| Tlx3 controls the development of C-low threshold mechanoreceptors. | Tlx3 controls the development of C-low threshold mechanoreceptors.
Wang H, Cao Z, Jiang X, Huang C, Cao C, Liu Z. | 09/24/2022 |
| Ectopic expression of TLX3 alone caused partially penetrant leukemia. TLX3 expression and loss of PHF6 combined caused fully penetrant early-onset leukemia. | PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia.
McRae HM, Garnham AL, Hu Y, Witkowski MT, Corbett MA, Dixon MP, May RE, Sheikh BN, Chiang W, Kueh AJ, Nguyen TA, Man K, Gloury R, Aubrey BJ, Policheni A, Di Rago L, Alexander WS, Gray DHD, Strasser A, Hawkins ED, Wilcox S, Gécz J, Kallies A, McCormack MP, Smyth GK, Voss AK, Thomas T., Free PMC Article | 12/28/2019 |
| These results demonstrate a novel role for Tlx3 and indicate that Pax6-Tlx3 expression and interaction is part of a region specific regulatory network in cerebellum and its deregulation during development could possibly lead to Autistic spectral disorders (ASD). | Regulation of Tlx3 by Pax6 is required for the restricted expression of Chrnα3 in Cerebellar Granule Neuron progenitors during development.
Divya TS, Lalitha S, Parvathy S, Subashini C, Sanalkumar R, Dhanesh SB, Rasheed VA, Divya MS, Tole S, James J., Free PMC Article | 04/14/2018 |
| Tlx3 promotes glutamatergic neuronal subtype specification through direct interactions with the chromatin modifier CBP. | Tlx3 promotes glutamatergic neuronal subtype specification through direct interactions with the chromatin modifier CBP.
Shimomura A, Patel D, Wilson SM, Koehler KR, Khanna R, Hashino E., Free PMC Article | 05/14/2016 |
| Tlx3 uses distinct mechanisms to tightly modulate Prrxl1 activity, either by controlling its transcriptional levels or by increasing Prrxl1 phosphorylation state. | Dual role of Tlx3 as modulator of Prrxl1 transcription and phosphorylation.
Regadas I, Soares-Dos-Reis R, Falcão M, Matos MR, Monteiro FA, Lima D, Reguenga C. | 01/17/2015 |
| The tlx2 knockout mice failed to exhibit escape response evoked by dynamic mechanical stimuli but retained the ability to sense innocuous cooling and/or warm and development of a subset of excitatory neurons located in laminae I and II was impaired. | Ontogeny of excitatory spinal neurons processing distinct somatic sensory modalities.
Xu Y, Lopes C, Wende H, Guo Z, Cheng L, Birchmeier C, Ma Q., Free PMC Article | 12/7/2013 |
| Tlx3 is required for the acquisition of cholinergic phenotype at the late embryonic stage as well as the expression and maintenance of cholinergic peptides | Tlx3 controls cholinergic transmitter and Peptide phenotypes in a subset of prenatal sympathetic neurons.
Huang T, Hu J, Wang B, Nie Y, Geng J, Cheng L., Free PMC Article | 09/7/2013 |
| This study demonistrated that Tlx3 and Runx1 act in combination to coordinate the development of nociceptors, thermoceptors, and pruriceptors. | Tlx3 and Runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors.
Lopes C, Liu Z, Xu Y, Ma Q., Free PMC Article | 09/29/2012 |
| Tlx1/3 and Ptf1a, the key transcription factors for fate determination of glutamatergic and GABAergic neurons in the dorsal spinal cord | Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.
Guo Z, Zhao C, Huang M, Huang T, Fan M, Xie Z, Chen Y, Zhao X, Xia G, Geng J, Cheng L., Free PMC Article | 09/1/2012 |
| The sequential and coordinated expression of the proneural and neuronal subtype-specific genes identifies Tlx3 as a selector gene in ES cells undergoing neural differentiation | Tlx3 exerts context-dependent transcriptional regulation and promotes neuronal differentiation from embryonic stem cells.
Kondo T, Sheets PL, Zopf DA, Aloor HL, Cummins TR, Chan RJ, Hashino E., Free PMC Article | 01/21/2010 |
| This study found that Tlx3 was required for specification of, and expressed in, glutamatergic neurons. and ectopic expression of Tlx3 was sufficient to suppress GABAergic differentiation and induce formation of glutamatergic neurons. | Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates.
Cheng L, Arata A, Mizuguchi R, Qian Y, Karunaratne A, Gray PA, Arata S, Shirasawa S, Bouchard M, Luo P, Chen CL, Busslinger M, Goulding M, Onimaru H, Ma Q. | 01/21/2010 |
| Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes. | Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes.
Cheng L, Samad OA, Xu Y, Mizuguchi R, Luo P, Shirasawa S, Goulding M, Ma Q. | 01/21/2010 |