| Relaxin reverses maladaptive remodeling of the aged heart through Wnt-signaling. | Relaxin reverses maladaptive remodeling of the aged heart through Wnt-signaling.
Martin B, Gabris B, Barakat AF, Henry BL, Giannini M, Reddy RP, Wang X, Romero G, Salama G., Free PMC Article | 11/21/2020 |
| Relaxin-1 mRNA in the hearts of diabetic rats was significantly increased and that relaxin-3 mRNA expression at different time points was decreased. In addition, significant down-regulation of the mRNA expression of RXFP1 and RXFP3 was observed at 4 weeks after Streptozocin. | Alterations of relaxin and its receptor system components in experimental diabetic cardiomyopathy rats.
Zhang X, Pan L, Yang K, Fu Y, Liu Y, Chen W, Ma X, Yin X. | 06/9/2018 |
| The digestive tract has been shown to express relaxin receptors; the hormone appears to exert site-specific effects acting at the neural or at the smooth muscle level, mainly by a nitric oxide-mediated mechanism. (Review) | Site-related Effects of Relaxin in the Gastrointestinal Tract Through Nitric Oxide Signalling: An Updated Report.
Garella R, Squecco R, Baccari MC. | 11/4/2017 |
| The aim of the present study was to explore a role of relaxin at specific stages of spermatogenesis using a co-culture of rat Sertoli and germ cells. | Effects of relaxin in a co-culture of Sertoli and germ cells.
Pimenta MT, Porto CS, Lazari MF. | 05/3/2014 |
| We have shown that relaxin stimulates Sertoli cell proliferation through the activation of MEK/ERK1/2 and PI3K/AKT pathways. | Relaxin and Sertoli cell proliferation.
Nascimento AR, Pimenta MT, Lucas TF, Porto CS, Lazari MF. | 05/3/2014 |
| Raxin is a mediator of the refractoriness of the mesangial cells to angiotensin II during pregnancy. | Mesangial cells cultured from pregnant rats display reduced reactivity to angiotensin II: the role of relaxin, nitric oxide and AT2 receptor.
Carvalho LN, Cristovam PC, Passos CS, Boim MA. | 06/1/2013 |
| Data demonstrate a functional role for relaxin in mediating uterine artery compliance in pregnant rats, which may be necessary to maintain adequate uterine blood flow to the uterus and placenta. | Relaxin mediates uterine artery compliance during pregnancy and increases uterine blood flow.
Vodstrcil LA, Tare M, Novak J, Dragomir N, Ramirez RJ, Wlodek ME, Conrad KP, Parry LJ., Free PMC Article | 12/22/2012 |
| A novel G-quadruplex in the relaxin gene, is reported. | The formation and stabilization of a novel G-quadruplex in the 5'-flanking region of the relaxin gene.
Lin S, Gu H, Xu M, Cui X, Zhang Y, Gao W, Yuan G., Free PMC Article | 06/30/2012 |
| Rln-1 was localized in the granulosa cells of the ovarian follicles, and immunoreactivity against Rln 1 was increased by orthodontic tooth movement in a time-dependent manner. | Relaxin is up-regulated in the rat ovary by orthodontic tooth movement.
Yang SY, Ko HM, Kang JH, Moon YH, Yoo HI, Jung NR, Kim MS, Cho JH, Oh WM, Kim SH. | 08/6/2011 |
| High glucose concentration could stimulate the expression of endogenous relaxin. | Effects of recombinant human relaxin upon proliferation of cardiac fibroblast and synthesis of collagen under high glucose condition.
Wang P, Li HW, Wang YP, Chen H, Zhang P. | 01/21/2010 |
| role for relaxin in the systemic hemodynamic changes of pregnancy, as well as novel therapeutic potential for relaxin in modifying arterial stiffness and cardiac afterload. | Relaxin modifies systemic arterial resistance and compliance in conscious, nonpregnant rats.
Conrad KP, Debrah DO, Novak J, Danielson LA, Shroff SG. | 01/21/2010 |
| relaxin regulates fibroblast proliferation, differentiation, and collagen deposition and may have therapeutic potential in diseased states characterized by cardiac fibrosis. | Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo.
Samuel CS, Unemori EN, Mookerjee I, Bathgate RA, Layfield SL, Mak J, Tregear GW, Du XJ. | 01/21/2010 |