| RNA-binding protein GIGYF2 orchestrates hepatic insulin resistance through STAU1/PTEN-mediated disruption of the PI3K/AKT signaling cascade. | RNA-binding protein GIGYF2 orchestrates hepatic insulin resistance through STAU1/PTEN-mediated disruption of the PI3K/AKT signaling cascade.
Lv Z, Ren Y, Li Y, Niu F, Li Z, Li M, Li X, Li Q, Huang D, Yu Y, Xiong Y, Qian L., Free PMC Article | 09/24/2024 |
| Translational repression of NMD targets by GIGYF2 and EIF4E2. | Translational repression of NMD targets by GIGYF2 and EIF4E2.
Zinshteyn B, Sinha NK, Enam SU, Koleske B, Green R., Free PMC Article | 12/4/2021 |
| Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease. | Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease.
Saini P, Rudakou U, Yu E, Ruskey JA, Asayesh F, Laurent SB, Spiegelman D, Fahn S, Waters C, Monchi O, Dauvilliers Y, Dupré N, Greenbaum L, Hassin-Baer S, Espay AJ, Rouleau GA, Alcalay RN, Fon EA, Postuma RB, Gan-Or Z., Free PMC Article | 11/13/2021 |
| 4EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay. | 4EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay.
Weber R, Chung MY, Keskeny C, Zinnall U, Landthaler M, Valkov E, Izaurralde E, Igreja C., Free PMC Article | 09/25/2021 |
| GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control. | GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control.
Hickey KL, Dickson K, Cogan JZ, Replogle JM, Schoof M, D'Orazio KN, Sinha NK, Hussmann JA, Jost M, Frost A, Green R, Weissman JS, Kostova KK., Free PMC Article | 10/3/2020 |
| GIGYF2 has two distinct mechanisms of repression: one depends on 4EHP binding and mainly affects translation; the other is 4EHP-independent and involves the CCR4/NOT complex and its deadenylation activity. | 4EHP-independent repression of endogenous mRNAs by the RNA-binding protein GIGYF2.
Amaya Ramirez CC, Hubbe P, Mandel N, Béthune J., Free PMC Article | 07/27/2019 |
| genetic analyses of indel loci in ACE, DJ-1, and GIGYF2 genes, was performed to explore the potential contribution of insertion (I)/deletion (D) polymorphisms (indels) to the risk of PD in a Chinese population. | Genetic analysis of indel markers in three loci associated with Parkinson's disease.
Huo Z, Luo X, Zhan X, Chu Q, Xu Q, Yao J, Pang H., Free PMC Article | 10/21/2017 |
| Full-length GIGYF2 coimmunoprecipitates with AGO2 in human cells, and upon tethering to a reporter mRNA, GIGYF2 exhibits strong, dose-dependent silencing activity, involving both mRNA destabilization and translational repression. | Post-transcriptional gene silencing activity of human GIGYF2.
Kryszke MH, Adjeriou B, Liang F, Chen H, Dautry F. | 05/13/2017 |
| required, this finding may shed light on the GIGYF2-associated mechanisms that lead to PD and suggests insulin dysregulation as a disease-specific mechanism for both PD and cognitive dysfunction. | GIGYF2 mutation in late-onset Parkinson's disease with cognitive impairment.
Ruiz-Martinez J, Krebs CE, Makarov V, Gorostidi A, Martí-Massó JF, Paisán-Ruiz C., Free PMC Article | 10/1/2016 |
| Results suggest that the N56S and N457T of GIGYF2 are risk factors for Parkinson's disease in Caucasians, but not in Asians | The contribution of GIGYF2 to Parkinson's disease: a meta-analysis.
Zhang Y, Sun QY, Yu RH, Guo JF, Tang BS, Yan XX. | 08/13/2016 |
| GIGYF2 and the zinc finger protein 598 (ZNF598) are identified as components of the 4EHP complex. | A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.
Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, Alain T, Fonseca BD, Karashchuk G, Bennett CF, Kabuta T, Higashi S, Larsson O, Topisirovic I, Smith RJ, Gingras AC, Sonenberg N., Free PMC Article | 11/3/2012 |
| Our result indicated that SCNA, LRRK2, UCHL1, HtrA2 and GIGYF2 genes' mutations might not be a main reason for Chinese Autosomal dorminant Parkinson's disease | Mutation analysis of LRRK2, SCNA, UCHL1, HtrA2 and GIGYF2 genes in Chinese patients with autosomal dorminant Parkinson's disease.
Tian JY, Guo JF, Wang L, Sun QY, Yao LY, Luo LZ, Shi CH, Hu YC, Yan XX, Tang BS. | 09/8/2012 |
| within the Chinese population, the c.297T>C p.Ala99Ala polymorphism of the GIGYF2 gene may be associated with an increased risk of developing Parkinson disease. | Follow-up study of variants of the GIGYF2 gene in Chinese patients with Parkinson’s disease.
Wang L, Guo JF, Zhang WW, Xu Q, Zuo X, Shi CH, Luo LZ, Liu J, Hu L, Hu YC, Yan XX, Tang BS. | 07/21/2012 |
| These data, together with those recently reported by other groups, suggest that GIGYF2 is unlikely to be the PARK11 gene. | Mutational screening and zebrafish functional analysis of GIGYF2 as a Parkinson-disease gene.
Guella I, Pistocchi A, Asselta R, Rimoldi V, Ghilardi A, Sironi F, Trotta L, Primignani P, Zini M, Zecchinelli A, Coviello D, Pezzoli G, Del Giacco L, Duga S, Goldwurm S. | 01/21/2012 |
| No clearly pathogenic mutations are identified in GIGYF2 and ATP13A2 in Brazilian patients with early-onset Parkinson's disease. | Mutational analysis of GIGYF2, ATP13A2 and GBA genes in Brazilian patients with early-onset Parkinson's disease.
Dos Santos AV, Pestana CP, Diniz KR, Campos M, Abdalla-Carvalho CB, de Rosso AL, Pereira JS, Nicaretta DH, de Carvalho WL, Dos Santos JM, Santos-Rebouças CB, Pimentel MM. | 08/20/2011 |
| The results of this study did not support a role for GIGYF2 in the genetic etiology of Belgian Parkinson disease. | GIGYF2 has no major role in Parkinson genetic etiology in a Belgian population.
Meeus B, Nuytemans K, Crosiers D, Engelborghs S, Pals P, Pickut B, Peeters K, Mattheijssens M, Corsmit E, Cras P, De Deyn PP, Theuns J, Van Broeckhoven C. | 04/2/2011 |
| GIGYF2 is unlikely to play a major role in PD in Japanese patients, similar to other populations. | No evidence for pathogenic role of GIGYF2 mutation in Parkinson disease in Japanese patients.
Li L, Funayama M, Tomiyama H, Li Y, Yoshino H, Sasaki R, Kokubo Y, Kuzuhara S, Mizuno Y, Hattori N. | 10/4/2010 |
| our findings suggest that GIGYF2 variants are not a frequent cause of Parkinson's disease in the Spanish population, since we found no clearly segregating GIGYF2 variants | Analysis of the GIGYF2 gene in familial and sporadic Parkinson disease in the Spanish population.
Samaranch L, Lorenzo E, Pastor MA, Riverol M, Luquin MR, Rodríguez-Oroz MC, Obeso JA, Pastor P. | 08/23/2010 |
| GIGYF2 variants are not associated with Parkinson's disease in the mainland Chinese Population. | The GIGYF2 variants are not associated with Parkinson's disease in the mainland Chinese population.
Cao L, Zhang T, Zheng L, Wang Y, Wang G, Zhang J, Fei QZ, Cui PJ, Wang XJ, Ma JF, Xiao Q, Chen SD. | 07/19/2010 |
| The results of this study do not support a major role of GIGYF2 in parkinson disease. | Follow-up study of the GIGYF2 gene in French families with Parkinson's disease.
Lesage S, Condroyer C, Lohman E, Troiano A, Tison F, Viallet F, Damier P, Tranchant C, Vidhaillet M, Ouvrard-Hernandez AM, Dürr A, Brice A, French Parkinson's Disease Genetics Study Group (FPDGSG). | 07/19/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| We identified nine novel variants in GIGYF2 gene, which might be associated with PD in the Chinese population. | Novel GIGYF2 gene variants in patients with Parkinson's disease in Chinese population.
Wang L, Guo JF, Zhang WW, Xu Q, Zuo X, Shi CH, Luo LZ, Liu J, Hu L, Hu YC, She L, Jiang H, Yan XX, Xia K, Pan Q, Tang BS. | 04/12/2010 |
| GIGYF2 mutations are not a frequent cause of Parkinson's disease | GIGYF2 mutations are not a frequent cause of familial Parkinson's disease.
Di Fonzo A, Fabrizio E, Thomas A, Fincati E, Marconi R, Tinazzi M, Breedveld GJ, Simons EJ, Chien HF, Ferreira JJ, Horstink MW, Abbruzzese G, Borroni B, Cossu G, Dalla Libera A, Fabbrini G, Guidi M, De Mari M, Lopiano L, Martignoni E, Marini P, Onofrj M, Padovani A, Stocchi F, Toni V, Sampaio C, Barbosa ER, Meco G, Italian Parkinson Genetics Network, Oostra BA, Bonifati V. | 01/21/2010 |
| The GIGYF2 Asn56Ser mutation is rare in Chinese PD patients. | GIGYF2 Asn56Ser mutation is rare in Chinese Parkinson's disease patients.
Zhang Y, Zheng L, Zhang T, Wang Y, Xiao Q, Fei QZ, Cui PJ, Cao L, Chen SD. | 01/21/2010 |
| This letter suggested that GIGYF2 is neither responsible for PARK11 nor a gene implicated in Parkinson disease. | GIGYF2 variants are not associated with Parkinson's disease in Italy.
Bonetti M, Ferraris A, Petracca M, Bentivoglio AR, Dallapiccola B, Valente EM. | 01/21/2010 |