| 1q amplification and PHF19 expressing high-risk cells are associated with relapsed/refractory multiple myeloma. | 1q amplification and PHF19 expressing high-risk cells are associated with relapsed/refractory multiple myeloma.
Johnson TS, Sudha P, Liu E, Becker N, Robertson S, Blaney P, Morgan G, Chopra VS, Dos Santos C, Nixon M, Huang K, Suvannasankha A, Zaid MA, Abonour R, Walker BA., Free PMC Article | 08/13/2024 |
| Regulation of hPCL3 isoforms' ubiquitination by TRIM21 in non-small cell lung cancer progression. | Regulation of hPCL3 isoforms' ubiquitination by TRIM21 in non-small cell lung cancer progression.
Xu Y, Liu W, Jiang X, Li J, Liu Q, Su F, Ruan S, Zhang Z, Tao F., Free PMC Article | 08/14/2023 |
| PHD finger protein 19 expression in multiple myeloma: Association with clinical features, induction therapy outcome, disease progression, and survival. | PHD finger protein 19 expression in multiple myeloma: Association with clinical features, induction therapy outcome, disease progression, and survival.
Li Y, Gong J, Zhang L., Free PMC Article | 01/29/2022 |
| PHF19 inhibition as a therapeutic target in multiple myeloma. | PHF19 inhibition as a therapeutic target in multiple myeloma.
Schinke CD, Bird JT, Qu P, Yaccoby S, Lyzogubov VV, Shelton R, Ling W, Boyle EM, Deshpande S, Byrum SD, Washam C, Mackintosh S, Stephens O, Thanendrarajan S, Zangari M, Shaughnessy J Jr, Zhan F, Barlogie B, van Rhee F, Walker BA., Free PMC Article | 01/22/2022 |
| PHF19 activates hedgehog signaling and promotes tumorigenesis in hepatocellular carcinoma. | PHF19 activates hedgehog signaling and promotes tumorigenesis in hepatocellular carcinoma.
Xiaoyun S, Yuyuan Z, Jie X, Yingjie N, Qing X, Yuezhen D, Haiguang X. | 10/23/2021 |
| LINC_00355 promotes gastric cancer progression by upregulating PHF19 expression through sponging miR-15a-5p. | LINC_00355 promotes gastric cancer progression by upregulating PHF19 expression through sponging miR-15a-5p.
Zhang J, Lv W, Liu Y, Fu W, Chen B, Ma Q, Gao X., Free PMC Article | 10/23/2021 |
| Downregulation of PHF19 inhibits cell growth and migration in gastric cancer. | Downregulation of PHF19 inhibits cell growth and migration in gastric cancer.
Wang H, Xu P, Sun G, Lv J, Cao J, Xu Z. | 07/3/2021 |
| Polycomb-like Protein 3 Induces Proliferation and Drug Resistance in Multiple Myeloma and Is Regulated by miRNA-15a. | Polycomb-like Protein 3 Induces Proliferation and Drug Resistance in Multiple Myeloma and Is Regulated by miRNA-15a.
Yu T, Du C, Ma X, Sui W, Yu Z, Liu L, Zhao L, Li Z, Xu J, Wei X, Zhou W, Deng S, Zou D, An G, Tai YT, Tricot G, Anderson KC, Qiu L, Zhan F, Hao M. | 07/3/2021 |
| PHF19 mediated regulation of proliferation and invasiveness in prostate cancer cells. | PHF19 mediated regulation of proliferation and invasiveness in prostate cancer cells.
Jain P, Ballare C, Blanco E, Vizan P, Di Croce L., Free PMC Article | 04/13/2021 |
| Multiple Myeloma DREAM Challenge reveals epigenetic regulator PHF19 as marker of aggressive disease. | Multiple Myeloma DREAM Challenge reveals epigenetic regulator PHF19 as marker of aggressive disease.
Mason MJ, Schinke C, Eng CLP, Towfic F, Gruber F, Dervan A, White BS, Pratapa A, Guan Y, Chen H, Cui Y, Li B, Yu T, Chaibub Neto E, Mavrommatis K, Ortiz M, Lyzogubov V, Bisht K, Dai HY, Schmitz F, Flynt E, Dan Rozelle, Danziger SA, Ratushny A, Multiple Myeloma DREAM Consortium, Dalton WS, Goldschmidt H, Avet-Loiseau H, Samur M, Hayete B, Sonneveld P, Shain KH, Munshi N, Auclair D, Hose D, Morgan G, Trotter M, Bassett D, Goke J, Walker BA, Thakurta A, Guinney J., Free PMC Article | 10/31/2020 |
| PHF19 is positively correlated with poorer clinic outcomes of multiple myeloma and essential for multiple myeloma growth in vitro and in vivo. PHF19 potentiates tumorigenicity via PRC2 activation and H3K27me3 spreading. | PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation.
Ren Z, Ahn JH, Liu H, Tsai YH, Bhanu NV, Koss B, Allison DF, Ma A, Storey AJ, Wang P, Mackintosh SG, Edmondson RD, Groen RWJ, Martens AC, Garcia BA, Tackett AJ, Jin J, Cai L, Zheng D, Wang GG., Free PMC Article | 02/1/2020 |
| PHF19 promotes the proliferation, migration, and chemosensitivity of glioblastoma to doxorubicin through modulation of the SIAH1/beta-catenin axis. | PHF19 promotes the proliferation, migration, and chemosensitivity of glioblastoma to doxorubicin through modulation of the SIAH1/β-catenin axis.
Deng Q, Hou J, Feng L, Lv A, Ke X, Liang H, Wang F, Zhang K, Chen K, Cui H., Free PMC Article | 12/14/2019 |
| human PCL3 has an oncogenic role in hepatocellular carcinoma by activating the beta-catenin/IL6 signaling axis to promote metastasis. | hPCL3s Promotes Hepatocellular Carcinoma Metastasis by Activating β-Catenin Signaling.
Cai Z, Qian ZY, Jiang H, Ma N, Li Z, Liu LY, Ren XX, Shang YR, Wang JJ, Li JJ, Liu DP, Zhang XP, Feng D, Ni QZ, Feng YY, Li N, Zhou XY, Wang X, Bao Y, Zhang XL, Deng YZ, Xie D. | 06/15/2019 |
| miR-124a suppresses PHF19 over-expression, EZH2 hyper-activation, and aberrant glioma cell proliferation | microRNA-124a suppresses PHF19 over-expression, EZH2 hyper-activation, and aberrant cell proliferation in human glioma.
Lu J, Ji H, Tang H, Xu Z. | 03/16/2019 |
| G9a promotes H3K27 methylation of the E-cadherin promoter by upregulating PCL3 to increase PRC2 promoter recruitment and by downregulating the H3K27 demethylase KDM7A to silence E-cadherin gene | G9a orchestrates PCL3 and KDM7A to promote histone H3K27 methylation.
Pan MR, Hsu MC, Chen LT, Hung WC., Free PMC Article | 12/17/2016 |
| These results provide evidence that PHF19 promotes Hepatocellular carcinoma and is regulated by the tumor-suppressor, miR-195-5p | MicroRNA-195-5p acts as an anti-oncogene by targeting PHF19 in hepatocellular carcinoma.
Xu H, Hu YW, Zhao JY, Hu XM, Li SF, Wang YC, Gao JJ, Sha YH, Kang CM, Lin L, Huang C, Zhao JJ, Zheng L, Wang Q. | 03/19/2016 |
| The histone H3K36me3 binding by the Tudor domains of PHF1, PHF19 and likely MTF2 provide another recruitment and regulatory mechanism for the PRC2 complex | Tudor domains of the PRC2 components PHF1 and PHF19 selectively bind to histone H3K36me3.
Qin S, Guo Y, Xu C, Bian C, Fu M, Gong S, Min J. | 06/29/2013 |
| propose a model whereby PHF19 functions during mouse embryonic stem cell differentiation to transiently bind the H3K36me3 mark via its Tudor domain | Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation.
Brien GL, Gambero G, O'Connell DJ, Jerman E, Turner SA, Egan CM, Dunne EJ, Jurgens MC, Wynne K, Piao L, Lohan AJ, Ferguson N, Shi X, Sinha KM, Loftus BJ, Cagney G, Bracken AP. | 02/9/2013 |
| PHF19 silencing reduces the cell proliferation rate and increases the transendothelial migration capacities of melanoma cell lines. | PHF19 and Akt control the switch between proliferative and invasive states in melanoma.
Ghislin S, Deshayes F, Middendorp S, Boggetto N, Alcaide-Loridan C. | 09/15/2012 |
| Functional characterization of human Polycomb-like 3 isoforms identifies them as components of distinct EZH2 protein complexes | Functional characterization of human Polycomb-like 3 isoforms identifies them as components of distinct EZH2 protein complexes.
Boulay G, Rosnoblet C, Guérardel C, Angrand PO, Leprince D. | 04/23/2011 |
| identification of a gene encoding a human homologue of the Drosophila polycomblike protein, hPCL3 gene, encoding two nuclear proteins, hPCL3S and hPCL3L; markedly overexpressed in many types of cancers | A novel human homologue of Drosophila polycomblike gene is up-regulated in multiple cancers.
Wang S, Robertson GP, Zhu J. | 01/21/2010 |