| The critical role of CCK in the regulation of food intake and diet-induced obesity. | The critical role of CCK in the regulation of food intake and diet-induced obesity.
Cawthon CR, de La Serre CB. | 01/15/2022 |
| The cholecystokinin receptor agonist, CCK-8, induces adiponectin production in rat white adipose tissue. | The cholecystokinin receptor agonist, CCK-8, induces adiponectin production in rat white adipose tissue.
Plaza A, Merino B, Del Olmo N, Ruiz-Gayo M., Free PMC Article | 09/12/2020 |
| results show that cholecystokinin promotes lipid storage in white adipose tissue by acting on adipocyte cholecystokinin-2 receptor | Cholecystokinin is involved in triglyceride fatty acid uptake by rat adipose tissue.
Plaza A, Merino B, Cano V, Domínguez G, Pérez-Castells J, Fernández-Alfonso MS, Sengenès C, Chowen JA, Ruiz-Gayo M. | 04/20/2019 |
| Study provides the first direct comparative and quantitative data showing that presynaptic GABAB receptors exert differential inhibition at cholecystokinin (CCK) and parvalbumin (PV) basket cell (BC) synapses, resulting from a higher surface expression of the receptor at all CCK BC terminals and a lower protein density present in a subpopulation of boutons of PV BCs. | Differential surface density and modulatory effects of presynaptic GABA(B) receptors in hippocampal cholecystokinin and parvalbumin basket cells.
Booker SA, Althof D, Degro CE, Watanabe M, Kulik Á, Vida I., Free PMC Article | 06/23/2018 |
| The two projections from CCK(NTS) neurons reduce food intake through opposite motivational states; one pathway signals positive valence (CCK(NTS)-->paraventricular nucleus of the hypothalamus ) and the other signals negative valence (CCK(NTS)-->parabrachial nucleus). | A tale of two circuits: CCK(NTS) neuron stimulation controls appetite and induces opposing motivational states by projections to distinct brain regions.
Roman CW, Sloat SR, Palmiter RD., Free PMC Article | 04/28/2018 |
| Taken together, these results demonstrate that DMH NPY descending signals affect CCK-induced satiety, at least in part, via modulation of NTS catecholaminergic neuronal signaling. | Dorsomedial hypothalamic NPY affects cholecystokinin-induced satiety via modulation of brain stem catecholamine neuronal signaling.
de La Serre CB, Kim YJ, Moran TH, Bi S., Free PMC Article | 07/1/2017 |
| We conclude that only a small fraction of neuronal CCK is nonsulfated. The intracellular distribution of nonsulfated CCK in neurons suggests that they contribute only modestly to the CCK transmitter activity. | Nonsulfated cholecystokinins in cerebral neurons.
Agersnap M, Zhang MD, Harkany T, Hökfelt T, Rehfeld JF. | 02/25/2017 |
| The favorable treatment strategy for acute pancreatitis is to keep the pancreas at rest during an early stage followed by pancreatic stimulation by promoting endogenous CCK release. | Effect of endogenous cholecystokinin on the course of acute pancreatitis in rats.
Jia D, Yamamoto M, Otsuki M., Free PMC Article | 03/19/2016 |
| Cardiac expression of pro-cholecystokinin is cell-specific, which differentiates the expression from that of intestinal endocrine cells and cerebral neurons. | Cardiomyocyte expression and cell-specific processing of procholecystokinin.
Goetze JP, Johnsen AH, Kistorp C, Gustafsson F, Johnbeck CB, Rehfeld JF., Free PMC Article | 05/30/2015 |
| Estrogen-induced anxiolytic effects were associated with changes of the cholecystokinin system in brain regions controlling anxiety-like behavior. | Acute effects on brain cholecystokinin-like concentration and anxiety-like behaviour in the female rat upon a single injection of 17β-estradiol.
Holm L, Liang W, Thorsell A, Hilke S. | 01/31/2015 |
| All together, this study clearly demonstrates an important protective role of cholecystokinin against sepsis induced by Staphylococcus aureus. | Cholecystokinin protects rats against sepsis induced by Staphylococcus aureus.
Zuelli FM, Cárnio EC, Saia RS. | 01/10/2015 |
| Data suggest that Cck (here synthetic peptide fragment Cck 1-8; but not peptide YY 3-36 or glucagon-like peptide 1) mediates anorexic behavioral responses of peripheral sensory neurons (presumably vagal afferent nerves in mucosa of small intestines). | Role of capsaicin-sensitive peripheral sensory neurons in anorexic responses to intravenous infusions of cholecystokinin, peptide YY-(3-36), and glucagon-like peptide-1 in rats.
Reidelberger R, Haver A, Anders K, Apenteng B., Free PMC Article | 12/20/2014 |
| CCK-8 octapeptide attenuates the effects of morphine and saline on hippocampal long-term potentiation through CCK2 receptors, suggesting an ameliorative function of CCK-8 on morphine-induced memory impairment. | Cholecystokinin-octapeptide restored morphine-induced hippocampal long-term potentiation impairment in rats.
Wen D, Zang G, Sun D, Yu F, Mei D, Ma C, Cong B. | 10/4/2014 |
| findings suggest that the fibroblast growth factor system is poised to modulate both CCK and FGF-R1 expression in the ventral tegmental area | Interaction between cholecystokinin and the fibroblast growth factor system in the ventral tegmental area of selectively bred high- and low-responder rats.
Ballaz SJ, Perez J, Waselus M, Akil H, Watson SJ., Free PMC Article | 08/16/2014 |
| Data suggest that Apo AIV (apolipoprotein AIV) in NTS (nucleus of the solitary tract) or/and peripheral Cck require vagal Cck1r (cholecystokinin receptor 1) signaling to elicit satiation; high-fat diet reduces satiating capacity of these signals. | Intraperitoneal CCK and fourth-intraventricular Apo AIV require both peripheral and NTS CCK1R to reduce food intake in male rats.
Lo CC, Davidson WS, Hibbard SK, Georgievsky M, Lee A, Tso P, Woods SC., Free PMC Article | 06/21/2014 |
| CCK-8 antagonizes electroacpuncture modulation of sympathoexcitatory cardiovascular responses through an opioid mechanism and that inhibition of CCK-8 can convert animals that initially are unresponsive to EA to become responsive. | Electroacupuncture modulation of reflex hypertension in rats: role of cholecystokinin octapeptide.
Li M, Tjen-A-Looi SC, Guo ZL, Longhurst JC., Free PMC Article | 11/2/2013 |
| A biliopancreatic diversion model in rats finds a pathophysiological mechanism of action resulting from weight loss and villi elongation. | Biliopancreatic diversion induces villi elongation and cholecystokinin and ghrelin increase.
Mendieta-Zerón H, Larrad-Jiménez Á, Burrell MA, Rodríguez MM, Da Boit K, Frühbeck G, Diéguez C. | 08/31/2013 |
| peripheral apo AIV requires an intact CCK system and vagal afferents to activate neurons in the hindbrain to reduce food intake | Apolipoprotein AIV requires cholecystokinin and vagal nerves to suppress food intake.
Lo CC, Langhans W, Georgievsky M, Arnold M, Caldwell JL, Cheng S, Liu M, Woods SC, Tso P., Free PMC Article | 02/2/2013 |
| Cholecystokinin has cellular actions within the periaqueductal gray that can both oppose and reinforce opioid and cannabinoid modulation of pain and anxiety within this brain structure. | Cholecystokinin exerts an effect via the endocannabinoid system to inhibit GABAergic transmission in midbrain periaqueductal gray.
Mitchell VA, Jeong HJ, Drew GM, Vaughan CW., Free PMC Article | 05/12/2012 |
| Synergistic interaction between leptin and cholecystokinin in the rat nodose ganglia is mediated by PI3K and STAT3 signaling pathways: implications for leptin as a regulator of short term satiety. | Synergistic interaction between leptin and cholecystokinin in the rat nodose ganglia is mediated by PI3K and STAT3 signaling pathways: implications for leptin as a regulator of short term satiety.
Heldsinger A, Grabauskas G, Song I, Owyang C., Free PMC Article | 06/4/2011 |
| Rats on a medium high-fat diet had significantly higher plasma leptin but lower cholecystokinin levels than rats on a low-fat diet. This corresponded to attenuated or reversed splanchnic nerve responses to cholecystokinin and leptin. | High-fat diet is associated with blunted splanchnic sympathoinhibitory responses to gastric leptin and cholecystokinin: implications for circulatory control.
How JM, Fam BC, Verberne AJ, Sartor DM. | 05/28/2011 |
| Unlike in the dorsal vagal complex (DVC), CCK-8 was only able to activate the myenteric neurons in older rats. This delayed activation compared to the DVC may reflect a delayed role for these neurons in CCK-related functions. | Cholecystokinin-8 activates myenteric neurons in 21- and 35-day old but not 4- and 14-day old rats.
Washington MC, Murry CR, Raboin SJ, Roberson AE, Mansour MM, Williams CS, Sayegh AI. | 05/7/2011 |
| High dose lithium reduces the expression of cholecystokinin in hippocampal neurons. | [Effects of lithium on rat hippocampus cholecystokinin protein expression and learning and memory].
Li JS, Yang F, Zhao X. | 08/2/2010 |
| Our results provide a cellular and molecular mechanism to explain the roles of CCK in the brain. | Cholecystokinin facilitates glutamate release by increasing the number of readily releasable vesicles and releasing probability.
Deng PY, Xiao Z, Jha A, Ramonet D, Matsui T, Leitges M, Shin HS, Porter JE, Geiger JD, Lei S., Free PMC Article | 05/31/2010 |
| CaR is the beta 51-63 peptide sensor responsible for the stimulation of CCK secretion in enteroendocrine STC-1 cells. | Soybean beta 51-63 peptide stimulates cholecystokinin secretion via a calcium-sensing receptor in enteroendocrine STC-1 cells.
Nakajima S, Hira T, Eto Y, Asano K, Hara H. | 03/1/2010 |