| These results suggest Salvador enhances the effects of Hippo kinase activity at multiple points in the Hippo pathway. | Salvador has an extended SARAH domain that mediates binding to Hippo kinase.
Cairns L, Tran T, Fowl BH, Patterson A, Kim YJ, Bothner B, Kavran JM., Free PMC Article | 12/22/2018 |
| In this work, we have explored the disc autonomous function of TGFbeta that promotes wing imaginal disc growth. We have studied the genetic interactions between TGFbeta signaling and other pathways regulating wing disc growth, such as the Insulin and Hippo/Salvador/Warts pathways, as well as cell cycle regulators. | A Search for Genes Mediating the Growth-Promoting Function of TGFβ in the Drosophila melanogaster Wing Disc.
Hevia CF, López-Varea A, Esteban N, de Celis JF., Free PMC Article | 07/15/2017 |
| the Salvador-Warts-Hippo pathway has a cell-autonomous function to prevent inappropriate differentiation due to transcription factor imbalance and monitors the intrinsic developmental status of progenitor cells | Salvador-Warts-Hippo pathway in a developmental checkpoint monitoring helix-loop-helix proteins.
Wang LH, Baker NE., Free PMC Article | 04/25/2015 |
| Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association | Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association.
Huang HL, Wang S, Yin MX, Dong L, Wang C, Wu W, Lu Y, Feng M, Dai C, Guo X, Li L, Zhao B, Zhou Z, Ji H, Jiang J, Zhao Y, Liu XY, Zhang L., Free PMC Article | 03/8/2014 |
| Serine-17 is a key residue for the regulation of Sav stability. | A conserved serine residue regulates the stability of Drosophila Salvador and human WW domain-containing adaptor 45 through proteasomal degradation.
Wu D, Wu S. | 06/15/2013 |
| The salvador protein pathway restrains tissue growth by phosphorylating and inactivating the oncoprotein Yorkie. | The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway.
Poon CL, Lin JI, Zhang X, Harvey KF. | 02/4/2012 |
| The Salvador pathway restrains tissue growth by phosphorylating and inactivating the oncoprotein Yorkie. | Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway.
Boggiano JC, Vanderzalm PJ, Fehon RG., Free PMC Article | 02/4/2012 |
| Data show that brain tumours in l(3)mbt mutants originate from overproliferation of neuroepithelial cells in the optic lobes caused by derepression of target genes in the Salvador-Warts-Hippo (SWH) pathway. | The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements.
Richter C, Oktaba K, Steinmann J, Müller J, Knoblich JA., Free PMC Article | 12/10/2011 |
| Results define an important role for Wbp2 as a downstream component of the Salvador-Warts-Hippo tissue growth-control pathway. | Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador-Warts-Hippo pathway.
Zhang X, Milton CC, Poon CL, Hong W, Harvey KF., Free PMC Article | 11/26/2011 |
| Salvador-Warts-Hippo pathway limits tissue growth by repressing the Yorkie transcriptional co-activator | The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster.
Grusche FA, Degoutin JL, Richardson HE, Harvey KF. | 04/2/2011 |
| Data show that mutations causing the loss of Salvador (Sav) or Scribble (Scrib) or activation of Ras transform normal stem cells into cancer stem cells through a multistep process in the adult Drosophila Malpighian tubules. | Tumor suppressors Sav/Scrib and oncogene Ras regulate stem-cell transformation in adult Drosophila malpighian tubules.
Zeng X, Singh SR, Hou D, Hou SX., Free PMC Article | 08/23/2010 |
| Kibra is a regulator of the Salvador/Warts/Hippo signaling network. | Kibra is a regulator of the Salvador/Warts/Hippo signaling network.
Genevet A, Wehr MC, Brain R, Thompson BJ, Tapon N., Free PMC Article | 04/12/2010 |
| The complexity employed by different SWH pathway proteins to control organ size at different stages of development. | Differential requirement of Salvador-Warts-Hippo pathway members for organ size control in Drosophila melanogaster.
Milton CC, Zhang X, Albanese NO, Harvey KF. | 03/22/2010 |
| Data show that salvador genes are dispensable in germline cells for their proliferation control. | Genes of Hippo signaling network act unconventionally in the control of germline proliferation in Drosophila.
Sun S, Zhao S, Wang Z. | 01/21/2010 |
| Results suggest that the Salvador Warts Hippo network controls the expression of Hindsight, the downstream effector of Notch, required for follicle cell mitotic cycle-endocycle switch. | Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch.
Polesello C, Tapon N. | 01/21/2010 |
| Study shows that the Salvador Warts Hippo tumor-suppressor pathway is required in the follicle cells in order to induce their Gurken- and Notch-dependent differentiation and to limit their proliferation. | The salvador-warts-hippo pathway is required for epithelial proliferation and axis specification in Drosophila.
Meignin C, Alvarez-Garcia I, Davis I, Palacios IM., Free PMC Article | 01/21/2010 |
| Data show that Hippo links Salvador and Warts to a key regulator of apoptosis | The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis.
Harvey KF, Pfleger CM, Hariharan IK. | 01/21/2010 |
| Data report the identification of Hippo, which regulates both cell proliferation and cell death in Drosophila and phosphorylates the tumor suppressor protein Salvador, which interacts with the Warts protein kinase. | hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts.
Wu S, Huang J, Dong J, Pan D. | 01/21/2010 |
| a gene, salvador, which is especially significant, because it not only regulates and coordinates both exit from the cell cycle and apoptosis, but also has a human homolog that may play a key role in tumorigenesis. | salvador--The persistence of proliferation.
Rothenberg ME, Jan YN. | 01/21/2010 |
| data identify Hippo (Hpo) as a partner of Salvador (Sav), and suggest that Hpo and Sav function together to restrict tissue growth in vivo | The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila.
Pantalacci S, Tapon N, Léopold P. | 01/21/2010 |
| Results suggest that Hippo acts together with Salvador and Warts in a signalling module that coordinately regulates cell proliferation and apoptosis. | Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway.
Udan RS, Kango-Singh M, Nolo R, Tao C, Halder G. | 01/21/2010 |