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    Stat3 signal transducer and activator of transcription 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25125, updated on 9-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Role of the JAK2/STAT3 pathway in angiotensin II-induced enhanced expression of Gialpha proteins and hyperproliferation of aortic vascular smooth muscle cells.

    Role of the JAK2/STAT3 pathway in angiotensin II-induced enhanced expression of Giα proteins and hyperproliferation of aortic vascular smooth muscle cells.
    Hossain E, Li Y, Anand-Srivastava MB.

    07/26/2024
    STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related protein 1) controlled-mitochondrial fission during the development of apoptotic-resistance in pulmonary arterial endothelial cells.

    STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related protein 1) controlled-mitochondrial fission during the development of apoptotic-resistance in pulmonary arterial endothelial cells.
    Zhang H, Chen L, Li J, Sun J, Zhao Q, Wang S, Li G., Free PMC Article

    06/28/2024
    Daucosterol regulates JAK2-STAT3 signaling pathway to promote megakaryocyte differentiation.

    Daucosterol regulates JAK2-STAT3 signaling pathway to promote megakaryocyte differentiation.
    Zhang Z, Shang G, Lu Z, Hu J, Liu H, Lu T, Lu X.

    06/12/2024
    Hypoxic-preconditioned mesenchymal stem cell-derived small extracellular vesicles promote the recovery of spinal cord injury by affecting the phenotype of astrocytes through the miR-21/JAK2/STAT3 pathway.

    Hypoxic-preconditioned mesenchymal stem cell-derived small extracellular vesicles promote the recovery of spinal cord injury by affecting the phenotype of astrocytes through the miR-21/JAK2/STAT3 pathway.
    Yang Z, Liang Z, Rao J, Xie H, Zhou M, Xu X, Lin Y, Lin F, Wang C, Chen C., Free PMC Article

    03/12/2024
    IFITM3 mediates inflammation induced myocardial injury through JAK2/STAT3 signaling pathway.

    IFITM3 mediates inflammation induced myocardial injury through JAK2/STAT3 signaling pathway.
    Xiong C, Li B, Song R, Ma Z, Huber SA, Liu W.

    03/1/2024
    Silencing suppressor of cytokine signaling 3 induces apoptosis and activates the p-STAT3/NF-kappaB pathway in hypoxic cultivated H9c2 cells.

    Silencing suppressor of cytokine signaling 3 induces apoptosis and activates the p-STAT3/NF-κB pathway in hypoxic cultivated H9c2 cells.
    Gu Q, Xiao YB, Wang Y.

    02/14/2024
    PCSK9 regulates myofibroblast transformation through the JAK2/STAT3 pathway to regulate fibrosis after myocardial infarction.

    PCSK9 regulates myofibroblast transformation through the JAK2/STAT3 pathway to regulate fibrosis after myocardial infarction.
    Bao H, Wang X, Zhou H, Zhou W, Liao F, Wei F, Yang S, Luo Z, Li W.

    02/2/2024
    FOXO1 reduces STAT3 activation and causes impaired mitochondrial quality control in diabetic cardiomyopathy.

    FOXO1 reduces STAT3 activation and causes impaired mitochondrial quality control in diabetic cardiomyopathy.
    Zhou L, Su W, Wang Y, Zhang Y, Xia Z, Lei S.

    01/11/2024
    Long noncoding RNA MEG8 induces an imbalance of Th17/Treg cells through the miR-107/STAT3 axis in Henoch-Schonlein purpura rats.

    Long noncoding RNA MEG8 induces an imbalance of Th17/Treg cells through the miR-107/STAT3 axis in Henoch-Schonlein purpura rats.
    Jiang M, Dai J, Jiang C, Pan Y, Ren M, Xing M., Free PMC Article

    12/28/2023
    Runx1 is upregulated by STAT3 and promotes proliferation of neonatal rat cardiomyocytes.

    Runx1 is upregulated by STAT3 and promotes proliferation of neonatal rat cardiomyocytes.
    Suzuki S, Tanaka S, Kametani Y, Umeda A, Nishinaka K, Egawa K, Okada Y, Obana M, Fujio Y., Free PMC Article

    12/6/2023
    Plasma exosomes improve peripheral neuropathy via miR-20b-3p/Stat3 in type I diabetic rats.

    Plasma exosomes improve peripheral neuropathy via miR-20b-3p/Stat3 in type I diabetic rats.
    Li J, Wu G, Li W, Zhou X, Li W, Xu X, Xu K, Cao R, Cui S., Free PMC Article

    12/1/2023
    The Regulatory Effects of JAK2/STAT3 on Spermatogenesis and the Redox Keap1/Nrf2 Axis in an Animal Model of Testicular Ischemia Reperfusion Injury.

    The Regulatory Effects of JAK2/STAT3 on Spermatogenesis and the Redox Keap1/Nrf2 Axis in an Animal Model of Testicular Ischemia Reperfusion Injury.
    Alnajem A, Al-Maghrebi M., Free PMC Article

    09/29/2023
    Knocking Down lncRNA HOXA-AS2 Mitigates the Progression of Epilepsy via Regulation of the miR-372-3p/STAT3 Axis.

    Knocking Down lncRNA HOXA-AS2 Mitigates the Progression of Epilepsy via Regulation of the miR-372-3p/STAT3 Axis.
    Song L, Li J, Sun Z.

    09/19/2023
    Folic acid deficiency exacerbates the inflammatory response of astrocytes after ischemia-reperfusion by enhancing the interaction between IL-6 and JAK-1/pSTAT3.

    Folic acid deficiency exacerbates the inflammatory response of astrocytes after ischemia-reperfusion by enhancing the interaction between IL-6 and JAK-1/pSTAT3.
    Cheng M, Liang X, Shi L, Zhang Q, Zhang L, Gong Z, Luo S, Wang X, Zhang X., Free PMC Article

    08/25/2023
    Reduced expression of Il10, Stat3, Hoxa10, and Itgb3 in the embryo implantation site of rat model with prenatal androgen-induced polycystic ovary syndrome.

    Reduced expression of Il10, Stat3, Hoxa10, and Itgb3 in the embryo implantation site of rat model with prenatal androgen-induced polycystic ovary syndrome.
    Changaei M, Javidan M, Ramezani Tehrani F, Mosaffa N, Noroozzadeh M, Hosseinzadeh R, Rajaei S.

    06/30/2023
    Inhibition of STAT3 signal pathway recovers postsynaptic plasticity to improve cognitive impairment caused by chronic intermittent hypoxia.

    Inhibition of STAT3 signal pathway recovers postsynaptic plasticity to improve cognitive impairment caused by chronic intermittent hypoxia.
    Wang J, Xu Z, Xu L, Xu P.

    06/1/2023
    Phosphorylation of STAT3 at Tyr705 contributes to TFEB-mediated autophagy-lysosomal pathway dysfunction and leads to ischemic injury in rats.

    Phosphorylation of STAT3 at Tyr705 contributes to TFEB-mediated autophagy-lysosomal pathway dysfunction and leads to ischemic injury in rats.
    Liu Y, Che X, Yu X, Shang H, Cui P, Fu X, Lu X, Liu Y, Wu C, Yang J., Free PMC Article

    05/22/2023
    Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse.

    Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse.
    Xiao X, Chen J, Zhai Q, Xin L, Zheng X, Wang S, Song J., Free PMC Article

    05/11/2023
    Activating alpha7nAChR helps post-myocardial infarction healing by regulating macrophage polarization via the STAT3 signaling pathway.

    Activating α7nAChR helps post-myocardial infarction healing by regulating macrophage polarization via the STAT3 signaling pathway.
    Niu XH, Liu RH, Lv X, He RL, Lv FZ, Wu SJ, Li XQ, Li L, Lin JF.

    04/28/2023
    Downregulation of TRIM27 alleviates hypoxic-ischemic encephalopathy through inhibiting inflammation and microglia cell activation by regulating STAT3/HMGB1 axis.

    Downregulation of TRIM27 alleviates hypoxic-ischemic encephalopathy through inhibiting inflammation and microglia cell activation by regulating STAT3/HMGB1 axis.
    Wang C, Zhang P, Li Y, Wang X, Guo L, Li J, Jiao H.

    04/21/2023
    Cyclic tensile force modifies calvarial osteoblast function via the interplay between ERK1/2 and STAT3.

    Cyclic tensile force modifies calvarial osteoblast function via the interplay between ERK1/2 and STAT3.
    Xiao X, Zou S, Chen J., Free PMC Article

    03/14/2023
    Histone deacetylase 5-induced deficiency of signal transducer and activator of transcription-3 acetylation contributes to spinal astrocytes degeneration in painful diabetic neuropathy.

    Histone deacetylase 5-induced deficiency of signal transducer and activator of transcription-3 acetylation contributes to spinal astrocytes degeneration in painful diabetic neuropathy.
    Fan T, Yu Y, Chen YL, Gu P, Wong S, Xia ZY, Liu JA, Cheung CW.

    02/27/2023
    Anti-apoptosis effect of recombinant human interleukin-11 in neonatal hypoxic-ischemic rats through activating the IL-11Ralpha/STAT3 signaling pathway.

    Anti-apoptosis effect of recombinant human interleukin-11 in neonatal hypoxic-ischemic rats through activating the IL-11Rα/STAT3 signaling pathway.
    Zuo D, Zheng Q, Xiao M, Wang X, Chen H, Xu J, Zhang Q, Xiong Y, Ye L, Feng Z.

    01/14/2023
    JAK2/STAT3 pathway mediates neuroprotective and pro-angiogenic treatment effects of adult human neural stem cells in middle cerebral artery occlusion stroke animal models.

    JAK2/STAT3 pathway mediates neuroprotective and pro-angiogenic treatment effects of adult human neural stem cells in middle cerebral artery occlusion stroke animal models.
    Ha GH, Kim EJ, Park JS, Kim JE, Nam H, Yeon JY, Lee SH, Lee K, Kim CK, Joo KM., Free PMC Article

    12/17/2022
    The effect of electroacupuncture on the expression of Sirt1 and STAT3 in hippocampus and amygdala of vascular dementia rats.

    The effect of electroacupuncture on the expression of Sirt1 and STAT3 in hippocampus and amygdala of vascular dementia rats.
    Zhao J, Li W, Wang Y, Jiang Y, Ding C, Li H, Ding J, Wang L.

    11/26/2022
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