| Enhanced endothelial motility and multicellular sprouting is mediated by the scaffold protein TKS4. | Enhanced endothelial motility and multicellular sprouting is mediated by the scaffold protein TKS4.
Mehes E, Barath M, Gulyas M, Bugyik E, Geiszt M, Szoor A, Lanyi A, Czirok A., Free PMC Article | 10/31/2020 |
| Beigeing process was more robust in the WAT of Tks4-KO mice compared to the wild-type animals. | Analysis of Tks4 Knockout Mice Suggests a Role for Tks4 in Adipose Tissue Homeostasis in the Context of Beigeing.
Vas V, Háhner T, Kudlik G, Ernszt D, Kvell K, Kuti D, Kovács KJ, Tóvári J, Trexler M, Merő BL, Szeder B, Koprivanacz K, Buday L., Free PMC Article | 04/18/2020 |
| together, these results establish a novel function for Tks4 in the regulation of mesenchymal stromal cells differentiation. | The scaffold protein Tks4 is required for the differentiation of mesenchymal stromal cells (MSCs) into adipogenic and osteogenic lineages.
Dülk M, Kudlik G, Fekete A, Ernszt D, Kvell K, Pongrácz JE, Merő BL, Szeder B, Radnai L, Geiszt M, Csécsy DE, Kovács T, Uher F, Lányi Á, Vas V, Buday L., Free PMC Article | 06/16/2018 |
| Suggest the importance of Tks adaptor proteins in melanoma growth and metastasis in vivo is likely via functional invadopodia formation. | The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma.
Iizuka S, Abdullah C, Buschman MD, Diaz B, Courtneidge SA., Free PMC Article | 02/24/2018 |
| eyes of B10-Sh3pxd2bnee mice exhibit multiple features of congenital glaucoma. | Anterior segment dysgenesis and early-onset glaucoma in nee mice with mutation of Sh3pxd2b.
Mao M, Hedberg-Buenz A, Koehn D, John SW, Anderson MG., Free PMC Article | 11/17/2012 |
| The mouse model with a mutation in the Sh3pxd2b gene (Sh3pxd2b(nee)) mirrors craniofacial dysmorphology and otitis media in humans. | Sh3pxd2b mice are a model for craniofacial dysmorphology and otitis media.
Yang B, Tian C, Zhang ZG, Han FC, Azem R, Yu H, Zheng Y, Jin G, Arnold JE, Zheng QY., Free PMC Article | 12/10/2011 |
| These findings establish a role for TKS4 in Frank-Ter Haar syndrome and embryonic development. | Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes the skeletal dysplasia, eye, and cardiac abnormalities of Frank-Ter Haar Syndrome.
Iqbal Z, Cejudo-Martin P, de Brouwer A, van der Zwaag B, Ruiz-Lozano P, Scimia MC, Lindsey JD, Weinreb R, Albrecht B, Megarbane A, Alanay Y, Ben-Neriah Z, Amenduni M, Artuso R, Veltman JA, van Beusekom E, Oudakker A, Millán JL, Hennekam R, Hamel B, Courtneidge SA, van Bokhoven H., Free PMC Article | 03/22/2010 |
| SH3PXD2B is a podosomal-adaptor protein required for postnatal growth and development. | The podosomal-adaptor protein SH3PXD2B is essential for normal postnatal development.
Mao M, Thedens DR, Chang B, Harris BS, Zheng QY, Johnson KR, Donahue LR, Anderson MG., Free PMC Article | 01/21/2010 |
| Tks4 has a role in the formation and function of podosomes. | The novel adaptor protein Tks4 (SH3PXD2B) is required for functional podosome formation.
Buschman MD, Bromann PA, Cejudo-Martin P, Wen F, Pass I, Courtneidge SA., Free PMC Article | 01/21/2010 |
| Silencing of C/EBPdelta impaired the expression of factor for adipocyte differentiation (fad) 49, which is up-regulated and plays a crucial role early in adipogenesis. | The role of C/EBPdelta in the early stages of adipogenesis.
Hishida T, Nishizuka M, Osada S, Imagawa M. | 01/21/2010 |
| Induction of the fad49 gene was observed in adipocyte differentiable 3T3-L1 cells, but not in non-adipogenic NIH-3T3 cells. | A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion.
Hishida T, Eguchi T, Osada S, Nishizuka M, Imagawa M. | 01/21/2010 |