| The TP53-activated E3 ligase RNF144B is a tumour suppressor that prevents genomic instability. | The TP53-activated E3 ligase RNF144B is a tumour suppressor that prevents genomic instability.
Abad E, Sandoz J, Romero G, Zadra I, Urgel-Solas J, Borredat P, Kourtis S, Ortet L, MartÃnez CM, Weghorn D, Sdelci S, Janic A., Free PMC Article | 05/1/2024 |
| RNF144B stimulates the proliferation and inhibits the apoptosis of human spermatogonial stem cells via the FCER2/NOTCH2/HES1 pathway and its abnormality is associated with azoospermia. | RNF144B stimulates the proliferation and inhibits the apoptosis of human spermatogonial stem cells via the FCER2/NOTCH2/HES1 pathway and its abnormality is associated with azoospermia.
Du L, Chen W, Li C, Cui Y, He Z. | 10/8/2022 |
| Our study identifies that RNF144B interaction with TBK1 is sufficient to inactivate TBK1 and delineates a previously unrecognized role for RNF144B in innate immune responses. | RNF144B inhibits LPS-induced inflammatory responses via binding TBK1.
Zhang Z, Zhang L, Wang B, Zhu X, Zhao L, Chu C, Guo Q, Wei R, Yin X, Zhang Y, Li X., Free PMC Article | 06/6/2020 |
| Inactivation of GSK3beta activity is associated with loss of PIR2 protein and consequent inhibition of cell proliferation in endometrial cancer cells. | Pir2/Rnf144b is a potential endometrial cancer biomarker that promotes cell proliferation.
Zhou Q, Eldakhakhny S, Conforti F, Crosbie EJ, Melino G, Sayan BS., Free PMC Article | 11/30/2019 |
| Low RNF144B expression is associated with gastric cancer. | miR-100 antagonism triggers apoptosis by inhibiting ubiquitination-mediated p53 degradation.
Yang G, Gong Y, Wang Q, Wang L, Zhang X. | 09/16/2017 |
| findings substantiate PIR2/Rnf144b as a potentially critical component of epithelial homeostasis, acting downstream of DeltaNp63alpha to regulate cellular levels of p21(WAF1/CIP1) and DeltaNp63alpha | PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21WAF1 and p63.
Conforti F, Yang AL, Piro MC, Mellone M, Terrinoni A, Candi E, Tucci P, Thomas GJ, Knight RA, Melino G, Sayan BS. | 11/23/2013 |
| PIR2, by being induced by TAp73 and degrading DeltaNp73, differentially regulates TAp73/DeltaNp73 stability. | Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2.
Sayan BS, Yang AL, Conforti F, Tucci P, Piro MC, Browne GJ, Agostini M, Bernardini S, Knight RA, Mak TW, Melino G, Sayan BS, Yang AL, Conforti F, Tucci P, Piro MC, Browne GJ, Agostini M, Bernardini S, Knight RA, Mak TW, Melino G., Free PMC Articles: PMC2919933, PMC2919933 | 10/29/2010 |
| PIR2/RNF144B/IBRDC2 regulates the stability of TAp73 and DNp73. | Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2.
Sayan BS, Yang AL, Conforti F, Tucci P, Piro MC, Browne GJ, Agostini M, Bernardini S, Knight RA, Mak TW, Melino G, Sayan BS, Yang AL, Conforti F, Tucci P, Piro MC, Browne GJ, Agostini M, Bernardini S, Knight RA, Mak TW, Melino G., Free PMC Articles: PMC2919933, PMC2919933 | 10/13/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| IBRDC2, an IBR-type RING-finger E3 ubiquitin ligase, regulates the levels of Bax and protects cells from unprompted Bax. activation and cell death. | IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation.
Benard G, Neutzner A, Peng G, Wang C, Livak F, Youle RJ, Karbowski M., Free PMC Article | 06/14/2010 |
| p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1. | p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1.
Ng CC, Arakawa H, Fukuda S, Kondoh H, Nakamura Y. | 01/21/2010 |