| Differences in the expression of catecholamine-synthesizing enzymes between vesicular monoamine transporter 1- and 2-immunoreactive glomus cells in the rat carotid body. | Differences in the expression of catecholamine-synthesizing enzymes between vesicular monoamine transporter 1- and 2-immunoreactive glomus cells in the rat carotid body.
Kato K, Yokoyama T, Kusakabe T, Hata K, Fushuku S, Nakamuta N, Yamamoto Y. | 01/16/2021 |
| Study identify mutants that alter the nature of the conformational equilibrium and mimic the protonated state of VMAT2. These mutants eliminate the requirement for a proton gradient normally necessary for reserpine binding and for reserpine inhibition of tetrabenazine binding. | Emulating proton-induced conformational changes in the vesicular monoamine transporter VMAT2 by mutagenesis.
Yaffe D, Vergara-Jaque A, Forrest LR, Schuldiner S., Free PMC Article | 04/21/2018 |
| Up-regulation of VMAT2 expression in aged male rats following chronic testosterone propionate treatment might be involved in the maintenance of dopaminergic function of the nigrostriatal dopaminergic system in aged male rats. | Deficits in coordinated motor behavior and in nigrostriatal dopaminergic system ameliorated and VMAT2 expression up-regulated in aged male rats by administration of testosterone propionate.
Wang L, Kang Y, Zhang G, Zhang Y, Cui R, Yan W, Tan H, Li S, Wu B, Cui H, Shi G. | 01/14/2017 |
| Data suggest the involvement of VMAT2 in the thermoregulatory, behavioral, and neurotoxic effects of MDMA. | Vesicular monoamine transporter 2 and the acute and long-term response to 3,4-(±)-methylenedioxymethamphetamine.
Lizarraga LE, Cholanians AB, Phan AV, Herndon JM, Lau SS, Monks TJ., Free PMC Article | 01/16/2016 |
| Data suggest that expression of Vmat2 and Dat1 (dopamine transporter 1) in dopaminergic neurons in striatum can be down-regulated by dietary factors (here, ingestion of acrylamide, a food contaminant created by heating starchy foods). | Acrylamide increases dopamine levels by affecting dopamine transport and metabolism related genes in the striatal dopaminergic system.
Pan X, Guo X, Xiong F, Cheng G, Lu Q, Yan H. | 07/25/2015 |
| Rotenone induces dopamine neuron death through a series of sequential events including microtubule destabilization, JNK3 activation, VMAT2 inhibition, accumulation of cytosolic dopamine, and generation of ROS. | JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death.
Choi WS, Kim HW, Xia Z., Free PMC Article | 03/28/2015 |
| These results demonstrate asymmetry in noradrenegic genes (Th, NET, and VMAT2) in the right and left stellate ganglia during stress and provide molecular evidence to help explain the difference in response to the stress. | Differential expression of tyrosine hydroxylase and transporters in the right and left stellate ganglion of socially isolated rats.
Jovanovic P, Spasojevic N, Stefanovic B, Dronjak S. | 11/8/2014 |
| Oxytocin treatment increases catecholamine content in the rat adrenal medulla modulating VMAT2 expression. | Peripheral oxytocin treatment affects the rat adreno-medullary catecholamine content modulating expression of vesicular monoamine transporter 2.
Jovanovic P, Spasojevic N, Stefanovic B, Bozovic N, Jasnic N, Djordjevic J, Dronjak S. | 09/6/2014 |
| contribution of distinct VGLUT3 and VMAT2 transporter expression induced by BDNF might be one of the mechanisms that BDNF regulates neuropathic pain | The expression of vesicular glutamate transporter 3 and vesicular monoamine transporter 2 induced by brain-derived neurotrophic factor in dorsal root ganglion neurons in vitro.
Liu D, Bi Y, Liu Z, Liu H, Li Z. | 08/23/2014 |
| study provides convinced morphologic evidence that VMAT2 is not present in beta cells | New perspectives of vesicular monoamine transporter 2 chemical characteristics in mammals and its constant expression in type 1 diabetes rat models.
Hong F, Liu L, Fan RF, Chen Y, Chen H, Zheng RP, Zhang Y, Gao Y, Zhu JX. | 04/5/2014 |
| novel insight into the mechanism of transport and TBZ binding by VMAT2. | Identification of conformationally sensitive residues essential for inhibition of vesicular monoamine transport by the noncompetitive inhibitor tetrabenazine.
Ugolev Y, Segal T, Yaffe D, Gros Y, Schuldiner S., Free PMC Article | 01/25/2014 |
| VMAT2 expression transiently increased in acute stages after epileptic seizures in pilocarpine-treated rats; however, it clearly decreased after spontaneous recurrent seizures. | Altered expression of vesicular monoamine transporter 2 in epileptic patients and experimental rats.
Jiang G, Cao Q, Li J, Zhang Y, Liu X, Wang Z, Guo F, Chen Y, Chen Y, Chen G, Wang X. | 11/16/2013 |
| Data suggest that pancreatic islets of mice and rats do not contain VMAT2, except in mast cells and sympathetic nerve terminals that innervate the islets. | Species-specific vesicular monoamine transporter 2 (VMAT2) expression in mammalian pancreatic beta cells: implications for optimising radioligand-based human beta cell mass (BCM) imaging in animal models.
Schäfer MK, Hartwig NR, Kalmbach N, Klietz M, Anlauf M, Eiden LE, Weihe E., Free PMC Article | 11/2/2013 |
| homology model of VMAT2 shows that molecular hinge points mediate alternating access | Identification of molecular hinge points mediating alternating access in the vesicular monoamine transporter VMAT2.
Yaffe D, Radestock S, Shuster Y, Forrest LR, Schuldiner S., Free PMC Article | 07/13/2013 |
| HIV-1 Tat protein impacts dopaminergic tone in corpus striatum synaptosomes by regulating both dopamine transporter and VMAT2 proteins. | HIV-1 Tat protein decreases dopamine transporter cell surface expression and vesicular monoamine transporter-2 function in rat striatal synaptosomes.
Midde NM, Gomez AM, Zhu J., Free PMC Article | 04/13/2013 |
| With social isolation, no changes were observed in protein levels of DBH and NET in the right hippocampus, whereas expression of this norepinephrine synthetizing enzyme and transporter were elevated in the left hippocampus. | Hippocampal asymmetry in expression of catecholamine synthesizing enzyme and transporters in socially isolated rats.
Spasojevic N, Stanisavljevic D, Gavrilovic L, Jovanovic P, Cucakovic A, Dronjak S. | 03/9/2013 |
| Letter: report predominant expression of VMAT2 in pancreatic alpha/delta cells but not in pancreatic beta cells. | The predominant distribution of vesicular monoamine transporter 2 in the α cells and δ cells, not β cells, in rat islets.
Gao Y, Liu L, Li X, Song Y, Zhang Y, Zhu J. | 01/14/2012 |
| VMAT2 is co-localized with tyrosine hydroxylase (TH) but not phenylethanolamine N-methyltransferase (PNMT), indicating its expression in norepinephrine (NE)-, but not epinephrine (Epi)-synthesizing chromaffin cells. | Vesicular monoamine transporters (VMATs) in adrenal chromaffin cells: stress-triggered induction of VMAT2 and expression in epinephrine synthesizing cells.
Tillinger A, Sollas A, Serova LI, Kvetnansky R, Sabban EL. | 04/16/2011 |
| VMAT2 segregates partially from VGLUT1 in the boutons of midbrain dopamine neurons. During the stimulus, the endocytosis of VMAT2 accelerates in midbrain dopamine but not hippocampal neurons. | Vesicular monoamine and glutamate transporters select distinct synaptic vesicle recycling pathways.
Onoa B, Li H, Gagnon-Bartsch JA, Elias LA, Edwards RH., Free PMC Article | 08/30/2010 |
| Biochemical and functional evidence uncovers an interaction between VMAT2 and the molecular chaperone Hsc70 in brain tissue, during which Hsc70 reduces VMAT2 activity. | The molecular chaperone Hsc70 interacts with the vesicular monoamine transporter-2.
Requena DF, Parra LA, Baust TB, Quiroz M, Leak RK, Garcia-Olivares J, Torres GE. | 01/21/2010 |
| fluoxetine inhibited the activity of VMAT2 by a mechanism different from that of reserpine and did not directly interact with the active site of VMAT2. | Inhibitory effect of selective serotonin reuptake inhibitors on the vesicular monoamine transporter 2.
Yasumoto S, Tamura K, Karasawa J, Hasegawa R, Ikeda K, Yamamoto T, Yamamoto H. | 01/21/2010 |
| VMAT2 regulates in vivo glucose homeostasis and insulin production, most likely via its role in vesicular transport and storage of monoamines in beta-cells. | Role of vesicular monoamine transporter type 2 in rodent insulin secretion and glucose metabolism revealed by its specific antagonist tetrabenazine.
Raffo A, Hancock K, Polito T, Xie Y, Andan G, Witkowski P, Hardy M, Barba P, Ferrara C, Maffei A, Freeby M, Goland R, Leibel RL, Sweet IR, Harris PE., Free PMC Article | 01/21/2010 |
| younger rats have a greater capacity to sequester cytoplasmic dopamine into membrane-associated vesicles due to kinetically upregulated VMAT-2 | Age-dependent differences in dopamine transporter and vesicular monoamine transporter-2 function and their implications for methamphetamine neurotoxicity.
Volz TJ, Farnsworth SJ, Rowley SD, Hanson GR, Fleckenstein AE., Free PMC Article | 01/21/2010 |
| These data demonstrate differential distribution of VMAT2 within different subpopulations of C1 neurons and suggest that this might reflect differences in somatodendritic vs. synaptic release of catecholamines. | C1 neurons in the rat rostral ventrolateral medulla differentially express vesicular monoamine transporter 2 in soma and axonal compartments.
Sevigny CP, Bassi J, Teschemacher AG, Kim KS, Williams DA, Anderson CR, Allen AM. | 01/21/2010 |
| These changes may be responsible for the loss of VMAT2 activity during aging and may contribute to the high susceptibility of aged midbrain dopaminergic cells to degeneration. | Deglycosylation and subcellular redistribution of VMAT2 in the mesostriatal system during normal aging.
Cruz-Muros I, Afonso-Oramas D, Abreu P, Rodríguez M, González MC, González-Hernández T. | 01/21/2010 |