| AC isoform, and not the others expressed in PC12 cells, may reside in a plasma membrane compartment that is uniquely accessible to the family B Gs-coupled GPCR PAC1. | Cyclic Adenosine 3',5'-Monophosphate Elevation and Biological Signaling through a Secretin Family Gs-Coupled G Protein-Coupled Receptor Are Restricted to a Single Adenylate Cyclase Isoform.
Emery AC, Liu XH, Xu W, Eiden MV, Eiden LE., Free PMC Article | 07/25/2015 |
| Alteration of hormonal sensitivity of adenylyl cyclase in the brain of rats with prolonged streptozotocin diabetes. | Alteration of hormonal sensitivity of adenylyl cyclase in the brain of rats with prolonged streptozotocin diabetes.
Shpakov AO, Derkach KV, Chistyakova OV, Moyseyuk IV, Bondareva VM. | 02/9/2013 |
| In primary hippocampal neurons and Neuro2A cells, elevated AC6 expression suppressed neurite outgrowth, whereas the downregulation or genetic removal of AC6 promoted neurite extension. | Type VI adenylyl cyclase regulates neurite extension by binding to Snapin and Snap25.
Wu CS, Lin JT, Chien CL, Chang WC, Lai HL, Chang CP, Chern Y., Free PMC Article | 01/28/2012 |
| AC6, but not the closely related AC5, plays a principal role in vasodilator signalling and regulation of the membrane potential in Vascular smooth muscle cells (VSMCs). | Principal role of adenylyl cyclase 6 in K⁺ channel regulation and vasodilator signalling in vascular smooth muscle cells.
Nelson CP, Rainbow RD, Brignell JL, Perry MD, Willets JM, Davies NW, Standen NB, Challiss RA., Free PMC Article | 12/31/2011 |
| Increased expression of adenylyl cyclases V and VI is a major determinant of increased GABAergic transmission in the substantia nigra pars reticulata of animals in which L-DOPA induces severe dyskinesia. | L-DOPA-induced dyskinesia in hemiparkinsonian rats is associated with up-regulation of adenylyl cyclase type V/VI and increased GABA release in the substantia nigra reticulata.
Rangel-Barajas C, Silva I, Lopéz-Santiago LM, Aceves J, Erlij D, Florán B. | 10/1/2011 |
| Isoproterenol activation of ACs promoted filamin phosphorylation, whereas thrombin inhibition of AC6 reduced filamin phosphorylation within the membrane fraction | Filamin A is a phosphorylation target of membrane but not cytosolic adenylyl cyclase activity.
Sayner SL, Balczon R, Frank DW, Cooper DM, Stevens T., Free PMC Article | 09/3/2011 |
| catalytically inactive mutant has same biological effects of intact enzyme, indicating that these effects do not require increased cAMP generation | Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant.
Gao MH, Tang T, Lai NC, Miyanohara A, Guo T, Tang R, Firth AL, Yuan JX, Hammond HK., Free PMC Article | 04/23/2011 |
| The distribution of Adenylyl cyclase type 6 to multiple cellular compartments appears to enable interactions with other proteins (e.g., PHLPP2) and activates cardioprotective signaling (PI3K/Akt). | beta(1)-Adrenergic receptor vs adenylyl cyclase 6 expression in cardiac myocytes: differences in transgene localization and intracellular signaling.
Gao MH, Tang T, Miyanohara A, Feramisco JR, Hammond HK., Free PMC Article | 03/1/2010 |
| increased expression of adenylyl cyclase VI activates Akt by phosphorylation at serine 473 and threonine 308 and is associated with increased nuclear phospho-Akt. Activated Akt phosphorylates phospholamban | Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes.
Gao MH, Tang T, Guo T, Miyanohara A, Yajima T, Pestonjamasp K, Feramisco JR, Hammond HK., Free PMC Article | 01/21/2010 |
| AC6 is completely compartmentized in lipid raft domains where it is activated solely by coresident G protein-coupled receptors to regulate cardiac fibroblast function. | Adenylyl cyclase type 6 overexpression selectively enhances beta-adrenergic and prostacyclin receptor-mediated inhibition of cardiac fibroblast function because of colocalization in lipid rafts.
Liu X, Thangavel M, Sun SQ, Kaminsky J, Mahautmr P, Stitham J, Hwa J, Ostrom RS., Free PMC Article | 01/21/2010 |
| K(ATP) channels localize adenylyl cyclase to smooth muscle membrane fractions containing caveolin. To permit protein kinase A-dependent activation, arterial K(ATP) channels need to be in the same lipid compartment as adenylyl cyclase. | Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels.
Sampson LJ, Hayabuchi Y, Standen NB, Dart C. | 01/21/2010 |
| co-localization of multiple signaling components in lipid rafts provides key spatial regulation of AC activity | Nitric oxide inhibition of adenylyl cyclase type 6 activity is dependent upon lipid rafts and caveolin signaling complexes.
Ostrom RS, Bundey RA, Insel PA. | 01/21/2010 |
| serotonin N-acetyltransferase regulation by bradykinin in rat pineal glands is affected by adenylyl cyclase VI | Rhythmic expression of adenylyl cyclase VI contributes to the differential regulation of serotonin N-acetyltransferase by bradykinin in rat pineal glands.
Han S, Kim TD, Ha DC, Kim KT. | 01/21/2010 |
| the N terminus of ACVI has a role in Galpha(i)-mediated regulation | An important functional role of the N terminus domain of type VI adenylyl cyclase in Galphai-mediated inhibition.
Kao YY, Lai HL, Hwang MJ, Chern Y. | 01/21/2010 |
| AC(VI) has a role in regulating phospholamban expression in cardiac myocytes via activating transcription factor 3 | Adenylyl cyclase type VI gene transfer reduces phospholamban expression in cardiac myocytes via activating transcription factor 3.
Gao MH, Tang T, Guo T, Sun SQ, Feramisco JR, Hammond HK. | 01/21/2010 |
| molecular mechanism underlying the inhibitory effect of PKC on ACVI (Type VI Adenylyl Cyclase) | Protein kinase C inhibits type VI adenylyl cyclase by phosphorylating the regulatory N domain and two catalytic C1 and C2 domains.
Lin TH, Lai HL, Kao YY, Sun CN, Hwang MJ, Chern Y. | 01/21/2010 |