| GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension. | GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension.
Zhu MM, Dai J, Dai Z, Peng Y, Zhao YY., Free PMC Article | 10/31/2024 |
| GCN2 drives diurnal patterns in the hepatic integrated stress response and maintains circadian rhythms in whole body metabolism during amino acid insufficiency. | GCN2 drives diurnal patterns in the hepatic integrated stress response and maintains circadian rhythms in whole body metabolism during amino acid insufficiency.
Levy JL, Mirek ET, Rodriguez EM, Tolentino MJ, Zalma BA, Roepke TA, Wek RC, Cao R, Anthony TG., | 10/7/2024 |
| Computational modeling of the synergistic role of GCN2 and the HPA axis in regulating the integrated stress response in the central circadian timing system. | Computational modeling of the synergistic role of GCN2 and the HPA axis in regulating the integrated stress response in the central circadian timing system.
Li Y, Lu L, Levy JL, Anthony TG, Androulakis IP. | 07/22/2024 |
| GCN2 is required to maintain core body temperature in mice during acute cold. | GCN2 is required to maintain core body temperature in mice during acute cold.
Levy JL, Mirek ET, Rodriguez EM, Zalma B, Burns J, Jonsson WO, Sampath H, Staschke KA, Wek RC, Anthony TG., Free PMC Article | 03/20/2024 |
| Role of liver AMPK and GCN2 kinases in the control of postprandial protein metabolism in response to mid-term high or low protein intake in mice. | Role of liver AMPK and GCN2 kinases in the control of postprandial protein metabolism in response to mid-term high or low protein intake in mice.
Chalvon-Demersay T, Gaudichon C, Moro J, Even PC, Khodorova N, Piedcoq J, Viollet B, Averous J, Maurin AC, Tomé D, Foretz M, Fafournoux P, Azzout-Marniche D. | 02/11/2023 |
| The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1). | The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1).
Farooq Z, Kusuma F, Burke P, Dufour CR, Lee D, Tabatabaei N, Toboz P, Radovani E, Greenblatt JF, Rehman J, Class J, Khoutorsky A, Fonseca BD, Richner JM, Mercier E, Bourque G, Giguère V, Subramaniam AR, Han J, Tahmasebi S., Free PMC Article | 10/22/2022 |
| The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages. | The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages.
Toboz P, Amiri M, Tabatabaei N, Dufour CR, Kim SH, Fillebeen C, Ayemoba CE, Khoutorsky A, Nairz M, Shao L, Pajcini KV, Kim KW, Giguère V, Oliveira RL, Constante M, Santos MM, Morales CR, Pantopoulos K, Sonenberg N, Pinho S, Tahmasebi S., Free PMC Article | 08/27/2022 |
| GCN2 adapts protein synthesis to scavenging-dependent growth. | GCN2 adapts protein synthesis to scavenging-dependent growth.
Nofal M, Wang T, Yang L, Jankowski CSR, Hsin-Jung Li S, Han S, Parsons L, Frese AN, Gitai Z, Anthony TG, Wühr M, Sabatini DM, Rabinowitz JD., Free PMC Article | 04/30/2022 |
| Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: Involvement of NRF2 regulation. | Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: Involvement of NRF2 regulation.
Yuan J, Yu Z, Gao J, Luo K, Shen X, Cui B, Lu Z., Free PMC Article | 03/12/2022 |
| Intermittent Leucine Deprivation Produces Long-lasting Improvement in Insulin Sensitivity by Increasing Hepatic Gcn2 Expression. | Intermittent Leucine Deprivation Produces Long-lasting Improvement in Insulin Sensitivity by Increasing Hepatic Gcn2 Expression.
Yin H, Yuan F, Jiao F, Niu Y, Jiang X, Deng J, Guo Y, Chen S, Zhai Q, Hu C, Li Y, Guo F. | 02/26/2022 |
| The Role of Indoleamine 2,3-Dioxygenase in Renal Tubular Epithelial Cells Senescence under Anoxia or Reoxygenation. | The Role of Indoleamine 2,3-Dioxygenase in Renal Tubular Epithelial Cells Senescence under Anoxia or Reoxygenation.
Eleftheriadis T, Pissas G, Filippidis G, Liakopoulos V, Stefanidis I., Free PMC Article | 01/22/2022 |
| IDO1 Signaling through GCN2 in a Subpopulation of Gr-1(+) Cells Shifts the IFNgamma/IL6 Balance to Promote Neovascularization. | IDO1 Signaling through GCN2 in a Subpopulation of Gr-1(+) Cells Shifts the IFNγ/IL6 Balance to Promote Neovascularization.
Dey S, Mondal A, DuHadaway JB, Sutanto-Ward E, Laury-Kleintop LD, Thomas S, Prendergast GC, Mandik-Nayak L, Muller AJ. | 01/8/2022 |
| The eIF2 kinase GCN2 directs keratinocyte collective cell migration during wound healing via coordination of reactive oxygen species and amino acids. | The eIF2 kinase GCN2 directs keratinocyte collective cell migration during wound healing via coordination of reactive oxygen species and amino acids.
Miles RR, Amin PH, Diaz MB, Misra J, Aukerman E, Das A, Ghosh N, Guith T, Knierman MD, Roy S, Spandau DF, Wek RC., Free PMC Article | 12/18/2021 |
| Experimentally based structural model of Yih1 provides insight into its function in controlling the key translational regulator Gcn2. | Experimentally based structural model of Yih1 provides insight into its function in controlling the key translational regulator Gcn2.
Harjes E, Jameson GB, Tu YH, Burr N, Loo TS, Goroncy AK, Edwards PJB, Harjes S, Munro B, Göbl C, Sattlegger E, Norris GE. | 07/31/2021 |
| Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress. | Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress.
Misra J, Holmes MJ, T Mirek E, Langevin M, Kim HG, Carlson KR, Watford M, Dong XC, Anthony TG, Wek RC., Free PMC Article | 06/26/2021 |
| The Amino Acid Sensor Eif2ak4/GCN2 Is Required for Proliferation of Osteoblast Progenitors in Mice. | The Amino Acid Sensor Eif2ak4/GCN2 Is Required for Proliferation of Osteoblast Progenitors in Mice.
Hu G, Yu Y, Tang YJ, Wu C, Long F, Karner CM., Free PMC Article | 06/19/2021 |
| Branched chain amino acids exacerbate myocardial ischemia/reperfusion vulnerability via enhancing GCN2/ATF6/PPAR-alpha pathway-dependent fatty acid oxidation. | Branched chain amino acids exacerbate myocardial ischemia/reperfusion vulnerability via enhancing GCN2/ATF6/PPAR-α pathway-dependent fatty acid oxidation.
Li Y, Xiong Z, Yan W, Gao E, Cheng H, Wu G, Liu Y, Zhang L, Li C, Wang S, Fan M, Zhao H, Zhang F, Tao L., Free PMC Article | 05/15/2021 |
| GCN2 Deficiency Enhances Protective Effects of Exercise on Hepatic Steatosis. | GCN2 Deficiency Enhances Protective Effects of Exercise on Hepatic Steatosis.
Luo X, Shi X, Sun Z, Xiao J, Song H, Lu G, Xu X., Free PMC Article | 05/8/2021 |
| Activation of GCN2/ATF4 signals in amygdalar PKC-delta neurons promotes WAT browning under leucine deprivation. | Activation of GCN2/ATF4 signals in amygdalar PKC-δ neurons promotes WAT browning under leucine deprivation.
Yuan F, Jiang H, Yin H, Jiang X, Jiao F, Chen S, Ying H, Chen Y, Zhai Q, Guo F., Free PMC Article | 08/22/2020 |
| These findings indicated that GCN2 suppression alleviated apoptosis and endoplasmic reticulum stress in cerebral ischemia through reducing FoxO3a-dependent reactive oxygen species production. | GCN2 suppression attenuates cerebral ischemia in mice by reducing apoptosis and endoplasmic reticulum (ER) stress through the blockage of FoxO3a-regulated ROS production.
Shi WZ, Tian Y, Li J. | 07/18/2020 |
| Our results reveal a novel role of GCN2 in TH9 cell differentiation | The amino acid sensor general control nonderepressible 2 (GCN2) controls T(H)9 cells and allergic airway inflammation.
Wang P, Xu Y, Zhang J, Shi L, Lei T, Hou Y, Lu Z, Zhao Y. | 06/20/2020 |
| The eukaryotic translation initiation factor 2alpha (eIF2alpha) kinase GCN2 is activated by amino acid starvation to elicit a rectifying physiological program known as the Integrated Stress Response (ISR). | The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells.
Harding HP, Ordonez A, Allen F, Parts L, Inglis AJ, Williams RL, Ron D., Free PMC Article | 05/30/2020 |
| Hepatic GCN2 controls FGF21 secretion under a low-protein diet and modulates a whole body postprandial oxidation profile. | Liver GCN2 controls hepatic FGF21 secretion and modulates whole body postprandial oxidation profile under a low-protein diet.
Chalvon-Demersay T, Moro J, Even PC, Chaumontet C, Tomé D, Averous J, Piedcoq J, Gaudichon C, Maurin AC, Fafournoux P, Azzout-Marniche D. | 04/18/2020 |
| results indicate that IMPACT contributes to GCN2-dependent and -independent mechanisms involved in the regulation of autonomic functions in response to energy availability. | The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control.
Pereira CM, Filev R, Dubiela FP, Brandão BB, Queiroz CM, Ludwig RG, Hipolide D, Longo BM, Mello LE, Mori MA, Castilho BA., Free PMC Article | 02/29/2020 |
| Results find that GCN2 gene deficiency improved inflammation and cardiac dysfunction suggesting its role in inflammation and cardiac disease. | Exercise Preconditioning Protects against Acute Cardiac Injury Induced by Lipopolysaccharide Through General Control Nonderepressible 2 Kinase.
Sun ZG, Lu G, Zhao LL, Zhang LZ, Li A, Jing J, Xu X. | 02/22/2020 |