| Id2 Represses Aldosterone-Stimulated Cardiac T-Type Calcium Channels Expression. | Id2 Represses Aldosterone-Stimulated Cardiac T-Type Calcium Channels Expression.
Ito J, Minemura T, Wälchli S, Niimi T, Fujihara Y, Kuroda S, Takimoto K, Maturana AD., Free PMC Article | 05/22/2021 |
| BMP-7/Smads-induced Id2 upregulation and Id2/Twist interaction was involved in attenuating diabetic renal tubulointerstitial fibrosis. | BMP-7/Smads-induced inhibitor of differentiation 2 (Id2) upregulation and Id2/Twist interaction was involved in attenuating diabetic renal tubulointerstitial fibrosis.
Xiao Y, Jiang X, Peng C, Zhang Y, Xiao Y, Liang D, Shi M, Wang Y, Zhang F, Guo B. | 03/21/2020 |
| these data strongly suggest that bone marrow stromal cells (BMSCs) can promote the differentiation of Neural stem cells (NSCs) into oligodendrocytes through mediating Id2 and Olig1/2 expression by blocking the BMP/Smad signaling pathway | BMSCs promote the differentiation of NSCs into oligodendrocytes via mediating Id2 and Olig expression through BMP/Smad signaling pathway.
Song P, Xia X, Han T, Fang H, Wang Y, Dong F, Zhang R, Ge P, Shen C., Free PMC Article | 05/18/2019 |
| Here, the authors discovered that, in the developing neuron from rat, Akt signaling regulates axon growth and growth cone formation through phosphorylation of serine 14 (S14) on Inhibitor of DNA binding 2 (Id2). | Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration.
Ko HR, Kwon IS, Hwang I, Jin EJ, Shin JH, Brennan-Minnella AM, Swanson R, Cho SW, Lee KH, Ahn JY., Free PMC Article | 10/21/2017 |
| Knockdown of Id2 alleviates neuropathic pain by inhibiting the NF-kappaB activation. | Silencing of Id2 Alleviates Chronic Neuropathic Pain Following Chronic Constriction Injury.
Jiang L, Wu Q, Yang T. | 03/11/2017 |
| The data support the implication of inhibitor of DNA binding/differentiation 2 in the modulation of hypoxia/ischemia-induced neuronal apoptosis. | Silencing of Id2 attenuates hypoxia/ischemia-induced neuronal injury via inhibition of neuronal apoptosis.
Guo L, Yang X, Lin X, Lin Y, Shen L, Nie Q, Ren L, Guo Q, Que S, Qiu Y. | 05/28/2016 |
| Hypoxia/ischemia (H/I) up-regulates Id2 expression in neuronal cells, and Id2 might play an important role in H/I-induced neuronal apoptosis. | Hypoxia/ischemia up-regulates Id2 expression in neuronal cells in vivo and in vitro.
Guo L, Lan J, Lin Y, Guo P, Nie Q, Mao Q, Ren L, Qiu Y. | 05/17/2014 |
| NF-kappaB p65 can facilitate early fracture healing of rat radius by elevating PGE2 production and regulating BMP-7 and Id2 expression. | [Promotion effect of nuclear factor kappa B p65 on early fracture healing of rat radius by elevating prostaglandins E2 production and regulating inhibitor of DNA binding 2 protein expression].
Niu Z, Wang L, Hu X, Wang H, Ouyang J, Huang W, Yu L, Qiu X. | 05/12/2012 |
| CpG-rich islands within the Id2 and Id4 genes were bound by PRMT5 and were hypomethylated in PRMT5-deficient cells, suggesting that PRMT5 plays a role in gene silencing during glial cell | Type II arginine methyltransferase PRMT5 regulates gene expression of inhibitors of differentiation/DNA binding Id2 and Id4 during glial cell differentiation.
Huang J, Vogel G, Yu Z, Almazan G, Richard S., Free PMC Article | 03/3/2012 |
| A novel transcriptional-dependent mechanism of Id2 regulation by GSH and oxidative stress induced by acetaminophen-overdose through the indirect modulation of the proteasome pathway. | Molecular mechanisms of Id2 down-regulation in rat liver after acetaminophen overdose. Protection by N-acetyl-L-cysteine.
Penella E, Sandoval J, Zaragozá R, García C, Viña JR, Torres L, García-Trevijano ER. | 01/22/2011 |
| TSH regulates Id2 expression, but that Id2 does not alter the expression of thyroid-specific genes, such as Tg, in FRTL-5 thyroid cells | Regulation of inhibitors of differentiation family proteins by thyroid-stimulating hormone in FRTL-5 thyroid cells.
Jo YS, Hwang ES, Lee JH, Lee Y, Kim SY, Choi YS, Bai YS, Hong JH, Kim YJ, Lee IS, Rha SY, Ro HK, Shong M., Free PMC Article | 01/21/2010 |
| Id2, Id3, and Id4 proteins have roles in vibrissae follicle development | Id2, Id3, and Id4 proteins show dynamic changes in expression during vibrissae follicle development.
Hammond NL, Jahoda CA. | 01/21/2010 |
| These observations suggest that Id2 may be mainly involved in terminal maturation of oligodendrocytes and myelination. | The inhibitor of DNA binding 2 is mainly expressed in oligodendrocyte lineage cells in adult rat brain.
Chen XS, Zhou DS, Yao ZX. | 01/21/2010 |
| Expression of all 4 members of the Id family of transcription factors is differentially regulated in response to orchidectomy along the epididymis. | Expression, localization, and regulation of inhibitor of DNA binding (Id) proteins in the rat epididymis.
Carroll M, Hamzeh M, Robaire B. | 01/21/2010 |
| induction of Id2 and resultant inhibition of basic helix-loop-helix transcription factor-regulated genes in Sertoli cells may contribute to the regulation of spermatogenesis | The Id2 transcriptional repressor is induced by follicle-stimulating hormone and cAMP.
Scobey MJ, Fix CA, Walker WH. | 01/21/2010 |
| Id2 & p53 were elevated in cytosolic fraction of suspended muscle in young & aged animals but not in the nuclear protein fraction; findings are consistent with the hypothesis that Id2 & p53 are responsive to unloading-induced muscle atrophy | Hindlimb unloading increases muscle content of cytosolic but not nuclear Id2 and p53 proteins in young adult and aged rats.
Siu PM, Pistilli EE, Murlasits Z, Alway SE. | 01/21/2010 |
| overexpression of ID1 and ID2 genes in a postmitotic, terminally differentiated cell type (Sertoli cells)have the capacity to induce reentry into the cell cycle | The helix-loop-helix inhibitor of differentiation (ID) proteins induce post-mitotic terminally differentiated Sertoli cells to re-enter the cell cycle and proliferate.
Chaudhary J, Sadler-Riggleman I, Ague JM, Skinner MK. | 01/21/2010 |
| Hypoxia did inhibit the downregulation of the trophoblast stem cell marker Id2. | Hypoxia inhibits differentiation of lineage-specific Rcho-1 trophoblast giant cells.
Gultice AD, Selesniemi KL, Brown TL. | 01/21/2010 |
| The results indicated that Id2 mRNA is expression in these regions include the amygdaloid complex, caudate putamen, globus pallidus, substantia nigra pars reticulata, suprachiasmatic nucleus, and the anterior part of the subventricular zone. | Localization of Id2 mRNA in the adult mouse brain.
Kitajima K, Takahashi R, Yokota Y. | 01/21/2010 |
| Id2 protein is integrated into the cell cycle regulatory cascade that results in SMC proliferation following vascular injury and suggest that this effect is at least in part via a cdk2-dependent inhibition of p21 gene expression. | Contribution of the helix-loop-helix factor Id2 to regulation of vascular smooth muscle cell proliferation.
Matsumura ME, Lobe DR, McNamara CA. | 01/21/2010 |
| A control role for Id2 in hepatocyte priming, through a p130 dissociation-independent regulation of c-myc, in regenerating rat liver is reported. | Id2 leaves the chromatin of the E2F4-p130-controlled c-myc promoter during hepatocyte priming for liver regeneration.
Rodríguez JL, Sandoval J, Serviddio G, Sastre J, Morante M, Perrelli MG, Martínez-Chantar ML, Viña J, Viña JR, Mato JM, Avila MA, Franco L, López-Rodas G, Torres L., Free PMC Article | 01/21/2010 |