| G protein-coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin. | G protein-coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin.
Varney MJ, Steyaert W, Coucke PJ, Delanghe JR, Uehling DE, Joseph B, Marcellus R, Al-Awar R, Benovic JL., Free PMC Article | 11/12/2022 |
| Role of GRK6 in the Regulation of Platelet Activation through Selective G Protein-Coupled Receptor (GPCR) Desensitization. | Role of GRK6 in the Regulation of Platelet Activation through Selective G Protein-Coupled Receptor (GPCR) Desensitization.
Chaudhary PK, Kim S, Jee Y, Lee SH, Park KM, Kim S., Free PMC Article | 04/3/2021 |
| These data indicate that GRK2, GRK5 and GRK6 redundantly modulate Smo-GATA crosstalk in fetal mouse hearts, orchestrating transcriptional pathways previously linked to clinical and experimental atrioventricular canal defects | G-protein receptor kinases 2, 5 and 6 redundantly modulate Smoothened-GATA transcriptional crosstalk in fetal mouse hearts.
Franco A, Zhang L, Matkovich SJ, Kovacs A, Dorn GW 2nd., Free PMC Article | 09/14/2019 |
| findings show that chemerin-activated CMKLR1 regulation in inflammatory macrophages is largely GRK6 and beta-arrestin mediated, which may impact innate immunity and have therapeutic implications in rheumatic disease. | Chemerin-activated functions of CMKLR1 are regulated by G protein-coupled receptor kinase 6 (GRK6) and β-arrestin 2 in inflammatory macrophages.
Serafin DS, Allyn B, Sassano MF, Timoshchenko RG, Mattox D, Brozowski JM, Siderovski DP, Truong YK, Esserman D, Tarrant TK, Billard MJ., Free PMC Article | 05/4/2019 |
| Conditions for optimal dendritic cells guidance are perfectly provided by the CCL21 gradients measured in vivo. Furthermore, CCR7 signal termination by the G-protein-coupled receptor kinase 6 (GRK6) is crucial for haptotactic but dispensable for chemotactic CCL21 gradient sensing in vitro and confirm those observations in vivo. | Dendritic Cells Interpret Haptotactic Chemokine Gradients in a Manner Governed by Signal-to-Noise Ratio and Dependent on GRK6.
Schwarz J, Bierbaum V, Vaahtomeri K, Hauschild R, Brown M, de Vries I, Leithner A, Reversat A, Merrin J, Tarrant T, Bollenbach T, Sixt M. | 08/4/2018 |
| These studies suggest a previously unrecognized and novel role for GRK6 in neutrophil migration specific to pulmonary tissue during bacterial infection. | Role of G protein-coupled receptor kinase-6 in Escherichia coli lung infection model in mice.
Lee T, Packiriswamy N, Lee E, Lucas PC, McCabe LR, Parameswaran N., Free PMC Article | 06/23/2018 |
| Silencing of GRK6 expression by siRNA impairs CXCR4-serine 339 phosphorylation and migration of cardiac stem cellss caused by SCF. In vivo, knockdown of GRK6 impairs the ability of CSCs to migrate into peri-infarcted areas. | SCF/c-kit transactivates CXCR4-serine 339 phosphorylation through G protein-coupled receptor kinase 6 and regulates cardiac stem cell migration.
Zuo K, Kuang D, Wang Y, Xia Y, Tong W, Wang X, Chen Y, Duan Y, Wang G., Free PMC Article | 04/7/2018 |
| This work demonstrates the importance of GRK6 in regulation of hematopoietic stem cell self-renewal and reveals its potential role in participation of stress response. | GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal.
Le Q, Yao W, Chen Y, Yan B, Liu C, Yuan M, Zhou Y, Ma L., Free PMC Article | 09/2/2017 |
| GRK6-mediated OXTR desensitization in labor is necessary for normal uterine contractile patterns and optimal fetal outcome. | Enhanced Uterine Contractility and Stillbirth in Mice Lacking G Protein-Coupled Receptor Kinase 6 (GRK6): Implications for Oxytocin Receptor Desensitization.
Grotegut CA, Mao L, Pierce SL, Swamy GK, Heine RP, Murtha AP., Free PMC Article | 12/24/2016 |
| It regulates apoptotic engulfment in phagocytes. (review) | [Research on Molecular Mechanisms of Engulfment of Apoptotic Cells].
Nakaya M. | 09/17/2016 |
| GRK6 directly phosphorylates Nfkbia at Ser32/Ser36. Knockdown of GRK6 suppresses TNF-alpha-induced NF-kappaappaB signaling. | GRK6 phosphorylates IκBα at Ser(32)/Ser(36) and enhances TNF-α-induced inflammation.
Ohba Y, Nakaya M, Watari K, Nagasaka A, Kurose H. | 08/1/2015 |
| these results indicate that GRK6 complexes with AGS3-Galphai2 to regulate CXCR2-mediated leukocyte functions at different levels, including downstream effector activation, receptor trafficking, and expression at the cell membrane. | G Protein-coupled receptor kinase-6 interacts with activator of G protein signaling-3 to regulate CXCR2-mediated cellular functions.
Singh V, Raghuwanshi SK, Smith N, Rivers EJ, Richardson RM., Free PMC Article | 04/19/2014 |
| data demonstrate that GRK6 plays a feedback regulatory role in CXCR2-mediated tumor development, invasion and metastasis | G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis.
Raghuwanshi SK, Smith N, Rivers EJ, Thomas AJ, Sutton N, Hu Y, Mukhopadhyay S, Chen XL, Leung T, Richardson RM., Free PMC Article | 07/6/2013 |
| G-protein-coupled receptor kinase 6 (GRK6) is involved in apoptotic cell clearance. | GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance.
Nakaya M, Tajima M, Kosako H, Nakaya T, Hashimoto A, Watari K, Nishihara H, Ohba M, Komiya S, Tani N, Nishida M, Taniguchi H, Sato Y, Matsumoto M, Tsuda M, Kuroda M, Inoue K, Kurose H., Free PMC Article | 06/22/2013 |
| Chemokine receptor CXCR2 interacts with GRK6 to negatively regulate receptor sensitization and trafficking, thus affecting cell signaling and angiogenesis. | The chemokine receptors CXCR1 and CXCR2 couple to distinct G protein-coupled receptor kinases to mediate and regulate leukocyte functions.
Raghuwanshi SK, Su Y, Singh V, Haynes K, Richmond A, Richardson RM., Free PMC Article | 12/8/2012 |
| Results identify GRK5/6 as novel kinases for the single transmembrane receptor LRP6 during Wnt signaling. | G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.
Chen M, Philipp M, Wang J, Premont RT, Garrison TR, Caron MG, Lefkowitz RJ, Chen W., Free PMC Article | 02/8/2010 |
| these results suggest that GRK6 may play a role in regulating some, but not all morphine-mediated responses. | Morphine-induced physiological and behavioral responses in mice lacking G protein-coupled receptor kinase 6.
Raehal KM, Schmid CL, Medvedev IO, Gainetdinov RR, Premont RT, Bohn LM., Free PMC Article | 01/21/2010 |
| Data show an important protective role for GRK6 against post-inflammatory visceral hyperalgesia. | GRK6, a gatekeeper of visceral hyperalgesia.
Murga C, Mayor F Jr. | 01/21/2010 |
| GRK6 and -2, but not GRK5, are involved in the pathogenesis of acute arthritis in the K/BxN model. In particular, GRK6 may dampen inflammatory responses by regulating granulocyte trafficking toward chemoattractants. | Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN).
Tarrant TK, Rampersad RR, Esserman D, Rothlein LR, Liu P, Premont RT, Lefkowitz RJ, Lee DM, Patel DD., Free PMC Article | 01/21/2010 |
| These results demonstrate previously unknown crucial regulatory mechanisms that alter ARR/GRK expression levels in macrophages that might modify many, if not all, GPCR-mediated innate immune responses. | Toll-like receptors differentially regulate GPCR kinases and arrestins in primary macrophages.
Loniewski K, Shi Y, Pestka J, Parameswaran N. | 01/21/2010 |
| In the absence of GRK6, the G-CSF-induced increase in circulating neutrophils is profoundly impaired. After injection of pegylated-G-CSF, significantly lower numbers of circulating neutrophils were observed in GRK6-/- as compared with wild-type (WT) mice. | GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to G-CSF in vivo.
Vroon A, Heijnen CJ, Raatgever R, Touw IP, Ploemacher RE, Premont RT, Kavelaars A. | 01/21/2010 |
| deficiency causes defective lymphocyte chemotaxis | Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.
Fong AM, Premont RT, Richardson RM, Yu YR, Lefkowitz RJ, Patel DD., Free PMC Article | 01/21/2010 |
| Postsynaptic D2-like dopamine receptors are physiological targets for GRK6 and suggests that this regulatory mechanism contributes to central dopaminergic supersensitivity. | Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice.
Gainetdinov RR, Bohn LM, Sotnikova TD, Cyr M, Laakso A, Macrae AD, Torres GE, Kim KM, Lefkowitz RJ, Caron MG, Premont RT. | 01/21/2010 |
| The results suggest that mouse G-protein-coupled receptor kinase isoform 6-C may be considered a basic, prototypic representative of the GRK4-like kinases. | The variable C-terminal extension of G-protein-coupled receptor kinase 6 constitutes an accessorial autoregulatory domain.
Vatter P, Stoesser C, Samel I, Gierschik P, Moepps B. | 01/21/2010 |