| Findings outlined in the current study demonstrated the dental pulp protecting function of let-7c-5p during LPS-induced inflammation, which was exerted by inhibiting the DMP1-mediated NF-kappaB pathway. | MicroRNA let-7c-5p Suppressed Lipopolysaccharide-Induced Dental Pulp Inflammation by Inhibiting Dentin Matrix Protein-1-Mediated Nuclear Factor kappa B (NF-κB) Pathway In Vitro and In Vivo.
Yuan H, Zhang H, Hong L, Zhao H, Wang J, Li H, Che H, Zhang Z., Free PMC Article | 12/22/2018 |
| Four genes are expressed significantly higher in basal bone than in alveolar bone: SOST, E-11, DMP-1, and MEPE. Three of the proteins (SOST, MEPE, and DMP-1) are associated with mature osteocytes, indicating that basal bone has more mature osteocyte phenotypes because the immature osteocyte converts to a mature osteocyte as a result of bone mineralization. | Inherent physical characteristics and gene expression differences between alveolar and basal bones.
Zakhary I, Alotibi F, Lewis J, ElSalanty M, Wenger K, Sharawy M, Messer RL., Free PMC Article | 08/12/2017 |
| The C-terminal Dmp1 is phosphorylated within osteocytes and then secreted into the pericanalicular matrix of mineralized bone. | Immunohistochemical analysis of dentin matrix protein 1 (Dmp1) phosphorylation by Fam20C in bone: implications for the induction of biomineralization.
Oya K, Ishida K, Nishida T, Sato S, Kishino M, Hirose K, Ogawa Y, Ikebe K, Takeshige F, Yasuda H, Komori T, Toyosawa S. | 04/29/2017 |
| bone-specific Dentin matrix protein 1overexpression changes the pattern in osteogenic gene expression pattern thereby influencing bone development | Bone-specific overexpression of DMP1 influences osteogenic gene expression during endochondral and intramembranous ossification.
Padovano JD, Ramachandran A, Bahmanyar S, Ravindran S, George A., Free PMC Article | 08/15/2015 |
| TCF11 may play an important role in the transcriptional regulation of Dentin matrix protein 1 gene | Transcriptional regulation of dentin matrix protein 1 (DMP1) in odontoblasts and osteoblasts.
Jacob A, Zhang Y, George A. | 08/15/2015 |
| GnRH induction of Dmp1 is mediated by the protein kinase C signaling pathway. | Female-specific induction of rat pituitary dentin matrix protein-1 by GnRH.
Kucka M, Bjelobaba I, Clokie SJ, Klein DC, Stojilkovic SS, Kucka M, Bjelobaba I, Clokie SJ, Klein DC, Stojilkovic SS., Free PMC Articles: PMC3805844, PMC3805844 | 06/21/2014 |
| Circulating DMP1 and levels of other biochemical markers (osteocalcin, Trap5b, Dkk-1, and SOST) were measured in 2-, 4-, 8-, 12-, 18-, 24-, 72-, and 96-week-old Wistar male rats. | Novel sandwich ELISAs for rat DMP1: age-related decrease of circulatory DMP1 levels in male rats.
Sato S, Hashimoto J, Usami Y, Ohyama K, Isogai Y, Hagiwara Y, Maruyama N, Komori T, Kuroda T, Toyosawa S. | 06/14/2014 |
| DMP1 may play a role in reproduction as indicated by the finding in this report that the peptide GnRH, that controls FSH and LH release from the pituitary gland, causes a 600-fold induction of DMP in adult female rats. DMP1 is secreted and might act in a paracrine manner through cell-cell communication; it might also be released into the circulation and function as a hormone. | Female-specific induction of rat pituitary dentin matrix protein-1 by GnRH.
Kucka M, Bjelobaba I, Clokie SJ, Klein DC, Stojilkovic SS, Kucka M, Bjelobaba I, Clokie SJ, Klein DC, Stojilkovic SS., Free PMC Articles: PMC3805844, PMC3805844 | 10/22/2013 |
| The expression of DMP1 became very active from the 7th to 14th day after mandibular fracture. | [Time effect of dentin matrix protein 1 and osteoclast expression during mandibular fracture healing in rats].
Hu TX, Li ZB, Li Z. | 08/9/2010 |
| distinct forms of DMP1 may work collectively in controlling the mineralization process | Different forms of DMP1 play distinct roles in mineralization.
Gericke A, Qin C, Sun Y, Redfern R, Redfern D, Fujimoto Y, Taleb H, Butler WT, Boskey AL., Free PMC Article | 04/12/2010 |
| data suggest that a peptide generated through proteolytic processing of DMP1 by MMP-2 can regulate differentiation of mesenchymal cells during dentinogenesis and thus sustain reparative dentin formation in pathological situations such as carious decay. | MMP2-cleavage of DMP1 generates a bioactive peptide promoting differentiation of dental pulp stem/progenitor cell.
Chaussain C, Eapen AS, Huet E, Floris C, Ravindran S, Hao J, Menashi S, George A., Free PMC Article | 02/15/2010 |
| the differential patterns of expression of NH2-terminal and COOH-terminal fragments of DMP1 reflect their potentially distinct roles in the biomineralization of dentin and bone matrices. | The NH2-terminal and COOH-terminal fragments of dentin matrix protein 1 (DMP1) localize differently in the compartments of dentin and growth plate of bone.
Maciejewska I, Cowan C, Svoboda K, Butler WT, D'Souza R, Qin C., Free PMC Article | 01/21/2010 |
| The different distribution of DMP1 fragments indicates that these DMP1 variants must perform distinct functions. | Distinct compartmentalization of dentin matrix protein 1 fragments in mineralized tissues and cells.
Maciejewska I, Qin D, Huang B, Sun Y, Mues G, Svoboda K, Bonewald L, Butler WT, Feng JQ, Qin C., Free PMC Article | 01/21/2010 |
| binding of DMP1 with GRP-78 receptor might be an important mechanism by which DMP1 is internalized and transported to the nucleus during bone and tooth development | Endoplasmic reticulum chaperone protein GRP-78 mediates endocytosis of dentin matrix protein 1.
Ravindran S, Narayanan K, Eapen AS, Hao J, Ramachandran A, Blond S, George A., Free PMC Article | 01/21/2010 |
| Results suggest that although MKP-1 increases DNA-binding activity of Runx2, DMP1 expression may require the collaboration of MKP-1 to stimulate Runx2-mediated DMP1 expression in dexamethasone-treated C26 cells. | Dexamethasone promotes DMP1 mRNA expression by inhibiting negative regulation of Runx2 in multipotential mesenchymal progenitor, ROB-C26.
Mikami Y, Takahashi T, Kato S, Takagi M. | 01/21/2010 |
| The expression of DMP1 mRNA coincides with the start of the mineral nucleation process and gradually decreases during the maturation of the mineralized matrix during odontogenesis. | Differential expression patterns of the dentin matrix proteins during mineralized tissue formation.
Hao J, Zou B, Narayanan K, George A. | 01/21/2010 |
| data show that the developmental expression patterns of Dmp1 in osteogenic differentiation differ from those of type I collagen and osteocalcin, and Dmp1 appears to be expressed by osteocytes throughout ossification in the skeleton. | Differential expression of dentin matrix protein 1, type I collagen and osteocalcin genes in rat developing mandibular bone.
Kamiya N, Takagi M. | 01/21/2010 |
| Type I collagen promotes the activity of dentin formation by dental pulp cells by down-regulating Dmp-1 gene expression and up-regulating osteocalcin gene expression. | Type I collagen regulated dentin matrix protein-1 (Dmp-1) and osteocalcin (OCN) gene expression of rat dental pulp cells.
Mizuno M, Miyamoto T, Wada K, Watatani S, Zhang GX. | 01/21/2010 |
| Dmp1 first appeared in hypertrophic cartilage cells, followed by osteoblasts, and later was expressed strongly in osteocytes. Dmp1 may play an important role in bone formation. | Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a unique bone marker gene.
Fen JQ, Zhang J, Dallas SL, Lu Y, Chen S, Tan X, Owen M, Harris SE, MacDougall M. | 01/21/2010 |
| DMP1 is a bone matrix protein specifically expressed in osteocytes and preosteocytes and suggest that DMP1 plays a role in bone homeostasis because of its high calcium ion-binding capacity. | Dentin matrix protein 1 is predominantly expressed in chicken and rat osteocytes but not in osteoblasts.
Toyosawa S, Shintani S, Fujiwara T, Ooshima T, Sato A, Ijuhin N, Komori T. | 01/21/2010 |
| proteolytic processing of DMP1 plays a crucial role during osteogenesis and dentinogenesis | Evidence for the proteolytic processing of dentin matrix protein 1. Identification and characterization of processed fragments and cleavage sites.
Qin C, Brunn JC, Cook RG, Orkiszewski RS, Malone JP, Veis A, Butler WT. | 01/21/2010 |
| DMP1 and DSPP play complementary and/or synergistic roles in formation and maintenance of healthy teeth | Colocalization of dentin matrix protein 1 and dentin sialoprotein at late stages of rat molar development.
Baba O, Qin C, Brunn JC, Wygant JN, McIntyre BW, Butler WT. | 01/21/2010 |
| The localization of DMP1 mRNA and protein in dentin and cementum was related to their mineralization | mRNA expression and protein localization of dentin matrix protein 1 during dental root formation.
Toyosawa S, Okabayashi K, Komori T, Ijuhin N. | 01/21/2010 |
| binding of DMP1 and possibly other noncollagenous proteins on the collagen fibril might be a key step in collagen matrix organization and mineralization | Dentin matrix protein 1 immobilized on type I collagen fibrils facilitates apatite deposition in vitro.
He G, George A. | 01/21/2010 |