| Interferon Regulatory Factor 5 Regulates the Phagocytosis of Microglia and Alleviate Alzheimer's Pathology. | Interferon Regulatory Factor 5 Regulates the Phagocytosis of Microglia and Alleviate Alzheimer's Pathology.
Fan Z, Zhang X, Zhao S, Zhong S, Li Z, Yan Y, Zhang B, Chen Y. | 03/19/2024 |
| The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection. | The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection.
Pereira M, Ramalho T, Andrade WA, Durso DF, Souza MC, Fitzgerald KA, Golenbock DT, Silverman N, Gazzinelli RT., Free PMC Article | 03/5/2024 |
| The TLR7/IRF-5 axis sensitizes memory CD4+ T cells to Fas-mediated apoptosis during HIV-1 infection. | The TLR7/IRF-5 axis sensitizes memory CD4+ T cells to Fas-mediated apoptosis during HIV-1 infection.
Carmona-Pérez L, Dagenais-Lussier X, Mai LT, Stögerer T, Swaminathan S, Isnard S, Rice MR, Barnes BJ, Routy JP, van Grevenynghe J, Stäger S., Free PMC Article | 07/12/2023 |
| Early macrophage response to obesity encompasses Interferon Regulatory Factor 5 regulated mitochondrial architecture remodelling. | Early macrophage response to obesity encompasses Interferon Regulatory Factor 5 regulated mitochondrial architecture remodelling.
Orliaguet L, Ejlalmanesh T, Humbert A, Ballaire R, Diedisheim M, Julla JB, Chokr D, Cuenco J, Michieletto J, Charbit J, Lindén D, Boucher J, Potier C, Hamimi A, Lemoine S, Blugeon C, Legoix P, Lameiras S, Baudrin LG, Baulande S, Soprani A, Castelli FA, Fenaille F, Riveline JP, Dalmas E, Rieusset J, Gautier JF, Venteclef N, Alzaid F., Free PMC Article | 09/17/2022 |
| microRNA-144/451 decreases dendritic cell bioactivity via targeting interferon-regulatory factor 5 to limit DSS-induced colitis. | microRNA-144/451 decreases dendritic cell bioactivity via targeting interferon-regulatory factor 5 to limit DSS-induced colitis.
Lin Z, Xie X, Gu M, Chen Q, Lu G, Jia X, Xiao W, Zhang J, Yu D, Gong W., Free PMC Article | 09/3/2022 |
| Interferon regulatory factor-5-dependent CD11c+ macrophages contribute to the formation of rupture-prone atherosclerotic plaques. | Interferon regulatory factor-5-dependent CD11c+ macrophages contribute to the formation of rupture-prone atherosclerotic plaques.
Edsfeldt A, Swart M, Singh P, Dib L, Sun J, Cole JE, Park I, Al-Sharify D, Persson A, Nitulescu M, Borges PDN, Kassiteridi C, Goddard ME, Lee R, Volkov P, Orho-Melander M, Maegdefessel L, Nilsson J, Udalova I, Goncalves I, Monaco C., Free PMC Article | 05/28/2022 |
| Interferon Regulatory Factor-5 in Resident Macrophage Promotes Polycystic Kidney Disease. | Interferon Regulatory Factor-5 in Resident Macrophage Promotes Polycystic Kidney Disease.
Zimmerman KA, Huang J, He L, Revell DZ, Li Z, Hsu JS, Fitzgibbon WR, Hazard ES, Hardiman G, Mrug M, Bell PD, Yoder BK, Saigusa T., Free PMC Article | 04/9/2022 |
| Myeloid cell-specific Irf5 deficiency stabilizes atherosclerotic plaques in Apoe(-/-) mice. | Myeloid cell-specific Irf5 deficiency stabilizes atherosclerotic plaques in Apoe(-/-) mice.
Leipner J, Dederichs TS, von Ehr A, Rauterberg S, Ehlert C, Merz J, Dufner B, Hoppe N, Krebs K, Heidt T, von Zur Muehlen C, Stachon P, Ley K, Wolf D, Zirlik A, Bode C, Hilgendorf I, Härdtner C., Free PMC Article | 03/26/2022 |
| One gut microbiota, Fusobacterium nucleatum aggravates Neonatal necrotizing enterocolitis by induction of IRF5 expression through lncRNA ENO1-IT1/miR-22-3p axis. | One gut microbiota, Fusobacterium nucleatum aggravates Neonatal necrotizing enterocolitis by induction of IRF5 expression through lncRNA ENO1-IT1/miR-22-3p axis.
Lin JC, Ma XY, Liu JY, Luo YZ, Lin L, Zhang LY. | 03/5/2022 |
| Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation. | Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation.
Ryzhakov G, Almuttaqi H, Corbin AL, Berthold DL, Khoyratty T, Eames HL, Bullers S, Pearson C, Ai Z, Zec K, Bonham S, Fischer R, Jostins-Dean L, Travis SPL, Kessler BM, Udalova IA., Free PMC Article | 01/1/2022 |
| Transforming Growth Factor-beta1 Promotes M1 Alveolar Macrophage Polarization in Acute Lung Injury by Up-Regulating DNMT1 to Mediate the microRNA-124/PELI1/IRF5 Axis. | Transforming Growth Factor-β1 Promotes M1 Alveolar Macrophage Polarization in Acute Lung Injury by Up-Regulating DNMT1 to Mediate the microRNA-124/PELI1/IRF5 Axis.
Wang Y, Wang X, Zhang H, Han B, Ye Y, Zhang M, Wang Y, Xue J, Wang C., Free PMC Article | 10/23/2021 |
| miR-31 from adipose stem cell-derived extracellular vesicles promotes recovery of neurological function after ischemic stroke by inhibiting TRAF6 and IRF5. | miR-31 from adipose stem cell-derived extracellular vesicles promotes recovery of neurological function after ischemic stroke by inhibiting TRAF6 and IRF5.
Lv H, Li J, Che Y. | 10/16/2021 |
| IRF5 regulates airway macrophage metabolic responses. | IRF5 regulates airway macrophage metabolic responses.
Albers GJ, Iwasaki J, McErlean P, Ogger PP, Ghai P, Khoyratty TE, Udalova IA, Lloyd CM, Byrne AJ., Free PMC Article | 10/2/2021 |
| The absence of oestrogen receptor beta disturbs collagen I type deposition during Achilles tendon healing by regulating the IRF5-CCL3 axis. | The absence of oestrogen receptor beta disturbs collagen I type deposition during Achilles tendon healing by regulating the IRF5-CCL3 axis.
Bian X, Liu T, Yang M, Gu C, He G, Zhou M, Tang H, Lu K, Lai F, Wang F, Yang Q, Gustafsson JÅ, Fan X, Tang K., Free PMC Article | 09/18/2021 |
| Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease. | Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease.
Ban T, Kikuchi M, Sato GR, Manabe A, Tagata N, Harita K, Nishiyama A, Nishimura K, Yoshimi R, Kirino Y, Yanai H, Matsumoto Y, Suzuki S, Hihara H, Ito M, Tsukahara K, Yoshimatsu K, Yamamoto T, Taniguchi T, Nakajima H, Ito S, Tamura T., Free PMC Article | 08/7/2021 |
| Interferon Regulatory Factor 5 Mediates Lipopolysaccharide-Induced Neuroinflammation. | Interferon Regulatory Factor 5 Mediates Lipopolysaccharide-Induced Neuroinflammation.
Fan Z, Zhao S, Zhu Y, Li Z, Liu Z, Yan Y, Tian J, Chen Y, Zhang B., Free PMC Article | 06/19/2021 |
| T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation. | T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation.
Yan J, Pandey SP, Barnes BJ, Turner JR, Abraham C., Free PMC Article | 05/1/2021 |
| Myeloid Cell-Intrinsic IRF5 Promotes T Cell Responses through Multiple Distinct Checkpoints In Vivo, and IRF5 Immune-Mediated Disease Risk Variants Modulate These Myeloid Cell Functions. | Myeloid Cell-Intrinsic IRF5 Promotes T Cell Responses through Multiple Distinct Checkpoints In Vivo, and IRF5 Immune-Mediated Disease Risk Variants Modulate These Myeloid Cell Functions.
Yan J, Hedl M, Abraham C., Free PMC Article | 03/27/2021 |
| Exacerbated Imiquimod-Induced Psoriasis-Like Skin Inflammation in IRF5-Deficient Mice. | Exacerbated Imiquimod-Induced Psoriasis-Like Skin Inflammation in IRF5-Deficient Mice.
Nakao M, Miyagaki T, Sugaya M, Sato S., Free PMC Article | 02/20/2021 |
| Inhibition of IRF5 hyperactivation protects from lupus onset and severity. | Inhibition of IRF5 hyperactivation protects from lupus onset and severity.
Song S, De S, Nelson V, Chopra S, LaPan M, Kampta K, Sun S, He M, Thompson CD, Li D, Shih T, Tan N, Al-Abed Y, Capitle E, Aranow C, Mackay M, Clapp WL, Barnes BJ., Free PMC Article | 02/20/2021 |
| IRF5 guides monocytes toward an inflammatory CD11c(+) macrophage phenotype and promotes intestinal inflammation. | IRF5 guides monocytes toward an inflammatory CD11c(+) macrophage phenotype and promotes intestinal inflammation.
Corbin AL, Gomez-Vazquez M, Berthold DL, Attar M, Arnold IC, Powrie FM, Sansom SN, Udalova IA., Free PMC Article | 01/2/2021 |
| IRF-5 Expression in Myeloid Cells Is Required for Splenomegaly in L. donovani Infected Mice. | IRF-5 Expression in Myeloid Cells Is Required for Splenomegaly in L. donovani Infected Mice.
Mai LT, Smans M, Silva-Barrios S, Fabié A, Stäger S., Free PMC Article | 11/21/2020 |
| M2 macrophages (MPhi) are suggested to be more efficient osteoclast precursors than M1 MPhi because of the attenuated expression of IRF5. | Modulation of macrophage subtypes by IRF5 determines osteoclastogenic potential.
Yang J, Park OJ, Kim J, Kwon Y, Yun CH, Han SH. | 06/13/2020 |
| A novel role of TRAF5 in skin wound healing that is mediated by IRF5-dependent function of pDCs. | TNF Receptor-Associated Factor 5 Limits Function of Plasmacytoid Dendritic Cells by Controlling IFN Regulatory Factor 5 Expression.
Kobayashi S, Sakurai T, So T, Shiota Y, Asao A, Phung HT, Tanaka R, Kawabe T, Maruyama T, Kanno E, Kawakami K, Owada Y, Ishii N. | 05/16/2020 |
| MyD88-dependent influx of monocytes and neutrophils impairs lymph node B cell responses via Irf5, Nos2 and Nox2 during chikungunya virus infection. | MyD88-dependent influx of monocytes and neutrophils impairs lymph node B cell responses to chikungunya virus infection via Irf5, Nos2 and Nox2.
McCarthy MK, Reynoso GV, Winkler ES, Mack M, Diamond MS, Hickman HD, Morrison TE., Free PMC Article | 05/9/2020 |