| The results demonstrated that the loss of estrogen elevated systolic blood pressure in ovariectomized (OVX) rats. OVX rat kidneys showed increased alpha-ENaC expression but decreased derlin-1 expression. | Estrogen negatively regulates the renal epithelial sodium channel (ENaC) by promoting Derlin-1 expression and AMPK activation.
Zhang X, Ge Y, Bukhari AA, Zhu Q, Shen Y, Li M, Sun H, Su D, Liang X., Free PMC Article | 06/20/2020 |
| Taken together, these findings indicate that the alphaENaC 3'UTR plays an important role in modulating transcript levels, and Dhx36 and Tial1 seem to be involved in posttranscriptional regulation of alphaENaC expression in alveolar epithelial cells. | Post-Transcriptional Modulation of aENaC mRNA in Alveolar Epithelial Cells: Involvement of its 3' Untranslated Region.
Migneault F, Gagnon F, Pascariu M, Laperle J, Roy A, Dagenais A, Berthiaume Y. | 05/4/2019 |
| Studied the effect and underlining mechanisms of MaR1(maresin 1) in modulating alveolar fluid clearance on LPS-induced acute lung injury; found MaR1 improved epithelial sodium channel (ENaC) and Na,K-adenosine triphosphatase expression and activity. | Maresin1 stimulates alveolar fluid clearance through the alveolar epithelial sodium channel Na,K-ATPase via the ALX/PI3K/Nedd4-2 pathway.
Zhang JL, Zhuo XJ, Lin J, Luo LC, Ying WY, Xie X, Zhang HW, Yang JX, Li D, Gao Smith F, Jin SW. | 08/19/2017 |
| middle ear mucosal expression increased in otitis media with effusion | Divergent expression of α-ENaC in middle ear mucosa in the course of otitis media with effusion induced by barotrauma.
Xu J, Zong Y, Li X, Zhang Y, Li J. | 02/13/2016 |
| Estradiol signaling through G protein-coupled estrogen receptor selectively activates alveolar ENaC through an effect on channel gating and channel density. | Estradiol activates epithelial sodium channels in rat alveolar cells through the G protein-coupled estrogen receptor.
Greenlee MM, Mitzelfelt JD, Yu L, Yue Q, Duke BJ, Harrell CS, Neigh GN, Eaton DC., Free PMC Article | 02/1/2014 |
| Na(+) displays a direct dose-related effect on osteoblasts by affecting differentiation, osteogenic gene expression profile, and ENaC-alpha gene expression. | [Effects of sodium on rat osteoblast and the role of epithelial sodium channel].
Lu L, Wu L, Chen J, Lin XH, Wan C, Li QN. | 05/11/2013 |
| It was found that mRNA deletion forms (a and b), products of alternative splicing of aENaC gene, are absent in the cortex of adult rat kidney. | Investigation on genetic heterogeneity of α-subunit of the epithelial sodium channel in rat renal cortex.
Logvinenko NS, Herbeck YE, Ivanova LN. | 08/4/2012 |
| Data indicate that functional ENaC (subunits Scnn1a, Scnn1b, and Scnn1g) may affect firing patterns of magnocellular cells (i.e., large neurons) in supraoptic nucleus and paraventricular nucleus and thus control secretion of vasopressin and oxytocin. | Epithelial Na⁺ sodium channels in magnocellular cells of the rat supraoptic and paraventricular nuclei.
Teruyama R, Sakuraba M, Wilson LL, Wandrey NE, Armstrong WE., Free PMC Article | 03/10/2012 |
| Persistent high expression of alphaENaC and increase in apical localization of beta and gammaENaC may contribute to greater retention of sodium in salt-resistant rats on a high-salt diet. | Enhanced expression of epithelial sodium channels in the renal medulla of Dahl S rats.
Amin MS, Reza E, El-Shahat E, Wang HW, Tesson F, Leenen FH. | 02/18/2012 |
| emotional stress has an effect on the expression of the alpha-ENaC gene mRNA in the kidney of hypertensive ISIAH rats | The effect of emotional stress on the expression of the α-ENaC gene mRNA in the kidney of hypertensive ISIAH rats.
Pylnik TO, Pletneva LS, Redina OE, Smolenskaya SE, Markel AL, Ivanova LN. | 11/26/2011 |
| Hyperaldosteronism and altered expression of an SGK1-dependent sodium transporter in ZDF rats leads to salt dependence of blood pressure. | Hyperaldosteronism and altered expression of an SGK1-dependent sodium transporter in ZDF rats leads to salt dependence of blood pressure.
Resch M, Bergler T, Fredersdorf S, Griese DP, Weil J, Kreuzer P, Brunner S, Riegger GA, Luchner A, Endemann DH. | 02/5/2011 |
| alpha-ENaC protein abundance and ENaC activity are increased in the late pregnant rat, thereby contributing to the positive sodium balance of pregnancy. | Increased renal alpha-epithelial sodium channel (ENAC) protein and increased ENAC activity in normal pregnancy.
West C, Zhang Z, Ecker G, Masilamani SM., Free PMC Article | 12/4/2010 |
| Expression of epithelial sodium channel alpha subunit is not affected by terbutaline treatment of acute lung injury. | [Role of epithelial sodium channel alpha subunit in terbutaline-induced transient enhancement of pulmonary edema clearance in adult rats with acute lung injury].
Huang DX, Li TP, He L. | 05/10/2010 |
| ENaC alpha-subunit mRNA showed significantly higher expression than beta- and gamma-subunit mRNAs in isolated rat alveolar type II cells. | [Epithelial sodium channel subunit mRNA expression in acutely isolated rat alveolar type II cells].
Zhou WM, He L, Li TP, You J. | 05/3/2010 |
| these results provide new evidence that contributes to a better understanding of the role of EP1 and EP3 receptors in the regulation of Na+ handling and ENaC expression in the setting of renin-angiotensin-aldosterone-system activation. | E Prostanoid-1 receptor regulates renal medullary alphaENaC in rats infused with angiotensin II.
González AA, Céspedes C, Villanueva S, Michea L, Vio CP. | 01/21/2010 |
| Immunohistochemistry analyses in rat testis localized ENaC-alpha expressed in the Leydig cell, Sertoli cell, Ap spermatogonium, spermatocyte, spermatid and residual body. | Blockade of epithelial sodium channels improves sperm motility in asthenospermia patients.
Kong XB, Ma HG, Li HG, Xiong CL. | 01/21/2010 |
| AR and ENaC are regulated by sex steroids. | Sex-specific regulation of ENaC and androgen receptor in female rat kidney.
Kienitz T, Allolio B, Strasburger CJ, Quinkler M. | 01/21/2010 |
| Altered renal expression of Scnn1a in protein-deprived rats. | Altered renal expression of Na(+) transporters and ROMK in protein-deprived rats.
Ruete MC, Carrizo LC, Bocanegra MV, Vallés PG. | 01/21/2010 |
| support a model in which protons modulate ENaC gating by relieving Na(+) self-inhibition | Extracellular protons regulate human ENaC by modulating Na+ self-inhibition.
Collier DM, Snyder PM., Free PMC Article | 01/21/2010 |
| activation of the NF-kappaB pathway down-regulates SGK1 expression, which might lead to decreased ENaC alpha-subunit expression, ultimately resulting in decreased Na(+) transport | NF-kappaB inhibits sodium transport via down-regulation of SGK1 in renal collecting duct principal cells.
de Seigneux S, Leroy V, Ghzili H, Rousselot M, Nielsen S, Rossier BC, Martin PY, Féraille E. | 01/21/2010 |
| Increased alpha-ENaC levels and function are partly dependent upon the early induction of SGK1 expression. | Induction of serum- and glucocorticoid-induced kinase-1 (SGK1) by cAMP regulates increases in alpha-ENaC.
Vasquez MM, Castro R, Seidner SR, Henson BM, Ashton DJ, Mustafa SB. | 01/21/2010 |
| Expressed at the apical membrane of the principal cells in rats; a low-Na diet or aldosterone perfusion prevents expression (a 30-kD resolution limit) | Surface expression of epithelial Na channel protein in rat kidney.
Frindt G, Ergonul Z, Palmer LG., Free PMC Article | 01/21/2010 |
| ENaC alpha is functionally related to regulatory volume increase and hypertonicity-induced cation channel activation in rat hepatocytes | Subunits alpha, beta and gamma of the epithelial Na+ channel (ENaC) are functionally related to the hypertonicity-induced cation channel (HICC) in rat hepatocytes.
Plettenberg S, Weiss EC, Lemor R, Wehner F., Free PMC Article | 01/21/2010 |
| Dietary sodium chloride reduced Scnn1a expression in vascular smooth muscle cells. | Dietary salt enhances benzamil-sensitive component of myogenic constriction in mesenteric arteries.
Jernigan NL, LaMarca B, Speed J, Galmiche L, Granger JP, Drummond HA. | 01/21/2010 |
| ENaC and Nedd4-2 are involved in the transition from lung fluid secretion to fluid absorption near term and at birth. | Involvement of {alpha}ENaC and Nedd4-2 in the conversion from lung fluid secretion to fluid absorption at birth in the rat as assayed by RNA interference analysis.
Li T, Koshy S, Folkesson HG. | 01/21/2010 |