| The effects of induced type I diabetes on developmental regulation of GDNF, NRTN, and NCAM proteins in the dentate gyrus of male rat offspring. | The effects of induced type I diabetes on developmental regulation of GDNF, NRTN, and NCAM proteins in the dentate gyrus of male rat offspring.
Mostafaee H, Idoon F, Mohasel-Roodi M, Alipour F, Lotfi N, Sadeghi A. | 03/19/2024 |
| Differential expression of RET and GDNF family receptor, GFR-alpha1, between striatum and substantia nigra following nigrostriatal lesion: A case for diminished GDNF-signaling. | Differential expression of RET and GDNF family receptor, GFR-α1, between striatum and substantia nigra following nigrostriatal lesion: A case for diminished GDNF-signaling.
Kasanga EA, Han Y, Navarrete W, McManus R, Shifflet MK, Parry C, Barahona A, Manfredsson FP, Nejtek VA, Richardson JR, Salvatore MF. | 06/13/2023 |
| GDNF Promotes Astrocyte Abnormal Proliferation and Migration Through the GFRalpha1/RET/MAPK/pCREB/LOXL2 Signaling Axis. | GDNF Promotes Astrocyte Abnormal Proliferation and Migration Through the GFRα1/RET/MAPK/pCREB/LOXL2 Signaling Axis.
Wang M, Han X, Zha W, Wang X, Liu L, Li Z, Shi Y, Kan X, Wang G, Gao D, Zhang B. | 09/24/2022 |
| Group II Metabotropic Glutamate Receptors Reduce Apoptosis and Regulate BDNF and GDNF Levels in Hypoxic-Ischemic Injury in Neonatal Rats. | Group II Metabotropic Glutamate Receptors Reduce Apoptosis and Regulate BDNF and GDNF Levels in Hypoxic-Ischemic Injury in Neonatal Rats.
Bratek-Gerej E, Ziembowicz A, Salinska E., Free PMC Article | 07/23/2022 |
| Exposure to di-(2-ethylhexyl) phthalate reduces secretion of GDNF via interfering with estrogen pathway and downregulating ERK/c-fos signaling pathway in astrocytes. | Exposure to di-(2-ethylhexyl) phthalate reduces secretion of GDNF via interfering with estrogen pathway and downregulating ERK/c-fos signaling pathway in astrocytes.
Wang J, Li X, Wang C, Li Y, Wang J, Fang R, Wang J, Chen J, Dong J. | 01/29/2022 |
| GDNF requires HIF-1alpha and RET activation for suppression of programmed cell death of enteric neurons by metabolic challenge. | GDNF requires HIF-1α and RET activation for suppression of programmed cell death of enteric neurons by metabolic challenge.
Kearon JE, Kocherry SC, Zoumboulakis D, Rivera D, Lourenssen SR, Blennerhassett MG. | 01/22/2022 |
| Maternal undernutrition during pregnancy and lactation increases transcription factors, ETV5 and GDNF, and alters regulation of apoptosis and heat shock proteins in the testis of adult offspring in the rat. | Maternal undernutrition during pregnancy and lactation increases transcription factors, ETV5 and GDNF, and alters regulation of apoptosis and heat shock proteins in the testis of adult offspring in the rat.
Pedrana G, Larrañaga C, Diaz A, Viotti H, Lombide P, Cavestany D, Vickers MH, Martin GB, Sloboda DM. | 11/27/2021 |
| MicroRNA-204 silencing relieves pain of cervical spondylotic radiculopathy by targeting GDNF. | MicroRNA-204 silencing relieves pain of cervical spondylotic radiculopathy by targeting GDNF.
Shen WS, Li CF, Zhou ZS, Zhai NN, Pan LP. | 09/18/2021 |
| Experimental diabetes negatively affects the spermatogonial stem cells' self-renewal by suppressing GDNF network interactions. | Experimental diabetes negatively affects the spermatogonial stem cells' self-renewal by suppressing GDNF network interactions.
Azarniad R, Razi M, Hasanzadeh S, Malekinejad H. | 08/7/2021 |
| Implantation of glial cell line-derived neurotrophic factor-expressing adipose tissue-derived stromal cells in a rat Parkinson's disease model. | Implantation of glial cell line-derived neurotrophic factor-expressing adipose tissue-derived stromal cells in a rat Parkinson's disease model.
Xu R, Wu J, Lang L, Hu J, Tang H, Xu J, Sun B. | 06/19/2021 |
| Glial-derived neurotrophic factor regulates enteric mast cells and ameliorates dextran sulfate sodium-induced experimental colitis. | Glial-derived neurotrophic factor regulates enteric mast cells and ameliorates dextran sulfate sodium-induced experimental colitis.
Xie Q, Chen X, Meng ZM, Huang XL, Zhang Q, Zhou JQ, Zhang L, He FQ, Zou YP, Gan HT. | 05/1/2021 |
| Synergistic interaction of nerve growth factor and glial cell-line derived neurotrophic factor in muscular mechanical hyperalgesia in rats. | Synergistic interaction of nerve growth factor and glial cell-line derived neurotrophic factor in muscular mechanical hyperalgesia in rats.
Murase S, Kobayashi K, Nasu T, Kihara C, Taguchi T, Mizumura K. | 04/24/2021 |
| Brain-derived neurotrophic factor and Glial cell line-derived neurotrophic factor expressions in the trigeminal root entry zone and trigeminal ganglion neurons of a trigeminal neuralgia rat model. | Brain-derived neurotrophic factor and Glial cell line-derived neurotrophic factor expressions in the trigeminal root entry zone and trigeminal ganglion neurons of a trigeminal neuralgia rat model.
Luo D, Luo L, Lin R, Lin L, Lin Q. | 04/3/2021 |
| MES23.5 DA Immortalized Neuroblastoma Cells Self-protect Against Early Injury by Overexpressing Glial Cell-derived Neurotrophic Factor via Akt1/Eya1/Six2 Signaling. | MES23.5 DA Immortalized Neuroblastoma Cells Self-protect Against Early Injury by Overexpressing Glial Cell-derived Neurotrophic Factor via Akt1/Eya1/Six2 Signaling.
Gao J, Kang XY, Sun S, Li L, Gao DS. | 02/13/2021 |
| Investigating the synergic effects of valproic acid and crocin on BDNF and GDNF expression in epidermal neural crest stem cells. | Investigating the synergic effects of valproic acid and crocin on BDNF and GDNF expression in epidermal neural crest stem cells.
Baharvand Z, Nabiuni M, Tahmaseb M, Amini E, Pandamooz S. | 01/2/2021 |
| Different time courses for the expression of alpha and Beta GDNF isoforms in the brain were identified following audiogenic seizures. | Time course of transient expression of pre-α-pro-GDNF and pre-β-pro-GDNF transcripts, and mGDNF mRNA region in Krushinsky-Molodkina rat brain after audiogenic seizures.
Solius G, Panteleev D, Pustogarov N, Revishchin A, Poletaeva I, Pavlova G. | 07/4/2020 |
| GDNF family ligand signaling pathways are involved in the pathogenesis of bone pain and could be targets for pharmacological manipulations to treat it | GDNF, Neurturin, and Artemin Activate and Sensitize Bone Afferent Neurons and Contribute to Inflammatory Bone Pain.
Nencini S, Ringuet M, Kim DH, Greenhill C, Ivanusic JJ., Free PMC Article | 10/26/2019 |
| The findings demonstrate that elevated GDNF levels can reduce the retinal injury, whereby down-regulated miR-216a aggravates the YAG laser-induced retinal injury by targeting the GDNF level through the GDNF/GFRa1/RET signaling pathway. | Down-regulation of microRNA-216a confers protection against yttrium aluminium garnet laser-induced retinal injury via the GDNF-mediated GDNF/GFRα1/RET signalling pathway.
Hu XB, Fu SH, Luo QI, He JZ, Qiu YF, Lai W, Zhong M. | 02/2/2019 |
| the inverse relationship between GFRalpha1 and C-Ret, as knocking down C-Ret led to increases in GFRalpha1 expression. | Vitamin D regulation of GDNF/Ret signaling in dopaminergic neurons.
Pertile RAN, Cui X, Hammond L, Eyles DW. | 10/27/2018 |
| considerable structure-specific differences in GDNF expression between highly aggressive and nonaggressive rats were shown | Glial cell line-derived neurotrophic factor in genetically defined fear-induced aggression.
Ilchibaeva TV, Tsybko AS, Kozhemyakina RV, Popova NK, Naumenko VS. | 02/3/2018 |
| findings indicate that EC-PAR acts as a neurotrophic enhancer by upregulating GDNF levels. This effect protects the remaining neurons following oxidative stress-induced brain damage, such as that seen with Parkinson disease | Extracellular poly(ADP-ribose) is a neurotrophic signal that upregulates glial cell line-derived neurotrophic factor (GDNF) levels in vitro and in vivo.
Nakajima H, Itakura M, Sato K, Nakamura S, Azuma YT, Takeuchi T. | 07/1/2017 |
| In addition, amyotrophic lateral sclerosis (ALS) rats receiving GDNF exhibited slower weight gain, reduced activity levels and decreased working memory. Collectively, these results confirm that caution should be applied when applying growth factors such as GDNF systemically to multiple tissues. | Systemic injection of AAV9-GDNF provides modest functional improvements in the SOD1(G93A) ALS rat but has adverse side effects.
Thomsen GM, Alkaslasi M, Vit JP, Lawless G, Godoy M, Gowing G, Shelest O, Svendsen CN., Free PMC Article | 05/13/2017 |
| hindlimb unweighting treatment induced damage of L5 DRG neurons, which was correlated with decreased total MBP protein expression, increased dgen-MBP expression, and reduced GDNF protein and mRNA expression | Effects of Hindlimb Unweighting on MBP and GDNF Expression and Morphology in Rat Dorsal Root Ganglia Neurons.
Zhang H, Ren NT, Zhou FQ, Li J, Lei W, Liu N, Bi L, Wu ZX, Zhang R, Zhang YG, Cui G. | 04/22/2017 |
| This study demonstrated that GDNF regulated dopamine transporter activity without affecting tyrosine hydroxylase expression in the rat mesostriatal system. | Long-term controlled GDNF over-expression reduces dopamine transporter activity without affecting tyrosine hydroxylase expression in the rat mesostriatal system.
Barroso-Chinea P, Cruz-Muros I, Afonso-Oramas D, Castro-Hernández J, Salas-Hernández J, Chtarto A, Luis-Ravelo D, Humbert-Claude M, Tenenbaum L, González-Hernández T. | 12/17/2016 |
| Reverse transcription-quantitative PCR and western blot analysis demonstrated that there was an increase in the mRNA and protein expression of NGF and GDNF, both of which are markers of SC neurotrophic secretion | Concentrated growth factor increases Schwann cell proliferation and neurotrophic factor secretion and promotes functional nerve recovery in vivo.
Qin J, Wang L, Sun Y, Sun X, Wen C, Shahmoradi M, Zhou Y. | 10/29/2016 |