| IFI16/Ifi202 released from breast cancer induces secretion of inflammatory cytokines from macrophages and promotes tumor growth. | IFI16/Ifi202 released from breast cancer induces secretion of inflammatory cytokines from macrophages and promotes tumor growth.
Lim GY, Cho SW, Ka NL, Lee KH, Im SA, Kim SS, Hwang S, Lee MO. | 07/25/2023 |
| Enforced expression of IFI16-b inhibits the activation of AIM2 inflammasome, whereas knockdown of IFI16-b augments interleukin-1b secretion triggered by dsDNA but not dsRNA Thus, cytoplasm-localized IFI16-b is functionally equivalent to mouse p202 that exerts an inhibitory effect on AIM2 inflammasome. . | Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16.
Wang PH, Ye ZW, Deng JJ, Siu KL, Gao WW, Chaudhary V, Cheng Y, Fung SY, Yuen KS, Ho TH, Chan CP, Zhang Y, Kok KH, Yang W, Chan CP, Jin DY., Free PMC Article | 06/8/2019 |
| p202 promotes osteogenesis in mouse bone marrow stromal cells. | The interferon-inducible protein p202 promotes osteogenesis in mouse bone marrow stromal cells.
Zhang L, Wang C, Zhang X, Li H., Free PMC Article | 03/16/2019 |
| Ifi202b and IFI16 have roles as obesity genes | Increased Ifi202b/IFI16 expression stimulates adipogenesis in mice and humans.
Stadion M, Schwerbel K, Graja A, Baumeier C, Rödiger M, Jonas W, Wolfrum C, Staiger H, Fritsche A, Häring HU, Klöting N, Blüher M, Fischer-Posovszky P, Schulz TJ, Joost HG, Vogel H, Schürmann A., Free PMC Article | 02/2/2019 |
| the expression level of Ifi202b showed the most sex difference in correlation with known immune-related genes | Sex Differences in Correlation with Gene Expression Levels between Ifi200 Family Genes and Four Sets of Immune Disease-Relevant Genes.
Cao Y, Wang L, Wang CY, Ye J, Wang Y, Li T, Garcia-Godoy F, Sun D, Gu W, Postlethwaite AE., Free PMC Article | 12/22/2018 |
| These results, together with the reported data on p202 HINb, lead to an interaction model for full-length p202 and dsDNA which provides a conceivable mechanism for the negative regulation of Aim2 inflammasome activation by p202. | Structural mechanism of DNA recognition by the p202 HINa domain: insights into the inhibition of Aim2-mediated inflammatory signalling.
Li H, Wang J, Wang J, Cao LS, Wang ZX, Wu JW., Free PMC Article | 08/30/2014 |
| p202 plays a role in mouse adipose-derived stem cell adipogenesis. | Role of interferon-inducible protein 202 (p202) in the regulation of adipogenesis in mouse adipose-derived stem cells.
Li H, Liu F, Guo H, Zhu Z, Jiao Y. | 08/23/2014 |
| Authors hypothesize that while p202 was evolutionarily selected to limit AIM2-mediated inflammation in some mouse strains, the same mechanism contributes to increased interferon production and lupus susceptibility. | Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation.
Yin Q, Sester DP, Tian Y, Hsiao YS, Lu A, Cridland JA, Sagulenko V, Thygesen SJ, Choubey D, Hornung V, Walz T, Stacey KJ, Wu H., Free PMC Article | 05/17/2014 |
| Ifi202b modulates fat accumulation through expression of adipogenic genes such as 11beta-Hsd1. | Loss of function of Ifi202b by a microdeletion on chromosome 1 of C57BL/6J mice suppresses 11β-hydroxysteroid dehydrogenase type 1 expression and development of obesity.
Vogel H, Scherneck S, Kanzleiter T, Benz V, Kluge R, Stadion M, Kryvych S, Blüher M, Klöting N, Joost HG, Schürmann A. | 12/22/2012 |
| Studies identify p202 as a regulator of murine BAFF. | Murine BAFF expression is up-regulated by estrogen and interferons: implications for sex bias in the development of autoimmunity.
Panchanathan R, Choubey D., Free PMC Article | 12/8/2012 |
| Our observations demonstrate that cell type and gender-dependent factors differentially regulate the expression of the Aim2 and p202 proteins | Cell type and gender-dependent differential regulation of the p202 and Aim2 proteins: implications for the regulation of innate immune responses in SLE.
Panchanathan R, Duan X, Arumugam M, Shen H, Liu H, Choubey D., Free PMC Article | 12/24/2011 |
| Our findings indicate a potential role for Ifi202b in the suppressive capacity of peptide-induced regulatory CD8(+) Ti cells. | Interferon-inducible gene 202b controls CD8(+) T cell-mediated suppression in anti-DNA Ig peptide-treated (NZB × NZW) F1 lupus mice.
Dinesh R, Hahn BH, La Cava A, Singh RP., Free PMC Article | 11/19/2011 |
| expression of Aim2 protein is required to maintain the expression of the Fcgr2b gene and also predict epistatic interactions between the Ifi200 genes and the Fcgr2b gene within the Nba2 interval | Aim2 deficiency in mice suppresses the expression of the inhibitory Fcgamma receptor (FcgammaRIIB) through the induction of the IFN-inducible p202, a lupus susceptibility protein.
Panchanathan R, Shen H, Duan X, Rathinam VA, Erickson LD, Fitzgerald KA, Choubey D., Free PMC Article | 10/8/2011 |
| Findings delineate a new role of the IFN-gamma signaling pathway in regulating T cell proliferation and apoptosis through upregulating survivin and ifi202 expression. | IFN-γ upregulates survivin and Ifi202 expression to induce survival and proliferation of tumor-specific T cells.
Zimmerman M, Yang D, Hu X, Liu F, Singh N, Browning D, Ganapathy V, Chandler P, Choubey D, Abrams SI, Liu K., Free PMC Article | 04/30/2011 |
| Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus. | Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus.
Panchanathan R, Duan X, Shen H, Rathinam VA, Erickson LD, Fitzgerald KA, Choubey D., Free PMC Article | 01/8/2011 |
| Results suggest that Ifi202 expression in the kidney and immune organs significantly increased with disease progression in autoimmune glomerulonephritis. | Overexpression of interferon-activated gene 202 (Ifi202) correlates with the progression of autoimmune glomerulonephritis associated with the MRL chromosome 1.
Ichii O, Kamikawa A, Otsuka S, Hashimoto Y, Sasaki N, Endoh D, Kon Y. | 11/6/2010 |
| female and male sex hormones differentially regulate the expression of Ifi202, thus providing support for the role of Ifi202 in sex bias in SLE. | Female and male sex hormones differentially regulate expression of Ifi202, an interferon-inducible lupus susceptibility gene within the Nba2 interval.
Panchanathan R, Shen H, Bupp MG, Gould KA, Choubey D., Free PMC Article | 01/21/2010 |
| study showed p202 is an inhibitor of DNA-induced caspase activation; conversely AIM2 was required for caspase activation by cytoplasmic dsDNA; work indicates HIN-200 proteins can act as pattern recognition receptors mediating response to cytoplasmic dsDNA | HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA.
Roberts TL, Idris A, Dunn JA, Kelly GM, Burnton CM, Hodgson S, Hardy LL, Garceau V, Sweet MJ, Ross IL, Hume DA, Stacey KJ. | 01/21/2010 |
| p202 protein is a novel, important mediator of chondrogenic and osteogenic differentiation. | Mediation of chondrogenic and osteogenic differentiation by an interferon-inducible p202 protein.
Kong L, Liu CJ., Free PMC Article | 01/21/2010 |
| demonstrate that stimulation of T cells up-regulates the Ifi202 expression in part through the JNK/c-Jun pathway | Stimulation of T cells up-regulates expression of Ifi202, an interferon-inducible lupus susceptibility gene, through activation of JNK/c-Jun pathway.
Chen J, Panchanathan R, Choubey D., Free PMC Article | 01/21/2010 |
| increased Ifi202 expression in certain strains of mice contributes to lupus susceptibility in part by inhibiting E2F1-mediated functions. | Disruption of mutually negative regulatory feedback loop between interferon-inducible p202 protein and the E2F family of transcription factors in lupus-prone mice.
Panchanathan R, Xin H, Choubey D., Free PMC Article | 01/21/2010 |
| p202 plays a role in regulating the proliferative capacity of hematopoietic cells. | The role of p202 in regulating hematopoietic cell proliferation and differentiation.
Ludlow LE, Purton LE, Klarmann K, Gough DJ, Hii LL, Trapani JA, Keller JR, Clarke CJ, Johnstone RW. | 01/21/2010 |
| Ifi202 is an important NF-kappaB activator in dendritic cells and is involved in IL-12 production, which may account for a T(h)1-prone phenotype of BWF1 mice | Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells.
Yamauchi M, Hashimoto M, Ichiyama K, Yoshida R, Hanada T, Muta T, Komune S, Kobayashi T, Yoshimura A. | 01/21/2010 |
| The candidate lupus susceptibility gene Ifi202a is largely dispensable for B-cell function. | The candidate lupus susceptibility gene Ifi202a is largely dispensable for B-cell function.
Gubbels Bupp MR, Li M, Pashine A, Aud D, Peng SL. | 01/21/2010 |
| Expression stimulation by Rb was dependent, in part, on a JunD/AP-1 DNA-binding site present in the 5'-regulatory region of the Ifi202 gene. transcriptional activation of Ifi202 gene by Rb/JunD may be important for cell growth and survival. | Retinoblastoma (Rb) protein upregulates expression of the Ifi202 gene encoding an interferon-inducible negative regulator of cell growth.
Xin H, Pramanik R, Choubey D. | 01/21/2010 |