| BCL-XL Overexpression Protects Pancreatic beta-Cells against Cytokine- and Palmitate-Induced Apoptosis. | BCL-XL Overexpression Protects Pancreatic β-Cells against Cytokine- and Palmitate-Induced Apoptosis.
Perez-Serna AA, Dos Santos RS, Ripoll C, Nadal A, Eizirik DL, Marroqui L., Free PMC Article | 03/31/2023 |
| Pharmacological preconditioning protects from ischemia/reperfusion-induced apoptosis by modulating Bcl-xL expression through a ROS-dependent mechanism. | Pharmacological preconditioning protects from ischemia/reperfusion-induced apoptosis by modulating Bcl-xL expression through a ROS-dependent mechanism.
Rozier R, Paul R, Madji Hounoum B, Villa E, Mhaidly R, Chiche J, Verhoeyen E, Marchetti S, Vandenberghe A, Raucoules M, Carles M, Ricci JE. | 07/24/2021 |
| evidence that impaired expression of CK2 results in destabilization of the Bcl-2 mammalian homolog Bcl-xL, which is known to stabilize the mitochondrial membrane potential, through a mechanism involving disruption of the chaperone function of heat shock protein 90. | Protein kinase CK2 regulates redox homeostasis through NF-κB and Bcl-xL in cardiomyoblasts.
Schaefer S, Guerra B. | 06/2/2018 |
| our results showed that the expression of platelet-derived miR-142-3p and the apoptosis were both significantly increased in ECs during hypertension. The present results suggested that platelet-derived miR-142-3p is delivered into ECs via PMPs, and may modulate the expression of target molecule- BCL2L1, which may subsequently display a negative function by modulating EC apoptosis in hypertension. | Platelet-derived miR-142-3p induces apoptosis of endothelial cells in hypertension.
Bao H, Yao QP, Huang K, Chen XH, Han Y, Jiang ZL, Gao LZ, Qi YX. | 02/17/2018 |
| PGAM5 controls cardiomyocyte apoptosis induced by MIRI through regulating Keap1-mediated Bcl-xL degradation, which may supply a novel molecular target for acute myocardial infarction (AMI) therapy. | Mitochondrial phosphatase PGAM5 regulates Keap1-mediated Bcl-xL degradation and controls cardiomyocyte apoptosis driven by myocardial ischemia/reperfusion injury.
Yang C, Liu X, Yang F, Zhang W, Chen Z, Yan D, You Q, Wu X. | 04/1/2017 |
| the expression of the genes that encode main pro- and antiapoptotic BAX and BCL-XL proteins, as well as caspase 3 (the main effector of apoptosis), in different brain structures of rats that were selected on a high aggression towards human (or its absence) was studied. | [Expression of apoptosis genes in the brain of rats with genetically defined fear-induced aggression].
Ilchibaeva TV, Tsybko AS, Kozhemyakina RV, Naumenko VS. | 03/25/2017 |
| The activation of Bcl-xL expression in the hippocampus by lithium, demonstrated for the first time in this study, suggests an important role of this protein in the therapeutic effects of lithium in the treatment of stress-induced psychoemotional disorders. | Effects of Short-Term Exposure to Lithium on Antiapoptotic Bcl-xL Protein Expression in Cortex and Hippocampus of Rats after Acute Stress.
Dygalo NN, Bannova AV, Sukhareva EV, Shishkina GT, Ayriyants KA, Kalinina TS. | 03/25/2017 |
| The dependence of the level of expression of Bcl-xL protein on the activity of neurons indicates that this protein possesses one more important property that is essential for participation in neuroplastic processes in the brain. | Optogenetic Stimulation Increases Level of Antiapoptotic Protein Bcl-xL in Neurons.
Lanshakov DA, Drozd US, Dygalo NN. | 03/25/2017 |
| miR-665 is involved in the neurotoxicity induced by propofol via a caspase-3 mediated mechanism by negatively regulating bcl-2-like protein 1. | Propofol-induced rno-miR-665 targets BCL2L1 and influences apoptosis in rodent developing hippocampal astrocytes.
Sun WC, Liang ZD, Pei L. | 10/22/2016 |
| Bcl-xL regulates neuronal outgrowth during development and protects neurites from hypoxic insult, as opposed by DR6. | Bcl-xL is necessary for neurite outgrowth in hippocampal neurons.
Park HA, Licznerski P, Alavian KN, Shanabrough M, Jonas EA., Free PMC Article | 09/26/2015 |
| cyclin B1-Cdk1 complex in the mitochondria phosphorylates the anti-apoptotic protein B-cell lymphoma extra-large | Regulation of Bcl-xL-ATP Synthase Interaction by Mitochondrial Cyclin B1-Cyclin-Dependent Kinase-1 Determines Neuronal Survival.
Veas-Pérez de Tudela M, Delgado-Esteban M, Maestre C, Bobo-Jiménez V, Jiménez-Blasco D, Vecino R, Bolaños JP, Almeida A., Free PMC Article | 09/12/2015 |
| data indicate that the BH4 domain of Bcl-XL, but not that of Bcl-2, selectively targets VDAC1 and inhibits apoptosis by decreasing VDAC1-mediated Ca(2+) uptake into the mitochondria | The BH4 domain of anti-apoptotic Bcl-XL, but not that of the related Bcl-2, limits the voltage-dependent anion channel 1 (VDAC1)-mediated transfer of pro-apoptotic Ca2+ signals to mitochondria.
Monaco G, Decrock E, Arbel N, van Vliet AR, La Rovere RM, De Smedt H, Parys JB, Agostinis P, Leybaert L, Shoshan-Barmatz V, Bultynck G., Free PMC Article | 06/20/2015 |
| The ratio of Bax/Bcl-2 and Bax/Bcl-xL decreased significantly in diabetic animals treated with aminoguanidine. | Aminoguanidine changes hippocampal expression of apoptosis-related genes, improves passive avoidance learning and memory in streptozotocin-induced diabetic rats.
Firouzjaei MA, Jafari MR, Eskandari M, Anarkoli IJ, Alipour M. | 02/14/2015 |
| Prohibitin inhibits apoptosis in granulosa cells through the ERK1/2 pathway and the Bcl2 and Bcl-xL. | Prohibitin (PHB) inhibits apoptosis in rat granulosa cells (GCs) through the extracellular signal-regulated kinase 1/2 (ERK1/2) and the Bcl family of proteins.
Chowdhury I, Thompson WE, Welch C, Thomas K, Matthews R., Free PMC Article | 07/19/2014 |
| down-regulation of miR-98 in rat uterus during the receptive phase is linked to the increase of cell proliferation via targeting Bcl-xl | MiR-98 is involved in rat embryo implantation by targeting Bcl-xl.
Xia HF, Jin XH, Cao ZF, Shi T, Ma X. | 04/5/2014 |
| Our results have demonstrated the protective effects of recombinant Bcl-xL protein against TNF-alpha-induced endothelial cell adherens junction damage and microvascular endothelial cell hyperpermeability. | Regulation of tumor necrosis factor-α-induced microvascular endothelial cell hyperpermeability by recombinant B-cell lymphoma-extra large.
Sawant DA, Tharakan B, Wilson RL, Stagg HW, Hunter FA, Childs EW., Free PMC Article | 11/16/2013 |
| Ginkgo biloba and Angelica archangelica bring back an impartial hepatic bcl-X protein to TP53 protein ratio after exposure to technetium 99mTc. | Ginkgo biloba and Angelica archangelica bring back an impartial hepatic apoptotic to anti-apoptotic protein ratio after exposure to technetium 99mTc.
Raafat BM, Saleh A, Shafaa MW, Khedr M, Ghafaar AA. | 07/13/2013 |
| Data suggest that expression of Bcl-xL in distal colonic mucosa can be up-regulated by dietary fiber (here, by a grape antioxidant dietary fiber preparation). | Grape antioxidant dietary fibre prevents mitochondrial apoptotic pathways by enhancing Bcl-2 and Bcl-xL expression and minimising oxidative stress in rat distal colonic mucosa.
López-Oliva ME, Pozuelo MJ, Rotger R, Muñoz-Martínez E, Goñi I. | 03/2/2013 |
| This study suggested that alternative splicing of bcl-x may be an important regulatory mechanism for apoptosis after acute neurological injury, and that splicing regulators may be potential targets for attenuating CNS injury. | Bcl-x pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia.
Xiao Q, Ford AL, Xu J, Yan P, Lee KY, Gonzales E, West T, Holtzman DM, Lee JM., Free PMC Article | 12/22/2012 |
| Estrogen treatment up regulated the expression Bcl-x(L) and Bcl-2. | The effect of estrogen on bone marrow-derived rat mesenchymal stem cell maintenance: inhibiting apoptosis through the expression of Bcl-xL and Bcl-2.
Ayaloglu-Butun F, Terzioglu-Kara E, Tokcaer-Keskin Z, Akcali KC. | 09/22/2012 |
| The data of this study showed that long-term fluoxetine treatment leads to changes in 5-HT and Bcl-xL responses to stress associated with antidepressant-like effects of the drug. | Stress-induced activation of the brainstem Bcl-xL gene expression in rats treated with fluoxetine: correlations with serotonin metabolism and depressive-like behavior.
Shishkina GT, Kalinina TS, Berezova IV, Dygalo NN. | 08/18/2012 |
| ER retention of p75NTR resulted in downregulation of mRNA levels of the anti-apoptotic protein Bcl-xL as well as in strong inhibition of NGF-induced neurite outgrowth in PC12 cells. | Suppression of p75 neurotrophin receptor surface expression with intrabodies influences Bcl-xL mRNA expression and neurite outgrowth in PC12 cells.
Zhang C, Helmsing S, Zagrebelsky M, Schirrmann T, Marschall AL, Schüngel M, Korte M, Hust M, Dübel S., Free PMC Article | 06/9/2012 |
| Bcl-xL is prominently expressed in adult neurons and can be cleaved by caspases to generate a pro-death fragment, DeltaN-Bcl-x(L). | N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death.
Ofengeim D, Chen YB, Miyawaki T, Li H, Sacchetti S, Flannery RJ, Alavian KN, Pontarelli F, Roelofs BA, Hickman JA, Hardwick JM, Zukin RS, Jonas EA., Free PMC Article | 05/19/2012 |
| In chronic mild stress, downregulated Bcl-xl level is reversed in both hippocampus and myocardium by venlafaxine treatment. | Venlafaxine modulates depression-induced behaviour and the expression of Bax mRNA and Bcl-xl mRNA in both hippocampus and myocardium.
Wang Y, Xiao Z, Liu X, Berk M. | 03/31/2012 |
| Increased mitochondrial energy metabolism efficiency via F1F0 ATPase synthase beta subunit contributes to the enhanced synaptic efficacy found in Bcl-x(L)-expressing neurons. | Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase.
Alavian KN, Li H, Collis L, Bonanni L, Zeng L, Sacchetti S, Lazrove E, Nabili P, Flaherty B, Graham M, Chen Y, Messerli SM, Mariggio MA, Rahner C, McNay E, Shore GC, Smith PJ, Hardwick JM, Jonas EA., Free PMC Article | 12/10/2011 |