| RSK4 promotes the macrophage recruitment and M2 polarization in esophageal squamous cell carcinoma. | RSK4 promotes the macrophage recruitment and M2 polarization in esophageal squamous cell carcinoma.
He S, Lu M, Zhang L, Wang Z. | 02/22/2024 |
| Ribosomal S6 kinase 4 (RSK4) tumor suppressor gene promoter methylation status in ovarian cancer. | Ribosomal S6 kinase 4 (RSK4) tumor suppressor gene promoter methylation status in ovarian cancer.
Arechavaleta-Velasco F, Dominguez-Lopez P, Acosta-Jimenez E, Diaz-Cueto L. | 08/3/2023 |
| High RSK4 expression constitutes a predictor of poor prognosis for patients with clear cell renal carcinoma. | High RSK4 expression constitutes a predictor of poor prognosis for patients with clear cell renal carcinoma.
Ma J, Wang K, Chai J, Xu T, Wei J, Liu Y, Wang Y, Xu J, Li M, Fan L. | 03/5/2022 |
| RSK4: a new prognostic factor in glioma. | RSK4: a new prognostic factor in glioma.
Chen L, Xu T, Jia Q, Wang X, Li M, Liang G. | 05/15/2021 |
| Hypermethylation of the RSK4 promoter associated with BRAF V600E promotes papillary thyroid carcinoma. | Hypermethylation of the RSK4 promoter associated with BRAF V600E promotes papillary thyroid carcinoma.
Yin Y, Che K, Hu J, Hua H, Dong A, Wang J, Yu J, Zhang Q, Zhao S, Zhao Y, Wang P, Wang F, Wang Y, Chi J, Sun W. | 02/13/2021 |
| Ribosomal S6 protein kinase 4 promotes radioresistance in esophageal squamous cell carcinoma. | Ribosomal S6 protein kinase 4 promotes radioresistance in esophageal squamous cell carcinoma.
Li MY, Fan LN, Han DH, Yu Z, Ma J, Liu YX, Li PF, Zhao DH, Chai J, Jiang L, Li SL, Xiao JJ, Duan QH, Ye J, Shi M, Nie YZ, Wu KC, Liao DJ, Shi Y, Wang Y, Yan QG, Guo SP, Bian XW, Zhu F, Zhang J, Wang Z., Free PMC Article | 02/6/2021 |
| Overexpression of RSK4 reverses doxorubicin resistance in human breast cancer cells via PI3K/AKT signalling pathway. | Overexpression of RSK4 reverses doxorubicin resistance in human breast cancer cells via PI3K/AKT signalling pathway.
Mei Y, Liao X, Zhu L, Yang H. | 01/9/2021 |
| E2 signaling may therefore act upstream of RSK4 to promote cancer progression. The results obtained in the current study suggested that RSK4 inhibited breast cancer cell invasiveness and that RSK4 promoter hypomethylation may serve as a novel prognostic marker for patients with breast cancer. | RSK4 inhibits breast cancer cell proliferation and invasion in vitro, and is correlated with estrogen receptor upregulation in breast cancer.
Huo H, Ye X, Yang H, Li Q, Jiang Y. | 04/4/2020 |
| High expression of RSK4 is associated with colorectal cancer. | Effect of RSK4 on biological characteristics of colorectal cancer.
Ye Q, Wang X, Jin M, Wang M, Hu Y, Yu S, Yang Y, Yang J, Cai J., Free PMC Article | 01/5/2019 |
| RSK4 constitutes a putative tumor suppressor gene for non-small cell lung carcinoma. | A Pilot Study of RSK4 Expression in Patients with Human Non-Small Cell Lung Carcinoma.
Li A, Liu D, Liu Y, Zhou Y, Du Z, Song J. | 11/17/2018 |
| The regulatory role of RSK4 in breast cancer development was mediated by AKT and extracellular signalregulated kinase (ERK) signaling pathways and the expression of RSK4 was altered by DNA methylation in promoter regions. | Aberrant expression of RSK4 in breast cancer and its role in the regulation of tumorigenicity.
Jiang Y, Ye X, Ji Y, Zhou X, Yang H, Wei W, Li Q. | 04/21/2018 |
| RSK4 is expressed at low levels in malignant ovarian tumors, which correlates with advanced stages of the disease. | Ribosomal S6 kinase 4 (RSK4) expression in ovarian tumors and its regulation by antineoplastic drugs in ovarian cancer cell lines.
Arechavaleta-Velasco F, Zeferino-Toquero M, Estrada-Moscoso I, Imani-Razavi FS, Olivares A, Perez-Juarez CE, Diaz-Cueto L. | 10/8/2016 |
| downregulation of RSK4 expression is indicated to be associated with tumor cell proliferation and invasion, and silencing of the RSK4 may be involved in the development and progression of breast cancer | RSK4 knockdown promotes proliferation, migration and metastasis of human breast adenocarcinoma cells.
Zhu J, Li QY, Liu JL, Wei W, Yang HW, Tang W. | 08/13/2016 |
| Low RSK4 expression is correlated with advanced clinical pathologic classifications and is a poor overall survival in colorectal cancer patients | Low expression of RSK4 predicts poor prognosis in patients with colorectal cancer.
Cai J, Ma H, Huang F, Zhu D, Zhao L, Yang Y, Bi J, Zhang T., Free PMC Article | 06/20/2015 |
| RSK4 mRNA is significantly decreased in most of breast cancer tissues compared with paired non-cancerous tissues, due to promoter hypermethylation; frequent epigenetic inactivation might have a role in precancerous lesions or early cancer | Frequent epigenetic inactivation of RSK4 by promoter methylation in cancerous and non-cancerous tissues of breast cancer.
Li Q, Jiang Y, Wei W, Ji Y, Gao H, Liu J. | 07/26/2014 |
| evaluated expression of RSK4 in renal cell carcinoma(RCC)tissues, analysed relationship between RSK4 expression and clinicopathological features of RCC patients and explored potential molecular mechanisms of RSK4 in RCC cell lines; expression pattern and molecular mechanisms of RSK4 in RCCs indicate it could be a potential independent prognostic factor | Ribosomal s6 protein kinase 4: a prognostic factor for renal cell carcinoma.
Fan L, Li P, Yin Z, Fu G, Liao DJ, Liu Y, Zhu J, Zhang Y, Wang L, Yan Q, Guo Y, Shao C, Huang G, Wang Z., Free PMC Article | 11/16/2013 |
| Overexpression of RSK3 or RSK4 supports tumor cell proliferation upon PI3K inhibition both in vitro and in vivo therby contributing to drug resistance. | RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer.
Serra V, Eichhorn PJ, García-García C, Ibrahim YH, Prudkin L, Sánchez G, Rodríguez O, Antón P, Parra JL, Marlow S, Scaltriti M, Pérez-Garcia J, Prat A, Arribas J, Hahn WC, Kim SY, Baselga J., Free PMC Article | 08/3/2013 |
| findings reveals a major role of PRKX, TTBK2 and RSK4 in triggering Sunitinib resistance formation; data suggest transcriptional regulation of these kinases together with other proteins might play an important role in formation of Sunitinib resistance by affecting transcription factors | PRKX, TTBK2 and RSK4 expression causes Sunitinib resistance in kidney carcinoma- and melanoma-cell lines.
Bender C, Ullrich A. | 11/24/2012 |
| Suggest that RSK4 may serve as a mediator of endothelial progenitor cell senescence in diabetes mellitus. | The possible role of ribosomal protein S6 kinase 4 in the senescence of endothelial progenitor cells in diabetes mellitus.
Yin Z, Fan L, Huang G, Wang H, Wang Z., Free PMC Article | 06/9/2012 |
| The expression level of RSK-4 mRNA in breast cancer was significantly lower than those in normal breast tissues and breast benign lesions tissues. The down-regulation of RSK-4 expression in breast caner suggests that it is a breast cancer suppressor gene. | [Abnormal expression of RSK-4 and its clinical significance in breast cancer].
Liu JL, Yang HW, Chen ZS, Jiang Y. | 05/26/2012 |
| A total of six novel and 11 known single nucleotide polymorphisms were identified. Further studies are warranted to analyze the candidate genes at Xq11.1-q21.33. | Fine mapping of Xq11.1-q21.33 and mutation screening of RPS6KA6, ZNF711, ACSL4, DLG3, and IL1RAPL2 for autism spectrum disorders (ASD).
Kantojärvi K, Kotala I, Rehnström K, Ylisaukko-Oja T, Vanhala R, von Wendt TN, von Wendt L, Järvelä I. | 12/10/2011 |
| Data indicate that RSK4 appears to be epigenetically silenced in endometrial cancer as evidenced by hypermethylation. | Aberrant methylation of the X-linked ribosomal S6 kinase RPS6KA6 (RSK4) in endometrial cancers.
Dewdney SB, Rimel BJ, Thaker PH, Thompson DM Jr, Schmidt A, Huettner P, Mutch DG, Gao F, Goodfellow PJ., Free PMC Article | 10/1/2011 |
| importance of RSK4 for regulating senescence and indicate that downregulation of this kinase could be an important element in facilitating cell transformation. | RSK4 inhibition results in bypass of stress-induced and oncogene-induced senescence.
López-Vicente L, Pons B, Coch L, Teixidó C, Hernández-Losa J, Armengol G, Ramon Y Cajal S. | 06/18/2011 |
| Results support the concept that RSK4 may be an important tumor suppressor gene by modulating senescence induction and contributing to cell proliferation control in colon carcinogenesis and renal cell carcinomas. | Regulation of replicative and stress-induced senescence by RSK4, which is down-regulated in human tumors.
López-Vicente L, Armengol G, Pons B, Coch L, Argelaguet E, Lleonart M, Hernández-Losa J, de Torres I, Ramon y Cajal S. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | X chromosomal variation is associated with slow progression to AIDS in HIV-1-infected women.
Siddiqui RA, Sauermann U, Altmüller J, Fritzer E, Nothnagel M, Dalibor N, Fellay J, Kaup FJ, Stahl-Hennig C, Nürnberg P, Krawczak M, Platzer M., Free PMC Article | 09/20/2009 |