| Histone variant macroH2A1 regulates synchronous firing of replication origins in the inactive X chromosome. | Histone variant macroH2A1 regulates synchronous firing of replication origins in the inactive X chromosome.
Arroyo M, Casas-Delucchi CS, Pabba MK, Prorok P, Pradhan SK, Rausch C, Lehmkuhl A, Maiser A, Buschbeck M, Pasque V, Bernstein E, Luck K, Cardoso MC., Free PMC Article | 11/13/2024 |
| Deficiency of histone variant macroH2A1.1 is associated with sexually dimorphic obesity in mice. | Deficiency of histone variant macroH2A1.1 is associated with sexually dimorphic obesity in mice.
Chiodi V, Rappa F, Lo Re O, Chaldakov GN, Lelouvier B, Micale V, Domenici MR, Vinciguerra M., Free PMC Article | 11/21/2023 |
| MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping. | MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping.
Filipescu D, Carcamo S, Agarwal A, Tung N, Humblin É, Goldberg MS, Vyas NS, Beaumont KG, Demircioglu D, Sridhar S, Ghiraldini FG, Capparelli C, Aplin AE, Salmon H, Sebra R, Kamphorst AO, Merad M, Hasson D, Bernstein E., Free PMC Article | 11/1/2023 |
| Histone macroH2A1 is a stronger regulator of hippocampal transcription and memory than macroH2A2 in mice. | Histone macroH2A1 is a stronger regulator of hippocampal transcription and memory than macroH2A2 in mice.
Singh G, Stefanelli G, Narkaj K, Brimble MA, Creighton SD, McLean TAB, Hall M, Mitchnick KA, Zakaria J, Phung T, Reda A, Leonetti AM, Monks A, Ianov L, Winters BD, Walters BJ, Davidoff AM, Mitchell JA, Zovkic IB., Free PMC Article | 05/28/2022 |
| Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice. | Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice.
Kim SP, Srivatsan SN, Chavez M, Shirai CL, White BS, Ahmed T, Alberti MO, Shao J, Nunley R, White LS, Bednarski J, Pehrson JR, Walter MJ., Free PMC Article | 02/19/2022 |
| The Histone Variant MacroH2A1 Regulates Key Genes for Myogenic Cell Fusion in a Splice-Isoform Dependent Manner. | The Histone Variant MacroH2A1 Regulates Key Genes for Myogenic Cell Fusion in a Splice-Isoform Dependent Manner.
Hurtado-Bagès S, Posavec Marjanovic M, Valero V, Malinverni R, Corujo D, Bouvet P, Lavigne AC, Bystricky K, Buschbeck M., Free PMC Article | 03/20/2021 |
| LSH mediates gene repression through macroH2A deposition. | LSH mediates gene repression through macroH2A deposition.
Ni K, Ren J, Xu X, He Y, Finney R, Braun SMG, Hathaway NA, Crabtree GR, Muegge K., Free PMC Article | 12/12/2020 |
| Epigenetic Regulation of DNA Repair Pathway Choice by MacroH2A1 Splice Variants Ensures Genome Stability. | Epigenetic Regulation of DNA Repair Pathway Choice by MacroH2A1 Splice Variants Ensures Genome Stability.
Sebastian R, Hosogane EK, Sun EG, Tran AD, Reinhold WC, Burkett S, Sturgill DM, Gudla PR, Pommier Y, Aladjem MI, Oberdoerffer P., Free PMC Article | 09/26/2020 |
| Data report for the first time that loss of macroH2A1.1 expression in mice led to the dysregulation of myeloid differentiation. Thus, macroH2A1.1 delineates its function in hematopoietic stem cell homeostasis and differentiation in mice. | Deficiency and haploinsufficiency of histone macroH2A1.1 in mice recapitulate hematopoietic defects of human myelodysplastic syndrome.
Bereshchenko O, Lo Re O, Nikulenkov F, Flamini S, Kotaskova J, Mazza T, Le Pannérer MM, Buschbeck M, Giallongo C, Palumbo G, Li Volti G, Pazienza V, Cervinek L, Riccardi C, Krejci L, Pospisilova S, Stewart AF, Vinciguerra M., Free PMC Article | 06/20/2020 |
| These data indicate that macroH2A1.1-containing chromatin regulates mitochondrial respiration by limiting nuclear NAD(+) consumption and establishing a buffer of NAD(+) precursors in differentiated cells. | MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD(+) consumption.
Posavec Marjanović M, Hurtado-Bagès S, Lassi M, Valero V, Malinverni R, Delage H, Navarro M, Corujo D, Guberovic I, Douet J, Gama-Perez P, Garcia-Roves PM, Ahel I, Ladurner AG, Yanes O, Bouvet P, Suelves M, Teperino R, Pospisilik JA, Buschbeck M., Free PMC Article | 11/18/2017 |
| Both histone H3 lysine 27 acetylation and recruitment of the transcription factor Pbx1 at prospective enhancers are regulated by mH2A1.2. | The Histone Variant MacroH2A1.2 Is Necessary for the Activation of Muscle Enhancers and Recruitment of the Transcription Factor Pbx1.
Dell'Orso S, Wang AH, Shih HY, Saso K, Berghella L, Gutierrez-Cruz G, Ladurner AG, O'Shea JJ, Sartorelli V, Zare H., Free PMC Article | 11/5/2016 |
| The Skp2-mH2A1-CDK8 axis has a critical role in breast cancer development via dysregulation of the G2/M transition, polyploidy, cell growth dysregulation, and loss of tumor suppression. | Skp2-macroH2A1-CDK8 axis orchestrates G2/M transition and tumorigenesis.
Xu D, Li CF, Zhang X, Gong Z, Chan CH, Lee SW, Jin G, Rezaeian AH, Han F, Wang J, Yang WL, Feng ZZ, Chen W, Wu CY, Wang YJ, Chow LP, Zhu XF, Zeng YX, Lin HK., Free PMC Article | 03/26/2016 |
| tumor suppressive histone variant macroH2A1 is a critical component of the positive feedback loop that maintains the cell senescence-associated secretory phenotype, including activation of ATM | MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype.
Chen H, Ruiz PD, McKimpson WM, Novikov L, Kitsis RN, Gamble MJ., Free PMC Article | 11/28/2015 |
| The macroH2A, a critical component of chromatin, suppresses the development of melanoma through regulating cyclin D1, cyclin D3 and CDK6 genes. | MacroH2A suppresses the proliferation of the B16 melanoma cell line.
Lei S, Long J, Li J. | 05/23/2015 |
| Data show that MacroH2A.1 and macroH2A.2 regulate gene expression with them acting synergistically on the expression of some genes and apparently having opposing effects on others. | Mice without macroH2A histone variants.
Pehrson JR, Changolkar LN, Costanzi C, Leu NA., Free PMC Article | 01/17/2015 |
| The results demonstrate that macroH2A1 is a new factor involved in the regulation of rDNA transcription. | macroH2A1 histone variant represses rDNA transcription.
Cong R, Das S, Douet J, Wong J, Buschbeck M, Mongelard F, Bouvet P., Free PMC Article | 02/22/2014 |
| Both macroH2A1 isoforms may play a role in hepatocellular carcinoma pathogenesis. | Immunopositivity for histone macroH2A1 isoforms marks steatosis-associated hepatocellular carcinoma.
Rappa F, Greco A, Podrini C, Cappello F, Foti M, Bourgoin L, Peyrou M, Marino A, Scibetta N, Williams R, Mazzoccoli G, Federici M, Pazienza V, Vinciguerra M., Free PMC Article | 07/27/2013 |
| macroH2A1 and macroH2A2, together with histone 3 lysine 27 methylated 3, co-occupy pluripotency genes in wild-type (wt) fibroblasts. | MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency.
Gaspar-Maia A, Qadeer ZA, Hasson D, Ratnakumar K, Leu NA, Leroy G, Liu S, Costanzi C, Valle-Garcia D, Schaniel C, Lemischka I, Garcia B, Pehrson JR, Bernstein E., Free PMC Article | 06/22/2013 |
| macroH2A1 is a critical chromatin component that regulates the delicate balance between self-renewal and differentiation of embryonic and adult stem cells | MacroH2A1 regulates the balance between self-renewal and differentiation commitment in embryonic and adult stem cells.
Creppe C, Janich P, Cantariño N, Noguera M, Valero V, Musulén E, Douet J, Posavec M, Martín-Caballero J, Sumoy L, Di Croce L, Benitah SA, Buschbeck M., Free PMC Article | 06/30/2012 |
| H2AFY is specifically overexpressed in two models of Huntington disease | Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse.
Hu Y, Chopra V, Chopra R, Locascio JJ, Liao Z, Ding H, Zheng B, Matson WR, Ferrante RJ, Rosas HD, Hersch SM, Scherzer CR., Free PMC Article | 12/17/2011 |
| MacroH2A1 does not localize to the centrosome. | The histone H2A variant macroH2A1 does not localize to the centrosome.
Friedman N, Barzily-Rokni M, Isaac S, Eden A., Free PMC Article | 09/3/2011 |
| Decreased stability of the inactive X chromosome is revealed in mouse epiblast stem cells, highlighting the importance of combinatorial epigenetic repression involving macroH2A in restricting transcriptional reprogramming by oocytes. | Histone variant macroH2A confers resistance to nuclear reprogramming.
Pasque V, Gillich A, Garrett N, Gurdon JB., Free PMC Article | 08/13/2011 |
| Knockdown of mH2A isoforms in melanoma cells of low malignancy results in significantly increased proliferation and migration in vitro and growth and metastasis in vivo | The histone variant macroH2A suppresses melanoma progression through regulation of CDK8.
Kapoor A, Goldberg MS, Cumberland LK, Ratnakumar K, Segura MF, Emanuel PO, Menendez S, Vardabasso C, Leroy G, Vidal CI, Polsky D, Osman I, Garcia BA, Hernando E, Bernstein E., Free PMC Article | 01/8/2011 |
| macroH2A1 functions primarily as a repressor in adult liver. This repressor activity is further supported by the substantial and relatively uniform macroH2A1 enrichment along the inactive X chromosome, which averages 4-fold. | Genome-wide distribution of macroH2A1 histone variants in mouse liver chromatin.
Changolkar LN, Singh G, Cui K, Berletch JB, Zhao K, Disteche CM, Pehrson JR., Free PMC Article | 12/11/2010 |
| C-terminal amino acids of H2A.X function specifically to target this variant histone into chromatin in embryos after fertilization and that the absence of H2A.Z and macroH2A from the chromatin is required for normal development. | Changes in the nuclear deposition of histone H2A variants during pre-implantation development in mice.
Nashun B, Yukawa M, Liu H, Akiyama T, Aoki F. | 11/13/2010 |