| Traumatic Brain Injury Induces Nociceptin/Orphanin FQ and Nociceptin Opioid Peptide Receptor Expression within 24 Hours. | Traumatic Brain Injury Induces Nociceptin/Orphanin FQ and Nociceptin Opioid Peptide Receptor Expression within 24 Hours.
Al Yacoub ON, Zhang Y, Patankar PS, Standifer KM., Free PMC Article | 02/28/2024 |
| An examination of the effects of nucleus accumbens core nociceptin on appetitive and consummatory motivation for food. | An examination of the effects of nucleus accumbens core nociceptin on appetitive and consummatory motivation for food.
Wilson L, Klausner M, Chuang S, Patel S, Pratt WE. | 02/23/2024 |
| Both Pnoc and FoxP1 were expressed at high levels in the rostromedial tegmental nucleus and colocalized strongly with previously established RMTg markers. | Gene expression and neurochemical characterization of the rostromedial tegmental nucleus (RMTg) in rats and mice.
Smith RJ, Vento PJ, Chao YS, Good CH, Jhou TC., Free PMC Article | 06/1/2019 |
| Nociceptin co-localized only with insulin in pancreatic beta cells. | Effect of nociceptin on insulin release in normal and diabetic rat pancreas.
Adeghate E, Saeed Z, D'Souza C, Tariq S, Kalász H, Tekes K, Adeghate EA. | 01/19/2019 |
| LPS-inoculation in rodents is an unsuitable model for studying possible changes in the NOP-N/OFQ system in sepsis. | Exploring LPS-induced sepsis in rats and mice as a model to study potential protective effects of the nociceptin/orphanin FQ system.
Thomas RC, Bath MF, Stover CM, Lambert DG, Thompson JP. | 08/1/2015 |
| Results suggest that CaMKII is involved in the inhibitory effect of N/OFQ on delayed rectifier potassium currents in acutely dissociated rat cerebral parietal cortical neurons | Nociceptin/orphanin FQ-induced inhibition of delayed rectifier potassium currents by calcium/calmodulin-dependent protein kinase type II.
Wang Y, Yue W, Wang W, Yu J, Liu R, Wang P, Cao Y, Zhang Q, Wang X, Qu L. | 05/30/2015 |
| Estradiol negatively modulates the pleiotropic inhibitory actions of nociceptin. | Estradiol negatively modulates the pleiotropic actions of orphanin FQ/nociceptin at proopiomelanocortin synapses.
Borgquist A, Kachani M, Tavitian N, Sinchak K, Wagner EJ., Free PMC Article | 03/22/2014 |
| These results suggest that N/OFQ can act directly in the nucleus accumbens shell to block cocaine-induced increases in extracellular dopamine levels | Retrodialysis of N/OFQ into the nucleus accumbens shell blocks cocaine-induced increases in extracellular dopamine and locomotor activity.
Vazquez-DeRose J, Stauber G, Khroyan TV, Xie XS, Zaveri NT, Toll L., Free PMC Article | 09/7/2013 |
| The findings suggest a link between N/OFQ and the development of hyperalgesia and allodynia in a rat model of PTSD. | Increased nociceptive sensitivity and nociceptin/orphanin FQ levels in a rat model of PTSD.
Zhang Y, Gandhi PR, Standifer KM., Free PMC Article | 06/8/2013 |
| The aim of the study was to determine by immunochemistry the expression of leptin, orexin A and orphanin FQ in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow. | Immunohistochemical expression and distribution of orexin, orphanin and leptin in the major salivary glands of some mammals.
Leone A, Spatola GF, Cucco D, Tessitore V, Bonaventura G, Uzzo ML. | 06/1/2013 |
| Orphanin FQ mRNA expression of hippocampus increased significantly after exposure to acute serious hypobaric hypoxia, but decreased after Morris water maze training. | [Effects of acute hypobaric hypoxia on spatial learning, memory and its relationship with orphanin FQ of hippocampus in rats].
Lin JX, Sui JF, Luo J, Li XC. | 12/22/2012 |
| data provide new evidence for an interaction between the nociceptin and CRF systems in the central amygdala | Nociceptin/orphanin FQ blockade of corticotropin-releasing factor-induced gamma-aminobutyric acid release in central amygdala is enhanced after chronic ethanol exposure.
Cruz MT, Herman MA, Kallupi M, Roberto M., Free PMC Article | 08/18/2012 |
| Data suggest that peripheral nociceptin/orphanin FQ/NOP receptor/ligand system contributes to abnormal pain sensitivity in inflammatory states. | Effects of intraplantar nocistatin and (±)-J 113397 injections on nociceptive behavior in a rat model of inflammation.
Scoto GM, Aricò G, Ronsisvalle S, Parenti C. | 05/5/2012 |
| This study demonistrated that prepronociceptin, N/OFQ and nocistatin concentrations are significantly altered at different tissues of two rat neuropathy pain models. | Elevated prepronociceptin, nociceptin/orphanin FQ and nocistatin concentrations in rat chronic constriction nerve injury and diabetic neuropathic pain models.
Liu EH, Li C, Govindasamy M, Neo HJ, Lee TL, Low CM, Tachibana S. | 04/28/2012 |
| Inactivation of endogenous orphanin FQ nociceptin receptor oprl1 system attenuates the rewarding effect of opioids and therefore offers a therapeutic target for the treatment of drug abuse and addiction. | Pharmacological blockade or genetic knockout of the NOP receptor potentiates the rewarding effect of morphine in rats.
Rutten K, De Vry J, Bruckmann W, Tzschentke TM. | 02/18/2012 |
| In conclusion, our study indicates N/OFQ as a robust endogenous regulator of MCH neurons, which may play a role in anxiety and drug addiction. | GIRK channel-mediated inhibition of melanin-concentrating hormone neurons by nociceptin/orphanin FQ.
Parsons MP, Hirasawa M. | 07/23/2011 |
| Inhibition of nociceptin in the substantia nigra of parkinsonian rats demonstrate its involvement (along with dopamine receptors) in the pathological and behavioral aspects of Parkinson disease. | Dopamine-nociceptin/orphanin FQ interactions in the substantia nigra reticulata of hemiparkinsonian rats: involvement of D2/D3 receptors and impact on nigro-thalamic neurons and motor activity.
Volta M, Viaro R, Trapella C, Marti M, Morari M. | 04/2/2011 |
| Conclude that the N/OFQ system promotes feeding by affecting the need to replenish lacking calories and by reducing aversive responsiveness. | Central nociceptin/orphanin FQ system elevates food consumption by both increasing energy intake and reducing aversive responsiveness.
Olszewski PK, Grace MK, Fard SS, Le Grevès M, Klockars A, Massi M, Schiöth HB, Levine AS., Free PMC Article | 09/13/2010 |
| The results obtained, demonstrating the presence of N/OFQ in some alpha-MSH- and in many orexin-containing hypothalamic neurones, suggest a functional relationship between these neuropeptides and N/OFQ in the control of feeding behaviour and body weight. | Nociceptin/orphanin FQ peptide in hypothalamic neurones associated with the control of feeding behaviour.
Maolood N, Meister B. | 08/23/2010 |
| These data suggest that the ERK-1/2 pathway, at least in part, mediates the inhibitory effect of N/OFQ on the I(K) in acutely dissociated rat cerebral parietal cortical neurons. | The role of ERK-1/2 in the N/OFQ-induced inhibition of delayed rectifier potassium currents.
Wang W, Cui Q, Li Y, Li B, Yang X, Cui L, Jin H, Qu L. | 05/31/2010 |
| these findings suggest that corticotropin-releasing factor and the nociceptin/orphanin FQ/NOP system interact in the dorsal raphe nucleus during stress to control 5HT transmission; this may play a role in stress-related neuropsychopathologies | Swim stress enhances nociceptin/orphanin FQ-induced inhibition of rat dorsal raphe nucleus activity in vivo and in vitro: role of corticotropin releasing factor.
Nazzaro C, Barbieri M, Varani K, Beani L, Valentino RJ, Siniscalchi A., Free PMC Article | 04/19/2010 |
| Data show that bradykinin-induced plasma extravasation is mediated by bradykinin B2 receptors and is inhibited by nociceptin. | Receptor mediation and nociceptin inhibition of bradykinin-induced plasma extravasation in the knee joint of the rat.
Moriyama K, Liu J, Jang Y, Chae YJ, Wang Y, Mitchell J, Grond S, Han X, Xing Y, Xie GX, Pierce Palmer P., Free PMC Article | 01/25/2010 |
| These results suggest that the N/OFQ-NOP receptor system is affected by acute stress exposure, particularly in limbic regions. | Nociceptin/orphanin FQ and NOP receptor gene regulation after acute or repeated social defeat stress.
Green MK, Devine DP., Free PMC Article | 01/21/2010 |
| nociceptin in the spinal cord mediates part of the electroacupuncture-related modulation of visceral reflex responses | Spinal nociceptin mediates electroacupuncture-related modulation of visceral sympathoexcitatory reflex responses in rats.
Zhou W, Mahajan A, Longhurst JC., Free PMC Article | 01/21/2010 |
| strains with low content of Cart gene expression had elevated N/OFQ-induced feeding, but contrary to expectations, strain 10, with the lowest Cart gene expression, exhibited low N/OFQ-induced feeding, on the order of that of the WOKW rats | Nociceptin/orphanin FQ-induced food intake and cocaine amphetamine regulated transcript gene expression in strains derived from rats prone (WOKW) and resistant (Dark Agouti) to metabolic syndrome.
Cifani C, Kloting I, Morini G, Grandi D, Massi M, Polidori C. | 01/21/2010 |