| Downregulation of Sirt6 by CD38 promotes cell senescence and aging. | Downregulation of Sirt6 by CD38 promotes cell senescence and aging.
Zhou H, Liu S, Zhang N, Fang K, Zong J, An Y, Chang X., Free PMC Article | 12/31/2022 |
| Oxytocin attenuates schizophrenia-like reduced sensorimotor gating in outbred and inbred rats in line with strain differences in CD38 gene expression. | Oxytocin attenuates schizophrenia-like reduced sensorimotor gating in outbred and inbred rats in line with strain differences in CD38 gene expression.
Tapias-Espinosa C, Cañete T, Sampedro-Viana D, Brudek T, Kaihøj A, Oliveras I, Tobeña A, Aznar S, Fernández-Teruel A. | 10/30/2021 |
| CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD(+)/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats. | CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD(+)/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats.
Ogura Y, Kitada M, Xu J, Monno I, Koya D., Free PMC Article | 03/13/2021 |
| Endothelial cells have high expression of CD38 which is activated by hypoxia-reoxygenation triggering CD38-mediated NADP(H) depletion with loss of eNOS-mediated NO generation and increased eNOS uncoupling. | Characterization of CD38 in the major cell types of the heart: endothelial cells highly express CD38 with activation by hypoxia-reoxygenation triggering NAD(P)H depletion.
Boslett J, Hemann C, Christofi FL, Zweier JL., Free PMC Article | 03/2/2019 |
| CD38 plays an essential role in cardiac hypertrophy probably via inhibition of SIRT3 expression and activation of Ca(2+) -NFAT signaling pathway. | CD38 promotes angiotensin II-induced cardiac hypertrophy.
Guan XH, Hong X, Zhao N, Liu XH, Xiao YF, Chen TT, Deng LB, Wang XL, Wang JB, Ji GJ, Fu M, Deng KY, Xin HB., Free PMC Article | 04/21/2018 |
| Study found that deletion of CD38 caused impaired astrocytic and oligodendrocytic development in the cortex, probably by increasing NAD+ levels and decreasing Cx43 expression levels. | CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously.
Hattori T, Kaji M, Ishii H, Jureepon R, Takarada-Iemata M, Minh Ta H, Manh Le T, Konno A, Hirai H, Shiraishi Y, Ozaki N, Yamamoto Y, Okamoto H, Yokoyama S, Higashida H, Kitao Y, Hori O. | 05/6/2017 |
| CD38 deficiency protects the heart from ischemia/reperfusion injury through activating SIRT1/FOXOs-mediated antioxidative stress pathway. | CD38 Deficiency Protects the Heart from Ischemia/Reperfusion Injury through Activating SIRT1/FOXOs-Mediated Antioxidative Stress Pathway.
Guan XH, Liu XH, Hong X, Zhao N, Xiao YF, Wang LF, Tang L, Jiang K, Qian YS, Deng KY, Ji G, Fu M, Xin HB., Free PMC Article | 03/18/2017 |
| CD38 activation after NADPH depletion triggers endothelial dysfunction in the postischemic heart | Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart.
Reyes LA, Boslett J, Varadharaj S, De Pascali F, Hemann C, Druhan LJ, Ambrosio G, El-Mahdy M, Zweier JL., Free PMC Article | 01/16/2016 |
| The mRNA level of CD38 in intermittent hypoxia -treated islets was significantly lower than that in normoxia-treated islets. | Attenuation of glucose-induced insulin secretion by intermittent hypoxia via down-regulation of CD38.
Ota H, Tamaki S, Itaya-Hironaka A, Yamauchi A, Sakuramoto-Tsuchida S, Morioka T, Takasawa S, Kimura H. | 04/7/2012 |
| observed the preferential localization of CD38 in the basolateral plasma membrane and intracellular granule-like membrane in sublingual acinar cells under resting conditions | CD38/ADP-ribosyl cyclase in the rat sublingual gland: subcellular localization under resting and saliva-secreting conditions.
Masuda W, Jimi E. | 10/15/2011 |
| The ecto-enzyme CD38 is a nicotinic acid adenine dinucleotide phosphate (NAADP) synthase that couples receptor activation to Ca2+ mobilization from lysosomes in pancreatic acinar cells | The ecto-enzyme CD38 is a nicotinic acid adenine dinucleotide phosphate (NAADP) synthase that couples receptor activation to Ca2+ mobilization from lysosomes in pancreatic acinar cells.
Cosker F, Cheviron N, Yamasaki M, Menteyne A, Lund FE, Moutin MJ, Galione A, Cancela JM., Free PMC Article | 01/1/2011 |
| CD38/cADPR/Ca2+ pathway promotes cell proliferation and delays nerve growth factor-induced differentiation in PC12 cells. | CD38/cADPR/Ca2+ pathway promotes cell proliferation and delays nerve growth factor-induced differentiation in PC12 cells.
Yue J, Wei W, Lam CM, Zhao YJ, Dong M, Zhang LR, Zhang LH, Lee HC., Free PMC Article | 01/21/2010 |
| Data show that perinatal brain injury led to a significant increase in enzyme expression during the first 3 days after brain hypoxia/ischemia. | Perinatal hypoxic and ischemic damage to the central nervous system causes changes in the expression of connexin 43 and CD38 and ADP-ribosyl cyclase activity in brain cells.
Salmina AB, Malinovskaya NA, Okuneva OS, Taranushenko TE, Fursov AA, Mikhutkina SV, Morgun AV, Prokopenko SV, Zykova LD. | 01/21/2010 |
| Inhibition of ADP-ribosyl cyclase attenuates angiotensin II-induced cardiac hypertrophy. | Inhibition of ADP-ribosyl cyclase attenuates angiotensin II-induced cardiac hypertrophy.
Gul R, Park JH, Kim SY, Jang KY, Chae JK, Ko JK, Kim UH. | 01/21/2010 |
| In the renal microcirculation in vivo, ET-1-induced vasoconstriction is mediated by ADP-ribosyl cyclase and ryanodine receptors, and ETA and ETB receptors activate this pathway. | ADP-ribosyl cyclase and ryanodine receptors mediate endothelin ETA and ETB receptor-induced renal vasoconstriction in vivo.
Thai TL, Arendshorst WJ., Free PMC Article | 01/21/2010 |
| Activation of ADPR-cyclase by ANG II entails a novel signaling pathway involving sequential activation of Src, PI 3-kinase/Akt, and PLC-gamma1/IP(3) and that the activation of ADPR-cyclase can lead to cardiac hypertrophy. | A novel signaling pathway of ADP-ribosyl cyclase activation by angiotensin II in adult rat cardiomyocytes.
Gul R, Kim SY, Park KH, Kim BJ, Kim SJ, Im MJ, Kim UH. | 01/21/2010 |
| ADP-ribosyl cyclase and ryanodine receptors participate in L-type channel-mediated renal vasoconstriction in vivo. | ADP-ribosyl cyclase and ryanodine receptor activity contribute to basal renal vasomotor tone and agonist-induced renal vasoconstriction in vivo.
Thai TL, Fellner SK, Arendshorst WJ. | 01/21/2010 |
| CD38 can act as a regulator of hepatic stellate cells activation and effector functions | Identification and functional characterization of the hepatic stellate cell CD38 cell surface molecule.
March S, Graupera M, Rosa Sarrias M, Lozano F, Pizcueta P, Bosch J, Engel P., Free PMC Article | 01/21/2010 |
| membrane-bound CD38 is present in pancreatic acinar cells | Hormonal control of ADP-ribosyl cyclase activity in pancreatic acinar cells from rats.
Sternfeld L, Krause E, Guse AH, Schulz I. | 01/21/2010 |
| first report of a functionally active ADP-ribosyl cyclase/CD38 in the spleen nuclear fraction | Identification and characterization of nuclear CD38 in the rat spleen.
Khoo KM, Chang CF. | 01/21/2010 |
| role in synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues | CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues.
Chini EN, Chini CC, Kato I, Takasawa S, Okamoto H., Free PMC Article | 01/21/2010 |