| Dieting reverses histone methylation and hypothalamic AgRP regulation in obese rats. | Dieting reverses histone methylation and hypothalamic AgRP regulation in obese rats.
Rapps K, Kisliouk T, Marco A, Weller A, Meiri N., Free PMC Article | 03/1/2023 |
| study suggests that passive PNS rats have innate impairments in leptin and ghrelin responses to starvation combined with prenatal stress associated impairments in Agrp and orexin expression in response to starvation. | Failure to upregulate Agrp and Orexin in response to activity based anorexia in weight loss vulnerable rats characterized by passive stress coping and prenatal stress experience.
Boersma GJ, Liang NC, Lee RS, Albertz JD, Kastelein A, Moody LA, Aryal S, Moran TH, Tamashiro KL., Free PMC Article | 05/6/2017 |
| Compared to the rats in the control group, the rats in the HF group had the expression levels of 12 genes with significant changes, Agrp, Ghrl, and Nr3c1, Apoa4, Cntf, Ghr, IL-1beta, Ins1, Lepr,Sort, Adcyap1r1 and Adrb1. | Green tea polyphenols reduce body weight in rats by modulating obesity-related genes.
Lu C, Zhu W, Shen CL, Gao W., Free PMC Article | 02/14/2015 |
| The obtained data demonstrate the role ofAGRP as a modulator of the functional activity of the dopaminergic brain neurons. | [Participation of Agouti related peptide in machanisms of wakefulness-sleep cycle regulation].
Romanova IV, Mikhrina AL. | 01/3/2015 |
| AGRP is up- and down-regulated in the hypothalamic arcuate nucleus depending on the general nutritional state. | Short-term regulation of the hypothalamic melanocortinergic system under fasting and defined glucose-refeeding conditions in rats: a laser capture microdissection (LMD)-based study.
Landmann EM, Schellong K, Melchior K, Rodekamp E, Ziska T, Harder T, Plagemann A. | 02/9/2013 |
| Mature neurons were obtained from differentiation of hypothalamic progenitor cells including NPY, AGRP, POMC, CART and Orexin-A positive neurons. mRNA expression of NPY, CART and Orexin-A increases after the differentiation of hypothalamic neurospheres | Proliferative hypothalamic neurospheres express NPY, AGRP, POMC, CART and Orexin-A and differentiate to functional neurons.
Sousa-Ferreira L, Álvaro AR, Aveleira C, Santana M, Brandão I, Kügler S, de Almeida LP, Cavadas C., Free PMC Article | 09/24/2011 |
| Anorectic tumor-bearing rats do not display the changes in hypothalamic AgRP expression observed in food-restricted weight-matched animals. | Hormonal, hypothalamic and striatal responses to reduced body weight gain are attenuated in anorectic rats bearing small tumors.
Pourtau L, Leemburg S, Roux P, Leste-Lasserre T, Costaglioli P, Garbay B, Drutel G, Konsman JP. | 09/3/2011 |
| Ghrelin-induced changes in the AMPK-CPT1 pathway are associated with increased levels of AgRP and NPY mRNA expression through modulation of BSX, pCREB, and FoxO1 in a gender-independent manner. | Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender.
Lage R, Vázquez MJ, Varela L, Saha AK, Vidal-Puig A, Nogueiras R, Diéguez C, López M., Free PMC Article | 09/13/2010 |
| in early-life diet-induced obesity, the rats showed increased expression of mRNA for orexigenic neuropeptide Y (NPY), agouti-related protein & anorexigenic pro-inflammatory cytokine IL-6 in the arcuate nucleus | Activation of hypothalamic NPY, AgRP, MC4R, AND IL-6 mRNA levels in young Lewis rats with early-life diet-induced obesity.
Stofkova A, Skurlova M, Kiss A, Zelezna B, Zorad S, Jurcovicova J. | 01/21/2010 |
| The present study reveals an atypical and divergent regulation of NPY and AgRP, which may relate to their separate roles with respect to growth and food intake, respectively. | Divergent regulation of hypothalamic neuropeptide Y and agouti-related protein by photoperiod in F344 rats with differential food intake and growth.
Ross AW, Johnson CE, Bell LM, Reilly L, Duncan JS, Barrett P, Heideman PD, Morgan PJ. | 01/21/2010 |
| AGRP may play an important role during pregnancy in the mother's and, possibly, also in the fetus's energy balance. | Changes of agouti-related protein in hypothalamus, placenta, and serum during pregnancy in the rat.
Szczepankiewicz D, Pruszyńska-Oszmałek E, Kaczmarek P, Skrzypski M, Andrałojć K, Wojciechowicz T, Sassek M, Nowak KW. | 01/21/2010 |
| The only neuropeptide mRNAs that responded (increasing) to the short-term periods of fasting used were those of NPY (transiently) and AgRP. | Induction of NPY/AgRP orexigenic peptide expression in rat hypothalamus is an early event in fasting: relationship with circulating leptin, insulin and glucose.
Palou M, Sánchez J, Rodríguez AM, Priego T, Picó C, Palou A. | 01/21/2010 |
| Monosodium glutamate treatment induced a decrease in the number of ARC cells and mRNA levels of neuropeptide Y and agouti-related protein in the hypothalamus. | Association of the suckling-weaning transition with development of the hypothalamic arcuate nucleus neurons in rat pups.
Miyata T, Minai Y, Haga M. | 01/21/2010 |
| Mere weight restoration is not sufficient to normalize hypothalamic gene expression levels and endocrine responses to a meal, and that meal-related ghrelin responses persist despite weight restoration for up to 4 wk. | Central and peripheral effects of chronic food restriction and weight restoration in the rat.
Kinzig KP, Hargrave SL, Tao EE., Free PMC Article | 01/21/2010 |
| These data suggest that Evo decreases food intake, and therefore body weight, partly by down-regulating NPY and AgRP mRNA expression and peptide expression in the ARC of the hypothalamus. | Intragastric administration of evodiamine suppresses NPY and AgRP gene expression in the hypothalamus and decreases food intake in rats.
Shi J, Yan J, Lei Q, Zhao J, Chen K, Yang D, Zhao X, Zhang Y. | 01/21/2010 |
| AgRP neurons may participate with arcuate nucleus proopiomelanocortin neurons in mediating the anorexic and metabolic responses to acute and chronic disease processes | Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation.
Scarlett JM, Zhu X, Enriori PJ, Bowe DD, Batra AK, Levasseur PR, Grant WF, Meguid MM, Cowley MA, Marks DL., Free PMC Article | 01/21/2010 |
| Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via adenosine monophosphate-activated protein kinase signaling in the arcuate nucleus. | Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via adenosine monophosphate-activated protein kinase signaling in the arcuate nucleus of rats.
Shimizu H, Arima H, Watanabe M, Goto M, Banno R, Sato I, Ozaki N, Nagasaki H, Oiso Y. | 01/21/2010 |
| AGRP and NPY gene expression in the ARC were markedly elevated in fasting rats, AGRP mRNA returning to baseline levels 12 h after refeeding and NPY mRNA remaining persistently elevated even at 24 h. | Differential effects of refeeding on melanocortin-responsive neurons in the hypothalamic paraventricular nucleus.
Sánchez E, Singru PS, Acharya R, Bodria M, Fekete C, Zavacki AM, Bianco AC, Lechan RM., Free PMC Article | 01/21/2010 |
| AgRP mRNA expression is up-regulated by food restriction in the rat placenta. Throughout pregnancy, hypothalamic mRNA expression levels of AgRP were decreased; levels increased during food restriction. | Food-intake-regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta.
Caminos JE, Bravo SB, González CR, Garcés MF, Cepeda LA, González AC, Cordido F, López M, Diéguez C., Free PMC Article | 01/21/2010 |
| the hypothalamic neuropeptides agouti-related protein (AGRP) is central to the regulation of food intake | Reduced expression of the KATP channel subunit, Kir6.2, is associated with decreased expression of neuropeptide Y and agouti-related protein in the hypothalami of Zucker diabetic fatty rats.
Gyte A, Pritchard LE, Jones HB, Brennand JC, White A. | 01/21/2010 |
| Amino acids can act within the brain to inhibit food intake via a direct, mTOR-dependent inhibition of Agrp gene expression. | Amino acids inhibit Agrp gene expression via an mTOR-dependent mechanism.
Morrison CD, Xi X, White CL, Ye J, Martin RJ., Free PMC Article | 01/21/2010 |
| AGRP does not play a significant role in the feedback regulation of the GH secretion | The effect of agouti-related protein on growth hormone secretion in adult male rats.
Tamura H, Kamegai J, Shimizu T, Ishii S, Sugihara H, Oikawa S. | 01/21/2010 |
| Both hypothalamic and fourth ventricle injections of AGRP significantly increased consumption of the intraorally-delivered milk. | Hypothalamic and hindbrain NPY, AGRP and NE increase consummatory feeding responses.
Taylor K, Lester E, Hudson B, Ritter S., Free PMC Article | 01/21/2010 |
| AGRP exerts changes in hypothalamic neuropeptide gene expression and metabolic effects that are independent of the effects on food intake and body weight | Effects of agouti-related protein on metabolism and hypothalamic neuropeptide gene expression.
Korner J, Wissig S, Kim A, Conwell IM, Wardlaw SL. | 01/21/2010 |
| conclude that leptin requires phosphatidylinositol 3-OH-kinase (PI3K) signaling both to inhibit hypothalamic neuropeptide Y and agouti-related peptide (Agrp) gene expression and activate neurons within the hypothalamic paraventricular nucleus (PVN) | Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling.
Morrison CD, Morton GJ, Niswender KD, Gelling RW, Schwartz MW. | 01/21/2010 |