| Correlation between peripheral blood alpha1-MG, DNMT1 expression, and the severity of diabetic nephropathy renal pathological damage. | Correlation between peripheral blood α1-MG, DNMT1 expression, and the severity of diabetic nephropathy renal pathological damage.
Jin L, Niu C, Ni Y., Free PMC Article | 10/30/2023 |
| Binding of the human antioxidation protein alpha1-microglobulin (A1M) to heparin and heparan sulfate. Mapping of binding site, molecular and functional characterization, and co-localization in vivo and in vitro. | Binding of the human antioxidation protein α(1)-microglobulin (A1M) to heparin and heparan sulfate. Mapping of binding site, molecular and functional characterization, and co-localization in vivo and in vitro.
Bergwik J, Kristiansson A, Larsson J, Ekström S, Åkerström B, Allhorn M., Free PMC Article | 08/21/2021 |
| Human radical scavenger alpha1-microglobulin protects against hemolysis in vitro and alpha1-microglobulin knockout mice exhibit a macrocytic anemia phenotype. | Human radical scavenger α(1)-microglobulin protects against hemolysis in vitro and α(1)-microglobulin knockout mice exhibit a macrocytic anemia phenotype.
Kristiansson A, Bergwik J, Alattar AG, Flygare J, Gram M, Hansson SR, Olsson ML, Storry JR, Allhorn M, Åkerström B. | 08/7/2021 |
| Ferryl Hemoglobin and Heme Induce A1-Microglobulin in Hemorrhaged Atherosclerotic Lesions with Inhibitory Function against Hemoglobin and Lipid Oxidation. | Ferryl Hemoglobin and Heme Induce A(1)-Microglobulin in Hemorrhaged Atherosclerotic Lesions with Inhibitory Function against Hemoglobin and Lipid Oxidation.
Pethő D, Gáll T, Hendrik Z, Nagy A, Beke L, Gergely AP, Méhes G, Tóth C, Gram M, Åkerström B, Balla G, Balla J., Free PMC Article | 07/24/2021 |
| The Role of alpha1-Microglobulin (A1M) in Erythropoiesis and Erythrocyte Homeostasis-Therapeutic Opportunities in Hemolytic Conditions. | The Role of α(1)-Microglobulin (A1M) in Erythropoiesis and Erythrocyte Homeostasis-Therapeutic Opportunities in Hemolytic Conditions.
Kristiansson A, Gram M, Flygare J, Hansson SR, Åkerström B, Storry JR., Free PMC Article | 02/27/2021 |
| Hemopexin and alpha1-microglobulin heme scavengers with differential involvement in preeclampsia and fetal growth restriction. | Hemopexin and α1-microglobulin heme scavengers with differential involvement in preeclampsia and fetal growth restriction.
Youssef L, Erlandsson L, Åkerström B, Miranda J, Paules C, Crovetto F, Crispi F, Gratacos E, Hansson SR., Free PMC Article | 11/21/2020 |
| Alpha-1 microglobulin as a potential therapeutic candidate for treatment of hypertension and oxidative stress in the STOX1 preeclampsia mouse model. | Alpha-1 microglobulin as a potential therapeutic candidate for treatment of hypertension and oxidative stress in the STOX1 preeclampsia mouse model.
Erlandsson L, Ducat A, Castille J, Zia I, Kalapotharakos G, Hedström E, Vilotte JL, Vaiman D, Hansson SR., Free PMC Article | 10/24/2020 |
| This study suggests that serum hypersensitive CRP levels independently associate with Urinary A1MG in patients with Type 2 Diabetes Mellitus. | The Association of Serum hsCRP and Urinary Alpha1-Microglobulin in Patients with Type 2 Diabetes Mellitus.
Wan X, Zhang L, Gu H, Wang S, Liu X., Free PMC Article | 12/14/2019 |
| possible association between AMBP SNP haplotypes and gene-environment interactions with atherothrombotic stroke susceptibility in a Han Chinese cohort | The Effect of AMBP SNPs, Their Haplotypes, and Gene-Environment Interactions on the Risk of Atherothrombotic Stroke Among the Chinese Population.
Liu H, Luo D, Qiu Y, Huang Y, Chen C, Song X, Gao L, Zhou Y. | 12/14/2019 |
| AMBP mRNA and protein levels were found to be significantly lower in the oral squamous cell carcinoma (OSCC) tumors and cell lines. The underexpression of AMBP was significantly associated with a high metastatic potential to cervical lymph nodes and a poor overall survival. AMBP was suggested to play an important role in the invasive and migratory ability of OSCC cells. | Underexpression of α-1-microglobulin/bikunin precursor predicts a poor prognosis in oral squamous cell carcinoma.
Sekikawa S, Onda T, Miura N, Nomura T, Takano N, Shibahara T, Honda K. | 03/9/2019 |
| There were significantly higher serum concentrations of fetal hemoglobin and alpha1-microglobulin and significantly lower first trimester serum concentrations of hemopexin in patients who later developed preeclampsia. | Fetal hemoglobin, α1-microglobulin and hemopexin are potential predictive first trimester biomarkers for preeclampsia.
Anderson UD, Gram M, Ranstam J, Thilaganathan B, Kerström B, Hansson SR. | 03/18/2017 |
| Prophylactic UTI maintains the endothelial barrier function, increases VE-cadherin expression, and inhibits the phosphorylation of VE-cadherin at Tyr658 under inflammatory conditions | Urinary trypsin inhibitor attenuates LPS-induced endothelial barrier dysfunction by upregulation of vascular endothelial-cadherin expression.
Chen J, Wang J, Su C, Qian W, Sun L, Sun H, Chen J, Zhang H, Zhang J. | 11/19/2016 |
| Data suggest that Mg2+ or Mn2+ (but not Ca2+) induce a conformational change in inter-alpha-inhibitor (ITIH1 and ITIH2) and a bikunin/chondroitin sulfate-dependent increase in thermodynamic stability; bikunin binds adjacent to the two heavy chains. | The Compact and Biologically Relevant Structure of Inter-α-inhibitor Is Maintained by the Chondroitin Sulfate Chain and Divalent Cations.
Scavenius C, Nikolajsen CL, Stenvang M, Thøgersen IB, Wyrożemski Ł, Wisniewski HG, Otzen DE, Sanggaard KW, Enghild JJ., Free PMC Article | 08/6/2016 |
| Data indicate that two heme groups can be bound simultaneously at separate sites in the antioxidant alpha1-microglobulin. | Structural and biochemical characterization of two heme binding sites on α1-microglobulin using site directed mutagenesis and molecular simulation.
Rutardottir S, Karnaukhova E, Nantasenamat C, Songtawee N, Prachayasittikul V, Rajabi M, Rosenlöf LW, Alayash AI, Åkerström B. | 05/21/2016 |
| results indicate a reduced UTI level in CSF of MS and NMO patients. The levels were associated with the severity of the two demyelinating diseases during relapse | Urinary trypsin inhibitor levels are reduced in cerebrospinal fluid of multiple sclerosis and neuromyelitis optica patients during relapse.
Shu Y, Li R, Yang Y, Dai Y, Qiu W, Chen Y, Zhao Z, Lu Z, Hu X. | 12/5/2015 |
| Proximal tubular dysfunction, indicated by urine alpha1-microglobulin, was independently associated with kidney function decline in HIV-infected and uninfected women and mortality risk among HIV-infected women. | Association of urine α1-microglobulin with kidney function decline and mortality in HIV-infected women.
Jotwani V, Scherzer R, Abraham A, Estrella MM, Bennett M, Cohen MH, Nowicki M, Sharma A, Young M, Tien PC, Ix JH, Sarnak MJ, Parikh CR, Shlipak MG., Free PMC Article | 09/12/2015 |
| placental alpha microglobulin-1 is a sensitive and specific test to assess rupture of membranes in patients with an equivocal diagnosis based on simple tests | Comparison of placental alpha microglobulin-1 in vaginal fluid with intra-amniotic injection of indigo carmine for the diagnosis of rupture of membranes.
Sosa CG, Herrera E, Restrepo JC, Strauss A, Alonso J. | 06/27/2015 |
| Heavy chain transfer by tumor necrosis factor-stimulated gene 6 to the bikunin proteoglycan. | Heavy chain transfer by tumor necrosis factor-stimulated gene 6 to the bikunin proteoglycan.
Lamkin E, Cheng G, Calabro A, Hascall VC, Joo EJ, Li L, Linhardt RJ, Lauer ME., Free PMC Article | 05/9/2015 |
| Decreased bikunin mRNA level in renal cells might be associated with poor prognosis of renal carcinoma. | Reduced gene expression of bikunin as a prognostic marker for renal cell carcinoma.
Bayraktar E, Igci M, Erturhan S, Igci YZ, Karakok M, Gogebakan B, Ulasli M, Cakmak EA, Arslan A. | 04/18/2015 |
| The antioxidative protection of cells and collagen by A1M is totally dependent on its C34 amino acid residue. | The cysteine 34 residue of A1M/α1-microglobulin is essential for protection of irradiated cell cultures and reduction of carbonyl groups.
Rutardottir S, Nilsson EJ, Pallon J, Gram M, Åkerström B. | 09/27/2014 |
| Label-free quantitative comparison of DN urinary exosomes vs control group and SRM further validation, resulted in the discovery of a panel of three proteins (AMBP, MLL3 and VDAC1) which changes in DN. | Diabetic nephropathy induces changes in the proteome of human urinary exosomes as revealed by label-free comparative analysis.
Zubiri I, Posada-Ayala M, Sanz-Maroto A, Calvo E, Martin-Lorenzo M, Gonzalez-Calero L, de la Cuesta F, Lopez JA, Fernandez-Fernandez B, Ortiz A, Vivanco F, Alvarez-Llamas G. | 09/20/2014 |
| The high level of serum AMBP could predict the poor response of the AGC patients. | High level of serum AMBP is associated with poor response to paclitaxel-capecitabine chemotherapy in advanced gastric cancer patients.
Huang H, Han Y, Gao J, Feng J, Zhu L, Qu L, Shen L, Shou C. | 09/6/2014 |
| In pre-term pregnant women with intact membranes, placental alpha-microglobulin-1 in cervicovaginal fluid test rates are more positive in cases of uterine contraction. | A comparative study of positive rate of placental α-microglobulin-1 test in pre-term pregnant women with and without uterine contraction.
Sukchaya K, Phupong V. | 07/19/2014 |
| our findings suggest that urine bikunin level, as well as proteinuria, could represent a useful parameter for monitoring renal function in those patients that do not present any symptoms of renal insufficiency. | Urine bikunin as a marker of renal impairment in Fabry's disease.
Lepedda AJ, Fancellu L, Zinellu E, De Muro P, Nieddu G, Deiana GA, Canu P, Concolino D, Sestito S, Formato M, Sechi G., Free PMC Article | 01/4/2014 |
| Determined is the first structure of human alpha-1-microglobulin with heavy electron density of the chromophore. | The crystal structure of human protein α1M reveals a chromophore-binding site and two putative protein-protein interfaces.
Zhang Y, Gao Z, Guo Z, Zhang H, Zhang Z, Luo M, Hou H, Huang A, Dong Y, Wang D. | 11/23/2013 |