| A2AR regulate inflammation through PKA/NF-kappaB signaling pathways in intervertebral disc degeneration. | A(2A)R regulate inflammation through PKA/NF-κB signaling pathways in intervertebral disc degeneration.
Liu W, Li Q, Fang W, Cai L, Wang Z, Kou B, Zhou C, Zhou Y, Yao Z, Wei M, Zhang S., Free PMC Article | 08/28/2024 |
| Abeta1-42 peptides blunt the adenosine A2A receptor-mediated control of the interplay between P2X7 and P2Y1 receptors mediated calcium responses in astrocytes. | Aβ(1-42) peptides blunt the adenosine A(2A) receptor-mediated control of the interplay between P(2)X(7) and P(2)Y(1) receptors mediated calcium responses in astrocytes.
Dias L, Madeira D, Dias R, Tomé ÂR, Cunha RA, Agostinho P., Free PMC Article | 08/6/2022 |
| Regulation of hippocampal postnatal and adult neurogenesis by adenosine A2A receptor: Interaction with brain-derived neurotrophic factor. | Regulation of hippocampal postnatal and adult neurogenesis by adenosine A(2A) receptor: Interaction with brain-derived neurotrophic factor.
Ribeiro FF, Ferreira F, Rodrigues RS, Soares R, Pedro DM, Duarte-Samartinho M, Aroeira RI, Ferreiro E, Valero J, Solá S, Mira H, Sebastião AM, Xapelli S. | 05/7/2022 |
| Attenuation of Tumor Development in Mammary Carcinoma Rats by Theacrine, an Antagonist of Adenosine 2A Receptor. | Attenuation of Tumor Development in Mammary Carcinoma Rats by Theacrine, an Antagonist of Adenosine 2A Receptor.
Jhuo CF, Hsu YY, Chen WY, Tzen JTC., Free PMC Article | 02/12/2022 |
| The Adenosine A2A Receptor Activation in Nucleus Accumbens Suppress Cue-Induced Reinstatement of Propofol Self-administration in Rats. | The Adenosine A2A Receptor Activation in Nucleus Accumbens Suppress Cue-Induced Reinstatement of Propofol Self-administration in Rats.
Dong Z, Huang B, Jiang C, Chen J, Lin H, Lian Q, Wu B., Free PMC Article | 10/2/2021 |
| Regulation of adenosine A2A receptor gene expression in a model of binge eating in the amygdaloid complex of female rats. | Regulation of adenosine A(2A) receptor gene expression in a model of binge eating in the amygdaloid complex of female rats.
Micioni Di Bonaventura MV, Pucci M, Giusepponi ME, Romano A, Lambertucci C, Volpini R, Micioni Di Bonaventura E, Gaetani S, Maccarrone M, D'Addario C, Cifani C. | 08/15/2020 |
| Low androgen status inhibits the AKT/eNOS/cGMP signaling pathways and the production of cAMP in the corpus cavernosum of castrated rats by downregulating the expression of A2B receptor with no significant difference in the expression of A2A receptor, and results in decreased of intra-cavernous pressure/mean arterial pressure. | Effect of low androgen status on the expression of adenosine A(2A) and A(2B) receptors in rat penile corpus cavernosum.
Kong X, Jiang J, Cheng B, Jiang R. | 02/15/2020 |
| Studied effect of exercise on memory and cerebral cortex physiology of NTPDase-1 (CD39), 5' nucleotidase ecto (CD73), and adenosine A2a receptor (A2ar). | Physical exercise prevents memory impairment in an animal model of hypertension through modulation of CD39 and CD73 activities and A2A receptor expression.
Cardoso AM, Manfredi LH, Zanini D, Bagatini MD, Gutierres JM, Carvalho F, Tremblay A, Belló-Klein A, Rubin MA, Morsch VM, Sévigny J, Schetinger MRC. | 01/25/2020 |
| results show that A2A receptors exert a positive postsynaptic modulatory effect over synaptic, but not extrasynaptic, NMDA receptors in CA1 neurons and, therefore, under non-pathological conditions may contribute to shift the dual role of NMDA receptors towards enhancement of synaptic plasticity | Adenosine A(2A) receptors facilitate synaptic NMDA currents in CA1 pyramidal neurons.
Mouro FM, Rombo DM, Dias RB, Ribeiro JA, Sebastião AM., Free PMC Article | 09/28/2019 |
| Chronic blockade of adenosine A2A receptors, ameliorated cognitive deficits, but not anxiety-like behavior in a model of anxiety and cognitive dysfunction. | Region-specific control of microglia by adenosine A(2A) receptors: uncoupling anxiety and associated cognitive deficits in female rats.
Duarte JM, Gaspar R, Caetano L, Patrício P, Soares-Cunha C, Mateus-Pinheiro A, Alves ND, Santos AR, Ferreira SG, Sardinha V, Oliveira JF, Fontes-Ribeiro C, Sousa N, Cunha RA, Ambrósio AF, Pinto L, Rodrigues AJ, Gomes CA. | 05/18/2019 |
| These results demonstrate that acute alpha2-adrenergic stimulation suppresses glucose oxidation in beta-cells independent of nutrient availability and insulin exocytosis, while cAMP concentrations are elevated. | Adrenergic receptor stimulation suppresses oxidative metabolism in isolated rat islets and Min6 cells.
Kelly AC, Camacho LE, Pendarvis K, Davenport HM, Steffens NR, Smith KE, Weber CS, Lynch RM, Papas KK, Limesand SW., Free PMC Article | 04/27/2019 |
| Exposure to hyperthermic insult resulted in seizures and depressive behavior accompanied by an increase in A2A receptor level. | Early-life hyperthermic seizures upregulate adenosine A(2A) receptors in the cortex and promote depressive-like behavior in adult rats.
Crespo M, León-Navarro DA, Martín M. | 03/30/2019 |
| Studied effect of Baicalin on rat hypoxia-induced pulmonary artery smooth muscle cell apoptosis and proliferation thru the C-X-C motif chemokine ligand 12 (SDF-1)and C-X-C motif chemokine receptor 4 (CXCR4) signal pathway by upregulation of adenosine A2a receptor (A2ar). | Baicalin promotes apoptosis and inhibits proliferation and migration of hypoxia-induced pulmonary artery smooth muscle cells by up-regulating A2a receptor via the SDF-1/CXCR4 signaling pathway.
Huang X, Mao W, Zhang T, Wang M, Wang X, Li Y, Zhang L, Yao D, Cai X, Wang L., Free PMC Article | 01/19/2019 |
| These findings demonstrate that inosine acts via an A2B receptor-mediated pathway that impinges on specific potassium channel effectors. | Inosine attenuates spontaneous activity in the rat neurogenic bladder through an A(2B) pathway.
Doyle C, Cristofaro V, Sack BS, Lukianov SN, Schäfer M, Chung YG, Sullivan MP, Adam RM., Free PMC Article | 11/10/2018 |
| the inhibition of SDF1CXC4 signaling by the activation of A2A receptor and subsequent increase in the level of cAMP may be a potential method to ameliorate pulmonary arterial hypertension. | Adenosine A(2A) receptor activation reverses hypoxia‑induced rat pulmonary artery smooth muscle cell proliferation via cyclic AMP‑mediated inhibition of the SDF1‑CXC4 signaling pathway.
Wang Y, Ying L, Jin KK, Nan Y, Hu S, Wu X, Qi R, Luo X, Wang L. | 09/29/2018 |
| The activation of Gs protein-coupled receptors (GsPCRs) and the GsPCRs-independent activation of Gs proteins and adenylyl cyclase by cholera toxin induce stimulation of cell surface adenosine receptors (A2A or A2B adenosine receptors). | Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors.
Pleli T, Mondorf A, Ferreiros N, Thomas D, Dvorak K, Biondi RM, Heringdorf DMZ, Zeuzem S, Geisslinger G, Zimmermann H, Waidmann O, Piiper A. | 06/23/2018 |
| these results provide a novel evidence for the use of adenosine A2AR antagonists as potential therapy for retinal ischemic diseases and demonstrate the effect of caffeine on the regulation of microglia-mediated neuroinflammation in the transient ischemic model | Treatment with A(2A) receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage.
Boia R, Elvas F, Madeira MH, Aires ID, Rodrigues-Neves AC, Tralhão P, Szabó EC, Baqi Y, Müller CE, Tomé ÂR, Cunha RA, Ambrósio AF, Santiago AR., Free PMC Article | 06/9/2018 |
| Study discloses a facilitatory action of adenosine A2A (A2AR) receptors upon axonal elongation and microtubule dynamics, providing new insights for A2ARs regulation of neuronal differentiation and axonal regeneration | Axonal elongation and dendritic branching is enhanced by adenosine A2A receptors activation in cerebral cortical neurons.
Ribeiro FF, Neves-Tomé R, Assaife-Lopes N, Santos TE, Silva RF, Brites D, Ribeiro JA, Sousa MM, Sebastião AM. | 09/23/2017 |
| Activation of adenosine A1 and A2A receptors and P2 purinoceptors potentially play a central role in the regulation of dopamine effects at the neuromuscular junction. | Modulation of dopamine-mediated facilitation at the neuromuscular junction of Wistar rats: A role for adenosine A1/A2A receptors and P2 purinoceptors.
Elnozahi NA, AlQot HE, Mohy El-Din MM, Bistawroos AE, Abou Zeit-Har MS. | 06/24/2017 |
| Our results suggest for the first time that septic hearts are more or less cardioprotected, the adenosine receptors AdorA2a and AdorA2b play predominant role for a reduced morphological and functional I/R injury in the septic heart. | Adenosine A2A and A2B Receptor Substantially Attenuate Ischemia/Reperfusion Injury in Septic rat Hearts.
Busse H, Bitzinger D, Höcherl K, Seyfried T, Gruber M, Graf BM, Zausig YA., Free PMC Article | 03/11/2017 |
| Suggest role for A1 and A2A adenosine receptors in dipyridamole-mediated attenuation of ischemia perfusion induced acute kidney injury in rats. | Dipyridamole attenuates ischemia reperfusion induced acute kidney injury through adenosinergic A1 and A2A receptor agonism in rats.
Puri N, Mohey V, Singh M, Kaur T, Pathak D, Buttar HS, Singh AP. | 12/17/2016 |
| additional evidence for the existence of an interaction between striatal Adenosine A2A receptors and cannabinoid CB1 receptors, playing a fundamental role in the regulation of striatal functions | Striatal adenosine-cannabinoid receptor interactions in rats over-expressing adenosine A2A receptors.
Chiodi V, Ferrante A, Ferraro L, Potenza RL, Armida M, Beggiato S, Pèzzola A, Bader M, Fuxe K, Popoli P, Domenici MR. | 08/27/2016 |
| ST1535 metabolites ST3932 and ST4206 are effective adenosine A2A receptor antagonists which maybe useful in treating Parkinson disease. | Animal models of Parkinson׳s disease: Effects of two adenosine A2A receptor antagonists ST4206 and ST3932, metabolites of 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine (ST1535).
Stasi MA, Minetti P, Lombardo K, Riccioni T, Caprioli A, Vertechy M, Di Serio S, Pace S, Borsini F. | 05/21/2016 |
| Chronic A2a AR stimulation prevents proteinuria and glomerular damage in experimental diabetes via an anti-inflammatory mechanism independent of oxidative stress and kidney hypoxia. | Adenosine A2 a receptor stimulation prevents proteinuria in diabetic rats by promoting an anti-inflammatory phenotype without affecting oxidative stress.
Persson P, Friederich-Persson M, Fasching A, Hansell P, Inagi R, Palm F. | 03/12/2016 |
| Adenosine, via activation of A(2A) receptors, may directly facilitate basolateral amygdala pyramidal cell output. | Postsynaptic adenosine A2A receptors modulate intrinsic excitability of pyramidal cells in the rat basolateral amygdala.
Rau AR, Ariwodola OJ, Weiner JL., Free PMC Article | 01/16/2016 |