| Autophagy regulates bone loss via the RANKL/RANK/OPG axis in an experimental rat apical periodontitis model. | Autophagy regulates bone loss via the RANKL/RANK/OPG axis in an experimental rat apical periodontitis model.
Wu Z, Duan S, Li M, Zhang A, Yang H, Luo J, Cheng R, Hu T. | 08/15/2024 |
| Mechanical force regulates root resorption in rats through RANKL and OPG. | Mechanical force regulates root resorption in rats through RANKL and OPG.
Zhou J, Guo L, Yang Y, Liu Y, Zhang C., Free PMC Article | 07/23/2022 |
| The Influence of Prenatal Fumonisin Exposure on Bone Properties, as well as OPG and RANKL Expression and Immunolocalization, in Newborn Offspring Is Sex and Dose Dependent. | The Influence of Prenatal Fumonisin Exposure on Bone Properties, as well as OPG and RANKL Expression and Immunolocalization, in Newborn Offspring Is Sex and Dose Dependent.
Tomaszewska E, Rudyk H, Świetlicka I, Hułas-Stasiak M, Donaldson J, Arczewska M, Muszyński S, Dobrowolski P, Puzio I, Kushnir V, Brezvyn O, Muzyka V, Kotsyumbas I., Free PMC Article | 02/5/2022 |
| The cross-talk between matrix metalloproteinase-9, RANKL/OPG system and cardiovascular risk factors in ovariectomized rat model of postmenopausal osteoporosis. | The cross-talk between matrix metalloproteinase-9, RANKL/OPG system and cardiovascular risk factors in ovariectomized rat model of postmenopausal osteoporosis.
Sabry M, Mostafa S, Kamar S, Rashed L, Estaphan S., Free PMC Article | 11/27/2021 |
| [Effect of different orthodontic forces on the expression of T helper cell 17 cell-related cytokines in the pressure side of periodontal tissue in rats]. | [Effect of different orthodontic forces on the expression of T helper cell 17 cell-related cytokines in the pressure side of periodontal tissue in rats].
Wang LY, Wang B, Cong BB, Cui T, Du YQ, Song Y., Free PMC Article | 04/17/2021 |
| Osteoprotegerin Prevents Intracranial Aneurysm Progression by Promoting Collagen Biosynthesis and Vascular Smooth Muscle Cell Proliferation. | Osteoprotegerin Prevents Intracranial Aneurysm Progression by Promoting Collagen Biosynthesis and Vascular Smooth Muscle Cell Proliferation.
Miyata T, Minami M, Kataoka H, Hayashi K, Ikedo T, Yang T, Yamamoto Y, Yokode M, Miyamoto S., Free PMC Article | 03/13/2021 |
| Chondroitin Sulfate Prevents STZ Induced Diabetic Osteoporosis through Decreasing Blood Glucose, AntiOxidative Stress, Anti-Inflammation and OPG/RANKL Expression Regulation. | Chondroitin Sulfate Prevents STZ Induced Diabetic Osteoporosis through Decreasing Blood Glucose, AntiOxidative Stress, Anti-Inflammation and OPG/RANKL Expression Regulation.
Zheng HX, Chen J, Zu YX, Wang EZ, Qi SS., Free PMC Article | 02/20/2021 |
| Effect of continuous compressive force on the expression of RANKL, OPG, and VEGF in osteocytes. | Effect of continuous compressive force on the expression of RANKL, OPG, and VEGF in osteocytes.
Yashima Y, Kaku M, Yamamoto T, Izumino J, Kagawa H, Ikeda K, Shimoe S, Tanimoto K. | 01/9/2021 |
| Substance P participates in periodontitis by upregulating HIF-1alpha and RANKL/OPG ratio. | Substance P participates in periodontitis by upregulating HIF-1α and RANKL/OPG ratio.
Yan K, Lin Q, Tang K, Liu S, Du Y, Yu X, Li S., Free PMC Article | 08/15/2020 |
| S-amlodipine inhibits inflammation and protects against endothelial dysfunction, likely via regulating the RANK/RANKL/OPG pathway, which appears to be downstream of miR-155. | S-amlodipine improves endothelial dysfunction via the RANK/RANKL/OPG system by regulating microRNA-155 in hypertension.
Yang J, Si D, Zhao Y, He C, Yang P. | 08/31/2019 |
| In OPG treated rats, both serum (45)Ca and serum TRACP5b were suppressed by >70% due to a 75% decrease in bone resorption, a 3-fold increase in bone formation, and a 50% increase in absorption. | Serum calcium concentration is maintained when bone resorption is suppressed by osteoprotegerin in young growing male rats.
Hohman EE, Hodges JK, Wastney ME, Lachcik PJ, Han CY, Dwyer D, Peacock M, Kostenuik PJ, Weaver CM. | 07/20/2019 |
| A decrease in the RANKL/OPG ratio, associated with PTH-dependent activation of the anabolic PTH1R/ATF4 pathway, seems to be responsible for the unexpected, beneficial effect of PTH on cortical bone accrual and strength. | RANKL/OPG system regulation by endogenous PTH and PTH1R/ATF4 axis in bone: Implications for bone accrual and strength in growing rats with mild uremia.
Znorko B, Pawlak D, Oksztulska-Kolanek E, Domaniewski T, Pryczynicz A, Roszczenko A, Rogalska J, Lipowicz P, Doroszko M, Brzoska MM, Pawlak K. | 05/4/2019 |
| Adipose-derived stem cell-released osteoprotegerin protects cardiomyocytes from reactive oxygen species-induced cell death. | Adipose-derived stem cell-released osteoprotegerin protects cardiomyocytes from reactive oxygen species-induced cell death.
Lee J, Lee S, Lee CY, Seo HH, Shin S, Choi JW, Kim SW, Park JC, Lim S, Hwang KC., Free PMC Article | 06/2/2018 |
| An upregulation of OPG was observed in the ovariectomized rats with streptozotocin-induced type 1 diabetes mellitus plus daily Zn supplementation group compared with the nonsupplemented and control groups. | Zinc supplementation reduces RANKL/OPG ratio and prevents bone architecture alterations in ovariectomized and type 1 diabetic rats.
Ferreira ECS, Bortolin RH, Freire-Neto FP, Souza KSC, Bezerra JF, Ururahy MAG, Ramos AMO, Himelfarb ST, Abreu BJ, Didone TVN, Pedrosa LFC, Medeiros AC, Doi SQ, Brandão-Neto J, Hirata RDC, Rezende LA, Almeida MG, Hirata MH, Rezende AA. | 03/10/2018 |
| the canonical Wnt pathway inhibitor DKK1 blocked the osteogenesis effect and rescued the ratio of RANKL/OPG in periodontal ligament stem cells under force treatment for 1h. | Mechanical stress regulates osteogenic differentiation and RANKL/OPG ratio in periodontal ligament stem cells by the Wnt/β-catenin pathway.
Zhang L, Liu W, Zhao J, Ma X, Shen L, Zhang Y, Jin F, Jin Y. | 11/4/2017 |
| FGF21 inhibited VSMCs calcification via OPG/RANKL system, and through P38 andPI3K/AKT pathways. | Fibroblast growth factor 21 plays an inhibitory role in vascular calcification in vitro through OPG/RANKL system.
Cao F, Liu X, Cao X, Wang S, Fu K, Zhao Y, Shen F, Liu J. | 09/16/2017 |
| this study shows that flavonoids of Astragalus exert protective effects against adjuvant arthritis by regulating OPG/RANKL/NF-kappaB pathway | Protective effects of total flavonoids of Astragalus against adjuvant-induced arthritis in rats by regulating OPG/RANKL/NF-κB pathway.
Liu XY, Xu L, Wang Y, Li JX, Zhang Y, Zhang C, Wang SS, Zhang XM. | 05/13/2017 |
| In addition, curcumin upregulated the mRNA expression levels of transcription factors that favor osteoblast differentiation and increased the ratio of OPG to RANKL. | Curcumin alleviates glucocorticoid-induced osteoporosis through the regulation of the Wnt signaling pathway.
Chen Z, Xue J, Shen T, Mu S, Fu Q., Free PMC Article | 10/29/2016 |
| The ratio of RANKL to OPG was very low during most of the arterial calcification period, which allowed for OPG to completely inhibit RANKL-induced osteoclast-like cell differentiation and to promote calcification. | The function and meaning of receptor activator of NF-κB ligand in arterial calcification.
Nie B, Zhou SQ, Fang X, Zhang SY, Guan SM. | 09/17/2016 |
| RANKL and OPG expressions were not changed by chronic exposure to fluoride in the drinking water during the studied periods; on the other hand, TRAP expression was changed (at 7 days) by chronic exposure to fluoride | Effects of fluoride in bone repair: an evaluation of RANKL, OPG and TRAP expression.
Fernandes Mda S, Yanai MM, Martins GM, Iano FG, Leite AL, Cestari TM, Taga R, Buzalaf MA, de Oliveira RC. | 10/17/2015 |
| Lowering the serum homocysteine level by a simultaneous supplementation with N-acetylcysteine improved OPG and FOXO1 expression and partially antagonized RANKL and proresorptive cytokine synthesis in the bone milieu | Homocysteine alters the osteoprotegerin/RANKL system in the osteoblast to promote bone loss: pivotal role of the redox regulator forkhead O1.
Vijayan V, Khandelwal M, Manglani K, Singh RR, Gupta S, Surolia A. | 08/22/2015 |
| High-dose diosgenin treatment up-regulated expression of OPG significantly in tibia from OVX rats compared to control. | High-dose diosgenin reduces bone loss in ovariectomized rats via attenuation of the RANKL/OPG ratio.
Zhang Z, Song C, Fu X, Liu M, Li Y, Pan J, Liu H, Wang S, Xiang L, Xiao GG, Ju D., Free PMC Article | 06/27/2015 |
| Data indicate that the highest expression level of osteoprotegerin(OPG) was observed in jump (J) group. | [Effect of different types of jumps on the expressions of IL-6, OPG and RANKL in rat tibia].
Wang T, Zhang X, Li S. | 02/14/2015 |
| Cadmium could enhance receptor-activated nuclear factor kappa B ligand expression (RANKL) and inhibit osteoprotegerin (OPG) expression. | Environmental level of cadmium exposure stimulates osteoclasts formation in male rats.
Chen X, Wang G, Li X, Gan C, Zhu G, Jin T, Wang Z. | 05/10/2014 |
| RANKL and OPG expression promotes osteoclast development and enhances its function under the condition of estrogen deficiency | [RANKL and OPG expression in bone marrow-derived mesenchymal stem cells of ovariectomied promotes osteoclast development and enhances its function].
Shao B, Yu Y, Fu X, Xue H, Qi M, Shuai Y, Zhou Z, Jin Y, Yang D. | 03/29/2014 |