechi K, Nakagawa K, Okabe H, Ishizaki T.

    01/21/2010
    Data suggest that monomeric transthyretin may represent an ischemia-specific CSF marker to indicate the sequential changes according to ischemic insults of the brain.

    Combined proteomic approach with SELDI-TOF-MS and peptide mass fingerprinting identified the rapid increase of monomeric transthyretin in rat cerebrospinal fluid after transient focal cerebral ischemia.
    Suzuyama K, Shiraishi T, Oishi T, Ueda S, Okamoto H, Furuta M, Mineta T, Tabuchi K.

    01/21/2010
    Comparison of binding interactions of dibromoflavonoids with transthyretin

    Comparison of binding interactions of dibromoflavonoids with transthyretin.
    Muzioł T, Cody V, Wojtczak A.

    01/21/2010
    Complex of rat transthyretin with tetraiodothyroacetic acid refined at 2.1 and 1.8 A resolution

    Complex of rat transthyretin with tetraiodothyroacetic acid refined at 2.1 and 1.8 A resolution.
    Muzioł T, Cody V, Luft JR, Pangborn W, Wojtczak A.

    01/21/2010
    Structural basis of negative cooperativity in transthyretin

    Structural basis of negative cooperativity in transthyretin.
    Neumann P, Cody V, Wojtczak A.

    01/21/2010
    data show the LR1 gene is up-regulated following short interval successive partial hepatectomy; it may play an important role in liver regeneration

    Cloning and analysing the up-regulated expression of transthyretin-related gene (LR1) in rat liver regeneration following short interval successive partial hepatectomy.
    Xu CS, Li YC, Lin JT, Zhang HY, Zhang YH., Free PMC Article

    01/21/2010
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