| Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos. | Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos.
Li L, Lai F, Liu L, Lu X, Hu X, Liu B, Lin Z, Fan Q, Kong F, Xu Q, Xie W. | 06/24/2024 |
| Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by DNA minor groove anchor competition. | Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by DNA minor groove anchor competition.
Kobayashi W, Sappler AH, Bollschweiler D, Kümmecke M, Basquin J, Arslantas EN, Ruangroengkulrith S, Hornberger R, Duderstadt K, Tachibana K., Free PMC Article | 06/5/2024 |
| Aberrant phosphorylation of human LRH1 at serine 510 is predictable of hepatocellular carcinoma recurrence. | Aberrant phosphorylation of human LRH1 at serine 510 is predictable of hepatocellular carcinoma recurrence.
Nishimagi A, Kobayashi M, Sugimoto K, Kofunato Y, Sato N, Haga J, Ishigame T, Kimura T, Kenjo A, Kobayashi Y, Hashimoto Y, Marubashi S, Chiba H., Free PMC Article | 12/22/2023 |
| Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia. | Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia.
Zapata RC, Zhang D, Libster A, Porcu A, Montilla-Perez P, Nur A, Xu B, Zhang Z, Correa SM, Liu C, Telese F, Osborn O., Free PMC Article | 11/16/2023 |
| MicroRNA-433-3p enhances chemosensitivity of glioma to cisplatin by downregulating NR5A2. | MicroRNA-433-3p enhances chemosensitivity of glioma to cisplatin by downregulating NR5A2.
Li J, Gu J, Wang J, You A, Zhang Y, Rao G, Li S, Ge X, Zhang K, Wang D., Free PMC Article | 12/31/2022 |
| LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance. | LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance.
Michalek S, Goj T, Plazzo AP, Marovca B, Bornhauser B, Brunner T., Free PMC Article | 09/17/2022 |
| Nuclear receptor subfamily 5 group A member 2 (NR5A2): role in health and diseases. | Nuclear receptor subfamily 5 group A member 2 (NR5A2): role in health and diseases.
Sandhu N, Rana S, Meena K. | 03/5/2022 |
| Nuclear-mitochondrial crosstalk: On the role of the nuclear receptor liver receptor homolog-1 (NR5A2) in the regulation of mitochondrial metabolism, cell survival, and cancer. | Nuclear-mitochondrial crosstalk: On the role of the nuclear receptor liver receptor homolog-1 (NR5A2) in the regulation of mitochondrial metabolism, cell survival, and cancer.
Michalek S, Brunner T. | 01/29/2022 |
| NF-kappaB Regulation of LRH-1 and ABCG5/8 Potentiates Phytosterol Role in the Pathogenesis of Parenteral Nutrition-Associated Cholestasis. | NF-κB Regulation of LRH-1 and ABCG5/8 Potentiates Phytosterol Role in the Pathogenesis of Parenteral Nutrition-Associated Cholestasis.
Ghosh S, Devereaux MW, Anderson AL, Gehrke S, Reisz JA, D'Alessandro A, Orlicky DJ, Lovell M, El Kasmi KC, Shearn CT, Sokol RJ., Free PMC Article | 01/22/2022 |
| Nuclear receptor NR5A2 negatively regulates cell proliferation and tumor growth in nervous system malignancies. | Nuclear receptor NR5A2 negatively regulates cell proliferation and tumor growth in nervous system malignancies.
Gkikas D, Stellas D, Polissidis A, Manolakou T, Kokotou MG, Kokotos G, Politis PK., Free PMC Article | 12/18/2021 |
| LRH-1 high expression in the ovarian granulosa cells of PCOS patients. | LRH-1 high expression in the ovarian granulosa cells of PCOS patients.
Yang X, Wang Q, Wang Y, Song T, Zheng Y, Wang W, Shi Y. | 10/30/2021 |
| GATA6 enhances the stemness of human colon cancer cells by creating a metabolic symbiosis through upregulating LRH-1 expression. | GATA6 enhances the stemness of human colon cancer cells by creating a metabolic symbiosis through upregulating LRH-1 expression.
Lai HT, Chiang CT, Tseng WK, Chao TC, Su Y., Free PMC Article | 07/3/2021 |
| Epithelial Nr5a2 heterozygosity cooperates with mutant Kras in the development of pancreatic cystic lesions. | Epithelial Nr5a2 heterozygosity cooperates with mutant Kras in the development of pancreatic cystic lesions.
Cobo I, Iglesias M, Flández M, Verbeke C, Del Pozo N, Llorente M, Lawlor R, Luchini C, Rusev B, Scarpa A, Real FX. | 06/12/2021 |
| Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist. | Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist.
Mays SG, Stec J, Liu X, D'Agostino EH, Whitby RJ, Ortlund EA., Free PMC Article | 05/8/2021 |
| Temporal activation of LRH-1 and RAR-gamma in human pluripotent stem cells induces a functional naive-like state. | Temporal activation of LRH-1 and RAR-γ in human pluripotent stem cells induces a functional naïve-like state.
Taei A, Kiani T, Taghizadeh Z, Moradi S, Samadian A, Mollamohammadi S, Sharifi-Zarchi A, Guenther S, Akhlaghpour A, Asgari Abibeiglou B, Najar-Asl M, Karamzadeh R, Khalooghi K, Braun T, Hassani SN, Baharvand H., Free PMC Article | 05/8/2021 |
| Impact of NR5A2 and RYR2 3'UTR polymorphisms on the risk of breast cancer in a Chinese Han population. | Impact of NR5A2 and RYR2 3'UTR polymorphisms on the risk of breast cancer in a Chinese Han population.
Wei Y, Wang X, Zhang Z, Zhao C, Chang Y, Bian Z, Zhao X. | 02/13/2021 |
| Regulation of liver receptor homologue-1 by DDB2 E3 ligase activity is critical for hepatic glucose metabolism. | Regulation of liver receptor homologue-1 by DDB2 E3 ligase activity is critical for hepatic glucose metabolism.
Lai TC, Hu MC., Free PMC Article | 10/3/2020 |
| This study describes a novel and critical role of LRH-1 in T cell maturation, functions, and immopathologies and proposes LRH-1 as an emerging pharmacological target in the treatment of T cell-mediated inflammatory diseases. | The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cell functions.
Seitz C, Huang J, Geiselhöringer AL, Galbani-Bianchi P, Michalek S, Phan TS, Reinhold C, Dietrich L, Schmidt C, Corazza N, Delgado E, Schnalzger T, Schoonjans K, Brunner T., Free PMC Article | 05/9/2020 |
| we have provided convincing evidence in vitro and in vivo demonstrating that Nr5a2 can induce lung CSC properties and promote tumorigenesis and progression through transcriptional up-regulation of Nanog. | Nr5a2 promotes cancer stem cell properties and tumorigenesis in nonsmall cell lung cancer by regulating Nanog.
Ye T, Li J, Sun Z, Liu Y, Kong L, Zhou S, Tang J, Wang J, Xing HR., Free PMC Article | 04/18/2020 |
| LRH-1-deficient adult mice fed high-fat diet displayed macrovesicular steatosis, liver injury, and glucose intolerance, all of which were reversed or improved by expressing wild-type human LRH-1. Results suggest that LRH-1 maintains the pool of arachidonoyl phospholipids, thus ensuring phospholipid diversity and normal lipid homeostasis in the adult liver. | LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity.
Miranda DA, Krause WC, Cazenave-Gassiot A, Suzawa M, Escusa H, Foo JC, Shihadih DS, Stahl A, Fitch M, Nyangau E, Hellerstein M, Wenk MR, Silver DL, Ingraham HA., Free PMC Article | 12/7/2019 |
| Using the cells derived from the model, novel SF-1/Ad4BP- and LRH-1-regulated genes were identified by combined DNA microarray and promoter tiling array analyses. The interaction of SF-1/Ad4BP and LRH-1 with transcriptional regulators in the regulation of ovarian steroidogenesis was also revealed. | Transcriptional Regulation of Ovarian Steroidogenic Genes: Recent Findings Obtained from Stem Cell-Derived Steroidogenic Cells.
Yazawa T, Imamichi Y, Sekiguchi T, Miyamoto K, Uwada J, Khan MRI, Suzuki N, Umezawa A, Taniguchi T., Free PMC Article | 08/31/2019 |
| The results of our study indicate that LRH1 predicts NSCLC progression, metastasis, and a dismal prognosis, emphasizing its promising role as a novel target in NSCLC therapies. | LRH1 as a promising prognostic biomarker and predictor of metastasis in patients with non-small cell lung cancer.
Liu Y, Xing Y, Wang H, Yan S, Wang X, Cai L., Free PMC Article | 08/17/2019 |
| study identified LRH1-driven pathway as a circuitry responsible for hepatocyte identity by using cistromic analysis, improving our understanding of liver pathophysiology and identifying novel therapeutic targets. | LRH1-driven transcription factor circuitry for hepatocyte identity: Super-enhancer cistromic analysis.
Joo MS, Koo JH, Kim TH, Kim YS, Kim SG., Free PMC Article | 06/29/2019 |
| These findings not only demonstrate the significant role of the nuclear receptor LRH-1 in the promotion of intratumoral androgen biosynthesis in castration-resistant prostate cancer (CRPC) via its direct transcriptional control of steroidogenesis, but also suggest targeting LRH-1 could be a potential therapeutic strategy for CRPC management. | Nuclear Receptor LRH-1 Functions to Promote Castration-Resistant Growth of Prostate Cancer via Its Promotion of Intratumoral Androgen Biosynthesis.
Xiao L, Wang Y, Xu K, Hu H, Xu Z, Wu D, Wang Z, You W, Ng CF, Yu S, Chan FL. | 05/18/2019 |
| rs2816948 not significantly associated with recurrent abortions | Association between LRH-1 single nucleotide polymorphisms and unexplained recurrent spontaneous abortion in Chinese Han couples.
Xu Z, Qu C, Li H, Yao L, Zhou Y, Liu L, Xu M, Qin Y. | 03/30/2019 |