| Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging. | Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging.
Guo R, Liu J, Min X, Zeng W, Shan B, Zhang M, He Z, Zhang Y, He K, Yuan J, Xu D. | 06/28/2024 |
| ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation. | ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation.
Zheng S, Que X, Wang S, Zhou Q, Xing X, Chen L, Hou C, Ma J, An P, Peng Y, Yao Y, Song Q, Li J, Zhang P, Pei H. | 04/2/2024 |
| ZDHHC5-mediated S-palmitoylation of FAK promotes its membrane localization and epithelial-mesenchymal transition in glioma. | ZDHHC5-mediated S-palmitoylation of FAK promotes its membrane localization and epithelial-mesenchymal transition in glioma.
Wang Y, Shen N, Yang Y, Xia Y, Zhang W, Lu Y, Wang Z, Yang Z, Wang Z., Free PMC Article | 01/30/2024 |
| The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike (S) protein and their effects on S protein's subcellular localization, palmitoylation and pseudovirus entry. | The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike (S) protein and their effects on S protein's subcellular localization, palmitoylation and pseudovirus entry.
Zeng XT, Yu XX, Cheng W., Free PMC Article | 01/29/2022 |
| Regulation and function of the palmitoyl-acyltransferase ZDHHC5. | Regulation and function of the palmitoyl-acyltransferase ZDHHC5.
Woodley KT, Collins MO. | 12/25/2021 |
| Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferase. | Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferase.
Plain F, Howie J, Kennedy J, Brown E, Shattock MJ, Fraser NJ, Fuller W., Free PMC Article | 06/26/2021 |
| DHHC5 Mediates beta-Adrenergic Signaling in Cardiomyocytes by Targeting Galpha Proteins. | DHHC5 Mediates β-Adrenergic Signaling in Cardiomyocytes by Targeting Gα Proteins.
Chen JJ, Marsden AN, Scott CA, Akimzhanov AM, Boehning D., Free PMC Article | 06/12/2021 |
| Study findings identified six miRNAs related to gastric adenocarcinoma prognosis and suggested that downregulated miR-96-5p might induce cell apoptosis via upregulating ZDHHC5 expression in MGC-803 cells. | MiR-96-5p inhibition induces cell apoptosis in gastric adenocarcinoma.
Zhou HY, Wu CQ, Bi EX., Free PMC Article | 06/6/2020 |
| This work uncovers a novel mechanism of DHHC5 regulation by Golga7b and demonstrates a role for the DHHC5/Golga7b complex in the regulation of cell adhesion. | S-acylated Golga7b stabilises DHHC5 at the plasma membrane to regulate cell adhesion.
Woodley KT, Collins MO., Free PMC Article | 05/16/2020 |
| ZDHHC5-mediated S-palmitoylation is indispensable for NOD1/2 recruitment to bacteria containing phagosomes. | Palmitoylation of NOD1 and NOD2 is required for bacterial sensing.
Lu Y, Zheng Y, Coyaud É, Zhang C, Selvabaskaran A, Yu Y, Xu Z, Weng X, Chen JS, Meng Y, Warner N, Cheng X, Liu Y, Yao B, Hu H, Xia Z, Muise AM, Klip A, Brumell JH, Girardin SE, Ying S, Fairn GD, Raught B, Sun Q, Neculai D. | 04/25/2020 |
| DHHC4 and DHHC5 function at different subcellular localizations to control the palmitoylation, plasma membrane localization, and fatty acid uptake activity of the scavenger receptor CD36. | DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane.
Wang J, Hao JW, Wang X, Guo H, Sun HH, Lai XY, Liu LY, Zhu M, Wang HY, Li YF, Yu LY, Xie C, Wang HR, Mo W, Zhou HM, Chen S, Liang G, Zhao TJ. | 03/21/2020 |
| High ZDHHC5 expression is associated with Glioma. | EZH2 Palmitoylation Mediated by ZDHHC5 in p53-Mutant Glioma Drives Malignant Development and Progression.
Chen X, Ma H, Wang Z, Zhang S, Yang H, Fang Z. | 11/4/2017 |
| We demonstrated that LXR stimulation decreases mRNA and protein expression of FLOT2 and DHHC5 in MCF-7 cells. LXR stimulation also reduces Akt phosphorylation and its localization at the plasma membrane | LXR Activation Down-regulates Lipid Raft Markers FLOT2 and DHHC5 in MCF-7 Breast Cancer Cells.
Carbonnelle D, Luu TH, Chaillou C, Huvelin JM, Bard JM, Nazih H. | 08/12/2017 |
| Data indicate that DHHC5 has oncogenic capacity and contributes to tumor formation in non-small cell lung cancer. | Systematic siRNA Screen Unmasks NSCLC Growth Dependence by Palmitoyltransferase DHHC5.
Tian H, Lu JY, Shao C, Huffman KE, Carstens RM, Larsen JE, Girard L, Liu H, Rodriguez-Canales J, Frenkel EP, Wistuba II, Minna JD, Hofmann SL., Free PMC Article | 02/6/2016 |
| ZDHHC5 and SSTR5 are colocalized at the plasma membrane and coexpression of ZDHHC5 increased palmitoylation of SSTR5 whereas knock-down of endogenous ZDHHC5 by siRNAs decreased it. | Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase.
Kokkola T, Kruse C, Roy-Pogodzik EM, Pekkinen J, Bauch C, Hönck HH, Hennemann H, Kreienkamp HJ. | 10/29/2011 |
| Data show that palmitoyl acyltransferases DHHC5, DHHC6, and DHHC8 appear to be S-acylated on three cysteine residues within a novel CCX(7-13)C(S/T) motif downstream of a conserved Asp-His-His-Cys cysteine-rich domain. | Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes.
Yang W, Di Vizio D, Kirchner M, Steen H, Freeman MR., Free PMC Article | 05/10/2010 |