| The C-type lectin DCIR contributes to the immune response and pathogenesis of colorectal cancer. | The C-type lectin DCIR contributes to the immune response and pathogenesis of colorectal cancer.
Trimaglio G, Sneperger T, Raymond BBA, Gilles N, Näser E, Locard-Paulet M, Ijsselsteijn ME, Brouwer TP, Ecalard R, Roelands J, Matsumoto N, Colom A, Habch M, de Miranda NFCC, Vergnolle N, Devaud C, Neyrolles O, Rombouts Y., Free PMC Article | 03/29/2024 |
| DCIR suppresses osteoclastic proliferation and resorption by downregulating M-CSF and RANKL signaling. | DCIR suppresses osteoclastic proliferation and resorption by downregulating M-CSF and RANKL signaling.
Kaifu T, Maruhashi T, Chung SH, Shimizu K, Nakamura A, Iwakura Y., Free PMC Article | 10/20/2023 |
| Blocking DCIR mitigates colitis and prevents colorectal tumors by enhancing the GM-CSF-STAT5 pathway. | Blocking DCIR mitigates colitis and prevents colorectal tumors by enhancing the GM-CSF-STAT5 pathway.
Sun H, Tang C, Chung SH, Ye XQ, Makusheva Y, Han W, Kubo M, Shichino S, Ueha S, Matsushima K, Ikeo K, Asano M, Iwakura Y. | 08/13/2022 |
| C-type lectin receptor CLEC4A2 promotes tissue adaptation of macrophages and protects against atherosclerosis. | C-type lectin receptor CLEC4A2 promotes tissue adaptation of macrophages and protects against atherosclerosis.
Park I, Goddard ME, Cole JE, Zanin N, Lyytikäinen LP, Lehtimäki T, Andreakos E, Feldmann M, Udalova I, Drozdov I, Monaco C., Free PMC Article | 02/12/2022 |
| DCIR and its ligand asialo-biantennary N-glycan regulate DC function and osteoclastogenesis. | DCIR and its ligand asialo-biantennary N-glycan regulate DC function and osteoclastogenesis.
Kaifu T, Yabe R, Maruhashi T, Chung SH, Tateno H, Fujikado N, Hirabayashi J, Iwakura Y., Free PMC Article | 01/1/2022 |
| DCIR modulates immunity to M. tuberculosis through sustaining type I IFN signaling in DCs, which reduces IL-12-p70 production and Th1 expansion. As a consequence, DCIR-deficient mice control M. tuberculosis infection better than their WT counterparts but also develop more immunopathology in the lungs. | C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells.
Troegeler A, Mercier I, Cougoule C, Pietretti D, Colom A, Duval C, Vu Manh TP, Capilla F, Poincloux R, Pingris K, Nigou J, Rademann J, Dalod M, Verreck FA, Al Saati T, Lugo-Villarino G, Lepenies B, Hudrisier D, Neyrolles O., Free PMC Article | 04/14/2018 |
| this study shows that upon injection of d-galactosamine and lipopolysaccharide, Dcir1-/- mice show decreased mortality rates and serum levels of alanine aminotransferase | Absence of DCIR1 reduces the mortality rate of endotoxemic hepatitis in mice.
Ishiguro T, Fukawa T, Akaki K, Nagaoka K, Takeda T, Iwakura Y, Inaba K, Takahara K. | 07/15/2017 |
| Dcir1 enhances the pathogenesis of DSS colitis by altering neutrophil recruitment and their functions. | Dendritic cell immunoreceptor 1 alters neutrophil responses in the development of experimental colitis.
Tokieda S, Komori M, Ishiguro T, Iwakura Y, Takahara K, Inaba K., Free PMC Article | 07/2/2016 |
| While DCIR1 was ubiquitously expressed on myeloid cells in various immune organs, significant expression of DCAR2 was detected only on subpopulations of conventional dendritic cells from bone marrow and skin-draining lymph nodes. | Ubiquitous versus restricted expression of the two mouse dendritic cell C-type lectin receptors, DCIR1 and DCAR2, among myeloid cells.
Kishimoto A, Watanabe M, Terauchi K, Kojima T, Kameda Y, Yamamoto K, Matsumoto N. | 02/6/2016 |
| MCL-/- as well as DCIR-/- mice exhibited only a slightly increased severity of disease compared to wild-type mice indicating a limited role for MCL and DCIR in the regulation of intestinal immunity. | Role of the C-type lectin receptors MCL and DCIR in experimental colitis.
Hütter J, Eriksson M, Johannssen T, Klopfleisch R, von Smolinski D, Gruber AD, Seeberger PH, Lepenies B., Free PMC Article | 11/14/2015 |
| our findings show that DCIR plays an important role in maintaining bone homeostasis. | DCIR maintains bone homeostasis by regulating IFN-γ production in T cells.
Maruhashi T, Kaifu T, Yabe R, Seno A, Chung SH, Fujikado N, Iwakura Y. | 08/22/2015 |
| DCIR is a novel receptor for IVIg, mediating interaction of innate and adaptive immunity in tolerogenic responses. | Dendritic cell immunoreceptor: a novel receptor for intravenous immunoglobulin mediates induction of regulatory T cells.
Massoud AH, Yona M, Xue D, Chouiali F, Alturaihi H, Ablona A, Mourad W, Piccirillo CA, Mazer BD. | 05/3/2014 |
| This study indicates that DCIR is critically involved in Cerebral malaria induction | The C-type lectin receptor DCIR is crucial for the development of experimental cerebral malaria.
Maglinao M, Klopfleisch R, Seeberger PH, Lepenies B. | 11/16/2013 |
| These results suggest that DCIR plays a protective role in limiting the Chikungunya virus-induced inflammatory response and subsequent tissue and joint damage. | Dendritic cell immunoreceptor regulates Chikungunya virus pathogenesis in mice.
Long KM, Whitmore AC, Ferris MT, Sempowski GD, McGee C, Trollinger B, Gunn B, Heise MT., Free PMC Article | 06/22/2013 |
| These observations indicate that Dcir is a negative regulator of dendritic cell expansion and has a crucial role in maintaining the homeostasis of the immune system. | Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells.
Fujikado N, Saijo S, Yonezawa T, Shimamori K, Ishii A, Sugai S, Kotaki H, Sudo K, Nose M, Iwakura Y. | 01/21/2010 |