Spinal nerve transection-induced upregulation of SAP97 via promoting membrane trafficking of GluA1-containing AMPA receptors in the dorsal horn contributes to the pathogenesis of neuropathic pain. | Spinal nerve transection-induced upregulation of SAP97 via promoting membrane trafficking of GluA1-containing AMPA receptors in the dorsal horn contributes to the pathogenesis of neuropathic pain. Liang Z, Li L, Bai L, Gao Y, Qiao Y, Wang X, Yv L, Xu JT. | 04/12/2024 |
The SF3B1(R625H) mutation promotes prolactinoma tumor progression through aberrant splicing of DLG1. | The SF3B1(R625H) mutation promotes prolactinoma tumor progression through aberrant splicing of DLG1. Guo J, Li C, Fang Q, Liu Y, Wang D, Chen Y, Xie W, Zhang Y., Free PMC Article | 05/14/2022 |
Schizophrenia-associated SAP97 mutations increase glutamatergic synapse strength in the dentate gyrus and impair contextual episodic memory in rats. | Schizophrenia-associated SAP97 mutations increase glutamatergic synapse strength in the dentate gyrus and impair contextual episodic memory in rats. Kay Y, Tsan L, Davis EA, Tian C, Décarie-Spain L, Sadybekov A, Pushkin AN, Katritch V, Kanoski SE, Herring BE., Free PMC Article | 03/5/2022 |
This study reveals plasticity in surface NMDAR localization driven by mutant HTT and identifies the similar but independent roles of SAP97 N-terminal isoforms in maintaining normal synaptic function in pathological states. | SAP97-mediated rescue of NMDA receptor surface distribution in a neuronal model of Huntington's disease. Ambroziak W, Fourie C, Montgomery JM. | 08/31/2019 |
Results indicate that the GluA1 subunit accessory protein SAP97 may represent a novel target for pharmacotherapeutic intervention in the treatment of cocaine craving | A Critical Role for the GluA1 Accessory Protein, SAP97, in Cocaine Seeking. White SL, Ortinski PI, Friedman SH, Zhang L, Neve RL, Kalb RG, Schmidt HD, Pierce RC., Free PMC Article | 10/8/2016 |
dendrite branching promoting action of full length SAP97 depends on ligand(s) that bind to the PDZ3 domain. | Structure-function analysis of SAP97, a modular scaffolding protein that drives dendrite growth. Zhang L, Hsu FC, Mojsilovic-Petrovic J, Jablonski AM, Zhai J, Coulter DA, Kalb RG., Free PMC Article | 01/16/2016 |
The data establish a prominent role for PDZ2 and I3 domains of SAP97 in organizing the ss1-adrenergic receptosome involved in connecting the ss1-AR to trafficking and signaling networks. | SAP97 controls the trafficking and resensitization of the beta-1-adrenergic receptor through its PDZ2 and I3 domains. Nooh MM, Naren AP, Kim SJ, Xiang YK, Bahouth SW., Free PMC Article | 12/28/2013 |
Acute BDNF treatment upregulates the interactions between AMPA receptor subunits (GluR1 and GluR2) with their scaffold proteins SAP97 and GRIP1, respectively. | Acute BDNF treatment upregulates GluR1-SAP97 and GluR2-GRIP1 interactions: implications for sustained AMPA receptor expression. Jourdi H, Kabbaj M., Free PMC Article | 09/7/2013 |
studies show that SAP97 interactions with CRFR1 attenuate CRFR1 endocytosis and that SAP97 is involved in coupling G protein-coupled receptors to the activation of the ERK1/2 signaling pathway. | Role of SAP97 protein in the regulation of corticotropin-releasing factor receptor 1 endocytosis and extracellular signal-regulated kinase 1/2 signaling. Dunn HA, Walther C, Godin CM, Hall RA, Ferguson SS., Free PMC Article | 08/10/2013 |
Scribble/Lgl/Dlg polarity protein complex is a regulator of blood-testis barrier dynamics and spermatid polarity during spermatogenesis | The Scribble/Lgl/Dlg polarity protein complex is a regulator of blood-testis barrier dynamics and spermatid polarity during spermatogenesis. Su W, Wong EW, Mruk DD, Cheng CY., Free PMC Article | 02/2/2013 |
Cx32 is differentially phosphorylated and exists in a complex with SAP97 and CaM. | Characterization of the structure and intermolecular interactions between the connexin 32 carboxyl-terminal domain and the protein partners synapse-associated protein 97 and calmodulin. Stauch K, Kieken F, Sorgen P., Free PMC Article | 11/17/2012 |
Overexpression of SAP97 was associated with overexpression of PSD-95 and recruitment of nNOS to the synapse and was accompanied by marked morphological changes, with spines enwrapping and engulfing presynaptic terminals. | Ultrastructural modifications of spine and synapse morphology by SAP97. Poglia L, Muller D, Nikonenko I. | 08/25/2012 |
SAP97 isoforms can regulate the ability of synapses to undergo plasticity by controlling the surface distribution of AMPA and NMDA receptors. | SAP97 directs NMDA receptor spine targeting and synaptic plasticity. Li D, Specht CG, Waites CL, Butler-Munro C, Leal-Ortiz S, Foote JW, Genoux D, Garner CC, Montgomery JM., Free PMC Article | 05/26/2012 |
investigation of structure of SAP97 isoforms: Data suggest conformation of SAP97 is determined by nature of N-terminus, which may, in turn, influence specific role of a particular splice variant. (signal sequence involved in mitochondrial targeting) | Conformational characterization of synapse-associated protein 97 by nuclear magnetic resonance and small-angle X-ray scattering shows compact and elongated forms. Tully MD, Grossmann JG, Phelan M, Pandelaneni S, Leyland M, Lian LY. | 03/24/2012 |
SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes. | SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes. Petitprez S, Zmoos AF, Ogrodnik J, Balse E, Raad N, El-Haou S, Albesa M, Bittihn P, Luther S, Lehnart SE, Hatem SN, Coulombe A, Abriel H. | 04/16/2011 |
Upregulation of SAP97 coincides with the redistribution of aquaporin (AQP)4 and inwardly-rectifying potassium channel (Kir) 4.1 in blue light-injured rat retina. | Müller cells upregulate the expression of SAP97 in light-injured rat retina. Ren H, Xu G, Qian J, Zhou M, Gonzales J, Ni Y. | 02/26/2011 |
In cardiac myocytes SAP97 regulates surface expression of channels underlying I(K1) | Regulation of cardiac inward rectifier potassium current (I(K1)) by synapse-associated protein-97. Vaidyanathan R, Taffet SM, Vikstrom KL, Anumonwo JM., Free PMC Article | 10/23/2010 |
Following acute injection of phencyclidine SAP-97 transcripts are upregulated in the adult neocortex. | The development- and phencyclidine-regulated induction of synapse-associated protein-97 gene in the rat neocortex. Hiraoka S, Kajii Y, Kuroda Y, Umino A, Nishikawa T. | 09/6/2010 |
findings show that, in Schwann cells, Dlg1 interacts with PTEN to inhibit axonal stimulation of myelination; this mechanism limits myelin sheath thickness & prevents overmyelination in sciatic nerves | Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination. Cotter L, Ozçelik M, Jacob C, Pereira JA, Locher V, Baumann R, Relvas JB, Suter U, Tricaud N. | 06/28/2010 |
CaMKIIalpha targets a specific SAP97 splice variant to disengage AKAP79/150 from regulating GluR1 AMPARs | Ca2+/calmodulin-dependent protein kinase II binds to and phosphorylates a specific SAP97 splice variant to disrupt association with AKAP79/150 and modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor (AMPAR) activity. Nikandrova YA, Jiao Y, Baucum AJ, Tavalin SJ, Colbran RJ., Free PMC Article | 02/1/2010 |
As monitored by circular dichroism and differential scanning calorimetry, SAP97 (T(m)=64 degrees C) is significantly more thermal stable than SAP90/PSD-95 (T(m)=52 degrees C) and follows a bimodal phase transition. | Structural differences between the SH3-HOOK-GuK domains of SAP90/PSD-95 and SAP97. Vandanapu RR, Singh AK, Mikhaylova M, Reddy PP, Kreutz MR, Sharma Y. | 01/25/2010 |
SAP97 regulates Kir2.3 channels by multiple mechanisms. | SAP97 regulates Kir2.3 channels by multiple mechanisms. Vikstrom KL, Vaidyanathan R, Levinsohn S, O'Connell RP, Qian Y, Crye M, Mills JH, Anumonwo JM., Free PMC Article | 01/21/2010 |
Our data demonstrate that the retention and trafficking of NMDARs in this endoplasmic reticulum subcompartment requires both CASK and SAP97. | SAP97 and CASK mediate sorting of NMDA receptors through a previously unknown secretory pathway. Jeyifous O, Waites CL, Specht CG, Fujisawa S, Schubert M, Lin EI, Marshall J, Aoki C, de Silva T, Montgomery JM, Garner CC, Green WN., Free PMC Article | 01/21/2010 |
N-terminal splicing of SAP97 controls synaptic strength by regulating distribution of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. | Synaptic SAP97 isoforms regulate AMPA receptor dynamics and access to presynaptic glutamate. Waites CL, Specht CG, Härtel K, Leal-Ortiz S, Genoux D, Li D, Drisdel RC, Jeyifous O, Cheyne JE, Green WN, Montgomery JM, Garner CC., Free PMC Article | 01/21/2010 |
SAP97 is a major partner for surface expression and CaMKII-dependent regulation of cardiac Kv4.2 and kv4.3 channels. | Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes. El-Haou S, Balse E, Neyroud N, Dilanian G, Gavillet B, Abriel H, Coulombe A, Jeromin A, Hatem SN. | 01/21/2010 |