| TMPRSS11D/ALR-mediated ER stress regulates the function of myeloid-derived suppressor cells in the cervical cancer microenvironment. | TMPRSS11D/ALR-mediated ER stress regulates the function of myeloid-derived suppressor cells in the cervical cancer microenvironment.
Feng S, Zhao J, Yang T, Li L. | 11/3/2023 |
| Polymorphism rs1046495 of the GFER Gene as a New Genetic Marker of Preposition to Type 2 Diabetes Mellitus. | Polymorphism rs1046495 of the GFER Gene as a New Genetic Marker of Preposition to Type 2 Diabetes Mellitus.
Klyosova EY, Shkurat EA, Azarova YE, Polonikov AV. | 04/16/2022 |
| Augmenter of liver regeneration regulates cellular iron homeostasis by modulating mitochondrial transport of ATP-binding cassette B8. | Augmenter of liver regeneration regulates cellular iron homeostasis by modulating mitochondrial transport of ATP-binding cassette B8.
Chang HC, Shapiro JS, Jiang X, Senyei G, Sato T, Geier J, Sawicki KT, Ardehali H., Free PMC Article | 09/18/2021 |
| Hepatic Deficiency of Augmenter of Liver Regeneration Predisposes to Nonalcoholic Steatohepatitis and Fibrosis. | Hepatic Deficiency of Augmenter of Liver Regeneration Predisposes to Nonalcoholic Steatohepatitis and Fibrosis.
Kumar S, Verma AK, Rani R, Sharma A, Wang J, Shah SA, Behari J, Salazar Gonzalez R, Kohli R, Gandhi CR., Free PMC Article | 05/8/2021 |
| Downregulation of WW domain-containing oxidoreductase leads to tamoxifen-resistance by the inactivation of Hippo signaling. | Downregulation of WW domain-containing oxidoreductase leads to tamoxifen-resistance by the inactivation of Hippo signaling.
Li J, Feng X, Li C, Liu J, Li P, Wang R, Chen H, Liu P., Free PMC Article | 06/13/2020 |
| Augmenter of liver regeneration (ALR) gene transfection alleviates mitochondrial injury, through inhibiting fission and promoting fusion of the mitochondrial inner membrane, both of which contribute to reduction of HK-2 cell apoptosis. Additionally, fission processes are mediated by promoting tubular cell survival through activating the mTOR/4E-BP1 signaling pathway. | Augmenter of Liver Regeneration Alleviates Renal Hypoxia-Reoxygenation Injury by Regulating Mitochondrial Dynamics in Renal Tubular Epithelial Cells.
Long RT, Peng JB, Huang LL, Jiang GP, Liao YJ, Sun H, Hu YD, Liao XH., Free PMC Article | 05/9/2020 |
| High levels of cytosolic short form of ALR reduced CYP7A1 mRNA expression and bile acids levels attributed to STAT3 activation. | Bile acid-induced apoptosis and bile acid synthesis are reduced by over-expression of Augmenter of Liver Regeneration (ALR) in a STAT3-dependent mechanism.
Ibrahim S, Dayoub R, Krautbauer S, Liebisch G, Wege AK, Melter M, Weiss TS. | 05/9/2020 |
| This study finds a previously unrecognized role of RASSF1A in the regulation of CTGF and CYR61 through mediation of Hippo pathway in UBC and supports the significance of this link as a potential therapeutic target for UBC. | RASSF1A-Hippo pathway link in patients with urothelial carcinoma of bladder: plausible therapeutic target.
Khandelwal M, Anand V, Appunni S, Seth A, Singh P, Mathur S, Sharma A. | 03/21/2020 |
| Results found that TGF-beta induced miRNA-181a, which in turn induced liver fibrosis, at least in part, by inhibiting ALR. ALR inhibited TGF-beta action by decreasing the expression of TGFbeta-RII, thereby inhibiting miRNA-181a expression and fibrosis markers. | TGF-β induces liver fibrosis via miRNA-181a-mediated down regulation of augmenter of liver regeneration in hepatic stellate cells.
Gupta P, Sata TN, Yadav AK, Mishra A, Vats N, Hossain MM, Sanal MG, Venugopal SK., Free PMC Article | 02/1/2020 |
| Knockdown of augmenter of liver regeneration (ALR) in human kidney HK-2 cells promotes apoptosis of renal tubular cells and aggravates mitochondrial injury. The production of reactive oxygen species is increased and ATP levels are decreased. The mitochondrial DNA copy number and membrane potential are decreased. Critical transcriptional regulators of mitochondrial biogenesis are depleted in the siRNA/ALR cells. | Augmenter of liver regeneration promotes mitochondrial biogenesis in renal ischemia-reperfusion injury.
Huang LL, Long RT, Jiang GP, Jiang X, Sun H, Guo H, Liao XH. | 10/5/2019 |
| Gene expression microarray and coexpression analyses showed that PLEKHO1 may be involved in the serine/threonineprotein kinase hippo and JNK signalling pathways. | PLEKHO1 knockdown inhibits RCC cell viability in vitro and in vivo, potentially by the Hippo and MAPK/JNK pathways.
Yu Z, Li Q, Zhang G, Lv C, Dong Q, Fu C, Kong C, Zeng Y., Free PMC Article | 10/5/2019 |
| Data (including data from studies in knockout mice) suggest that KIBRA plays important role in regulating HPO activity, YAP signaling, and actin cytoskeletal dynamics in podocytes; expression of KIBRA and YAP plus phosphorylation of YAP are up-regulated in glomeruli of patients with focal segmental glomerulosclerosis. (KIBRA = kidney/brain protein-KIBRA; HPO = hepatopoietin protein; YAP = Yes associated protein-1) | The Hippo pathway regulator KIBRA promotes podocyte injury by inhibiting YAP signaling and disrupting actin cytoskeletal dynamics.
Meliambro K, Wong JS, Ray J, Calizo RC, Towne S, Cole B, El Salem F, Gordon RE, Kaufman L, He JC, Azeloglu EU, Campbell KN., Free PMC Article | 11/17/2018 |
| Loss of DLG5 expression promoted breast cancer progression by inactivating the Hippo signaling pathway and increasing nuclear YAP. | Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway.
Liu J, Li J, Li P, Wang Y, Liang Z, Jiang Y, Li J, Feng C, Wang R, Chen H, Zhou C, Zhang J, Yang J, Liu P., Free PMC Article | 11/3/2018 |
| WWC2 functions as a tumor suppressor by negatively regulating the Hippo signaling pathway and may serve as a prognostic marker in hepatocellular carcinoma. | WWC2 is an independent prognostic factor and prevents invasion via Hippo signalling in hepatocellular carcinoma.
Zhang Y, Yan S, Chen J, Gan C, Chen D, Li Y, Wen J, Kremerskothen J, Chen S, Zhang J, Cao Y., Free PMC Article | 07/21/2018 |
| the results of this study demonstrated that targeted inhibition of the ALR expression in Jurkat cells triggered cell growth inhibition and sensitized cells to VCR via promoting apoptosis and regulating the cell cycle. | Decreased expression of the augmenter of liver regeneration results in growth inhibition and increased chemosensitivity of acute T lymphoblastic leukemia cells.
Shen Y, Liu Q, Lou S, Luo Y, Sun H, Zeng H, Deng J. | 07/7/2018 |
| IKBKE plays a pivotal role in regulating cell proliferation, invasion and epithelial-mesenchymal transition of malignant glioma cells in vitro and in vivo by impacting on the Hippo pathway. | IKBKE regulates cell proliferation and epithelial-mesenchymal transition of human malignant glioma via the Hippo pathway.
Lu J, Yang Y, Guo G, Liu Y, Zhang Z, Dong S, Nan Y, Zhao Z, Zhong Y, Huang Q., Free PMC Article | 04/28/2018 |
| we found 2 additional patients carrying compound heterozygous variants in GFER. Reverse phenotyping confirmed the phenotypical similarities between the 4 patients. Together with the first literature reports, the review of these 8 cases from 4 unrelated families enables us to better describe this apparently homogeneous disorder, with the clinical and biological stigmata of mitochondrial disease | Further delineation of a rare recessive encephalomyopathy linked to mutations in GFER thanks to data sharing of whole exome sequencing data.
Nambot S, Gavrilov D, Thevenon J, Bruel AL, Bainbridge M, Rio M, Goizet C, Rötig A, Jaeken J, Niu N, Xia F, Vital A, Houcinat N, Mochel F, Kuentz P, Lehalle D, Duffourd Y, Rivière JB, Thauvin-Robinet C, Beaudet AL, Faivre L. | 04/21/2018 |
| ese findings collectively indicate that ALR negatively regulates the autophagy process through an association with the AMPK/mTOR signaling pathway. Autophagy inhibit apoptosis and play a protective role under conditions of oxidative stress. | Augmenter of liver regeneration regulates autophagy in renal ischemia-reperfusion injury via the AMPK/mTOR pathway.
Pu T, Liao XH, Sun H, Guo H, Jiang X, Peng JB, Zhang L, Liu Q. | 03/17/2018 |
| HPO interaction with MOB1 is not essential for development and tissue growth control. | Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control.
Kulaberoglu Y, Lin K, Holder M, Gai Z, Gomez M, Assefa Shifa B, Mavis M, Hoa L, Sharif AAD, Lujan C, Smith ESJ, Bjedov I, Tapon N, Wu G, Hergovich A., Free PMC Article | 01/20/2018 |
| Overexpression of augmenter of liver regeneration (ALR) in liver cancer was studied and found to improve sensitivity to antitumor drugs by increasing the retention of intracellular drugs, at least partly through the modulation of the ABCB1 and ABCG2 signaling pathway. | Augmenter of liver regeneration potentiates doxorubicin anticancer efficacy by reducing the expression of ABCB1 and ABCG2 in hepatocellular carcinoma.
Guo YY, Wu Y, Jia XW, An W. | 12/16/2017 |
| role in regulating the mitochondrial fission machinery | Hepatic stimulator substance resists hepatic ischemia/reperfusion injury by regulating Drp1 translocation and activation.
Zhang C, Huang J, An W. | 12/2/2017 |
| It evidence demonstrating Hippo-independent regulation of TEADs and the potential impacts these studies may have on new cancer therapeutics. | Regulation of the Hippo Pathway Transcription Factor TEAD.
Lin KC, Park HW, Guan KL., Free PMC Article | 11/4/2017 |
| ALR protects steatotic hepatocytes from ischemia reperfusion injury by attenuating oxidative stress and mitochondrial dysfunction. | Alleviation of Ischemia-Reperfusion Injury in Liver Steatosis by Augmenter of Liver Regeneration Is Attributed to Antioxidation and Preservation of Mitochondria.
Weng J, Li W, Jia X, An W. | 10/21/2017 |
| Our results show that MARK4 acts as a negative regulator of the Hippo kinase cassette to promote YAP/TAZ activity and that loss of MARK4 restrains the tumorigenic properties of breast cancer cells. | MARK4 inhibits Hippo signaling to promote proliferation and migration of breast cancer cells.
Heidary Arash E, Shiban A, Song S, Attisano L., Free PMC Article | 08/19/2017 |
| ALR, dependent on its localization, changes the acute-phase response (APR) at least in part, by modifying STAT3 activation; dual signaling of ALR suggests that ALR is pivotal for the regulation of APR, a crucial event in liver injury and regeneration | Augmenter of liver regeneration (ALR) exhibits a dual signaling impact on hepatic acute-phase response.
Dayoub R, Buerger L, Ibrahim S, Melter M, Weiss TS. | 08/19/2017 |