Prohibitin1 maintains mitochondrial quality in isoproterenol-induced cardiac hypertrophy in H9C2 cells. | Prohibitin1 maintains mitochondrial quality in isoproterenol-induced cardiac hypertrophy in H9C2 cells. Chakrabarti M, Raut GK, Jain N, Bhadra MP. | 02/14/2023 |
Prohibitin-1 Is a Dynamically Regulated Blood Protein With Cardioprotective Effects in Sepsis. | Prohibitin-1 Is a Dynamically Regulated Blood Protein With Cardioprotective Effects in Sepsis. Mattox TA, Psaltis C, Weihbrecht K, Robidoux J, Kilburg-Basnyat B, Murphy MP, Gowdy KM, Anderson EJ., Free PMC Article | 10/30/2021 |
PHB1 contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells which involves AKT phosphorylation | Regulatory effects of Prohibitin 1 on proliferation and apoptosis of pulmonary arterial smooth muscle cells in monocrotaline-induced PAH rats. Cao YY, Ba HX, Li Y, Tang SY, Luo ZQ, Li XH. | 05/9/2020 |
This study concluded that prohibitin is an autoantigen that cross-reacts with H1N1 influenza virus hemagglutinin. | Antibodies against H1N1 influenza virus hemagglutinin cross-react with prohibitin. Sun L, Li H, Sun J, Guo C, Feng Y, Li Y, Zhao X, Xie X, Hu J. | 05/2/2020 |
gonadotroph-in-dependent steroidogenesis in undifferentiated GCs are influenced not only by the expression of the key steroidogenic enzymes, but also by the 30-kDa PHB/pPHB, which acts as an obligatory mitochondrial protein that regulates mitochondrial function and, thus plays a central role as a key modulator of GC differentiation. | Prohibitin regulates the FSH signaling pathway in rat granulosa cell differentiation. Chowdhury I, Thomas K, Zeleznik A, Thompson WE., Free PMC Article | 10/28/2017 |
results demonstrate that PHB confers cytoprotection against oxidative stress in ISO-induced hypertrophy and this process is associated with modulation of Akt/Gsk-3beta signaling mechanisms as evident from our PHB overexpression and knockdown experiments. | Prohibitin confers cytoprotection against ISO-induced hypertrophy in H9c2 cells via attenuation of oxidative stress and modulation of Akt/Gsk-3β signaling. Chowdhury D, Kumar D, Bhadra U, Devi TA, Bhadra MP. | 02/18/2017 |
Data suggest that prohibitin (PHB) may be a new therapeutic target for diabetic cardiomyopathy (DCM). | Prohibitin overexpression improves myocardial function in diabetic cardiomyopathy. Dong WQ, Chao M, Lu QH, Chai WL, Zhang W, Chen XY, Liang ES, Wang LB, Tian HL, Chen YG, Zhang MX., Free PMC Article | 11/5/2016 |
Study shows that PHB is highly expressed in white adipose tissue and liver which expression is regulated by estrogen. | Effect of estrogen on expression of prohibitin in white adipose tissue and liver of diet-induced obese rats. Choi M, Chaudhari HN, Ji YR, Ryoo ZY, Kim SW, Yun JW. | 06/4/2016 |
prohibitin acts as a positive regulator of mechanisms that counteract oxidative stress and extracellular matrix accumulation and therefore has an antioxidative effect. | Prohibitin is associated with antioxidative protection in hypoxia/reoxygenation-induced renal tubular epithelial cell injury. Zhou TB, Qin YH, Lei FY, Huang WF, Drummen GP., Free PMC Article | 10/17/2015 |
PHB1 plays an important role in the development of SCI and might provide a therapeutic target to promote recovery from SCI. | Prohibitin 1 gene delivery promotes functional recovery in rats with spinal cord injury. Li L, Guo JD, Wang HD, Shi YM, Yuan YL, Hou SX. | 09/26/2015 |
All-trans retinoic acid acts as a positive regulator of PHB1, PHB2 and ACE2, and as a negative regulator of ACE1, angiotensin I, and angiotensin II in a renal tubular epithelial cells model system under hypoxia/reoxygenation conditions. | Effect of all-trans retinoic acid treatment on prohibitin and renin-angiotensin-aldosterone system expression in hypoxia-induced renal tubular epithelial cell injury. Zhou TB, Ou C, Rong L, Drummen GP. | 05/23/2015 |
Prohibitin attenuates oxidative stress and extracellular matrix accumulation in renal interstitial fibrosis disease. | Prohibitin attenuates oxidative stress and extracellular matrix accumulation in renal interstitial fibrosis disease. Zhou TB, Qin YH, Lei FY, Huang WF, Drummen GP., Free PMC Article | 08/9/2014 |
Prohibitin inhibits apoptosis in granulosa cells through the ERK1/2 pathway and the Bcl2 and Bcl-xL. | Prohibitin (PHB) inhibits apoptosis in rat granulosa cells (GCs) through the extracellular signal-regulated kinase 1/2 (ERK1/2) and the Bcl family of proteins. Chowdhury I, Thompson WE, Welch C, Thomas K, Matthews R., Free PMC Article | 07/19/2014 |
PHB1 and PHB2 expression are reduced in renal interstitial fibrosis; PHB1 positively correlates with PHB2 in renal interstitium. | Prohibitin 1 expression is associated with prohibitin 2 expression in renal interstitial fibrosis rats. Zhou TB, Qin YH. | 06/21/2014 |
Prohibitin expression in different neuronal & non-neuronal cell populations in rat cell cultures showed strong expression in oligodendrocytes. It was localized to mitochondria & some cell nuclei. | Increased density of prohibitin-immunoreactive oligodendrocytes in the dorsolateral prefrontal white matter of subjects with schizophrenia suggests extraneuronal roles for the protein in the disease. Bernstein HG, Smalla KH, Dürrschmidt D, Keilhoff G, Dobrowolny H, Steiner J, Schmitt A, Kreutz MR, Bogerts B. | 05/11/2013 |
findings suggest that PHB is a novel negative regulator of FSH-induced steroidogenesis, and its action with chemerin may contribute to the dysregulation of steroidogenesis in the pathogenesis of polycystic ovarian syndrome | Inhibitory roles of prohibitin and chemerin in FSH-induced rat granulosa cell steroidogenesis. Wang Q, Leader A, Tsang BK. | 03/23/2013 |
Prohibitin down-regulation is associated with increased caspase-3 expression and cell apoptosis in renal interstitial fibrosis rats. | Less expression of prohibitin is associated with increased caspase-3 expression and cell apoptosis in renal interstitial fibrosis rats. Zhou TB, Qin YH, Zhou C, Lei FY, Zhao YJ, Chen J, Su LN, Huang WF. | 05/19/2012 |
Expression of prohibitin in cardiomyocytes under oxidative stress increased. Prohibitin translocated to mitochondria after oxidative stress. | [Changes of expression and distribution of prohibitin in oxidative stressed cardiomyocyte and its biological significance]. Ren Z, Qian LJ, Yang ZH. | 05/5/2012 |
Prohibitin is an endogenous neuroprotective protein involved in ischemic tolerance. | Prohibitin reduces mitochondrial free radical production and protects brain cells from different injury modalities. Zhou P, Qian L, D'Aurelio M, Cho S, Wang G, Manfredi G, Pickel V, Iadecola C., Free PMC Article | 03/10/2012 |
The increased prohibitin level in response to subtle caloric restriction (CR) suggests that this increase may be one of the early events leading to the expansion of lifespan in response to CR. | Mild caloric restriction up-regulates the expression of prohibitin: a proteome study. Takahashi S, Masuda J, Shimagami H, Ohta Y, Kanda T, Saito K, Kato H. | 04/9/2011 |
Prohibitin is involved in oxidative stress signaling in the retina and retinal pigment epithelium. | Prohibitin as an oxidative stress biomarker in the eye. Lee H, Arnouk H, Sripathi S, Chen P, Zhang R, Bartoli M, Hunt RC, Hrushesky WJ, Chung H, Lee SH, Jahng WJ., Free PMC Article | 02/12/2011 |
PHB is expressed in beta-cells, increases with oxidative stress and protects the cells against deleterious effects of ethanol. | Prohibitin is expressed in pancreatic beta-cells and protects against oxidative and proapoptotic effects of ethanol. Lee JH, Nguyen KH, Mishra S, Nyomba BL. | 02/8/2010 |
Data indicate that prohibitin protects cardiomyocytes from oxidative stress-induced damage. | Prohibitin protects against oxidative stress-induced cell injury in cultured neonatal cardiomyocyte. Liu X, Ren Z, Zhan R, Wang X, Wang X, Zhang Z, Leng X, Yang Z, Qian L., Free PMC Article | 01/21/2010 |
prohibitin could serve an antiapoptotic role in undifferentiated granulosa cells | Apoptosis of rat granulosa cells after staurosporine and serum withdrawal is suppressed by adenovirus-directed overexpression of prohibitin. Chowdhury I, Xu W, Stiles JK, Zeleznik A, Yao X, Matthews R, Thomas K, Thompson WE. | 01/21/2010 |
prohibitin is involved in thymic growth and may be important for maturation of T lymphocytes. | Gonadotropin-releasing hormone attenuates pregnancy-associated thymic involution and modulates the expression of antiproliferative gene product prohibitin. Dixit VD, Sridaran R, Edmonsond MA, Taub D, Thompson WE. | 01/21/2010 |