| STAT1 deficiency underlies a proinflammatory imprint of naive CD4[+] T cells in spondyloarthritis. | STAT1 deficiency underlies a proinflammatory imprint of naive CD4(+) T cells in spondyloarthritis.
Cherqaoui B, Crémazy F, Lauraine M, Shammas G, Said-Nahal R, Mambu Mambueni H, Costantino F, Fourmont M, Hulot A, Garchon HJ, Glatigny S, Araujo LM, Breban M., Free PMC Article | 11/10/2023 |
| MiRNA-338-3p Inhibits Neuroinflammation in the Corpus Callosum of LCV-LPS Rats Via STAT1 Signal Pathway. | MiRNA-338-3p Inhibits Neuroinflammation in the Corpus Callosum of LCV-LPS Rats Via STAT1 Signal Pathway.
Liu N, Zhou Q, Wang H, Li Q, Chen Z, Lin Y, Yi L, Jiang S, Chen C, Deng Y. | 09/6/2023 |
| Long non-coding RNA TLR8-AS1 induces preeclampsia through increasing TLR8/STAT1 axis. | Long non-coding RNA TLR8-AS1 induces preeclampsia through increasing TLR8/STAT1 axis.
Peng C, Zhu J, Guo H, Zhao L, Wu F, Liu B. | 07/12/2023 |
| The transcription factor Stat-1 is essential for Schwann cell differentiation, myelination and myelin sheath regeneration. | The transcription factor Stat-1 is essential for Schwann cell differentiation, myelination and myelin sheath regeneration.
Xu J, Zhang B, Cai J, Peng Q, Hu J, Askar P, Shangguan J, Su W, Zhu C, Sun H, Zhou S, Chen G, Yang X, Gu Y., Free PMC Article | 07/5/2023 |
| SOCS1, the feedback regulator of STAT1/3, inhibits the osteogenic differentiation of rat bone marrow mesenchymal stem cells. | SOCS1, the feedback regulator of STAT1/3, inhibits the osteogenic differentiation of rat bone marrow mesenchymal stem cells.
Zhang Y, Jing Z, Cao X, Wei Q, He W, Zhang N, Liu Y, Yuan Q, Zhuang Z, Dong Y, Hong Z, Li J, Li P, Zhang L, Wang H, Li W. | 03/19/2022 |
| STAT1 regulates interferon-gamma-induced angiotensinogen and MCP-1 expression in a bidirectional manner in primary cultured mesangial cells. | STAT1 regulates interferon-γ-induced angiotensinogen and MCP-1 expression in a bidirectional manner in primary cultured mesangial cells.
Penrose HM, Katsurada A, Miyata K, Urushihara M, Satou R., Free PMC Article | 07/17/2021 |
| Upregulated PKM2 in Macrophages Exacerbates Experimental Arthritis via STAT1 Signaling. | Upregulated PKM2 in Macrophages Exacerbates Experimental Arthritis via STAT1 Signaling.
Xu J, Jiang C, Wang X, Geng M, Peng Y, Guo Y, Wang S, Li X, Tao P, Zhang F, Han Y, Ning Q, Zhu W, Meng L, Lu S. | 03/13/2021 |
| MiR-144 acts as a proliferation inhibitor in cardiomyocytes via the TBX1/JAK2/STAT1 axis | MicroRNA-144 Regulates Cardiomyocyte Proliferation and Apoptosis by Targeting TBX1 through the JAK2/STAT1 Pathway.
Cao ML, Zhu BL, Sun YY, Qiu GR, Fu WN, Jiang HK. | 03/14/2020 |
| The investigation demonstrated that the serum levels of FGF23 and the phosphorylation levels of JAK2, STAT1, and STAT3 were up-regulated in the ovariectomy (OVX) + NVP-BGJ398 group while were down-regulated in the OVX + Anti-FGF23 group than that in the OVX group. | The participation of fibroblast growth factor 23 (FGF23) in the progression of osteoporosis via JAK/STAT pathway.
Xu L, Zhang L, Zhang H, Yang Z, Qi L, Wang Y, Ren S. | 12/22/2018 |
| that STAT1 contributes to bone cancer pain as a downstream mediator of ERK signaling by regulating MHC II expression in spinal microglia | STAT1 as a downstream mediator of ERK signaling contributes to bone cancer pain by regulating MHC II expression in spinal microglia.
Song Z, Xiong B, Zheng H, Manyande A, Guan X, Cao F, Ren L, Zhou Y, Ye D, Tian Y. | 08/18/2018 |
| our results suggest that STAT1-mediated up-regulation of caspase-3 is involved in osteoblast apoptosis induced by Dex and indicates that fludarabine may serve as a potential agent for the treatment of SANFH. | Fludarabine inhibits STAT1-mediated up-regulation of caspase-3 expression in dexamethasone-induced osteoblasts apoptosis and slows the progression of steroid-induced avascular necrosis of the femoral head in rats.
Feng Z, Zheng W, Tang Q, Cheng L, Li H, Ni W, Pan X. | 03/24/2018 |
| disruption of the STAT1 and STAT3 signaling pathways may in part explain the deleterious effects of maternal marginal zinc deficiency on fetal brain development | Zinc deficiency affects the STAT1/3 signaling pathways in part through redox-mediated mechanisms.
Supasai S, Aimo L, Adamo AM, Mackenzie GG, Oteiza PI., Free PMC Article | 11/26/2017 |
| The phosphatidylinositol 3-Kinases (PI3K)/signal transducer and activator of transcription 1 and 3 (STAT1/3) signaling pathway mediated high glucose (HG)-triggered extracellular matrix (ECM) accumulation and suppressor of cytokine signaling-3 (SOCS-3) upregulation in mesangial cells (RMCs). | Activation of PI3K in response to high glucose leads to regulation of SOCS-3 and STAT1/3 signals and induction of glomerular mesangial extracellular matrix formation.
Sheu ML, Shen CC, Jheng JR, Chiang CK., Free PMC Article | 08/5/2017 |
| Leading to a STAT1-IRF1 controlled upregulation of TLR3 expression in macrophages. | Pristane induces autophagy in macrophages, promoting a STAT1-IRF1-TLR3 pathway and arthritis.
Zhu W, Xu J, Jiang C, Wang B, Geng M, Wu X, Hussain N, Gao N, Han Y, Li D, Lan X, Ning Q, Zhang F, Holmdahl R, Meng L, Lu S. | 06/10/2017 |
| activation of the MAPK and PI3K-AKT pathways primarily regulated Ser-727 phosphorylation, whereas a physical interaction between RET/PTC3 and STAT1, followed by a direct tyrosine phosphorylation event, was necessary for STAT1 Tyr-701 phosphorylation. These data provide the first evidence of a direct link between IDO1 expression and the oncogenic activation of RET in thyroid carcinoma | Signal Transducer and Activator of Transcription 1 Plays a Pivotal Role in RET/PTC3 Oncogene-induced Expression of Indoleamine 2,3-Dioxygenase 1.
Moretti S, Menicali E, Nucci N, Voce P, Colella R, Melillo RM, Liotti F, Morelli S, Fallarino F, Macchiarulo A, Santoro M, Avenia N, Puxeddu E., Free PMC Article | 06/3/2017 |
| Bone marrow mesenchymal stromal cells expression CD47/STAT1/STAT3 prevent isoproterenol induced myocardial fibrosis. | Bone marrow mesenchymal stromal cells with CD47 high expression via the signal transducer and activators of transcription signaling pathway preventing myocardial fibrosis.
Deng W, Chen QW, Li XS, Yuan ZM, Li GQ, Ke DZ, Wang L, Wu ZQ, Luo SL., Free PMC Article | 10/1/2016 |
| findings indicated that OSM induces Mcl-1 expression via activation of ERK1/2, JAK1/2, STAT1/3, and CREB; furthermore, OSM-mediated Mcl-1 induction contributes to bioenergetic improvements | Oncostatin M-dependent Mcl-1 induction mediated by JAK1/2-STAT1/3 and CREB contributes to bioenergetic improvements and protective effects against mitochondrial dysfunction in cortical neurons.
Chang SH, Hwang CS, Yin JH, Chen SD, Yang DI. | 12/5/2015 |
| These data demonstrate for the first time that KRV-induced islet destruction is associated with beta cell infection and intra-islet innate immune upregulation early in the disease process. | Kilham Rat Virus-induced type 1 diabetes involves beta cell infection and intra-islet JAK-STAT activation prior to insulitis.
Alkanani AK, Hara N, Gianani R, Zipris D. | 02/21/2015 |
| Stat1 and Stat3 cooperate with Jmjd3 to induce the expression of pro-inflammatory genes. | The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia.
Przanowski P, Dabrowski M, Ellert-Miklaszewska A, Kloss M, Mieczkowski J, Kaza B, Ronowicz A, Hu F, Piotrowski A, Kettenmann H, Komorowski J, Kaminska B., Free PMC Article | 10/25/2014 |
| IL-1beta-mediated regulation of the CXCL1 and CXCL2 genes in pancreatic beta-cells requires stimulus-induced changes in histone chemical modifications, recruitment of the NF-kappaB and STAT1 transcription factors to genomic regulatory sequences within the proximal gene promoters, and increases in phosphorylated forms of RNA polymerase II. | NF-κB and STAT1 control CXCL1 and CXCL2 gene transcription.
Burke SJ, Lu D, Sparer TE, Masi T, Goff MR, Karlstad MD, Collier JJ., Free PMC Article | 03/15/2014 |
| conclude that the IL-6/STAT1/STAT3 signaling pathway and its responsive genes after a single bout of resistance exercise are an important event regulating the SC pool and behavior involved in muscle hypertrophy | Early activation of rat skeletal muscle IL-6/STAT1/STAT3 dependent gene expression in resistance exercise linked to hypertrophy.
Begue G, Douillard A, Galbes O, Rossano B, Vernus B, Candau R, Py G., Free PMC Article | 09/28/2013 |
| Secreted phospholipase PLA-IIA expression is regulated by the nitric oxide (NO)-JAK3-STAT1 pathway in microvascular endothelial cells of the injured brain. | Regulatory effects of the JAK3/STAT1 pathway on the release of secreted phospholipase A₂-IIA in microvascular endothelial cells of the injured brain.
Wang G, Qian P, Xu Z, Zhang J, Wang Y, Cheng S, Cai W, Qian G, Wang C, Decoster MA., Free PMC Article | 01/26/2013 |
| IFN-gamma biphasically regulates AGT expression in RPTCs via STAT3 activity modulated by STAT1-SOCS1 axis, suggesting the STAT1-SOCS1 axis is important in IFN-gamma-induced activation of the intrarenal renin-angiotensin system | Interferon-γ biphasically regulates angiotensinogen expression via a JAK-STAT pathway and suppressor of cytokine signaling 1 (SOCS1) in renal proximal tubular cells.
Satou R, Miyata K, Gonzalez-Villalobos RA, Ingelfinger JR, Navar LG, Kobori H., Free PMC Article | 06/30/2012 |
| PDGF-beta receptor and PKC have no effect on angiotensin II-induced JAK2 and STAT1 phosphorylation in vascular smooth muscle cells under high glucose condition. | PDGF-β receptor and PKC have no effect on angiotensin II-induced JAK2 and STAT1 phosphorylation in vascular smooth muscle cells under high glucose condition.
Öztürk OH, Çetin A, Tokay A, Uzuner F, Tanrıöver G, Yeşilkaya A. | 01/21/2012 |
| Withaferin A significantly inhibited LPS-induced STAT1 and STAT3 phosphorylation in a dose-dependent manner. | Withaferin A down-regulates lipopolysaccharide-induced cyclooxygenase-2 expression and PGE2 production through the inhibition of STAT1/3 activation in microglial cells.
Min KJ, Choi K, Kwon TK. | 01/14/2012 |