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    DGCR5 DiGeorge syndrome critical region gene 5 [ Homo sapiens (human) ]

    Gene ID: 26220, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Abnormal expression of long non-coding RNAs RMRP, CTC-487M23.5, and DGCR5 in the peripheral blood of patients with Bipolar disorder.

    Abnormal expression of long non-coding RNAs RMRP, CTC-487M23.5, and DGCR5 in the peripheral blood of patients with Bipolar disorder.
    Ghamari M, Mehrab Mohseni M, Taheri M, Neishabouri SM, Shirvani-Farsani Z.

    02/7/2024
    LncRNA DGCR5 Silencing Enhances the Radio-Sensitivity of Human Esophageal Squamous Cell Carcinoma via Negatively Regulating the Warburg Effect.

    LncRNA DGCR5 Silencing Enhances the Radio-Sensitivity of Human Esophageal Squamous Cell Carcinoma via Negatively Regulating the Warburg Effect.
    Wu J, Liu Y, Huang X, Cheng Y, Qian Z, Ni X, Chen S, Lin M, Luo J.

    03/10/2023
    Critical Functions of lncRNA DGCR5 in Cancers of the Digestive System.

    Critical Functions of lncRNA DGCR5 in Cancers of the Digestive System.
    Hu C, Xu W, Wang B, Chen J, Zhou Z, Zhou G, Yuan C.

    04/2/2022
    DGCR5 is activated by PAX5 and promotes pancreatic cancer via targeting miR-3163/TOP2A and activating Wnt/beta-catenin pathway.

    DGCR5 is activated by PAX5 and promotes pancreatic cancer via targeting miR-3163/TOP2A and activating Wnt/β-catenin pathway.
    Liu SL, Cai C, Yang ZY, Wu ZY, Wu XS, Wang XF, Dong P, Gong W., Free PMC Article

    01/15/2022
    LncRNA DiGeorge syndrome critical region gene 5: A crucial regulator in malignant tumors.

    LncRNA DiGeorge syndrome critical region gene 5: A crucial regulator in malignant tumors.
    Xia H, Huang Z, Liu S, Zhao X, He R, Wang Z, Shi W, Chen W, Li Z, Yu L, Huang P, Kang P, Su Z, Xu Y, Yam JWP, Cui Y.

    12/18/2021
    Long noncoding RNA DGCR5 involves in tumorigenesis of esophageal squamous cell carcinoma via SRSF1-mediated alternative splicing of Mcl-1.

    Long noncoding RNA DGCR5 involves in tumorigenesis of esophageal squamous cell carcinoma via SRSF1-mediated alternative splicing of Mcl-1.
    Duan Y, Jia Y, Wang J, Liu T, Cheng Z, Sang M, Lv W, Qin J, Liu L., Free PMC Article

    11/6/2021
    Silencing lncRNA-DGCR5 increased trophoblast cell migration, invasion and tube formation, and inhibited cell apoptosis via targeting miR-454-3p/GADD45A axis.

    Silencing lncRNA-DGCR5 increased trophoblast cell migration, invasion and tube formation, and inhibited cell apoptosis via targeting miR-454-3p/GADD45A axis.
    Yang Y, Shang H.

    09/11/2021
    LncRNA DGCR5 plays a tumor-suppressive role in glioma via the miR-21/Smad7 and miR-23a/PTEN axes.

    LncRNA DGCR5 plays a tumor-suppressive role in glioma via the miR-21/Smad7 and miR-23a/PTEN axes.
    He Z, Long J, Yang C, Gong B, Cheng M, Wang Q, Tang J., Free PMC Article

    04/24/2021
    Long non-coding RNA DGCR5 incudes tumorigenesis of triple-negative breast cancer by affecting Wnt/beta-catenin signaling pathway.

    Long non-coding RNA DGCR5 incudes tumorigenesis of triple-negative breast cancer by affecting Wnt/β-catenin signaling pathway.
    Jiang D, Wang C, He J.

    01/23/2021
    DGCR5 suppresses the EMT of pediatric primary glioblastoma multiforme cell and serves as a prognostic biomarker.

    DGCR5 suppresses the EMT of pediatric primary glioblastoma multiforme cell and serves as a prognostic biomarker.
    Yang F, Huang YL.

    10/24/2020
    DCGR5 depressed stemness of human laryngeal cancer cells through modulating miR-506 and Wnt signaling pathway.

    DGCR5 promotes cancer stem cell-like properties of radioresistant laryngeal carcinoma cells by sponging miR-506 via Wnt pathway.
    Tang T, Shan G.

    05/30/2020
    that knockdown of DGCR5 suppressed laryngeal carcinoma via targeting miR-195

    Knockdown of DGCR5 enhances the radiosensitivity of human laryngeal carcinoma cells via inducing miR-195.
    Tang T, Shan G, Zeng F.

    05/16/2020
    DGCR5 was involved in cervical cancer progression via modulating the Wnt pathway.

    Downregulation of long noncoding RNA DGCR5 contributes to the proliferation, migration, and invasion of cervical cancer by activating Wnt signaling pathway.
    Liu Y, Chang Y, Lu S, Xiang YY.

    05/9/2020
    our study demonstrated that downregulated DiGeorge syndrome critical region gene 5 may be a new promising biomarker for predicting clinical progression and prognosis in patients with ovarian cancer.

    Downregulated Long Noncoding RNA DGCR5 Acts as a New Promising Biomarker for the Diagnosis and Prognosis of Ovarian Cancer.
    Chen H, Tian X, Luan Y, Lu H., Free PMC Article

    05/9/2020
    our study demonstrated that DGCR5 transcriptionally promotes P21 expression to suppress bladder cancer progression

    Upregulation of lncRNA DGCR5 correlates with better prognosis and inhibits bladder cancer progression via transcriptionally facilitating P21 expression.
    Fang C, He W, Xu T, Dai J, Xu L, Sun F.

    03/28/2020
    DGCR5 could play tumor suppressive role by targeting Wnt signaling in hepatocellular carcinoma progression.

    Long noncoding RNA DGCR5 represses hepatocellular carcinoma progression by inactivating Wnt signaling pathway.
    Wang XL, Shi M, Xiang T, Bu YZ.

    02/29/2020
    LncRNA DGCR5 regulates the non-small cell lung cancer cell growth, migration, and invasion through regulating miR-211-5p/EPHB6 axis.

    LncRNA DGCR5 regulates the non-small cell lung cancer cell growth, migration, and invasion through regulating miR-211-5p/EPHB6 axis.
    Kang M, Shi J, Li B, Luo M, Xu S, Liu X.

    02/22/2020
    a potential role for DGCR5 in regulating certain Schizophrenia-related genes, was identified.

    The DGCR5 long noncoding RNA may regulate expression of several schizophrenia-related genes.
    Meng Q, Wang K, Brunetti T, Xia Y, Jiao C, Dai R, Fitzgerald D, Thomas A, Jay L, Eckart H, Grennan K, Imamura-Kawasawa Y, Li M, Sestan N, White KP, Chen C, Liu C., Free PMC Article

    10/12/2019
    we proved that DGCR5 can rescue the inhibited levels of KLF14 repressed by miR-346 mimics in MHCC-97H and Hep3B cells. Taken together, it was indicated in our study that DGCR5 can restrain the progression of HCC through sponging miR-346 and modulating KLF14 in vitro.

    LncRNA DGCR5 represses the development of hepatocellular carcinoma by targeting the miR-346/KLF14 axis.
    Wang YG, Liu J, Shi M, Chen FX.

    10/5/2019
    DGCR5 can act as a crucial regulator of cancer stem cells in non small cell lung cancer by modulating miR-330-5p/CD44 axis.

    LncRNA DGCR5 contributes to CSC-like properties via modulating miR-330-5p/CD44 in NSCLC.
    Wang R, Dong HX, Zeng J, Pan J, Jin XY.

    10/5/2019
    DGCR5 negatively regulates miR-30d-5p, and it up-regulates Runx2 through miR-30d-5p, thereby inducing osteogenic differentiation of hMSCs, which may help to delay Postmenopausal osteoporosis development.

    DGCR5 induces osteogenic differentiation by up-regulating Runx2 through miR-30d-5p.
    Wu ZH, Huang KH, Liu K, Wang GT, Sun Q.

    05/25/2019
    Gain and loss-of-function studies were performed to verify whether DGCR5 exerts its biological functions through regulating hsa-mir-22-3p in vitro. Overexpression of DGCR5 was able to reverse the tumor inhibitory effect of hsa-mir-22-3p mimics. Furthermore, in vivo tests tumor xenografts were established to detect the function of DGCR5 in lung adenocarcinoma tumorigenesis.

    LncRNA DGCR5 promotes lung adenocarcinoma (LUAD) progression via inhibiting hsa-mir-22-3p.
    Dong HX, Wang R, Jin XY, Zeng J, Pan J.

    02/23/2019
    Over-expression of LINC00037 in LINC00037 knockdown cells restored and enhanced cell proliferation and bind to epidermal growth factor receptor and increase the protein level of epidermal growth factor receptor.

    LINC00037 Inhibits Proliferation of Renal Cell Carcinoma Cells in an Epidermal Growth Factor Receptor-Dependent Way.
    Gong X, Du X, Xu Y, Zheng W.

    03/31/2018
    DGCR5 may be a participator in hepatocellular carcinoma (HCC) and can serve as potential biomarker for the diagnosis and prognosis in HCC.

    Down-Regulation of LncRNA DGCR5 Correlates with Poor Prognosis in Hepatocellular Carcinoma.
    Huang R, Wang X, Zhang W, Zhangyuan G, Jin K, Yu W, Xie Y, Xu X, Wang H, Sun B.

    02/18/2017
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