| A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity. | A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity.
Zdravković A, Daley JM, Dutta A, Niwa T, Murayama Y, Kanamaru S, Ito K, Maki T, Argunhan B, Takahashi M, Tsubouchi H, Sung P, Iwasaki H., Free PMC Article | 09/25/2021 |
| an important role for Ctp1-regulated DNA strand coordination required for DNA DSB repair in S. pombe | Ctp1 protein-DNA filaments promote DNA bridging and DNA double-strand break repair.
Andres SN, Li ZM, Erie DA, Williams RS., Free PMC Article | 05/11/2019 |
| CtIP/Ctp1/Sae2/Com1 role in removal of DNA double strand breaks through DSB repair by homologous recombination is reviewed. | CtIP/Ctp1/Sae2, molecular form fit for function.
Andres SN, Williams RS., Free PMC Article | 11/18/2017 |
| a mre11 mutant defective in endonucleolytic activity, the same mutant lacking Ctp1, or the triple mutant also lacking the putative hairpin nuclease Pso2 showed wild-type levels of repair. Thus, MRN (Mre11-Rad50-Nbs1)may act to recruit the hairpin opening activity that allows subsequent repair | Nonhomologous End-Joining with Minimal Sequence Loss Is Promoted by the Mre11-Rad50-Nbs1-Ctp1 Complex in Schizosaccharomyces pombe.
Li Y, Wang J, Zhou G, Lajeunesse M, Le N, Stawicki BN, Corcino YL, Berkner KL, Runge KW., Free PMC Article | 07/15/2017 |
| The authors concludes that the intracellular Ctp1 C-terminal portion is essential for clipping, while the N-terminal portion is sufficient for DNA double-strand break end-resection. | Two separable functions of Ctp1 in the early steps of meiotic DNA double-strand break repair.
Ma L, Milman N, Nambiar M, Smith GR., Free PMC Article | 12/19/2015 |
| Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair. | Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair.
Andres SN, Appel CD, Westmoreland JW, Williams JS, Nguyen Y, Robertson PD, Resnick MA, Williams RS., Free PMC Article | 04/11/2015 |
| these data propose that release of the MRN complex and Ku from DNA ends by Mre11 nuclease activity and Ctp1 is a critical step required to expose ssDNA for replication protein A localization and ensuing homologous recombination repair. | Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.
Langerak P, Mejia-Ramirez E, Limbo O, Russell P., Free PMC Article | 01/28/2012 |
| In fission yeast, found only one class of oligonucleotides bound to Rec12 ranging in length from 17 to 27 nucleotides. Ctp1, Rad50, and the nuclease activity of Rad32, the fission yeast homolog of Mre11, are required for endonucleolytic Rec12 removal. | Ctp1 and the MRN-complex are required for endonucleolytic Rec12 removal with release of a single class of oligonucleotides in fission yeast.
Rothenberg M, Kohli J, Ludin K., Free PMC Article | 03/8/2010 |
| Rad32 nuclease has the catalytic site for Rec12-oligonucleotide generation and is activated by Ctp1, which plays an additional role in meiotic recombination. | Meiotic DNA double-strand break repair requires two nucleases, MRN and Ctp1, to produce a single size class of Rec12 (Spo11)-oligonucleotide complexes.
Milman N, Higuchi E, Smith GR., Free PMC Article | 01/21/2010 |
| Tethering of Ctp1 to a flexible Nbs1 arm suggests a mechanism for restricting DNA end processing and homologous recombination activities of Sae2/Ctp1/CtIP to the immediate vicinity of double-strand breaks. | Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair.
Williams RS, Dodson GE, Limbo O, Yamada Y, Williams JS, Guenther G, Classen S, Glover JN, Iwasaki H, Russell P, Tainer JA., Free PMC Article | 01/21/2010 |
| Study finds that in the presence of the MRN (Rad32-Rad50-Nbs1) complex efficient recombination requires Ctp1, the ortholog of the nuclease Sae2, but not the nuclease activity of MRN. | Ctp1 and Exonuclease 1, alternative nucleases regulated by the MRN complex, are required for efficient meiotic recombination.
Farah JA, Cromie GA, Smith GR., Free PMC Article | 01/21/2010 |
| The Mre11-Rad50-Nbs1 S-phase checkpoint role is separate from its Ctp1- and resection-dependent role in double-strand break repair. | The role of MRN in the S-phase DNA damage checkpoint is independent of its Ctp1-dependent roles in double-strand break repair and checkpoint signaling.
Porter-Goff ME, Rhind N., Free PMC Article | 01/21/2010 |
| This study demonstrates for the first time that Mre11 (Schizosaccharomyces pombe Rad32(Mre11)) nuclease activity is required for the removal of Rec12(Spo11). | Ctp1CtIP and Rad32Mre11 nuclease activity are required for Rec12Spo11 removal, but Rec12Spo11 removal is dispensable for other MRN-dependent meiotic functions.
Hartsuiker E, Mizuno K, Molnar M, Kohli J, Ohta K, Carr AM., Free PMC Article | 01/21/2010 |
| Schizosaccharomyces pombe Rad32(Mre11) nuclease activity is involved in the removal of both Top2 from 5' DNA ends as well as Top1 from 3' ends in vivo and a ctp1(CtIP) deletion is defective for Top2 removal but overproficient for Top1 removal. | Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA.
Hartsuiker E, Neale MJ, Carr AM., Free PMC Article | 01/21/2010 |
| These data suggest that regulation of Ctp1 underlies cell-cycle control of homologous recombination. | Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination.
Limbo O, Chahwan C, Yamada Y, de Bruin RA, Wittenberg C, Russell P., Free PMC Article | 01/21/2010 |