| LncRNA HOTAIRM1 Involved in Nano NiO-Induced Pulmonary Fibrosis via Regulating PRKCB DNA Methylation-Mediated JNK/c-Jun Pathway. | LncRNA HOTAIRM1 Involved in Nano NiO-Induced Pulmonary Fibrosis via Regulating PRKCB DNA Methylation-Mediated JNK/c-Jun Pathway.
Zheng J, Wang J, Qin X, Li K, Gao Q, Yang M, Liu H, Li S, Chang X, Sun Y. | 01/28/2023 |
| The Mfn1-betaIIPKC Interaction Regulates Mitochondrial Dysfunction via Sirt3 Following Experimental Subarachnoid Hemorrhage. | The Mfn1-βIIPKC Interaction Regulates Mitochondrial Dysfunction via Sirt3 Following Experimental Subarachnoid Hemorrhage.
Chen T, Wang Y, Wang YH, Hang CH. | 08/27/2022 |
| Prenatal hypoxia attenuated contraction of offspring coronary artery associated with decreased PKCbeta Ser(660) phosphorylation and intracellular calcium. | Prenatal hypoxia attenuated contraction of offspring coronary artery associated with decreased PKCβ Ser(660) phosphorylation and intracellular calcium.
Chen X, Qi L, Su H, He Y, Li N, Gao Q, Li H, Xu T, Lu L, Xu Z, Tang J. | 11/28/2020 |
| Intermittent Hypoxia Augments Pulmonary Vasoconstrictor Reactivity through PKCbeta/Mitochondrial Oxidant Signaling. | Intermittent Hypoxia Augments Pulmonary Vasoconstrictor Reactivity through PKCβ/Mitochondrial Oxidant Signaling.
Snow JB, Norton CE, Sands MA, Weise-Cross L, Yan S, Herbert LM, Sheak JR, Gonzalez Bosc LV, Walker BR, Kanagy NL, Jernigan NL, Resta TC., Free PMC Article | 10/24/2020 |
| FBXL10 regulates cardiac dysfunction in diabetic cardiomyopathy via the PKC beta2 pathway. | FBXL10 regulates cardiac dysfunction in diabetic cardiomyopathy via the PKC β2 pathway.
Yin L, Fang Y, Song T, Lv D, Wang Z, Zhu L, Zhao Z, Yin X., Free PMC Article | 07/18/2020 |
| data suggest that TRB3 mediates AGE-induced oxidative injury in beta-cells through the PKCbeta2 pathway. | TRB3 mediates advanced glycation end product-induced apoptosis of pancreatic β-cells through the protein kinase C β pathway.
Wang M, Zhang W, Xu S, Peng L, Wang Z, Liu H, Fang Q, Deng T, Men X, Lou J., Free PMC Article | 03/17/2018 |
| The authors took a proteomics approach using a PKCB knockout mast cell model and found that the key mast cell secretory protein VAMP8 becomes phosphorylated by PKC at multiple residues in the SNARE domain. | Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion.
Malmersjö S, Di Palma S, Diao J, Lai Y, Pfuetzner RA, Wang AL, McMahon MA, Hayer A, Porteus M, Bodenmiller B, Brunger AT, Meyer T., Free PMC Article | 07/1/2017 |
| Our results provide compelling evidence that glucose-induced PKCalpha/PKCbeta-mediated inhibition of Kv current in vascular smooth muscle causes an enhanced constrictor response. Inhibition of Kv current causes a significant depolarization of vascular myocytes leading to marked vasoconstriction | Distinct and complementary roles for α and β isoenzymes of PKC in mediating vasoconstrictor responses to acutely elevated glucose.
Jackson R, Brennan S, Fielding P, Sims MW, Challiss RA, Adlam D, Squire IB, Rainbow RD., Free PMC Article | 12/17/2016 |
| reduced GLP-1R expression in spontaneously hypertensive rat renal arteries most likely mediated through PKCbeta upregulation | Protein kinase Cβ mediates downregulated expression of glucagon-like peptide-1 receptor in hypertensive rat renal arteries.
Liu L, Liu J, Gao Y, Ng CF, Yu X, Dou D, Huang Y. | 04/16/2016 |
| PRKCBII and PRKCD-dependent inactivation of p38 regulates cardiac fibroblast proliferation and collagen deposition in response to angiotensin II. | PKC δ and βII regulate angiotensin II-mediated fibrosis through p38: a mechanism of RV fibrosis in pulmonary hypertension.
Chichger H, Vang A, O'Connell KA, Zhang P, Mende U, Harrington EO, Choudhary G., Free PMC Article | 01/2/2016 |
| PKCbeta2 inhibition protects diabetic hearts from myocardial ischemia/reperfusion injury through Cav-3-dependent activation of Akt. | Inhibition of PKCβ2 overexpression ameliorates myocardial ischaemia/reperfusion injury in diabetic rats via restoring caveolin-3/Akt signaling.
Liu Y, Jin J, Qiao S, Lei S, Liao S, Ge ZD, Li H, Wong GT, Irwin MG, Xia Z. | 08/8/2015 |
| Urotensin-II potentiates ICa,L through the beta-gamma subunits of Gi/o-protein and downstream activation of the class I PI3K-dependent PKCB1 isoform. | Urotensin-II receptor stimulation of cardiac L-type Ca2+ channels requires the βγ subunits of Gi/o-protein and phosphatidylinositol 3-kinase-dependent protein kinase C β1 isoform.
Zhang Y, Ying J, Jiang D, Chang Z, Li H, Zhang G, Gong S, Jiang X, Tao J., Free PMC Article | 06/6/2015 |
| Over-activation of ROCK2 contributes to diabetic cardiomyopathy by multiple mechanisms, including direct phosphorylation and activation of protein kinase C beta II and interference with the PDK-1-mediated phosphorylation and activation of AKT. | Complex regulation of PKCβ2 and PDK-1/AKT by ROCK2 in diabetic heart.
Lin G, Brownsey RW, Macleod KM., Free PMC Article | 01/31/2015 |
| Conventional protein kinase C alpha and beta isozymes modulate LPA1 receptor phosphorylation state. | Conventional protein kinase C isoforms mediate phorbol ester-induced lysophosphatidic acid LPA1 receptor phosphorylation.
Hernández-Méndez A, Alcántara-Hernández R, Acosta-Cervantes GC, Martínez-Ortiz J, Avendaño-Vázquez SE, García-Sáinz JA. | 10/11/2014 |
| these data indicate a role of PKCbetaII in advanced glycation endproduct accumulation-induced myopathic changes in rat cardiomyocytes | Inhibition of protein kinase C βII isoform ameliorates methylglyoxal advanced glycation endproduct-induced cardiomyocyte contractile dysfunction.
Zhang L, Huang D, Shen D, Zhang C, Ma Y, Babcock SA, Chen B, Ren J. | 02/22/2014 |
| Identified a set of 22 alternative splicing events that undergo a developmental switch in splicing, and we confirmed that splicing reverts to an embryonic pattern in adult diabetic hearts. PKC isozymes alpha/beta control alternative splicing of these genes. | Reactivation of fetal splicing programs in diabetic hearts is mediated by protein kinase C signaling.
Verma SK, Deshmukh V, Liu P, Nutter CA, Espejo R, Hung ML, Wang GS, Yeo GW, Kuyumcu-Martinez MN., Free PMC Article | 02/15/2014 |
| The study identified the serine phosphorylation (p-Ser) sites induced by PKC-Beta activation or AngII, which inhibits insulin-induced p-Tyr sites on IRS2 and its signals in endothelial cells. | Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells.
Park K, Li Q, Rask-Madsen C, Mima A, Mizutani K, Winnay J, Maeda Y, D'Aquino K, White MF, Feener EP, King GL., Free PMC Article | 10/26/2013 |
| iNOS expression is highly modulated in alveolar epithelial cells by LPS via a Ca(2)/PKCalpha-beta1 pathway independent of ATP signaling. | Induction of nitric oxide synthase expression by lipopolysaccharide is mediated by calcium-dependent PKCα-β1 in alveolar epithelial cells.
Boncoeur É, Bouvet GF, Migneault F, Tardif V, Ferraro P, Radzioch D, de Sanctis JB, Eidelman D, Govindaraju K, Dagenais A, Berthiaume Y. | 09/28/2013 |
| In the kidneys of bile duct ligated rats melatonin inhibits protein kinase C beta to reduce p47phox superoxide production. | Melatonin regulates L-arginine transport and NADPH oxidase in young rats with bile duct ligation: role of protein kinase C.
Tain YL, Chen CC, Lee CT, Kao YH, Sheen JM, Yu HR, Huang LT. | 09/21/2013 |
| Antofine induces Cx43 gap junction disassembly by the PKCbeta signaling pathway in astrocytes. | Antofine-induced connexin43 gap junction disassembly in rat astrocytes involves protein kinase Cβ.
Huang YF, Liao CK, Lin JC, Jow GM, Wang HS, Wu JC. | 09/14/2013 |
| Exercise-induced benefits on diabetic myocardium are mediated by the modulation of molecules involved in PKC-betaII signaling. | Exercise-induced cardiac performance in autoimmune (type 1) diabetes is associated with a decrease in myocardial diacylglycerol.
Loganathan R, Novikova L, Boulatnikov IG, Smirnova IV., Free PMC Article | 07/13/2013 |
| EMAP-II induces blood tumor barrier opening via the RhoA/Rho kinase/PKC-alpha/beta signaling pathways, however, PKC-zeta is involved in this process by other mechanisms. | Signal mechanisms underlying low-dose endothelial monocyte-activating polypeptide-II-induced opening of the blood-tumor barrier.
Li Z, Liu YH, Xue YX, Liu LB, Wang P. | 01/12/2013 |
| In the diabetic heart, the RhoA/ROCK pathway contributes to contractile dysfunction at least in part by sustaining PKCbeta(2) activation and reactive oxygen species production via a positive feedback loop that requires an intact cytoskeleton. | Diabetes-induced increased oxidative stress in cardiomyocytes is sustained by a positive feedback loop involving Rho kinase and PKCβ2.
Soliman H, Gador A, Lu YH, Lin G, Bankar G, MacLeod KM., Free PMC Article | 12/29/2012 |
| Results provide evidence PKCbeta(II) modulates contractile function via intermediate downstream pathway(s) in cardiac myocytes. | PKCβII modulation of myocyte contractile performance.
Hwang H, Robinson DA, Stevenson TK, Wu HC, Kampert SE, Pagani FD, Dyke DB, Martin JL, Sadayappan S, Day SM, Westfall MV., Free PMC Article | 11/3/2012 |
| Data indicate PKCbetaII as a novel inhibitor of proteasomal function. | Protein quality control disruption by PKCβII in heart failure; rescue by the selective PKCβII inhibitor, βIIV5-3.
Ferreira JC, Boer BN, Grinberg M, Brum PC, Mochly-Rosen D., Free PMC Article | 09/1/2012 |