| Craniofacial studies in chicken embryos confirm the pathogenicity of human FZD2 variants associated with Robinow syndrome. | Craniofacial studies in chicken embryos confirm the pathogenicity of human FZD2 variants associated with Robinow syndrome.
Tophkhane SS, Fu K, Verheyen EM, Richman JM., Free PMC Article | 07/13/2024 |
| Integrated weighted gene coexpression network analysis identifies Frizzled 2 (FZD2) as a key gene in invasive malignant pleomorphic adenoma. | Integrated weighted gene coexpression network analysis identifies Frizzled 2 (FZD2) as a key gene in invasive malignant pleomorphic adenoma.
Han Z, Ren H, Sun J, Jin L, Wang Q, Guo C, Tian Z., Free PMC Article | 03/26/2022 |
| FZD2 acts as an oncogene in tongue cancer, promoting cell growth, invasion and migration. | FZD2 regulates cell proliferation and invasion in tongue squamous cell carcinoma.
Huang L, Luo EL, Xie J, Gan RH, Ding LC, Su BH, Zhao Y, Lin LS, Zheng DL, Lu YG., Free PMC Article | 05/9/2020 |
| Fz2 and Wnt5a, might be involved in human Amyotrophic lateral sclerosis pathology. | Wnt Signaling Alterations in the Human Spinal Cord of Amyotrophic Lateral Sclerosis Cases: Spotlight on Fz2 and Wnt5a.
González-Fernández C, Gonzalez P, Andres-Benito P, Ferrer I, Rodríguez FJ. | 02/1/2020 |
| FZD2 could promote clinically relevant EMT, CD44(+) stem-like properties, and the VM phenotype in HCC involving a potential Hippo signaling pathway-dependent mechanism, and should be considered as a promising therapeutic target for the treatment of HCC. | Frizzled 2-induced epithelial-mesenchymal transition correlates with vasculogenic mimicry, stemness, and Hippo signaling in hepatocellular carcinoma.
Ou H, Chen Z, Xiang L, Fang Y, Xu Y, Liu Q, Hu Z, Li X, Huang Y, Yang D., Free PMC Article | 04/20/2019 |
| The results indicate that OMOD2 or Robinow syndome-like phenotype can be caused by a heterozygous nonsense FZD2 mutation impairing Wnt signaling. | Nonsense mutations in FZD2 cause autosomal-dominant omodysplasia: Robinow syndrome-like phenotypes.
Nagasaki K, Nishimura G, Kikuchi T, Nyuzuki H, Sasaki S, Ogawa Y, Saitoh A. | 03/2/2019 |
| Down-regulation of miR-30a-3p/5p promotes esophageal squamous cell carcinoma cell proliferation by activating the Wnt signaling pathway through inhibition of Wnt2 and Fzd2. | Down-regulation of miR-30a-3p/5p promotes esophageal squamous cell carcinoma cell proliferation by activating the Wnt signaling pathway.
Qi B, Wang Y, Chen ZJ, Li XN, Qi Y, Yang Y, Cui GH, Guo HZ, Li WH, Zhao S., Free PMC Article | 08/4/2018 |
| this study presents the crystal structure of a TcdB fragment in complex with the cysteine-rich domain of human FZD2 at 2.5-angstrom resolution, which reveals an endogenous FZD-bound fatty acid acting as a co-receptor for TcdB binding. | Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B.
Chen P, Tao L, Wang T, Zhang J, He A, Lam KH, Liu Z, He X, Perry K, Dong M, Jin R., Free PMC Article | 07/7/2018 |
| our study suggests a role for FZD2 in high-risk neuroblastoma cell growth | Frizzled2 signaling regulates growth of high-risk neuroblastomas by interfering with β-catenin-dependent and β-catenin-independent signaling pathways.
Zins K, Schäfer R, Paulus P, Dobler S, Fakhari N, Sioud M, Aharinejad S, Abraham D., Free PMC Article | 01/13/2018 |
| Treatment of the cell lines with Fzd2 siRNA resulted in significantly reduced migration and invasiveness but did not affect proliferation.Patients with high Fzd2 expression had significantly poorer recurrencefree survival than those with low expression | Clinical implication of Frizzled 2 expression and its association with epithelial-to-mesenchymal transition in hepatocellular carcinoma.
Asano T, Yamada S, Fuchs BC, Takami H, Hayashi M, Sugimoto H, Fujii T, Tanabe KK, Kodera Y. | 07/29/2017 |
| Fzd2 did not influence the proliferation of EC cells. | Promotion of epithelial-mesenchymal transition by Frizzled2 is involved in the metastasis of endometrial cancer.
Bian Y, Chang X, Liao Y, Wang J, Li Y, Wang K, Wan X. | 03/11/2017 |
| FZD2 was downregulated in an adenoid cystic carcinoma cell line with high metastatic potential, vs another with low potential. Knockdown of FZD2 downregulated the expression of PAI-1. | FZD2 inhibits the cell growth and migration of salivary adenoid cystic carcinomas.
Ding LC, Huang XY, Zheng FF, Xie J, She L, Feng Y, Su BH, Zheng DL, Lu YG. | 10/22/2016 |
| Sonazoid enhanced sonoporation of the cells with the diagnostic US device and the suppression of proliferation of both HCC cell lines by shRNA-Fz2. | Suppression of hepatocellular carcinoma cell proliferation by short hairpin RNA of frizzled 2 with Sonazoid-enhanced irradiation.
Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N. | 09/24/2016 |
| the present study demonstrated that Fzd2 contributes to the migration and invasion of OSCC cells, at least partly through regulation of the STAT3 pathway | Frizzled2 mediates the migration and invasion of human oral squamous cell carcinoma cells through the regulation of the signal transducer and activator of transcription-3 signaling pathway.
Zhang E, Li Z, Xu Z, Duan W, Sun C, Lu L. | 08/13/2016 |
| CD82 enhanced the expression of miR-203 and directly downregulated FZD2 expression, suppressing cancer metastasis/cell migration by inhibiting the Wnt signaling pathway. | miR-203 Inhibits Frizzled-2 Expression via CD82/KAI1 Expression in Human Lung Carcinoma Cells.
Mine M, Yamaguchi K, Sugiura T, Chigita S, Yoshihama N, Yoshihama R, Hiyake N, Kobayashi Y, Mori Y., Free PMC Article | 04/9/2016 |
| the FRIZZLED2 mutation is a de novo, novel cause for autosomal dominant omodysplasia. | A mutation in FRIZZLED2 impairs Wnt signaling and causes autosomal dominant omodysplasia.
Saal HM, Prows CA, Guerreiro I, Donlin M, Knudson L, Sund KL, Chang CF, Brugmann SA, Stottmann RW., Free PMC Article | 02/6/2016 |
| Fz2 was positive in both the cell membrane and cytoplasm of gastric cancer tissues of moderately differentiated and poorly differentiated adenocarcinoma.Fz2 expression pattern in normal stomach tissues. | Gastric cancer cell proliferation is suppressed by frizzled-2 short hairpin RNA.
Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N. | 09/26/2015 |
| It is associated with poor prognosis in glioblastoma patients. | Immunoreactivity of Wnt5a, Fzd2, Fzd6, and Ryk in glioblastoma: evaluative methodology for DAB chromogenic immunostaining.
Hirano H, Yonezawa H, Yunoue S, Habu M, Uchida H, Yoshioka T, Kishida S, Kishida M, Oyoshi T, Fujio S, Sugata S, Yamahata H, Hanaya R, Arita K. | 06/20/2015 |
| Pharmacologic and genetic perturbations reveal that Fzd2 drives epithelial-mesenchymal transition and cell migration through a previously unrecognized, noncanonical pathway that includes Fyn and Stat3. | A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis.
Gujral TS, Chan M, Peshkin L, Sorger PK, Kirschner MW, MacBeath G., Free PMC Article | 03/21/2015 |
| Data suggest that an anti-Wnt5a antibody was capable of suppressing Wnt5a-dependent internalization of Fz2 receptor, resulting in the prevention of metastasis of gastric cancer cells by inhibiting the activation of Rac1 and the expression of laminin gamma2. | An anti-Wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis.
Hanaki H, Yamamoto H, Sakane H, Matsumoto S, Ohdan H, Sato A, Kikuchi A. | 11/24/2012 |
| altered expression of FZD2 might be associated with a proliferative status, thus playing a role in the biology of human medulloblastomas | Expression profile of frizzled receptors in human medulloblastomas.
Salsano E, Paterra R, Figus M, Menghi F, Maderna E, Pollo B, Solero CL, Massimi L, Finocchiaro G. | 03/31/2012 |
| Wnt5a activated Rac in the beta-catenin-independent pathway, and Frizzled2 (Fz2) and Ror1 or Ror2 were required for this action. | Wnt5a regulates distinct signalling pathways by binding to Frizzled2.
Sato A, Yamamoto H, Sakane H, Koyama H, Kikuchi A., Free PMC Article | 02/8/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesMaternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC. Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.
Ollila HM, Soronen P, Silander K, Palo OM, Kieseppä T, Kaunisto MA, Lönnqvist J, Peltonen L, Partonen T, Paunio T. | 04/8/2009 |
| Human Frizzled-2 does not couple to calcium-mediated signaling through Wnt-5 protein and has slowly accumulated in canonical signaling by Wnt-3 protein. | Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells.
Verkaar F, van Rosmalen JW, Smits JF, Blankesteijn WM, Zaman GJ. | 01/21/2010 |
| Ror2 positively modulates Wnt3a-activated canonical signaling in a lung carcinoma, H441 cell line. This activity of Ror2 is dependent on cooperative interactions with Fzd2 but not Fzd7. | Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2.
Li C, Chen H, Hu L, Xing Y, Sasaki T, Villosis MF, Li J, Nishita M, Minami Y, Minoo P., Free PMC Article | 01/21/2010 |