| The paradox of tPA in ischemic stroke: tPA knockdown following recanalization improves functional and histological outcomes. | The paradox of tPA in ischemic stroke: tPA knockdown following recanalization improves functional and histological outcomes.
Challa SR, Nalamolu KR, Fornal CA, Baker IM, Mohandass A, Mada SR, Wang BC, Pinson DM, Lahoti S, Klopfenstein JD, Veeravalli KK., Free PMC Article | 02/26/2024 |
| The interplay between MMP-12 and t-PA in the brain after ischemic stroke. | The interplay between MMP-12 and t-PA in the brain after ischemic stroke.
Challa SR, Nalamolu KR, Fornal CA, Mohandass A, Mussman JP, Schaibley C, Kashyap A, Sama V, Wang BC, Klopfenstein JD, Pinson DM, Kunamneni A, Veeravalli KK., Free PMC Article | 11/26/2022 |
| Astrocyte tissue plasminogen activator expression during brain development and its role in pyramidal neuron neurite outgrowth. | Astrocyte tissue plasminogen activator expression during brain development and its role in pyramidal neuron neurite outgrowth.
Goeke CM, Zhang X, Hashimoto JG, Guizzetti M., Free PMC Article | 03/19/2022 |
| Tissue-type plasminogen activator-primed human iPSC-derived neural progenitor cells promote motor recovery after severe spinal cord injury. | Tissue-type plasminogen activator-primed human iPSC-derived neural progenitor cells promote motor recovery after severe spinal cord injury.
Shiga Y, Shiga A, Mesci P, Kwon H, Brifault C, Kim JH, Jeziorski JJ, Nasamran C, Ohtori S, Muotri AR, Gonias SL, Campana WM., Free PMC Article | 11/21/2020 |
| t-PA expressed in ECs may help to form IT of the DA via activation of MMP-2 and disruption of IEL | Tissue-type plasminogen activator contributes to remodeling of the rat ductus arteriosus.
Saito J, Yokoyama U, Nicho N, Zheng YW, Ichikawa Y, Ito S, Umemura M, Fujita T, Ito S, Taniguchi H, Asou T, Masuda M, Ishikawa Y., Free PMC Article | 02/24/2018 |
| The use of G-CSF to protect the vasculature may improve the clinical outcome of tPA even outside the currently indicated therapeutic window for ischemic stroke. | Granulocyte colony-stimulating factor attenuates delayed tPA-induced hemorrhagic transformation in ischemic stroke rats by enhancing angiogenesis and vasculogenesis.
dela Peña IC, Yoo A, Tajiri N, Acosta SA, Ji X, Kaneko Y, Borlongan CV., Free PMC Article | 04/11/2015 |
| LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein. | LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein.
Mantuano E, Lam MS, Gonias SL., Free PMC Article | 02/8/2014 |
| Regulation of PAI-1 activity in astrocytes by valproic acid may affect both physiological and pathological processes in the brain by upregulating tPA activity. | Valproic acid induces astrocyte-dependent neurite outgrowth from cultured rat primary cortical neuron via modulation of tPA/PAI-1 activity.
Cho KS, Kwon KJ, Choi CS, Jeon SJ, Kim KC, Park JH, Ko HM, Lee SH, Cheong JH, Ryu JH, Han SH, Shin CY. | 12/21/2013 |
| Together, because CPAI blocks both proteolytic and nonproteolytic tPA neurotoxicity, it is a promising therapeutics of neonatal HI injury either with or without infection. | Plasminogen activator inhibitor-1 mitigates brain injury in a rat model of infection-sensitized neonatal hypoxia-ischemia.
Yang D, Sun YY, Nemkul N, Baumann JM, Shereen A, Dunn RS, Wills-Karp M, Lawrence DA, Lindquist DM, Kuan CY., Free PMC Article | 10/19/2013 |
| Designed t-PA mutants with molecular properties that, in contrast to t-PA, do not induce neurotoxicity. | Molecular requirements for safer generation of thrombolytics by bioengineering the tissue-type plasminogen activator A chain.
Parcq J, Bertrand T, Baron AF, Hommet Y, Anglès-Cano E, Vivien D. | 08/31/2013 |
| Tissue plasminogen activator prevents mortality from sulfur mustard analog-induced airway obstruction. | Tissue plasminogen activator prevents mortality from sulfur mustard analog-induced airway obstruction.
Veress LA, Hendry-Hofer TB, Loader JE, Rioux JS, Garlick RB, White CW., Free PMC Article | 05/25/2013 |
| NR2B as a novel proteolytic substrate of tPA, where tPA may directly interact with NR2B subunits leading to a change in pharmacological properties of NR2B-containing NMDA receptors. | Cleavage of the NR2B subunit amino terminus of N-methyl-D-aspartate (NMDA) receptor by tissue plasminogen activator: identification of the cleavage site and characterization of ifenprodil and glycine affinities on truncated NMDA receptor.
Ng KS, Leung HW, Wong PT, Low CM., Free PMC Article | 10/20/2012 |
| mRNA, protein and activity of matrix metalloproteinase (MMP)-2 and MMP-9 and mRNA of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1) were quantified in abdominal aorta (AA) and femoral artery (FA). | Physiological regulation of MMPs and tPA/PAI in the arterial wall of rats by noradrenergic tone and angiotensin II.
Dab H, Hachani R, Dhaouadi N, Hodroj W, Sakly M, Randon J, Bricca G, Kacem K. | 06/30/2012 |
| The induction of tPA by human marrow stromal cells after traumatic brain injury may be one of the mechanisms involved in promoting functional improvement after traumatic brain injury. | Treatment of TBI with collagen scaffolds and human marrow stromal cells increases the expression of tissue plasminogen activator.
Mahmood A, Qu C, Ning R, Wu H, Goussev A, Xiong Y, Irtenkauf S, Li Y, Chopp M., Free PMC Article | 05/26/2012 |
| Hydrocortisone up-regulates PAI-1 expression in a tissue-specific manner along with down-regulation of tPA activity in both normal and inflammatory conditions. | Regulation of tissue plasminogen activator/plasminogen activator inhibitor-1 by hydrocortisone in rat primary astrocytes.
Kwon KJ, Cho KS, Lee SH, Kim JN, Joo SH, Ryu JH, Ignarro LJ, Han SH, Shin CY. | 03/31/2012 |
| These results indicate that PDE4A and PLAT may be susceptibility genes for schizophrenia in the Japanese population. | Positive association of phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia.
Deng X, Takaki H, Wang L, Kuroki T, Nakahara T, Hashimoto K, Ninomiya H, Arinami T, Inada T, Ujike H, Itokawa M, Tochigi M, Watanabe Y, Someya T, Kunugi H, Iwata N, Ozaki N, Shibata H, Fukumaki Y. | 01/21/2012 |
| PACAP stimulates the release of tPA which promotes cerebellar granule cell survival by a mechanism dependent upon its proteolytic activity. | Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates the expression and the release of tissue plasminogen activator (tPA) in neuronal cells: involvement of tPA in the neuroprotective effect of PACAP.
Raoult E, Roussel BD, Bénard M, Lefebvre T, Ravni A, Ali C, Vivien D, Komuro H, Fournier A, Vaudry H, Vaudry D, Galas L. | 01/14/2012 |
| Massive up-regulation of plasminogen activator inhibitor-1 (PAI-1) in astrocytes during subchronic and chronic inflammatory conditions leads to decreased tPA activity in the later stages of reperfusion injury. | Biphasic regulation of tissue plasminogen activator activity in ischemic rat brain and in cultured neural cells: essential role of astrocyte-derived plasminogen activator inhibitor-1.
Kim JW, Lee SH, Ko HM, Kwon KJ, Cho KS, Choi CS, Park JH, Kim HY, Lee J, Han SH, Ignarro LJ, Cheong JH, Kim WK, Shin CY. | 12/31/2011 |
| Erigeron breviscapus injection can inhibit the expression of TNF-alpha and PAI-1, and increase the expression of tPA in rats with acute myocardial infarction. | [Effects of Erigeron breviscapus injection on TNF-alpha, PAI-1 and tPA in rats with acute myocardial infarction].
Huang KW, Guo JW, Chen JM, Qiu GQ, Deng ZJ, Li LM, Fu YH. | 05/7/2011 |
| Investigated the brain-protective molecular mechanism of TPA in rats. TPA derivates were intracerebroventricularly administered at 15 min before, and 15, 90, 120 min after middle cerebral artery occlusion. | The Kringle-2 domain of tissue plasminogen activator significantly reduces mortality and brain infarction in middle cerebral artery occlusion rats.
Zhang H, Bi F, Xiao C, Liu J, Wang Z, Liu JN, Zhang J. | 10/23/2010 |
| Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke. | Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke.
Zhu H, Fan X, Yu Z, Liu J, Murata Y, Lu J, Zhao S, Hajjar KA, Lo EH, Wang X., Free PMC Article | 06/28/2010 |
| High glucose decreased the expressions of tPA and uPA, and increased PAI1. Losartan could partly reverse partly this expression. | [Effects of losartan on expressions of plasminogen activator and plasminogen activator inhibitor-1 of rat proximal tubular epithelial cells cultured with high glucose].
Pu LJ, Huang SM, Liu F. | 05/31/2010 |
| alpha-synuclein up-regulated MMP-9 and down-regulated tPA activity in rat primary astrocytes and microglia in ERK1/2 dependent fashion; suggests a role of alpha-synuclein via regulation of protease systems through modulation of ERK1/2 activity in brain | Regulation of matrix metalloproteinase-9 and tissue plasminogen activator activity by alpha-synuclein in rat primary glial cells.
Joo SH, Kwon KJ, Kim JW, Kim JW, Hasan MR, Lee HJ, Han SH, Shin CY. | 04/19/2010 |
| t-PA and PAI-1 mRNA were decreased after sympathectomy and remained unchanged after AT1 receptors blockade | Differential control of MMP and t-PA/PAI-1 expressions by sympathetic and renin-angiotensin systems in rat left ventricle.
Dab H, Hachani R, Hodroj W, Sakly M, Bricca G, Kacem K. | 01/21/2010 |
| protein aggregates formed during neuronal injury provide a macromolecular, nonfibrin cofactor that promotes tPA-mediated plasmin formation and subsequent cell breakdown | A nonfibrin macromolecular cofactor for tPA-mediated plasmin generation following cellular injury.
Samson AL, Borg RJ, Niego B, Wong CH, Crack PJ, Yongqing T, Medcalf RL. | 01/21/2010 |