| In the presence of high-glucose levels, increased l-arginine uptake due to simvastatin treatment was associated with increased CAT-1 and eNOS mRNA levels, leading to higher NO production in immortalized rat inner blood-retinal barrier cell lines. | Effects of simvastatin on CAT-1-mediated arginine transport and NO level under high glucose conditions in conditionally immortalized rat inner blood-retinal barrier cell lines (TR-iBRB).
Tun T, Kang YS. | 10/7/2017 |
| CAT1 is involved in L-Arg uptake by retinal pericytes and this is expected to play an important role in the relaxation of retinal pericytes, thereby modulating the microcirculatory hemodynamics in the retina | Involvement of cationic amino acid transporter 1 in L-arginine transport in rat retinal pericytes.
Zakoji N, Akanuma S, Tachikawa M, Hosoya K. | 12/19/2015 |
| Aortic arginine transport by CAT-1 is attenuated in old male rats through upregulation of PKCalpha. | Aortic arginine transport is attenuated, through post-translational modulation of CAT-1 by PKCalpha, in old male rats.
Schwartz IF, Chernichovski T, Schwartz D. | 04/12/2010 |
| analysis of how a bifunctional intronic element regulates the expression of the arginine/lysine transporter Cat-1 via mechanisms involving the purine-rich element binding protein A (Pur alpha) | A bifunctional intronic element regulates the expression of the arginine/lysine transporter Cat-1 via mechanisms involving the purine-rich element binding protein A (Pur alpha).
Huang CC, Chiribau CB, Majumder M, Chiang CM, Wek RC, Kelm RJ Jr, Khalili K, Snider MD, Hatzoglou M., Free PMC Article | 01/21/2010 |
| Attenuated glomerular arginine transport by CAT-1 contributes to the age-dependent, NO-deficient state in old male rats through upregulation of PKCalpha. | Sexual dimorphism in glomerular arginine transport affects nitric oxide generation in old male rats.
Schwartz IF, Chernichovski T, Krishtol N, Grupper A, Laron I, Schwartz D. | 01/21/2010 |
| CAT1, CAT2, DDAH2, and arginase-1 expression in renal resistance vessels is regulated through the AT(1) receptor. | AT(1) receptor activation regulates the mRNA expression of CAT1, CAT2, arginase-1, and DDAH2 in preglomerular vessels from angiotensin II hypertensive rats.
Hultström M, Helle F, Iversen BM. | 01/21/2010 |
| bilateral ureteral ligation as a model for obstructive uropathy induces an increase in glomerular arginine transport via upregulation of CAT-1 | Arginine transport is augmented, through modulation of cationic amino acid transporter-1, in obstructive uropathy in rats.
Schwartz IF, Davidovitz A, Chernichovski T, Levin-Iaina N, Guzner-Gur H, Levo Y, Schwartz D. | 01/21/2010 |
| aortic arginine uptake is attenuated in hypercholesterolemia, through post-translational modulation of CAT-1 protein, possibly via upregulation of PKC alpha | Arginine uptake is attenuated, through post-translational regulation of cationic amino acid transporter-1, in hyperlipidemic rats.
Schwartz IF, Ingbir M, Chernichovski T, Reshef R, Chernin G, Litvak A, Weinstein T, Levo Y, Schwartz D. | 01/21/2010 |
| When CAT-1-mediated transport of extracellular l-arginine into endothelial cells was suppressed, the endothelial cell NO response to a wide range of physiological stimuli was strongly depressed | Transport of extracellular l-arginine via cationic amino acid transporter is required during in vivo endothelial nitric oxide production.
Zani BG, Bohlen HG. | 01/21/2010 |
| transient increase in cat-1 transcription is due to transcriptional activation caused by ATF4 followed by transcriptional repression by ATF3 via a feedback mechanism. | A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation.
Lopez AB, Wang C, Huang CC, Yaman I, Li Y, Chakravarty K, Johnson PF, Chiang CM, Snider MD, Wek RC, Hatzoglou M., Free PMC Article | 01/21/2010 |
| increase in cat-1 gene expression by cellular stress involves at least three types of coordinate regulation: regulation of transcription, regulation of mRNA stability, and regulation of mRNA translation | Transcriptional control of the arginine/lysine transporter, cat-1, by physiological stress.
Fernandez J, Lopez AB, Wang C, Mishra R, Zhou L, Yaman I, Snider MD, Hatzoglou M. | 01/21/2010 |