| SrGAP3 plays a role in neurodevelopmental disorders. | Morphological and behavioral characterization of adult mice deficient for SrGAP3.
Bertram J, Koschützke L, Pfannmöller JP, Esche J, van Diepen L, Kuss AW, Hartmann B, Bartsch D, Lotze M, von Bohlen Und Halbach O. | 05/20/2017 |
| This study found a more than 15-fold enlargement of the lateral ventricles of homozygous SrGAP3-deficient mice. | SrGAP3 knockout mice display enlarged lateral ventricles and specific cilia disturbances of ependymal cells in the third ventricle.
Koschützke L, Bertram J, Hartmann B, Bartsch D, Lotze M, von Bohlen und Halbach O. | 05/21/2016 |
| SrGAP3 dynamically regulates neuronal cytoskeletal reorganization through inhibition of the Rho GTPase Rac1 and interaction with actin remodeling proteins. | The cellular function of srGAP3 and its role in neuronal morphogenesis.
Bacon C, Endris V, Rappold GA. | 12/28/2013 |
| The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells. | The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells.
Ma Y, Mi YJ, Dai YK, Fu HL, Cui DX, Jin WL., Free PMC Article | 09/7/2013 |
| Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus | Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus.
Kim IH, Carlson BR, Heindel CC, Kim H, Soderling SH., Free PMC Article | 02/2/2013 |
| These results show neurodevelopmental aberration in Srgap3(-/-) mice, with many of the observed phenotypes matching several schizophrenia-related intermediate phenotypes. Mutations of SRGAP3 may thus contribute to various neurodevelopmental disorders. | Srgap3⁻/⁻ mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes.
Waltereit R, Leimer U, von Bohlen Und Halbach O, Panke J, Hölter SM, Garrett L, Wittig K, Schneider M, Schmitt C, Calzada-Wack J, Neff F, Becker L, Prehn C, Kutscherjawy S, Endris V, Bacon C, Fuchs H, Gailus-Durner V, Berger S, Schönig K, Adamski J, Klopstock T, Esposito I, Wurst W, de Angelis MH, Rappold G, Wieland T, Bartsch D. | 02/2/2013 |
| Following sciatic nerve transection, srGAP3 in neurons is significantly increased in the ipsilateral relative to contralateral dorsal root ganglions, which peak at day 7 to day 14. | Slit-Robo GTPase-activating proteins are differentially expressed in murine dorsal root ganglia: modulation by peripheral nerve injury.
Chen ZB, Zhang HY, Zhao JH, Zhao W, Zhao D, Zheng LF, Zhang XF, Liao XP, Yi XN. | 08/4/2012 |
| srGAP3 is an inhibitor of actin dynamics and lamellipodia formation in primary fibroblasts. srGAP3 influences focal adhesion formation through the downregulation of Rac1. | SrGAP3 interacts with lamellipodin at the cell membrane and regulates Rac-dependent cellular protrusions.
Endris V, Haussmann L, Buss E, Bacon C, Bartsch D, Rappold G. | 04/21/2012 |
| Data suggest a role for srGAP3 in the lateral positioning of post crossing axons within the ventrolateral funiculus. | Evidence for a role of srGAP3 in the positioning of commissural axons within the ventrolateral funiculus of the mouse spinal cord.
Bacon C, Endris V, Andermatt I, Niederkofler V, Waltereit R, Bartsch D, Stoeckli ET, Rappold G., Free PMC Article | 10/8/2011 |
| srGAP3 could regulate neuronal differentiation in a Rac1-dependent manner. | The mental retardation associated protein, srGAP3 negatively regulates VPA-induced neuronal differentiation of Neuro2A cells.
Chen K, Mi YJ, Ma Y, Fu HL, Jin WL. | 09/10/2011 |
| Results from these studies confirm that loss of WRP is linked to impaired learning and memory. | WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory.
Carlson BR, Lloyd KE, Kruszewski A, Kim IH, Rodriguiz RM, Heindel C, Faytell M, Dudek SM, Wetsel WC, Soderling SH., Free PMC Article | 04/2/2011 |
| Both Slit and Netrin-1 contribute to floor plate-derived chemorepulsion of cranial motor axons. | Slit and Netrin-1 guide cranial motor axon pathfinding via Rho-kinase, myosin light chain kinase and myosin II.
Murray A, Naeem A, Barnes SH, Drescher U, Guthrie S., Free PMC Article | 03/12/2011 |
| Data show that compared to srGAP2 and srGAP3, the onset of srGAP1 expression is later in most CNS tissues in mouse. | Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system.
Bacon C, Endris V, Rappold G. | 01/21/2010 |
| Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei. | Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.
Xu C, Fan CM., Free PMC Article | 01/21/2010 |
| WRP anchoring to WAVE-1 is a homeostatic mechanism that contributes to neuronal development and the fidelity of synaptic connectivity. | A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory.
Soderling SH, Guire ES, Kaech S, White J, Zhang F, Schutz K, Langeberg LK, Banker G, Raber J, Scott JD., Free PMC Article | 01/21/2010 |