| The Activation of PKM2 Induces Pyroptosis in Hippocampal Neurons via the NLRP3/Caspase-1/GSDMD Pathway in Neonatal Rats With Hypoxic-Ischemic Brain Injury. | The Activation of PKM2 Induces Pyroptosis in Hippocampal Neurons via the NLRP3/Caspase-1/GSDMD Pathway in Neonatal Rats With Hypoxic-Ischemic Brain Injury.
Sha S, Jin N, Zhou R, Ruan Y, Ouyang Y., Free PMC Article | 11/5/2024 |
| Nuclear translocation of metabolic enzyme PKM2 participates in high glucose-promoted HCC metastasis by strengthening immunosuppressive environment. | Nuclear translocation of metabolic enzyme PKM2 participates in high glucose-promoted HCC metastasis by strengthening immunosuppressive environment.
Qian J, Huang C, Wang M, Liu Y, Zhao Y, Li M, Zhang X, Gao X, Zhang Y, Wang Y, Huang J, Li J, Zhou Q, Liu R, Wang X, Cui J, Yang Y., Free PMC Article | 04/3/2024 |
| Silencing PKM2 Attenuates Brain Injury Induced by Status Epilepticus by Inhibiting the AKT/mTOR Pathway and the NLRP3 Inflammasome. | Silencing PKM2 Attenuates Brain Injury Induced by Status Epilepticus by Inhibiting the AKT/mTOR Pathway and the NLRP3 Inflammasome.
Cui X, Jia R, Zhao R, Ma N, Jiang F. | 01/10/2024 |
| Inhibition of Pyruvate kinase M2 (PKM2) by shikonin attenuates isoproterenol-induced acute myocardial infarction via reduction in inflammation, hypoxia, apoptosis, and fibrosis. | Inhibition of Pyruvate kinase M2 (PKM2) by shikonin attenuates isoproterenol-induced acute myocardial infarction via reduction in inflammation, hypoxia, apoptosis, and fibrosis.
Rihan M, Sharma SS. | 01/8/2024 |
| M-type pyruvate kinase 2 (PKM2) tetramerization alleviates the progression of right ventricle failure by regulating oxidative stress and mitochondrial dynamics. | M-type pyruvate kinase 2 (PKM2) tetramerization alleviates the progression of right ventricle failure by regulating oxidative stress and mitochondrial dynamics.
Guo L, Wang L, Qin G, Zhang J, Peng J, Li L, Chen X, Wang D, Qiu J, Wang E., Free PMC Article | 01/4/2024 |
| Pyruvate Kinase M2: A New Biomarker for the Early Detection of Diabetes-Induced Nephropathy. | Pyruvate Kinase M2: A New Biomarker for the Early Detection of Diabetes-Induced Nephropathy.
Park YS, Han JH, Park JH, Choi JS, Kim SH, Kim HS., Free PMC Article | 02/16/2023 |
| Shikonin improves pulmonary vascular remodeling in monocrotalineinduced pulmonary arterial hypertension via regulation of PKM2. | Shikonin improves pulmonary vascular remodeling in monocrotaline‑induced pulmonary arterial hypertension via regulation of PKM2.
Li W, Chen W, Peng H, Xiao Z, Liu J, Zeng Y, Huang T, Song Q, Wang X, Xiao Y., Free PMC Article | 02/11/2023 |
| Downregulation of miR-122-5p Activates Glycolysis via PKM2 in Kupffer Cells of Rat and Mouse Models of Non-Alcoholic Steatohepatitis. | Downregulation of miR-122-5p Activates Glycolysis via PKM2 in Kupffer Cells of Rat and Mouse Models of Non-Alcoholic Steatohepatitis.
Inomata Y, Oh JW, Taniguchi K, Sugito N, Kawaguchi N, Hirokawa F, Lee SW, Akao Y, Takai S, Kim KP, Uchiyama K., Free PMC Article | 05/21/2022 |
| Platelet-Derived TGF (Transforming Growth Factor)-beta1 Enhances the Aerobic Glycolysis of Pulmonary Arterial Smooth Muscle Cells by PKM2 (Pyruvate Kinase Muscle Isoform 2) Upregulation. | Platelet-Derived TGF (Transforming Growth Factor)-β1 Enhances the Aerobic Glycolysis of Pulmonary Arterial Smooth Muscle Cells by PKM2 (Pyruvate Kinase Muscle Isoform 2) Upregulation.
Zhu Y, Shu D, Gong X, Lu M, Feng Q, Zeng XB, Zhang H, Gao J, Guo YW, Liu L, Ma R, Zhu L, Hu Q, Ming ZY. | 04/23/2022 |
| Bile acids attenuate PKM2 pathway activation in proinflammatory microglia. | Bile acids attenuate PKM2 pathway activation in proinflammatory microglia.
Romero-Ramírez L, García-Rama C, Wu S, Mey J., Free PMC Article | 03/12/2022 |
| Hyperpolarized pyruvate to measure the influence of PKM2 activation on glucose metabolism in the healthy kidney. | Hyperpolarized pyruvate to measure the influence of PKM2 activation on glucose metabolism in the healthy kidney.
Bertelsen LB, Hansen ESS, Sadowski T, Ruf S, Laustsen C. | 02/19/2022 |
| PKM2 Aggravates Cerebral Ischemia Reperfusion-Induced Neuroinflammation via TLR4/MyD88/TRAF6 Signaling Pathway. | PKM2 Aggravates Cerebral Ischemia Reperfusion-Induced Neuroinflammation via TLR4/MyD88/TRAF6 Signaling Pathway.
Zhang B, Shen J, Zhong Z, Zhang L. | 10/30/2021 |
| Ablation of PKM2 ameliorated ER stress-induced apoptosis and associated inflammation response in IL-1beta-treated chondrocytes via blocking Rspo2-mediated Wnt/beta-catenin signaling. | Ablation of PKM2 ameliorated ER stress-induced apoptosis and associated inflammation response in IL-1β-treated chondrocytes via blocking Rspo2-mediated Wnt/β-catenin signaling.
Li ZZ, Wang F, Liu S, Li H, Wang Y. | 07/17/2021 |
| Upregulated PKM2 in Macrophages Exacerbates Experimental Arthritis via STAT1 Signaling. | Upregulated PKM2 in Macrophages Exacerbates Experimental Arthritis via STAT1 Signaling.
Xu J, Jiang C, Wang X, Geng M, Peng Y, Guo Y, Wang S, Li X, Tao P, Zhang F, Han Y, Ning Q, Zhu W, Meng L, Lu S. | 03/13/2021 |
| PKM2 regulates angiogenesis of VR-EPCs through modulating glycolysis, mitochondrial fission, and fusion. | PKM2 regulates angiogenesis of VR-EPCs through modulating glycolysis, mitochondrial fission, and fusion.
Ren R, Guo J, Shi J, Tian Y, Li M, Kang H. | 03/13/2021 |
| Pyruvate Kinase M2 Mediates Glycolysis in the Lymphatic Endothelial Cells and Promotes the Progression of Lymphatic Malformations. | Pyruvate Kinase M2 Mediates Glycolysis in the Lymphatic Endothelial Cells and Promotes the Progression of Lymphatic Malformations.
Jiang H, Zou Y, Zhao J, Li X, Yang S, Zhou X, Mou D, Zhong W, Cai Y. | 01/23/2021 |
| Study found that the Warburg effect was increased in liver precancerous lesions in rats. Pkm2 and phosphorylated Stat3 were upregulated in activated oval cells in liver precancerous lesions. Stat3 activation promoted the clonal formation rate, aneuploidy, alpha-fetoprotein expression, PCNA expression, G1/S phase transition, the Warburg effect, Pkm2 phosphorylation, and nuclear translocation in transformed WB-F344 cells. | Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions.
Bi YH, Han WQ, Li RF, Wang YJ, Du ZS, Wang XJ, Jiang Y., Free PMC Article | 12/14/2019 |
| SIRT1 may regulate acetylation level of NSE and PKM through deacetylation and further regulate their catalytic activity. | SIRT 1 binding with PKM and NSE and modulate their acetylation and activities.
Zhang ZH, Zhang H, Wang YR, Liu XL, Huang H, Xu XH. | 11/30/2019 |
| PKM2 is involved in promoting apoptosis in newborn rat ipsilateral cortical neurons via AKT signaling after hypoxic-ischemic encephalopathy. | PKM2 Involved in Neuronal Apoptosis on Hypoxic-ischemic Encephalopathy in Neonatal Rats.
Wu Q, Ge W, Chen Y, Kong X, Xian H. | 08/17/2019 |
| Alpha-synuclein induces microglial migration via PKM2-dependent glycolysis | Alpha-synuclein induces microglial migration via PKM2-dependent glycolysis.
Qiao H, He X, Zhang Q, Yuan H, Wang D, Li L, Hui Y, Wu Z, Li W, Zhang N. | 08/3/2019 |
| Monocrotaline-induced rats developed severe pulmonary arterial hypertension and right ventricular hypertrophy, with a significant increase in the phosphorylated PKM2 activity. | Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to the development of pulmonary arterial hypertension.
Guo D, Gu J, Jiang H, Ahmed A, Zhang Z, Gu Y. | 11/12/2016 |
| After light-induced retinal damage in retinal ganglion cells PKM2 was up-regulated. | Up-Regulation of PKM2 Relates to Retinal Ganglion Cell Apoptosis After Light-Induced Retinal Damage in Adult Rats.
Yang X, Chen H, Zhu M, Zhu R, Qin B, Fang H, Dai M, Sang A, Liu X. | 07/30/2016 |
| Nuclear translocation of PKM2 promotes astrocytes proliferation after spinal cord injury through modulating p27 cell cycle signaling. | Nuclear translocation of PKM2 modulates astrocyte proliferation via p27 and -catenin pathway after spinal cord injury.
Zhang J, Feng G, Bao G, Xu G, Sun Y, Li W, Wang L, Chen J, Jin H, Cui Z., Free PMC Article | 05/28/2016 |
| PKM2 may regulate the survival of cardiomyocytes in acute rejection after heart transplantation in rat | Pyruvate kinase isoenzyme M2 expression correlates with survival of cardiomyocytes after allogeneic rat heterotopic heart transplantation.
Shi J, Yang X, Yang D, Li Y, Liu Y. | 10/17/2015 |
| Data suggest M2PK is modulated in mast cell degranulation via IgE/FCERI (IgE high affinity I receptor) signaling; immediate inhibition of M2PK involves tyrosine phosphorylation; subsequently fructose-1,6-biphosphate accumulates and activates M2PK. | Dual regulation of mast cell degranulation through IgE receptor-mediated modulation of M₂-type pyruvate kinase.
Zheng M, Cho DI, Le HT, Cheon SH, Kim KM. | 05/16/2015 |