| IDH2-NADPH pathway protects against acute pancreatitis via suppressing acinar cell ferroptosis. | IDH2-NADPH pathway protects against acute pancreatitis via suppressing acinar cell ferroptosis.
Peng Q, Li B, Song P, Wang R, Jiang J, Jin X, Shen J, Bao J, Ni J, Han X, Hu G. | 10/18/2024 |
| IDH2 regulates macrophage polarization and tumorigenesis by modulating mitochondrial metabolism in macrophages. | IDH2 regulates macrophage polarization and tumorigenesis by modulating mitochondrial metabolism in macrophages.
Lee SW, Kim S, Kim B, Seong JB, Park YH, Lee HJ, Choi DK, Yeom E, Lee DS., Free PMC Article | 09/18/2024 |
| Enhancement of de novo lipogenesis by the IDH1 and IDH2-dependent reverse TCA cycle maintains the growth and angiogenic capacity of bone marrow-derived endothelial progenitor cells under hypoxia. | Enhancement of de novo lipogenesis by the IDH1 and IDH2-dependent reverse TCA cycle maintains the growth and angiogenic capacity of bone marrow-derived endothelial progenitor cells under hypoxia.
He Q, Yu T, Chen J, Liang J, Lin D, Yan K, Xie Z, Song Y, Chen Z. | 02/22/2024 |
| Hepatic IDH2 regulates glycolysis and gluconeogenesis. | Hepatic IDH2 regulates glycolysis and gluconeogenesis.
Wang H, Xiong Q, He G, Tang J, Sun L, Cheng S, Ke M, Chen S, Hu Y, Feng J, Song L, Tong B, Zhang Z, Dai Z, Xu Y. | 05/4/2023 |
| IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment. | IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment.
Leca J, Lemonnier F, Meydan C, Foox J, El Ghamrasni S, Mboumba DL, Duncan GS, Fortin J, Sakamoto T, Tobin C, Hodgson K, Haight J, Smith LK, Elia AJ, Butler D, Berger T, de Leval L, Mason CE, Melnick A, Gaulard P, Mak TW. | 02/23/2023 |
| Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells. | Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells.
Fortin J, Chiang MF, Meydan C, Foox J, Ramachandran P, Leca J, Lemonnier F, Li WY, Gams MS, Sakamoto T, Chu M, Tobin C, Laugesen E, Robinson TM, You-Ten A, Butler DJ, Berger T, Minden MD, Levine RL, Guidos CJ, Melnick AM, Mason CE, Mak TW., Free PMC Article | 01/28/2023 |
| Nrf2 transcriptional upregulation of IDH2 to tune mitochondrial dynamics and rescue angiogenic function of diabetic EPCs. | Nrf2 transcriptional upregulation of IDH2 to tune mitochondrial dynamics and rescue angiogenic function of diabetic EPCs.
Dai X, Wang K, Fan J, Liu H, Fan X, Lin Q, Chen Y, Chen H, Li Y, Liu H, Chen O, Chen J, Li X, Ren D, Li J, Conklin DJ, Wintergerst KA, Li Y, Cai L, Deng Z, Yan X, Tan Y., Free PMC Article | 10/8/2022 |
| SIRT5 alleviates hepatic ischemia and reperfusion injury by diminishing oxidative stress and inflammation via elevating SOD1 and IDH2 expression. | SIRT5 alleviates hepatic ischemia and reperfusion injury by diminishing oxidative stress and inflammation via elevating SOD1 and IDH2 expression.
Zheng D, Qiwen Zeng, He D, He Y, Yang J. | 09/24/2022 |
| Oncogenesis induced by combined Phf6 and Idh2 mutations through increased oncometabolites and impaired DNA repair. | Oncogenesis induced by combined Phf6 and Idh2 mutations through increased oncometabolites and impaired DNA repair.
Chen TC, Yao CY, Chen YR, Yuan CT, Lin CC, Hsu YC, Chuang PH, Kao CJ, Li YH, Hou HA, Chou WC, Tien HF. | 04/30/2022 |
| Meta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models. | Meta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models.
Schulten HJ, Al-Adwani F, Saddeq HAB, Alkhatabi H, Alganmi N, Karim S, Hussein D, Al-Ghamdi KB, Jamal A, Al-Maghrabi J, Al-Qahtani MH., Free PMC Article | 02/26/2022 |
| Hypertrophic preconditioning attenuates post-myocardial infarction injury through deacetylation of isocitrate dehydrogenase 2. | Hypertrophic preconditioning attenuates post-myocardial infarction injury through deacetylation of isocitrate dehydrogenase 2.
Ma LL, Kong FJ, Ma YJ, Guo JJ, Wang SJ, Dong Z, Sun AJ, Zou YZ, Ge JB., Free PMC Article | 02/5/2022 |
| Cancer-associated IDH mutations induce Glut1 expression and glucose metabolic disorders through a PI3K/Akt/mTORC1-Hif1alpha axis. | Cancer-associated IDH mutations induce Glut1 expression and glucose metabolic disorders through a PI3K/Akt/mTORC1-Hif1α axis.
Liu X, Yamaguchi K, Takane K, Zhu C, Hirata M, Hikiba Y, Maeda S, Furukawa Y, Ikenoue T., Free PMC Article | 11/22/2021 |
| Oxidative stress following acute kidney injury causes disruption of lung cell cilia and their release into the bronchoaveolar lavage fluid and lung injury, which are exacerbated by Idh2 deletion. | Oxidative stress following acute kidney injury causes disruption of lung cell cilia and their release into the bronchoaveolar lavage fluid and lung injury, which are exacerbated by Idh2 deletion.
Han YK, Kim JS, Lee GB, Lim JH, Park KM., Free PMC Article | 10/30/2021 |
| AMPKalpha1 regulates Idh2 transcription through H2B O-GlcNAcylation during brown adipogenesis. | AMPKα1 regulates Idh2 transcription through H2B O-GlcNAcylation during brown adipogenesis.
Cao Y, Liu X, Zhao J, Du M. | 06/19/2021 |
| SUMOylation enhances the activity of IDH2 under oxidative stress. | SUMOylation enhances the activity of IDH2 under oxidative stress.
Yu Y, Chen Y, Liu K, Cheng J, Tu J. | 03/13/2021 |
| IDH2 Deficiency Is Critical in Myogenesis and Fatty Acid Metabolism in Mice Skeletal Muscle. | IDH2 Deficiency Is Critical in Myogenesis and Fatty Acid Metabolism in Mice Skeletal Muscle.
Pan JH, Tang J, Kim YJ, Lee JH, Shin EC, Zhao J, Kim KH, Hwang KA, Huang Y, Kim JK., Free PMC Article | 02/20/2021 |
| Reactive oxygen species-mediated senescence is accelerated by inhibiting Cdk2 in Idh2-deficient conditions. | Reactive oxygen species-mediated senescence is accelerated by inhibiting Cdk2 in Idh2-deficient conditions.
Chae U, Park JW, Lee SR, Lee HJ, Lee HS, Lee DS., Free PMC Article | 09/5/2020 |
| IDH2 deficiency increases bone mass with reduced osteoclastogenesis by limiting RANKL expression in osteoblasts. | IDH2 deficiency increases bone mass with reduced osteoclastogenesis by limiting RANKL expression in osteoblasts.
Lee SH, Lee SH, Lee JH, Park JW, Kim JE. | 08/29/2020 |
| these results established IDH2 as a critical suppressor of steatohepatitis | IDH2 protects against nonalcoholic steatohepatitis by alleviating dyslipidemia regulated by oxidative stress.
Gong F, Gao L, Ding T. | 06/20/2020 |
| IDH2 deficiency delayed cutaneous wound healing and impaired dermal fibroblast function. | IDH2 deficiency impairs cutaneous wound healing via ROS-dependent apoptosis.
Kim SH, Park JW. | 05/30/2020 |
| One of the PCAF targets is the isocitrate dehydrogenase 2 (IDH2) acetylated at lysine 180. | P300/CBP-associated factor regulates transcription and function of isocitrate dehydrogenase 2 during muscle differentiation.
Savoia M, Cencioni C, Mori M, Atlante S, Zaccagnini G, Devanna P, Di Marcotullio L, Botta B, Martelli F, Zeiher AM, Pontecorvi A, Farsetti A, Spallotta F, Gaetano C. | 05/9/2020 |
| Cisplatin induces the impairment of the mitochondrial IDH2-NADPH-GSH antioxidant system and IDH2 deficiency aggravates cisplatin-induced mitochondrial oxidative damage, inducing more severe nephrotoxicity. | Mitochondrial NADP(+)-dependent isocitrate dehydrogenase deficiency increases cisplatin-induced oxidative damage in the kidney tubule cells.
Kong MJ, Han SJ, Kim JI, Park JW, Park KM., Free PMC Article | 04/4/2020 |
| IDH2 KO caused a decrease in hepatic de novo lipogenesis via the activation of the fatty acid beta-oxidation process. | Hepatic Transcriptomics Reveals that Lipogenesis Is a Key Signaling Pathway in Isocitrate Dehydrogenase 2 Deficient Mice.
Pan JH, Tang J, Redding MC, Beane KE, Conner CL, Cho YJ, Zhao J, Kim JH, Kong BC, Lee JH, Kim JK., Free PMC Article | 02/15/2020 |
| This was accompanied by decreased NADPH redox state and decreased activity of TXNRD2 in the mitochondria of the HEI-OC1 cells. Therefore, IDH2 functions as the principal source of NADPH for the mitochondrial thioredoxin antioxidant defense and plays an essential role in protecting hair cells and neurons against oxidative stress in the cochlea of male mice. | Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice.
White K, Kim MJ, Han C, Park HJ, Ding D, Boyd K, Walker L, Linser P, Meneses Z, Slade C, Hirst J, Santostefano K, Terada N, Miyakawa T, Tanokura M, Salvi R, Someya S., Free PMC Article | 10/5/2019 |
| The IDH2 deficiency induced endothelial inflammation via p66shc-mediated mitochondrial oxidative stress. | Isocitrate dehydrogenase 2 deficiency induces endothelial inflammation via p66sh-mediated mitochondrial oxidative stress.
Choi SJ, Piao S, Nagar H, Jung SB, Kim S, Lee I, Kim SM, Song HJ, Shin N, Kim DW, Irani K, Jeon BH, Park JW, Kim CS. | 03/16/2019 |