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    GJA1 gap junction protein alpha 1 [ Homo sapiens (human) ]

    Gene ID: 2697, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Mutations of the Cx43 Gene in Non-Small Cell Lung Cancer: Association with Aberrant Localization of Cx43 Protein Expression and Tumor Progression.

    Mutations of the Cx43 Gene in Non-Small Cell Lung Cancer: Association with Aberrant Localization of Cx43 Protein Expression and Tumor Progression.
    Chen JC, Yeh KT, Lin YM, Cheng YW., Free PMC Article

    11/4/2024
    Endothelial-adipocyte Cx43 Mediated Gap Junctions Can Regulate Adiposity.

    Endothelial-adipocyte Cx43 Mediated Gap Junctions Can Regulate Adiposity.
    Luse MA, Dunaway LS, Nyshadham S, Carvalho A, Sedovy MW, Ruddiman CA, Tessema R, Hirschi K, Johnstone SR, Isakson BE., Free PMC Article

    10/30/2024
    Connexin 43 controls metastatic behavior in triple negative breast cancer through TGFbeta1-Smad3-intergin alphaV signaling axis Based on optical image diagnosis.

    Connexin 43 controls metastatic behavior in triple negative breast cancer through TGFβ1-Smad3-intergin αV signaling axis Based on optical image diagnosis.
    Fu Y, Sun X, He Q, Gu Z, Jia X, Zhuang Z.

    10/25/2024
    Connexin 43 regulates intercellular mitochondrial transfer from human mesenchymal stromal cells to chondrocytes.

    Connexin 43 regulates intercellular mitochondrial transfer from human mesenchymal stromal cells to chondrocytes.
    Irwin RM, Thomas MA, Fahey MJ, Mayán MD, Smyth JW, Delco ML., Free PMC Article

    10/19/2024
    Connexin 43 Modulation in Human Chondrocytes, Osteoblasts and Cartilage Explants: Implications for Inflammatory Joint Disorders.

    Connexin 43 Modulation in Human Chondrocytes, Osteoblasts and Cartilage Explants: Implications for Inflammatory Joint Disorders.
    Della Morte E, Giannasi C, Valenza A, Cadelano F, Aldegheri A, Zagra L, Niada S, Brini AT., Free PMC Article

    09/18/2024
    Human coronavirus OC43 infection remodels connexin 43-mediated gap junction intercellular communication in vitro.

    Human coronavirus OC43 infection remodels connexin 43-mediated gap junction intercellular communication in vitro.
    Karmakar S, Das Sarma J., Free PMC Article

    08/22/2024
    NGF increases Connexin-43 expression and function in pulmonary arterial smooth muscle cells to induce pulmonary artery hyperreactivity.

    NGF increases Connexin-43 expression and function in pulmonary arterial smooth muscle cells to induce pulmonary artery hyperreactivity.
    Cardouat G, Douard M, Bouchet C, Roubenne L, Kmecová Z, Esteves P, Brette F, Guignabert C, Tu L, Campagnac M, Robillard P, Coste F, Delcambre F, Thumerel M, Begueret H, Maurac A, Belaroussi Y, Klimas J, Ducret T, Quignard JF, Vacher P, Baudrimont I, Marthan R, Berger P, Guibert C, Freund-Michel V.

    05/2/2024
    The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation.

    The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation.
    Totland MZ, Knudsen LM, Rasmussen NL, Omori Y, Sørensen V, Elster VCW, Stenersen JM, Larsen M, Jensen CL, Zickfeldt Lade AA, Bruusgaard E, Basing S, Kryeziu K, Brech A, Aasen T, Lothe RA, Leithe E., Free PMC Article

    04/24/2024
    KLF5 promotes the ossification process of ligamentum flavum by transcriptionally activating CX43.

    KLF5 promotes the ossification process of ligamentum flavum by transcriptionally activating CX43.
    Guo H, Yang L, Liu J, Chen L, Huang Y, Li J., Free PMC Article

    04/22/2024
    Post translational modifications of connexin 43 in ventricular arrhythmias after myocardial infarction.

    Post translational modifications of connexin 43 in ventricular arrhythmias after myocardial infarction.
    Yang F, Zhang XL, Liu HH, Qian LL, Wang RX.

    04/3/2024
    Casein Kinase 1 Phosphomimetic Mutations Negatively Impact Connexin-43 Gap Junctions in Human Pluripotent Stem Cell-Derived Cardiomyocytes.

    Casein Kinase 1 Phosphomimetic Mutations Negatively Impact Connexin-43 Gap Junctions in Human Pluripotent Stem Cell-Derived Cardiomyocytes.
    Al-Attar R, Jargstorf J, Romagnuolo R, Jouni M, Alibhai FJ, Lampe PD, Solan JL, Laflamme MA., Free PMC Article

    02/12/2024
    Connexin 43 in Dermatofibroma and Dermatofibrosarcoma Protuberans: Diagnostic, Pathogenic, and Therapeutic Implications.

    Connexin 43 in Dermatofibroma and Dermatofibrosarcoma Protuberans: Diagnostic, Pathogenic, and Therapeutic Implications.
    Fernandez-Flores A, Varela-Vazquez A, Mayan MD, Fonseca E.

    02/1/2024
    Human Cx50 Isoleucine177 prevents heterotypic docking and formation of functional gap junction channels with Cx43.

    Human Cx50 Isoleucine177 prevents heterotypic docking and formation of functional gap junction channels with Cx43.
    Wong RS, Chen H, Li YX, Esseltine JL, Stathopulos PB, Bai D.

    01/31/2024
    Stabilization of Cx43 mRNA via RNA-binding protein HuR regulated by polyamines enhances intestinal epithelial barrier function.

    Stabilization of Cx43 mRNA via RNA-binding protein HuR regulated by polyamines enhances intestinal epithelial barrier function.
    Wang SR, Mallard CG, Cairns CA, Chung HK, Yoo D, Jaladanki SK, Xiao L, Wang JY.,

    12/6/2023
    NAD[+] rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis.

    NAD(+) rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis.
    Zhan R, Meng X, Tian D, Xu J, Cui H, Yang J, Xu Y, Shi M, Xue J, Yu W, Hu G, Li K, Ge X, Zhang Q, Zhao M, Du J, Guo X, Xu W, Gao Y, Yao C, Chen F, Chen Y, Shan W, Zhu Y, Ji L, Pan B, Yu Y, Li W, Zhao X, He Q, Liu X, Huang Y, Liao S, Zhou B, Chui D, Chen YE, Sun Z, Dong E, Wang Y, Zheng L.

    11/22/2023
    Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells.

    Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells.
    Martins-Marques T, Witschas K, Ribeiro I, Zuzarte M, Catarino S, Ribeiro-Rodrigues T, Caramelo F, Aasen T, Carreira IM, Goncalves L, Leybaert L, Girao H., Free PMC Article

    11/3/2023
    MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction.

    MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction.
    Tang Y, Chu Q, Xie G, Tan Y, Ye Z, Qin C., Free PMC Article

    11/3/2023
    Connexin 43 mediated collective cell migration is independent of Golgi orientation.

    Connexin 43 mediated collective cell migration is independent of Golgi orientation.
    Sharma M, Mukherjee S, Shaw AK, Mondal A, Behera A, Das J, Bose A, Sinha B, Sarma JD., Free PMC Article

    11/2/2023
    SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca[2+] dynamics.

    SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca(2+) dynamics.
    Prieto-Villalobos J, Lucero CM, Rovegno M, Gómez GI, Retamal MA, Orellana JA., Free PMC Article

    10/28/2023
    Connexin-43 hemichannels orchestrate NOD-like receptor protein-3 (NLRP3) inflammasome activation and sterile inflammation in tubular injury.

    Connexin-43 hemichannels orchestrate NOD-like receptor protein-3 (NLRP3) inflammasome activation and sterile inflammation in tubular injury.
    Roger E, Chadjichristos CE, Kavvadas P, Price GW, Cliff CL, Hadjadj S, Renciot J, Squires PE, Hills CE., Free PMC Article

    10/2/2023
    Genome-wide association study reveals HSF2, GJA1 and TRIM36 as susceptibility genes for preeclampsia: a community-based population study in Tianjin, China.

    Genome-wide association study reveals HSF2, GJA1 and TRIM36 as susceptibility genes for preeclampsia: a community-based population study in Tianjin, China.
    Cao Z, Ma L, Cai W, Niu X, Yang N, Ni J, Wang X, Wei M, Chen S, Li Y.

    09/27/2023
    20 kDa isoform of connexin-43 augments spatial reorganization of the brain endothelial junctional complex and lesion leakage in cerebral cavernous malformation type-3.

    20 kDa isoform of connexin-43 augments spatial reorganization of the brain endothelial junctional complex and lesion leakage in cerebral cavernous malformation type-3.
    Phillips CM, Johnson AM, Stamatovic SM, Keep RF, Andjelkovic AV.

    09/25/2023
    Cx43 regulates mechanotransduction mechanisms in human preterm amniotic membrane defects.

    Cx43 regulates mechanotransduction mechanisms in human preterm amniotic membrane defects.
    Costa E, Thrasivoulou C, Becker DL, Deprest JA, David AL, Chowdhury TT.

    09/14/2023
    The role of the Cx43/Cx45 gap junction voltage gating on wave propagation and arrhythmogenic activity in cardiac tissue.

    The role of the Cx43/Cx45 gap junction voltage gating on wave propagation and arrhythmogenic activity in cardiac tissue.
    Maciunas K, Snipas M, Kraujalis T, Kraujalienė L, Panfilov AV., Free PMC Article

    09/11/2023
    Connexin 43 gap junction affects survival and drug resistance of multiple myeloma side population cells.

    Connexin 43 gap junction affects survival and drug resistance of multiple myeloma side population cells.
    Wang Z, Fu JX, Zhang XH, Sun Y, Ge XP.

    09/8/2023
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