| Conditional Loss of Nmp4 in Mesenchymal Stem Progenitor Cells Enhances PTH-Induced Bone Formation. | Conditional Loss of Nmp4 in Mesenchymal Stem Progenitor Cells Enhances PTH-Induced Bone Formation.
Atkinson EG, Adaway M, Horan DJ, Korff C, Klunk A, Orr AL, Ratz K, Bellido T, Plotkin LI, Robling AG, Bidwell JP., Free PMC Article | 01/14/2023 |
| NMP4 regulates the innate immune response to influenza A virus infection. | NMP4 regulates the innate immune response to influenza A virus infection.
Yang S, Adaway M, Du J, Huang S, Sun J, Bidwell JP, Zhou B., Free PMC Article | 10/16/2021 |
| loss of Nmp4 increases the magnitude of glycolysis upon the metabolic switch, which fuels the conversion of the osteoblast into a super-secretor of matrix resulting in more bone with improvements in intrinsic quality. | Loss of Nmp4 optimizes osteogenic metabolism and secretion to enhance bone quality.
Shao Y, Wichern E, Childress PJ, Adaway M, Misra J, Klunk A, Burr DB, Wek RC, Mosley AL, Liu Y, Robling AG, Brustovetsky N, Hamilton J, Jacobs K, Vashishth D, Stayrook KR, Allen MR, Wallace JM, Bidwell JP., Free PMC Article | 01/4/2020 |
| The heightened osteoanabolism of the Nmp4-/- skeleton enhances the effectiveness of diverse osteoporosis treatments, in part by increasing hyperanabolic osteoprogenitors. Nmp4 provides a promising target pathway for identifying barriers to pharmacologically induced bone formation. | Improving Combination Osteoporosis Therapy in a Preclinical Model of Heightened Osteoanabolism.
Shao Y, Hernandez-Buquer S, Childress P, Stayrook KR, Alvarez MB, Davis H, Plotkin LI, He Y, Condon KW, Burr DB, Warden SJ, Robling AG, Yang FC, Wek RC, Allen MR, Bidwell JP., Free PMC Article | 10/7/2017 |
| Sustained protein synthesis sensitized cells to pharmacological induction of the Unfolded Protein Response (UPR), and the observed decrease in cell viability was restored upon inhibition of GADD34 activity. We conclude that NMP4 is a key regulator of ribosome biogenesis and the UPR, which together play a central role in determining cell viability during endoplasmic reticulum stress. | Nuclear Matrix Protein 4 Is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response via Repression of Gadd34 Expression.
Young SK, Shao Y, Bidwell JP, Wek RC., Free PMC Article | 12/17/2016 |
| NMP4 deficiency suppressed the arthritis-induced increase in bone resorption, expression of RANKL and MMP-3 mRNA. | Mice Deficient in CIZ/NMP4 Develop an Attenuated Form of K/BxN-Serum Induced Arthritis.
Nakamoto T, Izu Y, Kawasaki M, Notomi T, Hayata T, Noda M, Ezura Y. | 10/29/2016 |
| Nmp4/CIZ limits the parathyroid hormone anabolic window by restricting the number of bone marrow stem, progenitor, and blood cells that support anabolic bone remodeling. | Nmp4/CIZ suppresses the parathyroid hormone anabolic window by restricting mesenchymal stem cell and osteoprogenitor frequency.
He Y, Childress P, Hood M Jr, Alvarez M, Kacena MA, Hanlon M, McKee B, Bidwell JP, Yang FC., Free PMC Article | 06/29/2013 |
| The CIZ/NMP4 expression levels are correlated to the metastatic activity in divergent types of melanoma cells. | CIZ/NMP4 is expressed in B16 melanoma and forms a positive feedback loop with RANKL to promote migration of the melanoma cells.
Sakuma T, Nakamoto T, Hemmi H, Kitazawa S, Kitazawa R, Notomi T, Hayata T, Ezura Y, Amagasa T, Noda M. | 07/21/2012 |
| Together these results provide experimental support for the concept that Nmp4/CIZ plays an inhibitory role in the response of bone cells to mechanical stimulation induced by OFSS. | Nmp4/CIZ inhibits mechanically induced beta-catenin signaling activity in osteoblasts.
Yang Z, Bidwell JP, Young SR, Gerard-O'Riley R, Wang H, Pavalko FM., Free PMC Article | 05/10/2010 |
| Nmp4/CIZ within the context of the PTH-induced anabolic response is described. | Nmp4/CIZ: road block at the intersection of PTH and load.
Childress P, Robling AG, Bidwell JP., Free PMC Article | 05/3/2010 |
| Nmp4 contributes to fluid shear stress induced MMP13 gene induction in osteoblasts. | Nmp4/CIZ contributes to fluid shear stress induced MMP-13 gene induction in osteoblasts.
Charoonpatrapong-Panyayong K, Shah R, Yang J, Alvarez M, Pavalko FM, Gerard-O'Riley R, Robling AG, Templeton E, Bidwell JP. | 03/18/2010 |
| Histomorphometric analysis revealed that unloading suppressed the levels of osteoblastic bone formation parameters, and such suppression of bone formation parameters was blocked by CIZ-deficiency. | Deficiency of CIZ, a nucleocytoplasmic shuttling protein, prevents unloading-induced bone loss through the enhancement of osteoblastic bone formation in vivo.
Hino K, Nakamoto T, Nifuji A, Morinobu M, Yamamoto H, Ezura Y, Noda M. | 03/18/2010 |
| localization in the cytoplasm of osteoblasts | Osteoblast intracellular localization of Nmp4 proteins.
Torrungruang K, Shah R, Alvarez M, Bowen DK, Gerard R, Pavalko FM, Elmendorf JS, Charoonpatrapong K, Hock J, Rhodes SJ, Bidwell JP. | 03/18/2010 |
| Impaired spermatogenesis and male infertility occurred in Nmp4-disrupted mice. | Impaired spermatogenesis and male fertility defects in CIZ/Nmp4-disrupted mice.
Nakamoto T, Shiratsuchi A, Oda H, Inoue K, Matsumura T, Ichikawa M, Saito T, Seo S, Maki K, Asai T, Suzuki T, Hangaishi A, Yamagata T, Aizawa S, Noda M, Nakanishi Y, Hirai H. | 03/18/2010 |
| transformation of 3T3 fibroblasts by CIZ/NMP4 fusions is dependent on DNA-binding and might involve transactivation of CIZ target genes | Cellular transformation of NIH3T3 fibroblasts by CIZ/NMP4 fusions.
Corveleyn A, Janssen H, Martini A, Somers R, Cools J, Marynen P. | 03/18/2010 |
| Two adjacent promoters of Nmp4 P(1) [-2521 nucleotide (nt)/-597 nt] and P(2) (-2521 nt/+1 nt) initiate transcription of alternative first exons (U(1) and U(2)). | Two promoters control the mouse Nmp4/CIZ transcription factor gene.
Alvarez M, Shah R, Rhodes SJ, Bidwell JP. | 03/18/2010 |