| Insulin-Like Growth Factor Binding Protein 2 Drives Neurodegeneration in Parkinson's Disease: Insights From In Vivo and In Vitro Studies. | Insulin-Like Growth Factor Binding Protein 2 Drives Neurodegeneration in Parkinson's Disease: Insights From In Vivo and In Vitro Studies.
An J, Wen L, Yu H, Bu Z, Feng J., Free PMC Article | 10/23/2024 |
| Insulin-like growth factor 2 (IGF2) is an important regulator of fetal growth. | Prenatal administration of retinoic acid increases the trophoblastic insulin-like growth factor 2 protein expression in the nitrofen model of congenital diaphragmatic hernia.
Kutasy B, Friedmacher F, Duess JW, Puri P. | 11/8/2014 |
| Abnormal expression of IGFBP-2 correlates with hyperoxia-induced lung injury in neonatal rats. | [Relation of insulin-like growth factor binding protein-2 with hyperoxia-induced lung injury in term and premature neonatal rats].
Liu HC, Chang LW, Rong ZH, Zhu HP, Zhang QS, Chen HB, Li WB. | 02/8/2010 |
| A brain region- and cell type-specific responses to estrogen in rat brain, suggesting that Igf signaling may mediate the estrogen function in the hippocampus. | Identification of Igf2, Igfbp2 and Enpp2 as estrogen-responsive genes in rat hippocampus.
Takeo C, Ikeda K, Horie-Inoue K, Inoue S. | 01/21/2010 |
| In conclusion, MMP-9-induced IGFBP2 proteolysis may be regarded as an important post-translational event involved in astrocytoma aggressiveness. These new findings support drug targeting of MMP-9 as an interesting approach in the treatment of | Matrix metalloproteinase-9 interplays with the IGFBP2-IGFII complex to promote cell growth and motility in astrocytomas.
Rorive S, Berton A, D'haene N, Takacs CN, Debeir O, Decaestecker C, Salmon I. | 01/21/2010 |
| Growth inhibition, which was supported by the strong induction of p21CIP1/WAF1, was correlated with increased secretion of IGFBP-2 and, unexpectedly, with its increased localization in the nucleus and particularly in the cytoplasm. | Intracellular colocalization and interaction of IGF-binding protein-2 with the cyclin-dependent kinase inhibitor p21CIP1/WAF1 during growth inhibition.
Terrien X, Bonvin E, Corroyer S, Tabary O, Clement A, Henrion Caude A., Free PMC Article | 01/21/2010 |
| cathepsin L created a 14-kDa carboxyl IGFBP-2 fragment that corresponded to the sole antigen detected in IEC-18 cell lysates as well as a 16.5-kDa fragment found in the media | A 14-kDa cathepsin L-derived carboxyl IGFBP-2 fragment is sequestered by cultured rat ileal crypt cells.
Gordon PV, Paxton JB, Kuemmerle JF, Fox NS. | 01/21/2010 |
| retinoic acid modulates the secreted IGFBP-2 and -3 during O(2) exposure and inhibits the increase in collagen that occurs during lung injury | Modulation of IGF-binding protein-2 and -3 in hyperoxic injury in developing rat lung.
Chetty A, Manzo N, Waxman AB, Nielsen HC. | 01/21/2010 |
| Depolarization induces insulin-like growth factor binding protein-2 expression in vivo via NMDA receptor stimulation. | Depolarization induces insulin-like growth factor binding protein-2 expression in vivo via NMDA receptor stimulation.
Holmin S, Mathiesen T, Langmoen IA, Sandberg Nordqvist AC. | 01/21/2010 |
| IGFBP-2 plays a role in the lamellar bone formation process. | In vivo mechanical loading modulates insulin-like growth factor binding protein-2 gene expression in rat osteocytes.
Reijnders CM, Bravenboer N, Holzmann PJ, Bhoelan F, Blankenstein MA, Lips P., Free PMC Article | 01/21/2010 |
| results show that liver growth and cell proliferation in association with insulin-like growth factor-I and insulin-like growth factor binding proteins 1 and 2 levels are affected in utero by fetal undernutrition | Isocaloric maternal low-protein diet alters IGF-I, IGFBPs, and hepatocyte proliferation in the fetal rat.
El-Khattabi I, Grégoire F, Remacle C, Reusens B. | 01/21/2010 |
| In proliferating astrocytes, IGFBP-2 may help target insulin-like growth factors (IGFs) to IGF-1 receptors, and IGFBP-2 proteases may play a role in enhancing the availability of IGFs. | Enhanced production and proteolytic degradation of insulin-like growth factor binding protein-2 in proliferating rat astrocytes.
Chesik D, Kühl NM, Wilczak N, De Keyser J. | 01/21/2010 |