| Dopamine D4 receptors in the lateral habenula regulate depression-related behaviors via a pre-synaptic mechanism in experimental Parkinson's disease. | Dopamine D(4) receptors in the lateral habenula regulate depression-related behaviors via a pre-synaptic mechanism in experimental Parkinson's disease.
Hui Y, Du C, Xu T, Zhang Q, Tan H, Liu J. | 09/4/2021 |
| Theexpression level of D4 receptor was also dramatically down-regulated in the arterial endothelium of rats with streptozotocin-(STZ)-induced diabetes, and the STZ-induced impairment of acetylcholine-induced vasodilation was reversed by activation of D4 receptor. | Dopamine D(4) receptor protected against hyperglycemia-induced endothelial dysfunction via PI3K /eNOS pathway.
Wang H, Yao Y, Liu J, Cao Y, Si C, Zheng R, Zeng C, Guan H, Li L. | 06/13/2020 |
| Data provide novel evidence that the dopamine D4 receptor does not alter incentive motivation in response to cues on simple behavioural tasks. | Elucidating the role of D4 receptors in mediating attributions of salience to incentive stimuli on Pavlovian conditioned approach and conditioned reinforcement paradigms.
Cocker PJ, Vonder Haar C, Winstanley CA. | 12/23/2017 |
| Dopamine D4 receptor (D4R) antagonism in the prelimbic area (PL) decreases the expression of innate fear-behavior indicating that the activation of D4R in the PL is necessary for the expression of innate fear-behavior. | Activation of type 4 dopaminergic receptors in the prelimbic area of medial prefrontal cortex is necessary for the expression of innate fear behavior.
Vergara MD, Keller VN, Fuentealba JA, Gysling K. | 12/16/2017 |
| Data indicate that the anterior cingulate cortex is critically involved in parsing the appropriate response when competing stimulus-outcome associations are activated, and that signalling via dopamine D4 receptors may play a particularly important role in gating the temporal and spatial summation of salient events. | Activation of dopamine D4 receptors within the anterior cingulate cortex enhances the erroneous expectation of reward on a rat slot machine task.
Cocker PJ, Hosking JG, Murch WS, Clark L, Winstanley CA. | 06/24/2017 |
| Regulatory role of the D(4) receptor on AT(1a) receptor expression and function in VSMCs and suggest that targeting the action of the D(4) receptor may represent an effective therapeutic approach for the treatment of cardiovascular diseases. | Activation of the D4 dopamine receptor attenuates proliferation and migration of vascular smooth muscle cells through downregulation of AT1a receptor expression.
Yu C, Chen J, Guan W, Han Y, Wang WE, Wang X, Wang H, Jose PA, Zeng C., Free PMC Article | 06/11/2016 |
| Activation of DRD4 receptors suppresses the proliferation and migration of vascular smooth muscle cells, thereby inhibiting atherosclerosis via reducing the effects of insulin on artery remodeling. | Dopamine D₄ receptors inhibit proliferation and migration of vascular smooth muscle cells induced by insulin via down-regulation of insulin receptor expression.
Yu C, Wang Z, Han Y, Liu Y, Wang WE, Chen C, Wang H, Jose PA, Zeng C., Free PMC Article | 11/8/2014 |
| Following chronic ethanol exposure, dopamine D4 receptor activity is disrupted in the medial prefrontal cortex. | Chronic alcohol disrupts dopamine receptor activity and the cognitive function of the medial prefrontal cortex.
Trantham-Davidson H, Burnett EJ, Gass JT, Lopez MF, Mulholland PJ, Centanni SW, Floresco SB, Chandler LJ., Free PMC Article | 05/3/2014 |
| The restoration of PFC glutamatergic transmission in stress conditions may enable D4 receptors to serve as a synaptic stabilizer in normal and pathological conditions. | Restoration of glutamatergic transmission by dopamine D4 receptors in stressed animals.
Yuen EY, Zhong P, Li X, Wei J, Yan Z., Free PMC Article | 02/8/2014 |
| D4R activation affects fast-spiking interneuron synchronization and thereby increases gamma power by an NMDA receptor-dependent mechanism. | Dopamine D4 receptor activation increases hippocampal gamma oscillations by enhancing synchronization of fast-spiking interneurons.
Andersson R, Johnston A, Fisahn A., Free PMC Article | 03/23/2013 |
| Neuregulin and dopamine modulation of hippocampal gamma oscillations is dependent on dopamine D4 receptors. | Neuregulin and dopamine modulation of hippocampal gamma oscillations is dependent on dopamine D4 receptors.
Andersson RH, Johnston A, Herman PA, Winzer-Serhan UH, Karavanova I, Vullhorst D, Fisahn A, Buonanno A., Free PMC Article | 10/20/2012 |
| distinct signaling mechanisms underlying the homeostatic regulation of glutamatergic transmission by D(4) receptors, which may be important for cognitive and emotional processes in which dopamine is involved | Cellular mechanisms for dopamine D4 receptor-induced homeostatic regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.
Yuen EY, Yan Z., Free PMC Article | 01/28/2012 |
| Bioinformatic analysis complemented by functional analysis of the DRD4 gene locus has identified a) a strong enhancer that functions in neurons and b) a transcription factor that may modulate the function of that enhancer. | An evolutionary conserved region (ECR) in the human dopamine receptor D4 gene supports reporter gene expression in primary cultures derived from the rat cortex.
Paredes UM, Bubb VJ, Haddley K, Macho GA, Quinn JP., Free PMC Article | 09/17/2011 |
| Our data demonstrate that the activation of presynaptic D(4) receptors regulates GABA release from globus pallidus efferents but not thalamic reticular nucleus collaterals | Regulation of inhibitory synapses by presynaptic D₄ dopamine receptors in thalamus.
Govindaiah G, Wang T, Gillette MU, Crandall SR, Cox CL., Free PMC Article | 02/26/2011 |
| Homeostatic regulation of glutamatergic transmission by dopamine D4 receptors. | Homeostatic regulation of glutamatergic transmission by dopamine D4 receptors.
Yuen EY, Zhong P, Yan Z., Free PMC Article | 02/5/2011 |
| Results indicate that Drd4 is the dominant dopamine receptor gene expressed in the pineal gland. | Thyroid hormone and adrenergic signaling interact to control pineal expression of the dopamine receptor D4 gene (Drd4).
Kim JS, Bailey MJ, Weller JL, Sugden D, Rath MF, Møller M, Klein DC, Kim JS, Bailey MJ, Weller JL, Sugden D, Rath MF, Møller M, Klein DC., Free PMC Articles: PMC2783391, PMC2783391 | 01/21/2010 |
| hypodopaminergic mice exhibit severe impairments to retrieve rewards in two operant positive reinforcement tasks, but these deleterious effects are totally prevented in the absence of functional D4Rs. | Reward-seeking and discrimination deficits displayed by hypodopaminergic mice are prevented in mice lacking dopamine D4 receptors.
Nemirovsky SI, Avale ME, Brunner D, Rubinstein M. | 01/21/2010 |
| Coactivation of both thyroid hormone and norepinephrine/cyclic AMP signalling pathways is required for the large daily increase in Drd4 expression to occur in the pineal gland. | Thyroid hormone and adrenergic signaling interact to control pineal expression of the dopamine receptor D4 gene (Drd4).
Kim JS, Bailey MJ, Weller JL, Sugden D, Rath MF, Møller M, Klein DC, Kim JS, Bailey MJ, Weller JL, Sugden D, Rath MF, Møller M, Klein DC., Free PMC Articles: PMC2783391, PMC2783391 | 07/24/2009 |
| the density of surface clusters of GABA(A)R beta2/3 subunits was reduced by D(4), suggesting that the D(4) reduction of GABA(A)R current is associated with a decrease in functional GABA(A)Rs at the plasma membrane. | Dopamine D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism.
Graziane NM, Yuen EY, Yan Z., Free PMC Article | 01/21/2010 |
| The highest level of expression of Drd4 gene occurs in the pineal gland, in which night values increase to levels that are 50-fold higher than the median expression level in other tissues. High expression is also seen in the retina. | Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.
Bailey MJ, Coon SL, Carter DA, Humphries A, Kim JS, Shi Q, Gaildrat P, Morin F, Ganguly S, Hogenesch JB, Weller JL, Rath MF, Møller M, Baler R, Sugden D, Rangel ZG, Munson PJ, Klein DC., Free PMC Article | 02/24/2009 |
| The present findings support a major role of the dopamine D(4) receptor in mediating the transmission of cortical dopamine and noradrenaline nerve terminal plexuses. | Cellular localization and distribution of dopamine D(4) receptors in the rat cerebral cortex and their relationship with the cortical dopaminergic and noradrenergic nerve terminal networks.
Rivera A, Peñafiel A, Megías M, Agnati LF, López-Téllez JF, Gago B, Gutiérrez A, de la Calle A, Fuxe K. | 01/21/2010 |
| The results of our investigation show for the first time a functional interplay between D1R and D4R that mediates coincident G protein-independent and dependent regulation of NMDARs. | D1 and D4 dopaminergic receptor interplay mediates coincident G protein-independent and dependent regulation of glutamate NMDA receptors in the lateral amygdala.
Martina M, Bergeron R. | 01/21/2010 |
| Monoclonal antibodies against all three D(2)-like receptors were used to localize receptors in Ntera-2 (NT-2) cells, the human neuronal precursor cell line and rat cerebral cortex and hippocampus. | Endosomal location of dopamine receptors in neuronal cell cytoplasm.
Wolstencroft EC, Simic G, thi Man N, Holt I, Lam le T, Buckland PR, Morris GE. | 01/21/2010 |
| are heterogeneously distributed in the striosomes/matrix compartments of the striatum. | Dopamine D4 receptors are heterogeneously distributed in the striosomes/matrix compartments of the striatum.
Rivera A, Cuéllar B, Girón FJ, Grandy DK, de la Calle A, Moratalla R. | 01/21/2010 |
| Dopamine D4 receptors were observed in the substantia nigra pars reticulata, the entopeduncular nucleus and the globus pallidus, and they were found, using electron microscopy, to be located presynaptically. | Expression of D4 dopamine receptors in striatonigral and striatopallidal neurons in the rat striatum.
Rivera A, Trías S, Peñafiel A, Angel Narváez J, Díaz-Cabiale Z, Moratalla R, de la Calle A. | 01/21/2010 |