| FBXO7 ubiquitinates PRMT1 to suppress serine synthesis and tumor growth in hepatocellular carcinoma. | FBXO7 ubiquitinates PRMT1 to suppress serine synthesis and tumor growth in hepatocellular carcinoma.
Luo L, Wu X, Fan J, Dong L, Wang M, Zeng Y, Li S, Yang W, Jiang J, Wang K., Free PMC Article | 06/13/2024 |
| FBXO7 Confers Mesenchymal Properties and Chemoresistance in Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing. | FBXO7 Confers Mesenchymal Properties and Chemoresistance in Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing.
Li S, Chen Y, Xie Y, Zhan H, Zeng Y, Zeng K, Wang L, Zhan Z, Li C, Zhao L, Chen X, Tan Y, Wang Z, Bu J, Song Y, Deng F, Zhou A., Free PMC Article | 11/30/2023 |
| USP7 attenuates endoplasmic reticulum stress-induced apoptotic cell death through deubiquitination and stabilization of FBXO7. | USP7 attenuates endoplasmic reticulum stress-induced apoptotic cell death through deubiquitination and stabilization of FBXO7.
Lee SH, Chung KC., Free PMC Article | 11/15/2023 |
| FBXO7, a tumor suppressor in endometrial carcinoma, suppresses INF2-associated mitochondrial division. | FBXO7, a tumor suppressor in endometrial carcinoma, suppresses INF2-associated mitochondrial division.
Zhang H, Zhao Y, Wang J, Li J, Xia J, Lin Y, Zhong Y, Cao X, Jin J, Li X, Yang W, Ye M, Jin X., Free PMC Article | 06/23/2023 |
| The characteristics of FBXO7 and its role in human diseases. | The characteristics of FBXO7 and its role in human diseases.
Zhong Y, Li J, Ye M, Jin X. | 12/3/2022 |
| Novel bi-allelic FBXO7 variants in a family with early-onset typical Parkinson's disease. | Novel bi-allelic FBXO7 variants in a family with early-onset typical Parkinson's disease.
Keller Sarmiento IJ, Afshari M, Kinsley L, Silani V, Akhtar RS, Simuni T, Lubbe SJ, Krainc D, Mencacci NE. | 11/19/2022 |
| Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells. | Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells.
Harris R, Yang M, Schmidt C, Royet C, Singh S, Natarajan A, Morris M, Frezza C, Laman H., Free PMC Article | 06/11/2022 |
| The F-box protein, FBXO7, is required to maintain chromosome stability in humans. | The F-box protein, FBXO7, is required to maintain chromosome stability in humans.
Palmer MCL, Neudorf NM, Farrell AC, Razi T, Lichtensztejn Z, McManus KJ., Free PMC Article | 05/14/2022 |
| FBXO7 triggers caspase 8-mediated proteolysis of the transcription factor FOXO4 and exacerbates neuronal cytotoxicity. | FBXO7 triggers caspase 8-mediated proteolysis of the transcription factor FOXO4 and exacerbates neuronal cytotoxicity.
Lee SH, Jung S, Lee YJ, Hyun M, Chung KC., Free PMC Article | 01/29/2022 |
| Novel compound heterozygous FBXO7 mutations in a family with early onset Parkinson's disease. | Novel compound heterozygous FBXO7 mutations in a family with early onset Parkinson's disease.
Lorenzo-Betancor O, Lin YH, Samii A, Jayadev S, Kim HM, Longfellow K, Distad BJ, Yearout D, Mata IF, Zabetian CP., Free PMC Article | 01/8/2022 |
| The p105 NF-kB precursor is a pseudo substrate of the ubiquitin ligase FBXO7, and its binding to the ligase stabilizes it and results in stimulated cell proliferation. | The p105 NF-ĸB precursor is a pseudo substrate of the ubiquitin ligase FBXO7, and its binding to the ligase stabilizes it and results in stimulated cell proliferation.
Udasin RG, Gottfried Y, Fabre B, Bercovich B, Ziv T, Ciechanover A. | 08/28/2021 |
| Compound heterozygous variants of the FBXO7 gene resulting in infantile-onset Parkinsonian-pyramidal syndrome in siblings of a Chinese family. | Compound heterozygous variants of the FBXO7 gene resulting in infantile-onset Parkinsonian-pyramidal syndrome in siblings of a Chinese family.
Jin X, An L, Hao S, Liu Q, Zhang Q, Wang X, Feng X, Zhang C, Cao X, Yan Y, Ma X., Free PMC Article | 08/21/2021 |
| Analysis of the FBXO7 promoter reveals overlapping Pax5 and c-Myb binding sites functioning in B cells. | Analysis of the FBXO7 promoter reveals overlapping Pax5 and c-Myb binding sites functioning in B cells.
Harris R, Randle S, Laman H., Free PMC Article | 07/17/2021 |
| Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1. | Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1.
Liu Y, Lear TB, Verma M, Wang KZ, Otero PA, McKelvey AC, Dunn SR, Steer E, Bateman NW, Wu C, Jiang Y, Weathington NM, Rojas M, Chu CT, Chen BB, Mallampalli RK., Free PMC Article | 05/22/2021 |
| Fbxo7 and Pink1 play a reciprocal role in regulating their protein levels. | Fbxo7 and Pink1 play a reciprocal role in regulating their protein levels.
Huang T, Fang L, He R, Weng H, Chen X, Ye Q, Qu D., Free PMC Article | 05/8/2021 |
| The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-kappaB signaling pathway. | The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-κB signaling pathway.
Spagnol V, Oliveira CAB, Randle SJ, Passos PMS, Correia CRSTB, Simaroli NB, Oliveira JS, Mevissen TET, Medeiros AC, Gomes MD, Komander D, Laman H, Teixeira FR., Free PMC Article | 01/16/2021 |
| Results suggest that FBXO7 gene doesn't seem to be a risk factor to develop sporadic Parkinson's disease in Chinese population. | Genetic analysis of ATP13A2, PLA2G6 and FBXO7 in a cohort of Chinese patients with early-onset Parkinson's disease.
Shen T, Pu J, Lai HY, Xu L, Si X, Yan Y, Jiang Y, Zhang B., Free PMC Article | 11/2/2019 |
| The pathological mechanisms concerning FBXO7-relevant protein aggregation, mitochondria impairment, reactive oxygen species (ROS) generation and mitophagy modulation in PARK15 pathogenesis are highlighted and discussed in the current review. | Pathophysiological mechanisms linking F-box only protein 7 (FBXO7) and Parkinson's disease (PD).
Zhou ZD, Lee JCT, Tan EK. | 04/20/2019 |
| we highlight the recent research on FBXO7, which advances our knowledge of the etiopathological pathways and fills unexpected gaps therein, justifying the dedicated study of rare variants of Parkinson disease--{REVIEW} | Mechanistic contributions of FBXO7 to Parkinson disease.
Joseph S, Schulz JB, Stegmüller J. | 03/16/2019 |
| Fbxo7 deficiency is associated with reduced cellular NAD(+) levels, which results in increased mitochondrial NADH redox index and impaired activity of complex I in the electron transport chain. | Deficiency of Parkinson's disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation.
Delgado-Camprubi M, Esteras N, Soutar MP, Plun-Favreau H, Abramov AY., Free PMC Article | 01/20/2018 |
| Structure and function of Fbxo7 in Parkinson's disease has been summarized. (Review) | Structure and Function of Fbxo7/PARK15 in Parkinson's Disease.
Randle SJ, Laman H. | 11/4/2017 |
| Gsk3beta and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease | Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.
Teixeira FR, Randle SJ, Patel SP, Mevissen TE, Zenkeviciute G, Koide T, Komander D, Laman H., Free PMC Article | 06/24/2017 |
| Mutations in the F-box only protein 7 (FBXO7) gene, located on chromosome 22q12-q13, have been identified as having distinct clinical features in patients with hereditary Parkinson's disease (PD). | FBXO7 mutations in Parkinson's disease and multiple system atrophy.
Conedera S, Apaydin H, Li Y, Yoshino H, Ikeda A, Matsushima T, Funayama M, Nishioka K, Hattori N. | 12/17/2016 |
| The mutations of F-box protein 7 (FBXO7) gene (T22M, R378G and R498X) are associated with autosomal recessive juvenile-onset Parkinson's disease We demonstrated wild-type FBXO7 is a stress response protein with both cytoprotective and neurotoxic roles | F-box protein 7 mutations promote protein aggregation in mitochondria and inhibit mitophagy.
Zhou ZD, Xie SP, Sathiyamoorthy S, Saw WT, Sing TY, Ng SH, Chua HP, Tang AM, Shaffra F, Li Z, Wang H, Ho PG, Lai MK, Angeles DC, Lim TM, Tan EK. | 09/17/2016 |
| This is first time a FBXO7 mutation has been identified that causes phenotype compatible with typical idiopathic Parkinson's disease and presents with some of its common nonmotor features | A new F-box protein 7 gene mutation causing typical Parkinson's disease.
Lohmann E, Coquel AS, Honoré A, Gurvit H, Hanagasi H, Emre M, Leutenegger AL, Drouet V, Sahbatou M, Guven G, Erginel-Unaltuna N, Deleuze JF, Lesage S, Brice A. | 05/7/2016 |